BAG domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBY1_LEIMA

TriTrypDb:

LmjF.22.0140 , LMJLV39_220006500 , LMJSD75_220006600

Length:

551

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBY1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBY1

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0005515	protein binding	2	8
GO:0051087	protein-folding chaperone binding	3	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	219	223	PF00656	0.632
CLV_C14_Caspase3-7	539	543	PF00656	0.476
CLV_MEL_PAP_1	2	8	PF00089	0.386
CLV_NRD_NRD_1	241	243	PF00675	0.760
CLV_NRD_NRD_1	391	393	PF00675	0.601
CLV_NRD_NRD_1	501	503	PF00675	0.280
CLV_NRD_NRD_1	529	531	PF00675	0.254
CLV_NRD_NRD_1	67	69	PF00675	0.371
CLV_NRD_NRD_1	84	86	PF00675	0.422
CLV_PCSK_FUR_1	527	531	PF00082	0.247
CLV_PCSK_FUR_1	82	86	PF00082	0.452
CLV_PCSK_KEX2_1	257	259	PF00082	0.783
CLV_PCSK_KEX2_1	390	392	PF00082	0.734
CLV_PCSK_KEX2_1	529	531	PF00082	0.247
CLV_PCSK_KEX2_1	82	84	PF00082	0.455
CLV_PCSK_PC1ET2_1	257	259	PF00082	0.783
CLV_PCSK_SKI1_1	132	136	PF00082	0.377
CLV_PCSK_SKI1_1	15	19	PF00082	0.377
CLV_PCSK_SKI1_1	287	291	PF00082	0.632
CLV_PCSK_SKI1_1	476	480	PF00082	0.276
CLV_PCSK_SKI1_1	511	515	PF00082	0.254
CLV_PCSK_SKI1_1	535	539	PF00082	0.286
CLV_Separin_Metazoa	508	512	PF03568	0.454
DEG_MDM2_SWIB_1	45	53	PF02201	0.412
DEG_Nend_Nbox_1	1	3	PF02207	0.414
DEG_SCF_FBW7_1	202	207	PF00400	0.553
DOC_CKS1_1	170	175	PF01111	0.449
DOC_CYCLIN_RxL_1	12	22	PF00134	0.374
DOC_CYCLIN_RxL_1	508	517	PF00134	0.454
DOC_MAPK_gen_1	111	120	PF00069	0.397
DOC_MAPK_gen_1	390	397	PF00069	0.615
DOC_MAPK_gen_1	68	76	PF00069	0.403
DOC_MAPK_HePTP_8	2	14	PF00069	0.370
DOC_MAPK_MEF2A_6	114	122	PF00069	0.404
DOC_MAPK_MEF2A_6	390	397	PF00069	0.579
DOC_MAPK_MEF2A_6	5	14	PF00069	0.358
DOC_MAPK_MEF2A_6	68	76	PF00069	0.403
DOC_MAPK_RevD_3	70	84	PF00069	0.425
DOC_PP1_RVXF_1	509	515	PF00149	0.454
DOC_PP2B_LxvP_1	120	123	PF13499	0.393
DOC_PP4_FxxP_1	206	209	PF00568	0.534
DOC_USP7_MATH_1	164	168	PF00917	0.376
DOC_USP7_MATH_1	215	219	PF00917	0.691
DOC_USP7_MATH_1	267	271	PF00917	0.600
DOC_USP7_MATH_1	323	327	PF00917	0.769
DOC_USP7_MATH_1	341	345	PF00917	0.664
DOC_USP7_MATH_1	349	353	PF00917	0.675
DOC_USP7_MATH_1	354	358	PF00917	0.708
DOC_USP7_MATH_1	376	380	PF00917	0.708
DOC_USP7_MATH_1	87	91	PF00917	0.448
DOC_USP7_UBL2_3	264	268	PF12436	0.685
DOC_USP7_UBL2_3	531	535	PF12436	0.521
DOC_WW_Pin1_4	169	174	PF00397	0.452
DOC_WW_Pin1_4	17	22	PF00397	0.390
DOC_WW_Pin1_4	200	205	PF00397	0.551
DOC_WW_Pin1_4	211	216	PF00397	0.618
DOC_WW_Pin1_4	242	247	PF00397	0.662
DOC_WW_Pin1_4	302	307	PF00397	0.678
DOC_WW_Pin1_4	335	340	PF00397	0.627
DOC_WW_Pin1_4	362	367	PF00397	0.740
DOC_WW_Pin1_4	445	450	PF00397	0.454
DOC_WW_Pin1_4	492	497	PF00397	0.367
LIG_14-3-3_CanoR_1	180	184	PF00244	0.641
LIG_14-3-3_CanoR_1	266	274	PF00244	0.648
LIG_14-3-3_CanoR_1	32	37	PF00244	0.400
LIG_14-3-3_CanoR_1	392	398	PF00244	0.453
LIG_14-3-3_CanoR_1	5	11	PF00244	0.363
LIG_14-3-3_CanoR_1	52	62	PF00244	0.345
LIG_14-3-3_CanoR_1	84	90	PF00244	0.451
LIG_BIR_III_4	542	546	PF00653	0.474
LIG_BRCT_BRCA1_1	56	60	PF00533	0.378
LIG_Clathr_ClatBox_1	479	483	PF01394	0.298
LIG_DCNL_PONY_1	1	4	PF03556	0.411
LIG_eIF4E_1	163	169	PF01652	0.469
LIG_FHA_1	115	121	PF00498	0.401
LIG_FHA_1	123	129	PF00498	0.371
LIG_FHA_1	143	149	PF00498	0.239
LIG_FHA_1	208	214	PF00498	0.613
LIG_FHA_1	258	264	PF00498	0.637
LIG_FHA_1	35	41	PF00498	0.386
LIG_FHA_1	514	520	PF00498	0.454
LIG_FHA_2	111	117	PF00498	0.507
LIG_FHA_2	170	176	PF00498	0.407
LIG_FHA_2	217	223	PF00498	0.631
LIG_GBD_Chelix_1	127	135	PF00786	0.426
LIG_LIR_Apic_2	203	209	PF02991	0.529
LIG_LIR_Gen_1	57	67	PF02991	0.362
LIG_LIR_Nem_3	162	168	PF02991	0.466
LIG_LIR_Nem_3	57	63	PF02991	0.369
LIG_LIR_Nem_3	95	101	PF02991	0.492
LIG_MYND_1	430	434	PF01753	0.495
LIG_NRBOX	13	19	PF00104	0.369
LIG_Pex14_2	45	49	PF04695	0.412
LIG_SH2_CRK	149	153	PF00017	0.454
LIG_SH2_NCK_1	236	240	PF00017	0.622
LIG_SH2_NCK_1	471	475	PF00017	0.379
LIG_SH2_STAP1	236	240	PF00017	0.622
LIG_SH2_STAP1	506	510	PF00017	0.454
LIG_SH2_STAT3	99	102	PF00017	0.557
LIG_SH2_STAT5	159	162	PF00017	0.416
LIG_SH2_STAT5	66	69	PF00017	0.371
LIG_SH3_3	182	188	PF00018	0.664
LIG_SH3_3	192	198	PF00018	0.715
LIG_SH3_3	298	304	PF00018	0.697
LIG_SH3_3	306	312	PF00018	0.655
LIG_SH3_3	360	366	PF00018	0.620
LIG_SH3_3	73	79	PF00018	0.427
LIG_SH3_4	433	440	PF00018	0.421
LIG_SUMO_SIM_anti_2	475	481	PF11976	0.430
LIG_SUMO_SIM_anti_2	483	490	PF11976	0.448
LIG_SUMO_SIM_par_1	15	20	PF11976	0.380
LIG_SUMO_SIM_par_1	478	485	PF11976	0.343
LIG_TRAF2_1	198	201	PF00917	0.522
LIG_TRAF2_2	356	361	PF00917	0.629
LIG_TYR_ITIM	147	152	PF00017	0.483
LIG_WRC_WIRS_1	131	136	PF05994	0.412
LIG_WW_3	183	187	PF00397	0.626
MOD_CDK_SPK_2	362	367	PF00069	0.725
MOD_CDK_SPxxK_3	445	452	PF00069	0.446
MOD_CK1_1	207	213	PF00069	0.778
MOD_CK1_1	26	32	PF00069	0.419
MOD_CK1_1	276	282	PF00069	0.737
MOD_CK1_1	357	363	PF00069	0.690
MOD_CK1_1	365	371	PF00069	0.676
MOD_CK1_1	416	422	PF00069	0.391
MOD_CK1_1	495	501	PF00069	0.521
MOD_CK1_1	54	60	PF00069	0.381
MOD_CK1_1	88	94	PF00069	0.557
MOD_CK2_1	110	116	PF00069	0.421
MOD_CK2_1	242	248	PF00069	0.669
MOD_GlcNHglycan	219	222	PF01048	0.626
MOD_GlcNHglycan	237	240	PF01048	0.588
MOD_GlcNHglycan	269	272	PF01048	0.739
MOD_GlcNHglycan	313	316	PF01048	0.781
MOD_GlcNHglycan	325	328	PF01048	0.685
MOD_GlcNHglycan	352	355	PF01048	0.622
MOD_GlcNHglycan	378	381	PF01048	0.692
MOD_GSK3_1	110	117	PF00069	0.465
MOD_GSK3_1	175	182	PF00069	0.570
MOD_GSK3_1	19	26	PF00069	0.406
MOD_GSK3_1	200	207	PF00069	0.601
MOD_GSK3_1	211	218	PF00069	0.646
MOD_GSK3_1	275	282	PF00069	0.696
MOD_GSK3_1	292	299	PF00069	0.686
MOD_GSK3_1	341	348	PF00069	0.637
MOD_GSK3_1	350	357	PF00069	0.638
MOD_GSK3_1	365	372	PF00069	0.622
MOD_GSK3_1	54	61	PF00069	0.378
MOD_GSK3_1	87	94	PF00069	0.578
MOD_N-GLC_1	258	263	PF02516	0.690
MOD_N-GLC_1	345	350	PF02516	0.783
MOD_NEK2_1	4	9	PF00069	0.371
MOD_NEK2_1	58	63	PF00069	0.365
MOD_PIKK_1	175	181	PF00454	0.596
MOD_PIKK_1	281	287	PF00454	0.635
MOD_PIKK_1	341	347	PF00454	0.766
MOD_PIKK_1	354	360	PF00454	0.565
MOD_PIKK_1	88	94	PF00454	0.486
MOD_PK_1	32	38	PF00069	0.398
MOD_PK_1	85	91	PF00069	0.448
MOD_PKA_1	257	263	PF00069	0.707
MOD_PKA_2	110	116	PF00069	0.441
MOD_PKA_2	179	185	PF00069	0.558
MOD_PKA_2	207	213	PF00069	0.782
MOD_PKA_2	257	263	PF00069	0.710
MOD_PKA_2	4	10	PF00069	0.370
MOD_PKA_2	51	57	PF00069	0.398
MOD_PKB_1	83	91	PF00069	0.449
MOD_Plk_1	155	161	PF00069	0.399
MOD_Plk_1	26	32	PF00069	0.419
MOD_Plk_1	414	420	PF00069	0.403
MOD_Plk_4	155	161	PF00069	0.402
MOD_Plk_4	164	170	PF00069	0.353
MOD_Plk_4	54	60	PF00069	0.381
MOD_Plk_4	94	100	PF00069	0.453
MOD_ProDKin_1	169	175	PF00069	0.459
MOD_ProDKin_1	17	23	PF00069	0.395
MOD_ProDKin_1	200	206	PF00069	0.553
MOD_ProDKin_1	211	217	PF00069	0.619
MOD_ProDKin_1	242	248	PF00069	0.666
MOD_ProDKin_1	302	308	PF00069	0.675
MOD_ProDKin_1	335	341	PF00069	0.624
MOD_ProDKin_1	362	368	PF00069	0.740
MOD_ProDKin_1	445	451	PF00069	0.448
MOD_ProDKin_1	492	498	PF00069	0.367
MOD_SUMO_rev_2	542	551	PF00179	0.642
TRG_DiLeu_BaEn_1	475	480	PF01217	0.433
TRG_DiLeu_BaEn_2	129	135	PF01217	0.430
TRG_DiLeu_BaEn_3	507	513	PF01217	0.454
TRG_DiLeu_BaLyEn_6	12	17	PF01217	0.360
TRG_DiLeu_BaLyEn_6	143	148	PF01217	0.460
TRG_ENDOCYTIC_2	149	152	PF00928	0.462
TRG_ENDOCYTIC_2	506	509	PF00928	0.470
TRG_ER_diArg_1	390	392	PF00400	0.650
TRG_ER_diArg_1	526	529	PF00400	0.447
TRG_ER_diArg_1	82	85	PF00400	0.455

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6G1	Leptomonas seymouri	48%	100%
A0A3Q8IB32	Leishmania donovani	91%	100%
A4HC67	Leishmania braziliensis	69%	100%
A4HZP2	Leishmania infantum	91%	100%
C9ZSD2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AVJ8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BK86	Trypanosoma cruzi	33%	100%