Chromosome segregation protein SMC

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBY2_LEIMA

TriTrypDb:

LmjF.22.0120 , LMJLV39_220006300 , LMJSD75_220006400

Length:

244

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QBY2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBY2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.537
CLV_C14_Caspase3-7	211	215	PF00656	0.652
CLV_NRD_NRD_1	103	105	PF00675	0.353
CLV_NRD_NRD_1	198	200	PF00675	0.513
CLV_NRD_NRD_1	30	32	PF00675	0.580
CLV_NRD_NRD_1	84	86	PF00675	0.517
CLV_NRD_NRD_1	92	94	PF00675	0.469
CLV_PCSK_FUR_1	90	94	PF00082	0.591
CLV_PCSK_KEX2_1	103	105	PF00082	0.442
CLV_PCSK_KEX2_1	90	92	PF00082	0.482
CLV_PCSK_PC1ET2_1	103	105	PF00082	0.474
CLV_PCSK_SKI1_1	14	18	PF00082	0.525
CLV_PCSK_SKI1_1	200	204	PF00082	0.550
DEG_APCC_DBOX_1	30	38	PF00400	0.486
DEG_Nend_UBRbox_2	1	3	PF02207	0.646
DOC_USP7_MATH_1	240	244	PF00917	0.584
LIG_14-3-3_CanoR_1	125	130	PF00244	0.572
LIG_14-3-3_CanoR_1	168	176	PF00244	0.444
LIG_14-3-3_CanoR_1	31	35	PF00244	0.570
LIG_14-3-3_CanoR_1	56	66	PF00244	0.581
LIG_14-3-3_CterR_2	239	244	PF00244	0.548
LIG_Actin_WH2_2	225	241	PF00022	0.530
LIG_FHA_1	5	11	PF00498	0.533
LIG_FHA_1	78	84	PF00498	0.477
LIG_LIR_Gen_1	214	223	PF02991	0.598
LIG_LIR_Nem_3	214	219	PF02991	0.593
LIG_PDZ_Class_2	239	244	PF00595	0.528
LIG_RPA_C_Fungi	128	140	PF08784	0.555
LIG_SH2_STAP1	147	151	PF00017	0.371
LIG_TRAF2_1	208	211	PF00917	0.609
LIG_TRAF2_1	33	36	PF00917	0.503
LIG_WRC_WIRS_1	126	131	PF05994	0.543
MOD_CK1_1	167	173	PF00069	0.493
MOD_CK1_1	4	10	PF00069	0.563
MOD_CK2_1	129	135	PF00069	0.562
MOD_CK2_1	22	28	PF00069	0.571
MOD_CK2_1	30	36	PF00069	0.585
MOD_CK2_1	57	63	PF00069	0.546
MOD_GlcNHglycan	59	62	PF01048	0.576
MOD_GSK3_1	125	132	PF00069	0.570
MOD_GSK3_1	18	25	PF00069	0.573
MOD_GSK3_1	26	33	PF00069	0.581
MOD_GSK3_1	51	58	PF00069	0.552
MOD_N-GLC_1	18	23	PF02516	0.607
MOD_N-GLC_1	56	61	PF02516	0.559
MOD_NEK2_1	1	6	PF00069	0.556
MOD_NEK2_1	99	104	PF00069	0.553
MOD_PIKK_1	77	83	PF00454	0.618
MOD_PKA_2	124	130	PF00069	0.610
MOD_PKA_2	167	173	PF00069	0.524
MOD_PKA_2	30	36	PF00069	0.616
MOD_PKA_2	55	61	PF00069	0.576
MOD_PKB_1	123	131	PF00069	0.586
MOD_Plk_1	1	7	PF00069	0.635
MOD_Plk_2-3	22	28	PF00069	0.600
MOD_SUMO_for_1	76	79	PF00179	0.528
MOD_SUMO_rev_2	114	120	PF00179	0.536
MOD_SUMO_rev_2	154	163	PF00179	0.568
MOD_SUMO_rev_2	177	182	PF00179	0.487
MOD_SUMO_rev_2	205	215	PF00179	0.576
TRG_DiLeu_BaEn_1	95	100	PF01217	0.615
TRG_DiLeu_BaLyEn_6	136	141	PF01217	0.509
TRG_ER_diArg_1	90	93	PF00400	0.508
TRG_NLS_Bipartite_1	85	107	PF00514	0.532
TRG_Pf-PMV_PEXEL_1	233	237	PF00026	0.601
TRG_Pf-PMV_PEXEL_1	32	36	PF00026	0.586

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6U5	Leptomonas seymouri	74%	100%
A0A0S4JJT7	Bodo saltans	29%	98%
A0A1X0NT26	Trypanosomatidae	52%	100%
A0A3Q8IFD0	Leishmania donovani	95%	100%
A0A3R7M6L3	Trypanosoma rangeli	50%	100%
A4HC65	Leishmania braziliensis	87%	100%
C9ZSC9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	97%
E9AVJ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5AVS9	Trypanosoma cruzi	49%	80%