DNA repair protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

DNA repair protein

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBY7_LEIMA

TriTrypDb:

LmjF.22.0070 , LMJLV39_220005700 , LMJSD75_220005800

Length:

289

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0000109	nucleotide-excision repair complex	3	2
GO:0000110	nucleotide-excision repair factor 1 complex	4	2
GO:0032991	protein-containing complex	1	2
GO:0070522	ERCC4-ERCC1 complex	4	2
GO:0140513	nuclear protein-containing complex	2	2
GO:0005634	nucleus	5	6
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043231	intracellular membrane-bounded organelle	4	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QBY7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBY7

Function

Biological processes
Term	Name	Level	Count
GO:0000710	meiotic mismatch repair	4	2
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006259	DNA metabolic process	4	8
GO:0006281	DNA repair	5	8
GO:0006296	obsolete nucleotide-excision repair, DNA incision, 5'-to lesion	7	2
GO:0006298	mismatch repair	6	2
GO:0006310	DNA recombination	5	2
GO:0006312	mitotic recombination	6	2
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0006950	response to stress	2	8
GO:0006974	DNA damage response	4	8
GO:0008152	metabolic process	1	8
GO:0009314	response to radiation	3	2
GO:0009411	response to UV	5	2
GO:0009416	response to light stimulus	4	2
GO:0009628	response to abiotic stimulus	2	2
GO:0009987	cellular process	1	8
GO:0022402	cell cycle process	2	2
GO:0022414	reproductive process	1	2
GO:0033554	cellular response to stress	3	8
GO:0033683	obsolete nucleotide-excision repair, DNA incision	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0034644	cellular response to UV	6	2
GO:0043170	macromolecule metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0046483	heterocycle metabolic process	3	8
GO:0050896	response to stimulus	1	8
GO:0051716	cellular response to stimulus	2	8
GO:0061982	meiosis I cell cycle process	3	2
GO:0070914	UV-damage excision repair	6	2
GO:0071214	cellular response to abiotic stimulus	3	2
GO:0071478	cellular response to radiation	4	2
GO:0071482	cellular response to light stimulus	5	2
GO:0071704	organic substance metabolic process	2	8
GO:0090304	nucleic acid metabolic process	4	8
GO:0090305	nucleic acid phosphodiester bond hydrolysis	5	2
GO:0104004	cellular response to environmental stimulus	3	2
GO:1901360	organic cyclic compound metabolic process	3	8
GO:1903046	meiotic cell cycle process	2	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003677	DNA binding	4	8
GO:0003684	damaged DNA binding	5	8
GO:0003697	single-stranded DNA binding	5	2
GO:0005488	binding	1	8
GO:0097159	organic cyclic compound binding	2	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	179	183	PF00656	0.524
CLV_NRD_NRD_1	175	177	PF00675	0.563
CLV_NRD_NRD_1	198	200	PF00675	0.642
CLV_NRD_NRD_1	24	26	PF00675	0.592
CLV_NRD_NRD_1	270	272	PF00675	0.635
CLV_PCSK_FUR_1	22	26	PF00082	0.570
CLV_PCSK_KEX2_1	24	26	PF00082	0.554
CLV_PCSK_KEX2_1	269	271	PF00082	0.647
DEG_Nend_UBRbox_3	1	3	PF02207	0.499
DEG_SCF_FBW7_1	208	215	PF00400	0.637
DOC_CKS1_1	209	214	PF01111	0.632
DOC_MAPK_gen_1	22	31	PF00069	0.583
DOC_MAPK_MEF2A_6	22	31	PF00069	0.566
DOC_MAPK_MEF2A_6	59	68	PF00069	0.597
DOC_MAPK_MEF2A_6	74	83	PF00069	0.421
DOC_PP1_RVXF_1	94	100	PF00149	0.491
DOC_PP4_FxxP_1	209	212	PF00568	0.615
DOC_USP7_MATH_1	132	136	PF00917	0.495
DOC_USP7_MATH_1	183	187	PF00917	0.516
DOC_USP7_MATH_1	238	242	PF00917	0.771
DOC_USP7_MATH_2	254	260	PF00917	0.625
DOC_WW_Pin1_4	158	163	PF00397	0.507
DOC_WW_Pin1_4	208	213	PF00397	0.624
LIG_14-3-3_CanoR_1	176	181	PF00244	0.621
LIG_14-3-3_CanoR_1	270	280	PF00244	0.536
LIG_14-3-3_CanoR_1	43	48	PF00244	0.315
LIG_14-3-3_CanoR_1	96	100	PF00244	0.531
LIG_BRCT_BRCA1_1	134	138	PF00533	0.609
LIG_FHA_1	1	7	PF00498	0.551
LIG_FHA_1	159	165	PF00498	0.469
LIG_FHA_1	16	22	PF00498	0.526
LIG_FHA_1	209	215	PF00498	0.588
LIG_FHA_1	253	259	PF00498	0.813
LIG_FHA_1	75	81	PF00498	0.527
LIG_FHA_2	132	138	PF00498	0.564
LIG_FHA_2	164	170	PF00498	0.446
LIG_LIR_Gen_1	98	107	PF02991	0.512
LIG_LIR_Nem_3	189	194	PF02991	0.553
LIG_LIR_Nem_3	98	102	PF02991	0.513
LIG_PCNA_yPIPBox_3	210	224	PF02747	0.617
LIG_Pex14_2	209	213	PF04695	0.525
LIG_SH2_STAT5	124	127	PF00017	0.480
LIG_SH2_STAT5	145	148	PF00017	0.506
LIG_SH2_STAT5	49	52	PF00017	0.451
LIG_SUMO_SIM_par_1	111	117	PF11976	0.543
LIG_SUMO_SIM_par_1	151	156	PF11976	0.377
LIG_SUMO_SIM_par_1	3	10	PF11976	0.466
LIG_WRC_WIRS_1	220	225	PF05994	0.669
MOD_CK1_1	186	192	PF00069	0.594
MOD_CK1_1	230	236	PF00069	0.738
MOD_CK1_1	241	247	PF00069	0.612
MOD_CK1_1	259	265	PF00069	0.722
MOD_CK1_1	42	48	PF00069	0.549
MOD_CK1_1	7	13	PF00069	0.485
MOD_CK2_1	131	137	PF00069	0.550
MOD_CK2_1	186	192	PF00069	0.511
MOD_CK2_1	85	91	PF00069	0.612
MOD_Cter_Amidation	197	200	PF01082	0.428
MOD_Cter_Amidation	267	270	PF01082	0.713
MOD_GlcNHglycan	273	276	PF01048	0.676
MOD_GlcNHglycan	53	56	PF01048	0.591
MOD_GSK3_1	132	139	PF00069	0.502
MOD_GSK3_1	208	215	PF00069	0.519
MOD_GSK3_1	224	231	PF00069	0.524
MOD_GSK3_1	244	251	PF00069	0.794
MOD_GSK3_1	252	259	PF00069	0.727
MOD_GSK3_1	39	46	PF00069	0.454
MOD_NEK2_1	136	141	PF00069	0.582
MOD_NEK2_1	213	218	PF00069	0.575
MOD_PIKK_1	15	21	PF00454	0.434
MOD_PIKK_1	156	162	PF00454	0.484
MOD_PIKK_1	213	219	PF00454	0.560
MOD_PIKK_1	241	247	PF00454	0.756
MOD_PIKK_1	74	80	PF00454	0.535
MOD_PK_1	176	182	PF00069	0.547
MOD_PK_1	43	49	PF00069	0.313
MOD_PKA_1	176	182	PF00069	0.535
MOD_PKA_2	175	181	PF00069	0.624
MOD_PKA_2	252	258	PF00069	0.770
MOD_PKA_2	42	48	PF00069	0.480
MOD_PKA_2	95	101	PF00069	0.542
MOD_PKB_1	269	277	PF00069	0.621
MOD_PKB_1	72	80	PF00069	0.543
MOD_Plk_1	90	96	PF00069	0.521
MOD_Plk_2-3	256	262	PF00069	0.725
MOD_Plk_4	219	225	PF00069	0.701
MOD_Plk_4	43	49	PF00069	0.539
MOD_Plk_4	60	66	PF00069	0.317
MOD_Plk_4	95	101	PF00069	0.496
MOD_ProDKin_1	158	164	PF00069	0.500
MOD_ProDKin_1	208	214	PF00069	0.629
TRG_ER_diArg_1	21	24	PF00400	0.477
TRG_ER_diArg_1	269	271	PF00400	0.666

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P2V1	Leptomonas seymouri	58%	100%
A0A1X0NUS6	Trypanosomatidae	29%	100%
A0A3Q8IC77	Leishmania donovani	92%	100%
A0A3S5IQI3	Trypanosoma rangeli	33%	100%
A4HC59	Leishmania braziliensis	78%	100%
E9AGY7	Leishmania infantum	93%	73%
E9AVJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%