Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBW8_LEIMA

TriTrypDb:

LmjF.22.0275 , LMJLV39_220007800 , LMJSD75_220007900

Length:

134

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QBW8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBW8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.548
CLV_PCSK_KEX2_1	2	4	PF00082	0.548
CLV_PCSK_SKI1_1	10	14	PF00082	0.548
DEG_Nend_UBRbox_1	1	4	PF02207	0.556
DEG_ODPH_VHL_1	75	87	PF01847	0.565
DEG_SPOP_SBC_1	33	37	PF00917	0.633
DOC_CYCLIN_yCln2_LP_2	74	80	PF00134	0.577
DOC_MAPK_MEF2A_6	126	133	PF00069	0.486
DOC_PP1_RVXF_1	128	134	PF00149	0.490
DOC_PP2B_LxvP_1	74	77	PF13499	0.556
DOC_PP4_FxxP_1	28	31	PF00568	0.652
DOC_USP7_MATH_1	33	37	PF00917	0.613
DOC_USP7_MATH_1	67	71	PF00917	0.578
DOC_WW_Pin1_4	113	118	PF00397	0.680
DOC_WW_Pin1_4	19	24	PF00397	0.514
DOC_WW_Pin1_4	41	46	PF00397	0.562
LIG_14-3-3_CanoR_1	10	17	PF00244	0.511
LIG_14-3-3_CanoR_1	112	119	PF00244	0.645
LIG_14-3-3_CanoR_1	130	134	PF00244	0.709
LIG_14-3-3_CanoR_1	2	6	PF00244	0.541
LIG_Actin_WH2_2	116	132	PF00022	0.476
LIG_BRCT_BRCA1_1	115	119	PF00533	0.461
LIG_FHA_1	24	30	PF00498	0.548
LIG_LIR_Apic_2	26	31	PF02991	0.567
LIG_NRBOX	70	76	PF00104	0.600
LIG_NRBOX	87	93	PF00104	0.593
LIG_SH3_3	39	45	PF00018	0.620
MOD_GlcNHglycan	53	56	PF01048	0.557
MOD_GlcNHglycan	60	63	PF01048	0.566
MOD_GlcNHglycan	65	68	PF01048	0.539
MOD_GSK3_1	19	26	PF00069	0.525
MOD_GSK3_1	63	70	PF00069	0.597
MOD_GSK3_1	83	90	PF00069	0.583
MOD_N-GLC_1	95	100	PF02516	0.500
MOD_N-GLC_2	18	20	PF02516	0.537
MOD_NEK2_1	1	6	PF00069	0.545
MOD_NEK2_1	111	116	PF00069	0.629
MOD_NEK2_1	34	39	PF00069	0.621
MOD_NEK2_1	8	13	PF00069	0.501
MOD_NEK2_1	87	92	PF00069	0.578
MOD_OFUCOSY	93	100	PF10250	0.525
MOD_PIKK_1	10	16	PF00454	0.538
MOD_PIKK_1	69	75	PF00454	0.602
MOD_PKA_2	1	7	PF00069	0.548
MOD_PKA_2	111	117	PF00069	0.576
MOD_Plk_1	67	73	PF00069	0.617
MOD_Plk_4	87	93	PF00069	0.592
MOD_ProDKin_1	113	119	PF00069	0.683
MOD_ProDKin_1	19	25	PF00069	0.516
MOD_ProDKin_1	41	47	PF00069	0.562
TRG_ER_diArg_1	1	3	PF00400	0.566

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HX62	Leptomonas seymouri	67%	100%
A0A1X0NTL3	Trypanosomatidae	46%	100%
A0A3S7WWX1	Leishmania donovani	93%	100%
A0A422NSM5	Trypanosoma rangeli	43%	100%
A4HZQ5	Leishmania infantum	93%	100%
C9ZSE7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AIQ6	Leishmania braziliensis	69%	94%
E9AVL1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%