RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBX6_LEIMA

TriTrypDb:

LmjF.22.0190 , LMJLV39_220007000 , LMJSD75_220007100

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QBX6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBX6

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0016567	protein ubiquitination	7	2
GO:0019538	protein metabolic process	3	2
GO:0032446	protein modification by small protein conjugation	6	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	17
GO:0043167	ion binding	2	17
GO:0043169	cation binding	3	17
GO:0046872	metal ion binding	4	17
GO:0003824	catalytic activity	1	2
GO:0004842	ubiquitin-protein transferase activity	4	2
GO:0005509	calcium ion binding	5	11
GO:0016740	transferase activity	2	2
GO:0019787	ubiquitin-like protein transferase activity	3	2
GO:0061630	ubiquitin protein ligase activity	5	2
GO:0061659	ubiquitin-like protein ligase activity	4	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	275	277	PF00675	0.353
CLV_NRD_NRD_1	354	356	PF00675	0.501
CLV_NRD_NRD_1	404	406	PF00675	0.461
CLV_PCSK_FUR_1	331	335	PF00082	0.285
CLV_PCSK_FUR_1	405	409	PF00082	0.331
CLV_PCSK_KEX2_1	275	277	PF00082	0.375
CLV_PCSK_KEX2_1	333	335	PF00082	0.366
CLV_PCSK_KEX2_1	353	355	PF00082	0.494
CLV_PCSK_KEX2_1	404	406	PF00082	0.338
CLV_PCSK_KEX2_1	407	409	PF00082	0.325
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.355
CLV_PCSK_PC1ET2_1	407	409	PF00082	0.338
CLV_PCSK_SKI1_1	247	251	PF00082	0.537
CLV_PCSK_SKI1_1	255	259	PF00082	0.524
CLV_PCSK_SKI1_1	333	337	PF00082	0.349
CLV_PCSK_SKI1_1	404	408	PF00082	0.346
CLV_PCSK_SKI1_1	63	67	PF00082	0.439
DOC_ANK_TNKS_1	38	45	PF00023	0.342
DOC_CKS1_1	58	63	PF01111	0.425
DOC_CYCLIN_RxL_1	330	340	PF00134	0.304
DOC_CYCLIN_yCln2_LP_2	144	150	PF00134	0.547
DOC_MAPK_gen_1	404	412	PF00069	0.330
DOC_PP1_RVXF_1	230	237	PF00149	0.472
DOC_PP1_RVXF_1	406	413	PF00149	0.328
DOC_PP4_FxxP_1	212	215	PF00568	0.352
DOC_PP4_FxxP_1	362	365	PF00568	0.427
DOC_PP4_FxxP_1	412	415	PF00568	0.359
DOC_USP7_MATH_1	130	134	PF00917	0.668
DOC_USP7_MATH_1	139	143	PF00917	0.579
DOC_USP7_MATH_1	363	367	PF00917	0.444
DOC_WW_Pin1_4	133	138	PF00397	0.666
DOC_WW_Pin1_4	152	157	PF00397	0.793
DOC_WW_Pin1_4	57	62	PF00397	0.414
LIG_14-3-3_CanoR_1	185	195	PF00244	0.544
LIG_14-3-3_CanoR_1	344	348	PF00244	0.388
LIG_BIR_II_1	1	5	PF00653	0.499
LIG_BRCT_BRCA1_1	260	264	PF00533	0.315
LIG_CaM_NSCaTE_8	184	191	PF13499	0.458
LIG_Clathr_ClatBox_1	298	302	PF01394	0.414
LIG_Clathr_ClatBox_1	306	310	PF01394	0.386
LIG_FHA_1	111	117	PF00498	0.422
LIG_FHA_1	23	29	PF00498	0.432
LIG_FHA_1	257	263	PF00498	0.358
LIG_FHA_1	377	383	PF00498	0.329
LIG_FHA_1	45	51	PF00498	0.429
LIG_FHA_1	8	14	PF00498	0.620
LIG_FHA_2	189	195	PF00498	0.409
LIG_FHA_2	427	433	PF00498	0.379
LIG_FHA_2	54	60	PF00498	0.354
LIG_FHA_2	82	88	PF00498	0.366
LIG_KLC1_Yacidic_2	120	124	PF13176	0.423
LIG_LIR_Apic_2	211	215	PF02991	0.351
LIG_LIR_Apic_2	359	365	PF02991	0.443
LIG_LIR_Apic_2	411	415	PF02991	0.332
LIG_LIR_Gen_1	261	272	PF02991	0.324
LIG_LIR_Gen_1	287	296	PF02991	0.495
LIG_LIR_Gen_1	326	336	PF02991	0.328
LIG_LIR_Gen_1	84	93	PF02991	0.432
LIG_LIR_Nem_3	199	205	PF02991	0.464
LIG_LIR_Nem_3	207	212	PF02991	0.436
LIG_LIR_Nem_3	261	267	PF02991	0.375
LIG_LIR_Nem_3	287	292	PF02991	0.452
LIG_LIR_Nem_3	326	332	PF02991	0.333
LIG_LIR_Nem_3	84	88	PF02991	0.334
LIG_LIR_Nem_3	90	96	PF02991	0.422
LIG_Pex14_1	81	85	PF04695	0.350
LIG_SH2_SRC	122	125	PF00017	0.356
LIG_SH2_STAP1	289	293	PF00017	0.444
LIG_SH2_STAT5	122	125	PF00017	0.445
LIG_SH2_STAT5	319	322	PF00017	0.398
LIG_SH2_STAT5	4	7	PF00017	0.348
LIG_SH2_STAT5	402	405	PF00017	0.347
LIG_SH3_3	211	217	PF00018	0.354
LIG_SH3_3	237	243	PF00018	0.333
LIG_SH3_3	442	448	PF00018	0.402
LIG_SUMO_SIM_par_1	25	32	PF11976	0.325
LIG_SUMO_SIM_par_1	297	302	PF11976	0.332
LIG_TRAF2_1	429	432	PF00917	0.387
LIG_WRC_WIRS_1	140	145	PF05994	0.514
MOD_CDK_SPxK_1	57	63	PF00069	0.425
MOD_CK1_1	133	139	PF00069	0.677
MOD_CK1_1	187	193	PF00069	0.492
MOD_CK1_1	346	352	PF00069	0.431
MOD_CK2_1	100	106	PF00069	0.628
MOD_CK2_1	195	201	PF00069	0.474
MOD_CK2_1	390	396	PF00069	0.362
MOD_CK2_1	426	432	PF00069	0.613
MOD_GlcNHglycan	124	128	PF01048	0.672
MOD_GlcNHglycan	131	135	PF01048	0.751
MOD_GlcNHglycan	349	352	PF01048	0.654
MOD_GlcNHglycan	365	368	PF01048	0.393
MOD_GlcNHglycan	76	79	PF01048	0.369
MOD_GSK3_1	184	191	PF00069	0.420
MOD_GSK3_1	343	350	PF00069	0.451
MOD_GSK3_1	431	438	PF00069	0.437
MOD_GSK3_1	53	60	PF00069	0.436
MOD_NEK2_1	123	128	PF00069	0.483
MOD_NEK2_1	188	193	PF00069	0.482
MOD_NEK2_1	258	263	PF00069	0.473
MOD_NEK2_1	347	352	PF00069	0.536
MOD_NEK2_1	358	363	PF00069	0.534
MOD_NEK2_1	421	426	PF00069	0.447
MOD_NEK2_1	435	440	PF00069	0.381
MOD_NEK2_1	69	74	PF00069	0.454
MOD_OFUCOSY	41	48	PF10250	0.345
MOD_PIKK_1	69	75	PF00454	0.345
MOD_PKA_2	184	190	PF00069	0.481
MOD_PKA_2	343	349	PF00069	0.388
MOD_Plk_1	358	364	PF00069	0.501
MOD_Plk_1	421	427	PF00069	0.452
MOD_Plk_1	431	437	PF00069	0.297
MOD_Plk_1	7	13	PF00069	0.461
MOD_Plk_4	139	145	PF00069	0.553
MOD_Plk_4	343	349	PF00069	0.415
MOD_Plk_4	431	437	PF00069	0.386
MOD_ProDKin_1	133	139	PF00069	0.664
MOD_ProDKin_1	152	158	PF00069	0.796
MOD_ProDKin_1	57	63	PF00069	0.425
MOD_SUMO_for_1	128	131	PF00179	0.517
MOD_SUMO_for_1	385	388	PF00179	0.342
MOD_SUMO_rev_2	100	110	PF00179	0.538
MOD_SUMO_rev_2	244	249	PF00179	0.340
TRG_DiLeu_BaEn_1	201	206	PF01217	0.461
TRG_DiLeu_BaEn_1	431	436	PF01217	0.373
TRG_DiLeu_BaLyEn_6	229	234	PF01217	0.311
TRG_DiLeu_BaLyEn_6	331	336	PF01217	0.379
TRG_DiLeu_BaLyEn_6	64	69	PF01217	0.438
TRG_ENDOCYTIC_2	202	205	PF00928	0.566
TRG_ENDOCYTIC_2	289	292	PF00928	0.433
TRG_ENDOCYTIC_2	85	88	PF00928	0.333
TRG_ER_diArg_1	353	355	PF00400	0.490
TRG_ER_diArg_1	403	405	PF00400	0.352
TRG_Pf-PMV_PEXEL_1	203	207	PF00026	0.355
TRG_Pf-PMV_PEXEL_1	247	251	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	313	317	PF00026	0.310

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILD7	Leptomonas seymouri	59%	99%
A0A1X0NTS2	Trypanosomatidae	34%	100%
A0A3Q8IMS6	Leishmania donovani	24%	100%
A0A3S5H5B1	Leishmania donovani	22%	76%
A0A3S7WWY0	Leishmania donovani	90%	100%
A0A3S7WYG1	Leishmania donovani	27%	100%
A4HS49	Leishmania infantum	22%	76%
A4HZP7	Leishmania infantum	90%	100%
A4I0X7	Leishmania infantum	25%	100%
A4I0X8	Leishmania infantum	27%	100%
E9AVK3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
E9AWY1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	25%	100%
E9AWY2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
O97201	Leishmania major	23%	76%
Q4QAJ2	Leishmania major	27%	100%
Q4QAJ3	Leishmania major	25%	100%