DUF3883 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBW7_LEIMA

TriTrypDb:

LmjF.22.0280 , LMJLV39_220007900 , LMJSD75_220008000

Length:

841

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBW7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBW7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	530	534	PF00656	0.572
CLV_C14_Caspase3-7	540	544	PF00656	0.482
CLV_C14_Caspase3-7	720	724	PF00656	0.513
CLV_C14_Caspase3-7	809	813	PF00656	0.644
CLV_NRD_NRD_1	37	39	PF00675	0.519
CLV_NRD_NRD_1	389	391	PF00675	0.457
CLV_NRD_NRD_1	58	60	PF00675	0.714
CLV_NRD_NRD_1	606	608	PF00675	0.740
CLV_NRD_NRD_1	650	652	PF00675	0.657
CLV_NRD_NRD_1	658	660	PF00675	0.569
CLV_NRD_NRD_1	662	664	PF00675	0.476
CLV_NRD_NRD_1	670	672	PF00675	0.481
CLV_NRD_NRD_1	795	797	PF00675	0.701
CLV_NRD_NRD_1	839	841	PF00675	0.540
CLV_PCSK_FUR_1	648	652	PF00082	0.553
CLV_PCSK_FUR_1	668	672	PF00082	0.404
CLV_PCSK_KEX2_1	232	234	PF00082	0.523
CLV_PCSK_KEX2_1	58	60	PF00082	0.714
CLV_PCSK_KEX2_1	606	608	PF00082	0.728
CLV_PCSK_KEX2_1	648	650	PF00082	0.675
CLV_PCSK_KEX2_1	658	660	PF00082	0.524
CLV_PCSK_KEX2_1	662	664	PF00082	0.390
CLV_PCSK_KEX2_1	670	672	PF00082	0.435
CLV_PCSK_KEX2_1	839	841	PF00082	0.540
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.380
CLV_PCSK_PC7_1	645	651	PF00082	0.484
CLV_PCSK_PC7_1	658	664	PF00082	0.401
CLV_PCSK_SKI1_1	108	112	PF00082	0.383
CLV_PCSK_SKI1_1	232	236	PF00082	0.372
CLV_PCSK_SKI1_1	254	258	PF00082	0.582
CLV_PCSK_SKI1_1	327	331	PF00082	0.520
CLV_PCSK_SKI1_1	390	394	PF00082	0.460
CLV_PCSK_SKI1_1	607	611	PF00082	0.587
CLV_PCSK_SKI1_1	61	65	PF00082	0.547
CLV_PCSK_SKI1_1	640	644	PF00082	0.526
CLV_PCSK_SKI1_1	663	667	PF00082	0.421
CLV_PCSK_SKI1_1	670	674	PF00082	0.403
CLV_PCSK_SKI1_1	735	739	PF00082	0.508
DEG_SPOP_SBC_1	536	540	PF00917	0.651
DOC_AGCK_PIF_2	673	678	PF00069	0.393
DOC_CKS1_1	563	568	PF01111	0.438
DOC_CYCLIN_RxL_1	102	114	PF00134	0.539
DOC_CYCLIN_RxL_1	58	68	PF00134	0.499
DOC_CYCLIN_RxL_1	667	677	PF00134	0.395
DOC_CYCLIN_yCln2_LP_2	225	231	PF00134	0.437
DOC_CYCLIN_yCln2_LP_2	573	579	PF00134	0.544
DOC_CYCLIN_yCln2_LP_2	9	15	PF00134	0.457
DOC_MAPK_DCC_7	221	231	PF00069	0.396
DOC_MAPK_DCC_7	353	362	PF00069	0.525
DOC_MAPK_gen_1	353	362	PF00069	0.485
DOC_MAPK_gen_1	452	461	PF00069	0.454
DOC_MAPK_gen_1	58	65	PF00069	0.585
DOC_MAPK_MEF2A_6	606	615	PF00069	0.549
DOC_PP1_RVXF_1	250	256	PF00149	0.400
DOC_PP2B_LxvP_1	786	789	PF13499	0.662
DOC_USP7_MATH_1	172	176	PF00917	0.505
DOC_USP7_MATH_1	18	22	PF00917	0.621
DOC_USP7_MATH_1	265	269	PF00917	0.606
DOC_USP7_MATH_1	278	282	PF00917	0.470
DOC_USP7_MATH_1	309	313	PF00917	0.474
DOC_USP7_MATH_1	544	548	PF00917	0.436
DOC_USP7_MATH_1	740	744	PF00917	0.477
DOC_USP7_MATH_1	835	839	PF00917	0.574
DOC_WW_Pin1_4	207	212	PF00397	0.445
DOC_WW_Pin1_4	224	229	PF00397	0.258
DOC_WW_Pin1_4	258	263	PF00397	0.603
DOC_WW_Pin1_4	26	31	PF00397	0.754
DOC_WW_Pin1_4	267	272	PF00397	0.764
DOC_WW_Pin1_4	343	348	PF00397	0.456
DOC_WW_Pin1_4	483	488	PF00397	0.427
DOC_WW_Pin1_4	532	537	PF00397	0.659
DOC_WW_Pin1_4	562	567	PF00397	0.422
DOC_WW_Pin1_4	601	606	PF00397	0.628
DOC_WW_Pin1_4	690	695	PF00397	0.520
DOC_WW_Pin1_4	8	13	PF00397	0.539
LIG_14-3-3_CanoR_1	221	226	PF00244	0.406
LIG_14-3-3_CanoR_1	267	271	PF00244	0.660
LIG_14-3-3_CanoR_1	367	376	PF00244	0.599
LIG_14-3-3_CanoR_1	43	52	PF00244	0.602
LIG_14-3-3_CanoR_1	444	448	PF00244	0.376
LIG_14-3-3_CanoR_1	650	660	PF00244	0.532
LIG_14-3-3_CanoR_1	86	91	PF00244	0.557
LIG_14-3-3_CterR_2	839	841	PF00244	0.581
LIG_Actin_WH2_2	430	446	PF00022	0.437
LIG_AP2alpha_2	801	803	PF02296	0.613
LIG_APCC_Cbox_2	101	107	PF00515	0.382
LIG_BIR_III_2	372	376	PF00653	0.496
LIG_BIR_III_2	533	537	PF00653	0.565
LIG_BIR_III_2	626	630	PF00653	0.476
LIG_BIR_III_4	304	308	PF00653	0.311
LIG_BRCT_BRCA1_1	202	206	PF00533	0.461
LIG_BRCT_BRCA1_1	552	556	PF00533	0.505
LIG_FHA_1	112	118	PF00498	0.445
LIG_FHA_1	178	184	PF00498	0.448
LIG_FHA_1	208	214	PF00498	0.568
LIG_FHA_1	259	265	PF00498	0.670
LIG_FHA_1	391	397	PF00498	0.498
LIG_FHA_1	46	52	PF00498	0.734
LIG_FHA_1	483	489	PF00498	0.420
LIG_FHA_1	549	555	PF00498	0.455
LIG_FHA_1	563	569	PF00498	0.345
LIG_FHA_1	725	731	PF00498	0.532
LIG_FHA_1	793	799	PF00498	0.684
LIG_FHA_2	210	216	PF00498	0.459
LIG_FHA_2	538	544	PF00498	0.507
LIG_FHA_2	755	761	PF00498	0.543
LIG_FHA_2	96	102	PF00498	0.434
LIG_GBD_Chelix_1	635	643	PF00786	0.383
LIG_HCF-1_HBM_1	561	564	PF13415	0.385
LIG_LIR_Apic_2	240	246	PF02991	0.427
LIG_LIR_Apic_2	293	298	PF02991	0.346
LIG_LIR_Gen_1	11	19	PF02991	0.558
LIG_LIR_Gen_1	150	158	PF02991	0.423
LIG_LIR_Gen_1	509	518	PF02991	0.463
LIG_LIR_Gen_1	801	811	PF02991	0.653
LIG_LIR_Nem_3	100	106	PF02991	0.438
LIG_LIR_Nem_3	11	17	PF02991	0.556
LIG_LIR_Nem_3	150	155	PF02991	0.467
LIG_LIR_Nem_3	432	438	PF02991	0.535
LIG_LIR_Nem_3	509	514	PF02991	0.461
LIG_LIR_Nem_3	525	529	PF02991	0.560
LIG_LIR_Nem_3	664	669	PF02991	0.376
LIG_LIR_Nem_3	677	681	PF02991	0.464
LIG_LIR_Nem_3	801	806	PF02991	0.625
LIG_MLH1_MIPbox_1	552	556	PF16413	0.505
LIG_NRBOX	106	112	PF00104	0.453
LIG_PTB_Apo_2	797	804	PF02174	0.651
LIG_REV1ctd_RIR_1	553	562	PF16727	0.523
LIG_REV1ctd_RIR_1	663	672	PF16727	0.369
LIG_SH2_CRK	14	18	PF00017	0.561
LIG_SH2_CRK	295	299	PF00017	0.463
LIG_SH2_CRK	669	673	PF00017	0.364
LIG_SH2_CRK	681	685	PF00017	0.435
LIG_SH2_NCK_1	238	242	PF00017	0.367
LIG_SH2_PTP2	771	774	PF00017	0.554
LIG_SH2_SRC	238	241	PF00017	0.428
LIG_SH2_STAP1	238	242	PF00017	0.367
LIG_SH2_STAP1	369	373	PF00017	0.537
LIG_SH2_STAP1	676	680	PF00017	0.532
LIG_SH2_STAP1	681	685	PF00017	0.532
LIG_SH2_STAT5	106	109	PF00017	0.456
LIG_SH2_STAT5	301	304	PF00017	0.445
LIG_SH2_STAT5	369	372	PF00017	0.563
LIG_SH2_STAT5	564	567	PF00017	0.500
LIG_SH2_STAT5	594	597	PF00017	0.636
LIG_SH2_STAT5	678	681	PF00017	0.435
LIG_SH2_STAT5	771	774	PF00017	0.438
LIG_SH3_1	796	802	PF00018	0.675
LIG_SH3_2	262	267	PF14604	0.583
LIG_SH3_2	605	610	PF14604	0.613
LIG_SH3_3	152	158	PF00018	0.461
LIG_SH3_3	259	265	PF00018	0.570
LIG_SH3_3	501	507	PF00018	0.440
LIG_SH3_3	592	598	PF00018	0.751
LIG_SH3_3	602	608	PF00018	0.671
LIG_SH3_3	627	633	PF00018	0.429
LIG_SH3_3	689	695	PF00018	0.561
LIG_SH3_3	796	802	PF00018	0.675
LIG_SUMO_SIM_anti_2	446	451	PF11976	0.385
LIG_SUMO_SIM_par_1	446	451	PF11976	0.426
LIG_SUMO_SIM_par_1	632	637	PF11976	0.468
LIG_TRAF2_1	528	531	PF00917	0.533
LIG_TRAF2_1	569	572	PF00917	0.527
LIG_TRAF2_2	334	339	PF00917	0.479
LIG_TYR_ITIM	433	438	PF00017	0.431
LIG_WRC_WIRS_1	545	550	PF05994	0.517
MOD_CDK_SPK_2	562	567	PF00069	0.483
MOD_CDK_SPK_2	601	606	PF00069	0.590
MOD_CDK_SPxK_1	601	607	PF00069	0.543
MOD_CDK_SPxxK_3	483	490	PF00069	0.507
MOD_CK1_1	166	172	PF00069	0.357
MOD_CK1_1	207	213	PF00069	0.490
MOD_CK1_1	224	230	PF00069	0.352
MOD_CK1_1	368	374	PF00069	0.526
MOD_CK1_1	378	384	PF00069	0.405
MOD_CK1_1	479	485	PF00069	0.474
MOD_CK1_1	717	723	PF00069	0.519
MOD_CK2_1	209	215	PF00069	0.449
MOD_CK2_1	544	550	PF00069	0.373
MOD_CK2_1	613	619	PF00069	0.518
MOD_Cter_Amidation	388	391	PF01082	0.454
MOD_DYRK1A_RPxSP_1	267	271	PF00069	0.519
MOD_GlcNHglycan	207	210	PF01048	0.601
MOD_GlcNHglycan	287	290	PF01048	0.536
MOD_GlcNHglycan	311	314	PF01048	0.509
MOD_GlcNHglycan	377	380	PF01048	0.499
MOD_GlcNHglycan	640	643	PF01048	0.539
MOD_GlcNHglycan	67	70	PF01048	0.651
MOD_GlcNHglycan	719	722	PF01048	0.496
MOD_GlcNHglycan	742	745	PF01048	0.561
MOD_GlcNHglycan	781	784	PF01048	0.727
MOD_GlcNHglycan	790	793	PF01048	0.597
MOD_GSK3_1	106	113	PF00069	0.501
MOD_GSK3_1	117	124	PF00069	0.356
MOD_GSK3_1	18	25	PF00069	0.738
MOD_GSK3_1	195	202	PF00069	0.565
MOD_GSK3_1	205	212	PF00069	0.435
MOD_GSK3_1	263	270	PF00069	0.779
MOD_GSK3_1	305	312	PF00069	0.562
MOD_GSK3_1	472	479	PF00069	0.547
MOD_GSK3_1	532	539	PF00069	0.633
MOD_GSK3_1	544	551	PF00069	0.502
MOD_GSK3_1	715	722	PF00069	0.607
MOD_GSK3_1	775	782	PF00069	0.632
MOD_GSK3_1	788	795	PF00069	0.704
MOD_GSK3_1	86	93	PF00069	0.672
MOD_N-GLC_1	166	171	PF02516	0.325
MOD_N-GLC_1	309	314	PF02516	0.481
MOD_N-GLC_1	762	767	PF02516	0.535
MOD_NEK2_1	110	115	PF00069	0.582
MOD_NEK2_1	195	200	PF00069	0.438
MOD_NEK2_1	204	209	PF00069	0.370
MOD_NEK2_1	285	290	PF00069	0.540
MOD_NEK2_1	311	316	PF00069	0.473
MOD_NEK2_1	44	49	PF00069	0.557
MOD_NEK2_1	443	448	PF00069	0.446
MOD_NEK2_1	461	466	PF00069	0.442
MOD_NEK2_1	499	504	PF00069	0.425
MOD_NEK2_1	522	527	PF00069	0.413
MOD_NEK2_1	548	553	PF00069	0.515
MOD_NEK2_1	65	70	PF00069	0.616
MOD_NEK2_1	715	720	PF00069	0.466
MOD_NEK2_1	72	77	PF00069	0.587
MOD_NEK2_1	764	769	PF00069	0.520
MOD_NEK2_1	81	86	PF00069	0.569
MOD_NEK2_1	94	99	PF00069	0.550
MOD_NEK2_2	579	584	PF00069	0.500
MOD_PIKK_1	195	201	PF00454	0.433
MOD_PIKK_1	290	296	PF00454	0.437
MOD_PIKK_1	715	721	PF00454	0.460
MOD_PIKK_1	754	760	PF00454	0.351
MOD_PK_1	86	92	PF00069	0.573
MOD_PKA_1	390	396	PF00069	0.454
MOD_PKA_2	111	117	PF00069	0.417
MOD_PKA_2	266	272	PF00069	0.546
MOD_PKA_2	44	50	PF00069	0.569
MOD_PKA_2	443	449	PF00069	0.426
MOD_PKA_2	701	707	PF00069	0.604
MOD_PKA_2	90	96	PF00069	0.667
MOD_PKB_1	43	51	PF00069	0.485
MOD_PKB_1	649	657	PF00069	0.474
MOD_Plk_1	166	172	PF00069	0.358
MOD_Plk_1	177	183	PF00069	0.330
MOD_Plk_1	461	467	PF00069	0.400
MOD_Plk_1	579	585	PF00069	0.572
MOD_Plk_2-3	319	325	PF00069	0.485
MOD_Plk_2-3	805	811	PF00069	0.564
MOD_Plk_4	121	127	PF00069	0.629
MOD_Plk_4	297	303	PF00069	0.349
MOD_Plk_4	311	317	PF00069	0.421
MOD_Plk_4	443	449	PF00069	0.396
MOD_Plk_4	544	550	PF00069	0.427
MOD_Plk_4	579	585	PF00069	0.524
MOD_Plk_4	764	770	PF00069	0.541
MOD_ProDKin_1	207	213	PF00069	0.437
MOD_ProDKin_1	224	230	PF00069	0.259
MOD_ProDKin_1	258	264	PF00069	0.606
MOD_ProDKin_1	26	32	PF00069	0.754
MOD_ProDKin_1	267	273	PF00069	0.764
MOD_ProDKin_1	343	349	PF00069	0.452
MOD_ProDKin_1	483	489	PF00069	0.422
MOD_ProDKin_1	532	538	PF00069	0.655
MOD_ProDKin_1	562	568	PF00069	0.425
MOD_ProDKin_1	601	607	PF00069	0.630
MOD_ProDKin_1	690	696	PF00069	0.531
MOD_ProDKin_1	8	14	PF00069	0.540
MOD_SUMO_for_1	609	612	PF00179	0.609
MOD_SUMO_rev_2	175	181	PF00179	0.406
MOD_SUMO_rev_2	808	816	PF00179	0.651
TRG_DiLeu_BaEn_1	619	624	PF01217	0.312
TRG_DiLeu_BaLyEn_6	350	355	PF01217	0.475
TRG_DiLeu_BaLyEn_6	356	361	PF01217	0.509
TRG_ENDOCYTIC_2	14	17	PF00928	0.564
TRG_ENDOCYTIC_2	238	241	PF00928	0.443
TRG_ENDOCYTIC_2	244	247	PF00928	0.469
TRG_ENDOCYTIC_2	435	438	PF00928	0.554
TRG_ENDOCYTIC_2	511	514	PF00928	0.508
TRG_ENDOCYTIC_2	526	529	PF00928	0.457
TRG_ENDOCYTIC_2	669	672	PF00928	0.420
TRG_ENDOCYTIC_2	676	679	PF00928	0.420
TRG_ENDOCYTIC_2	681	684	PF00928	0.424
TRG_ER_diArg_1	251	254	PF00400	0.506
TRG_ER_diArg_1	465	468	PF00400	0.403
TRG_ER_diArg_1	58	61	PF00400	0.684
TRG_ER_diArg_1	605	607	PF00400	0.685
TRG_ER_diArg_1	648	651	PF00400	0.677
TRG_ER_diArg_1	658	660	PF00400	0.516
TRG_ER_diArg_1	661	663	PF00400	0.392
TRG_ER_diArg_1	669	671	PF00400	0.476
TRG_NES_CRM1_1	451	462	PF08389	0.419
TRG_Pf-PMV_PEXEL_1	353	358	PF00026	0.571
TRG_Pf-PMV_PEXEL_1	390	394	PF00026	0.460
TRG_Pf-PMV_PEXEL_1	454	458	PF00026	0.340
TRG_Pf-PMV_PEXEL_1	497	501	PF00026	0.537
TRG_Pf-PMV_PEXEL_1	650	655	PF00026	0.504
TRG_Pf-PMV_PEXEL_1	728	733	PF00026	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3S2	Leptomonas seymouri	41%	94%
A0A3Q8IC86	Leishmania donovani	91%	100%
A0A422NSI7	Trypanosoma rangeli	26%	100%
A4HC78	Leishmania braziliensis	72%	100%
A4HZQ6	Leishmania infantum	91%	100%
C9ZSE8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AVL2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5BB53	Trypanosoma cruzi	27%	100%