zf-Tim10_DDP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tim10/DDP family zinc finger, putative

Species:

Leishmania major

UniProt:

Q4QBW9_LEIMA

TriTrypDb:

LmjF.22.0270 , LMJLV39_220007700 , LMJSD75_220007800

Length:

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005743	mitochondrial inner membrane	5	2
GO:0016020	membrane	2	2
GO:0019866	organelle inner membrane	4	2
GO:0031090	organelle membrane	3	2
GO:0031966	mitochondrial membrane	4	2
GO:0032991	protein-containing complex	1	2
GO:0042719	mitochondrial intermembrane space protein transporter complex	3	2
GO:0098798	mitochondrial protein-containing complex	2	2
GO:0110165	cellular anatomical entity	1	2
GO:1990351	transporter complex	2	2

Expansion

Sequence features

Q4QBW9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBW9

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006839	mitochondrial transport	4	2
GO:0006886	intracellular protein transport	4	2
GO:0006996	organelle organization	4	2
GO:0007005	mitochondrion organization	5	2
GO:0007006	mitochondrial membrane organization	5	2
GO:0007007	inner mitochondrial membrane organization	6	2
GO:0008104	protein localization	4	2
GO:0009987	cellular process	1	2
GO:0015031	protein transport	4	2
GO:0016043	cellular component organization	3	2
GO:0033036	macromolecule localization	2	2
GO:0033365	protein localization to organelle	5	2
GO:0045039	protein insertion into mitochondrial inner membrane	6	2
GO:0045184	establishment of protein localization	3	2
GO:0046907	intracellular transport	3	2
GO:0051179	localization	1	2
GO:0051204	protein insertion into mitochondrial membrane	5	2
GO:0051205	protein insertion into membrane	5	2
GO:0051234	establishment of localization	2	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0051668	localization within membrane	3	2
GO:0061024	membrane organization	4	2
GO:0070585	protein localization to mitochondrion	6	2
GO:0070727	cellular macromolecule localization	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0072594	establishment of protein localization to organelle	4	2
GO:0072655	establishment of protein localization to mitochondrion	5	2
GO:0072657	protein localization to membrane	4	2
GO:0090150	establishment of protein localization to membrane	4	2
GO:0090151	establishment of protein localization to mitochondrial membrane	4	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	64	66	PF00675	0.541
DEG_Nend_UBRbox_3	1	3	PF02207	0.523
DOC_USP7_MATH_1	14	18	PF00917	0.231
DOC_USP7_UBL2_3	29	33	PF12436	0.304
LIG_14-3-3_CanoR_1	47	51	PF00244	0.360
LIG_EH1_1	9	17	PF00400	0.360
LIG_FHA_1	53	59	PF00498	0.360
LIG_FHA_2	36	42	PF00498	0.300
LIG_LIR_Nem_3	49	53	PF02991	0.360
LIG_Rb_LxCxE_1	21	41	PF01857	0.231
LIG_SH2_STAT5	52	55	PF00017	0.300
MOD_CK2_1	15	21	PF00069	0.381
MOD_CK2_1	35	41	PF00069	0.228
MOD_Cter_Amidation	70	73	PF01082	0.620
MOD_N-GLC_2	25	27	PF02516	0.416
MOD_NEK2_1	15	20	PF00069	0.361
MOD_PIKK_1	64	70	PF00454	0.576
MOD_PKA_2	46	52	PF00069	0.360
MOD_PKA_2	64	70	PF00069	0.498
MOD_SUMO_for_1	5	8	PF00179	0.421
MOD_SUMO_rev_2	60	67	PF00179	0.494
TRG_DiLeu_BaEn_4	21	27	PF01217	0.328
TRG_ER_diLys_1	72	75	PF00400	0.629

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCN4	Leptomonas seymouri	81%	100%
A0A3S7WX00	Leishmania donovani	97%	100%
A4HC77	Leishmania braziliensis	88%	100%
A4HZQ4	Leishmania infantum	97%	100%
C9ZSE6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	96%
E9AVL0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%