Zinc finger (CCCH type) motif-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBX9_LEIMA

TriTrypDb:

LmjF.22.0160 , LMJLV39_220006700 , LMJSD75_220006800

Length:

410

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QBX9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBX9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	10
GO:0043167	ion binding	2	10
GO:0043169	cation binding	3	10
GO:0046872	metal ion binding	4	10
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	202	206	PF00656	0.590
CLV_C14_Caspase3-7	344	348	PF00656	0.658
CLV_NRD_NRD_1	254	256	PF00675	0.325
DEG_Kelch_Keap1_1	191	196	PF01344	0.658
DOC_ANK_TNKS_1	271	278	PF00023	0.340
DOC_CKS1_1	139	144	PF01111	0.442
DOC_CYCLIN_yCln2_LP_2	84	90	PF00134	0.399
DOC_MAPK_MEF2A_6	215	222	PF00069	0.447
DOC_PP2B_LxvP_1	243	246	PF13499	0.508
DOC_PP2B_LxvP_1	84	87	PF13499	0.367
DOC_PP4_FxxP_1	139	142	PF00568	0.464
DOC_PP4_FxxP_1	303	306	PF00568	0.589
DOC_USP7_MATH_1	126	130	PF00917	0.443
DOC_USP7_MATH_1	188	192	PF00917	0.734
DOC_USP7_MATH_1	21	25	PF00917	0.623
DOC_USP7_MATH_1	275	279	PF00917	0.509
DOC_USP7_MATH_1	310	314	PF00917	0.613
DOC_USP7_MATH_1	365	369	PF00917	0.681
DOC_USP7_MATH_1	393	397	PF00917	0.672
DOC_USP7_MATH_1	403	407	PF00917	0.632
DOC_USP7_MATH_1	47	51	PF00917	0.647
DOC_USP7_MATH_1	69	73	PF00917	0.526
DOC_USP7_MATH_2	168	174	PF00917	0.531
DOC_WW_Pin1_4	138	143	PF00397	0.423
DOC_WW_Pin1_4	286	291	PF00397	0.607
DOC_WW_Pin1_4	53	58	PF00397	0.561
LIG_14-3-3_CanoR_1	292	297	PF00244	0.619
LIG_14-3-3_CanoR_1	394	402	PF00244	0.669
LIG_BIR_II_1	1	5	PF00653	0.629
LIG_FHA_1	13	19	PF00498	0.635
LIG_FHA_1	226	232	PF00498	0.338
LIG_FHA_2	200	206	PF00498	0.641
LIG_FHA_2	364	370	PF00498	0.676
LIG_FHA_2	87	93	PF00498	0.568
LIG_IBAR_NPY_1	400	402	PF08397	0.520
LIG_LIR_Apic_2	137	142	PF02991	0.519
LIG_LIR_Apic_2	302	306	PF02991	0.592
LIG_LIR_Gen_1	264	275	PF02991	0.290
LIG_LIR_Nem_3	264	270	PF02991	0.290
LIG_MYND_1	376	380	PF01753	0.589
LIG_SH2_NCK_1	325	329	PF00017	0.524
LIG_SH2_NCK_1	402	406	PF00017	0.627
LIG_SH2_SRC	402	405	PF00017	0.652
LIG_SH2_STAP1	3	7	PF00017	0.470
LIG_SH2_STAT5	3	6	PF00017	0.635
LIG_SH2_STAT5	67	70	PF00017	0.587
LIG_UBA3_1	241	249	PF00899	0.430
LIG_WW_3	166	170	PF00397	0.548
MOD_CDK_SPxK_1	286	292	PF00069	0.582
MOD_CK1_1	2	8	PF00069	0.666
MOD_CK1_1	208	214	PF00069	0.550
MOD_CK1_1	308	314	PF00069	0.701
MOD_CK1_1	38	44	PF00069	0.641
MOD_CK1_1	387	393	PF00069	0.779
MOD_CK1_1	72	78	PF00069	0.560
MOD_CK1_1	9	15	PF00069	0.617
MOD_CK2_1	126	132	PF00069	0.415
MOD_CK2_1	190	196	PF00069	0.657
MOD_CK2_1	230	236	PF00069	0.447
MOD_CK2_1	275	281	PF00069	0.580
MOD_CK2_1	363	369	PF00069	0.728
MOD_CK2_1	86	92	PF00069	0.359
MOD_GlcNHglycan	172	175	PF01048	0.690
MOD_GlcNHglycan	186	189	PF01048	0.624
MOD_GlcNHglycan	19	22	PF01048	0.591
MOD_GlcNHglycan	207	210	PF01048	0.599
MOD_GlcNHglycan	277	280	PF01048	0.583
MOD_GlcNHglycan	312	315	PF01048	0.683
MOD_GlcNHglycan	40	43	PF01048	0.668
MOD_GlcNHglycan	74	77	PF01048	0.442
MOD_GSK3_1	17	24	PF00069	0.552
MOD_GSK3_1	184	191	PF00069	0.649
MOD_GSK3_1	2	9	PF00069	0.656
MOD_GSK3_1	282	289	PF00069	0.684
MOD_GSK3_1	292	299	PF00069	0.666
MOD_GSK3_1	301	308	PF00069	0.632
MOD_GSK3_1	319	326	PF00069	0.672
MOD_GSK3_1	333	340	PF00069	0.696
MOD_GSK3_1	346	353	PF00069	0.625
MOD_GSK3_1	359	366	PF00069	0.702
MOD_GSK3_1	403	410	PF00069	0.559
MOD_GSK3_1	47	54	PF00069	0.650
MOD_GSK3_1	72	79	PF00069	0.429
MOD_GSK3_1	82	89	PF00069	0.496
MOD_N-GLC_1	184	189	PF02516	0.697
MOD_N-GLC_1	341	346	PF02516	0.596
MOD_N-GLC_2	224	226	PF02516	0.450
MOD_N-GLC_2	263	265	PF02516	0.375
MOD_NEK2_1	1	6	PF00069	0.699
MOD_NEK2_1	230	235	PF00069	0.491
MOD_NEK2_1	284	289	PF00069	0.767
MOD_NEK2_1	29	34	PF00069	0.565
MOD_NEK2_1	291	296	PF00069	0.723
MOD_NEK2_1	333	338	PF00069	0.631
MOD_NEK2_1	346	351	PF00069	0.700
MOD_NEK2_1	58	63	PF00069	0.502
MOD_PIKK_1	319	325	PF00454	0.634
MOD_PIKK_1	337	343	PF00454	0.641
MOD_PIKK_1	350	356	PF00454	0.559
MOD_PIKK_1	58	64	PF00454	0.535
MOD_PKA_2	291	297	PF00069	0.650
MOD_PKA_2	393	399	PF00069	0.685
MOD_PKA_2	47	53	PF00069	0.629
MOD_Plk_1	263	269	PF00069	0.405
MOD_Plk_1	403	409	PF00069	0.611
MOD_Plk_4	126	132	PF00069	0.509
MOD_Plk_4	263	269	PF00069	0.405
MOD_Plk_4	334	340	PF00069	0.697
MOD_Plk_4	341	347	PF00069	0.705
MOD_Plk_4	40	46	PF00069	0.656
MOD_ProDKin_1	138	144	PF00069	0.414
MOD_ProDKin_1	286	292	PF00069	0.609
MOD_ProDKin_1	53	59	PF00069	0.559
TRG_DiLeu_BaEn_1	40	45	PF01217	0.591
TRG_DiLeu_BaEn_1	98	103	PF01217	0.540
TRG_DiLeu_BaEn_3	236	242	PF01217	0.518
TRG_DiLeu_BaLyEn_6	373	378	PF01217	0.588
TRG_DiLeu_BaLyEn_6	54	59	PF01217	0.527
TRG_ER_diArg_1	45	48	PF00400	0.669
TRG_NES_CRM1_1	100	112	PF08389	0.378

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HY30	Leptomonas seymouri	57%	99%
A0A1X0NUJ7	Trypanosomatidae	36%	100%
A0A3R7MUT8	Trypanosoma rangeli	36%	100%
A0A3S7WWZ1	Leishmania donovani	94%	100%
A4HC69	Leishmania braziliensis	74%	100%
A4HZP4	Leishmania infantum	94%	100%
E9AVK0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5DBU7	Trypanosoma cruzi	37%	100%