Mitochondrial carrier protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial carrier protein, putative

Species:

Leishmania major

UniProt:

Q4QBW6_LEIMA

TriTrypDb:

LmjF.22.0290 , LMJLV39_220008000 , LMJSD75_220008100

Length:

464

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0016020	membrane	2	12
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QBW6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBW6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	243	247	PF00656	0.542
CLV_C14_Caspase3-7	387	391	PF00656	0.527
CLV_NRD_NRD_1	196	198	PF00675	0.403
CLV_NRD_NRD_1	374	376	PF00675	0.742
CLV_NRD_NRD_1	63	65	PF00675	0.425
CLV_PCSK_KEX2_1	196	198	PF00082	0.403
CLV_PCSK_KEX2_1	202	204	PF00082	0.454
CLV_PCSK_KEX2_1	374	376	PF00082	0.744
CLV_PCSK_KEX2_1	63	65	PF00082	0.436
CLV_PCSK_KEX2_1	70	72	PF00082	0.390
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.468
CLV_PCSK_PC1ET2_1	70	72	PF00082	0.522
CLV_PCSK_PC7_1	59	65	PF00082	0.420
CLV_PCSK_SKI1_1	154	158	PF00082	0.422
CLV_PCSK_SKI1_1	160	164	PF00082	0.382
CLV_PCSK_SKI1_1	202	206	PF00082	0.465
CLV_PCSK_SKI1_1	254	258	PF00082	0.550
CLV_PCSK_SKI1_1	9	13	PF00082	0.437
DEG_COP1_1	342	352	PF00400	0.668
DEG_SCF_FBW7_1	215	222	PF00400	0.538
DEG_SPOP_SBC_1	219	223	PF00917	0.436
DEG_SPOP_SBC_1	363	367	PF00917	0.733
DOC_ANK_TNKS_1	241	248	PF00023	0.546
DOC_CDC14_PxL_1	320	328	PF14671	0.463
DOC_CKS1_1	216	221	PF01111	0.605
DOC_CKS1_1	311	316	PF01111	0.538
DOC_CYCLIN_yCln2_LP_2	299	305	PF00134	0.514
DOC_MAPK_MEF2A_6	54	62	PF00069	0.420
DOC_PP1_RVXF_1	152	159	PF00149	0.449
DOC_PP1_RVXF_1	438	444	PF00149	0.454
DOC_PP1_RVXF_1	57	63	PF00149	0.420
DOC_PP4_FxxP_1	216	219	PF00568	0.563
DOC_PP4_FxxP_1	73	76	PF00568	0.414
DOC_USP7_MATH_1	129	133	PF00917	0.398
DOC_USP7_MATH_1	2	6	PF00917	0.586
DOC_USP7_MATH_1	230	234	PF00917	0.560
DOC_USP7_MATH_1	361	365	PF00917	0.650
DOC_WW_Pin1_4	115	120	PF00397	0.439
DOC_WW_Pin1_4	215	220	PF00397	0.576
DOC_WW_Pin1_4	222	227	PF00397	0.626
DOC_WW_Pin1_4	298	303	PF00397	0.365
DOC_WW_Pin1_4	310	315	PF00397	0.401
DOC_WW_Pin1_4	398	403	PF00397	0.552
LIG_14-3-3_CanoR_1	154	159	PF00244	0.475
LIG_14-3-3_CanoR_1	196	205	PF00244	0.500
LIG_14-3-3_CanoR_1	338	344	PF00244	0.579
LIG_APCC_ABBA_1	163	168	PF00400	0.396
LIG_BIR_II_1	1	5	PF00653	0.678
LIG_BRCT_BRCA1_1	299	303	PF00533	0.416
LIG_BRCT_BRCA1_1	92	96	PF00533	0.382
LIG_FHA_1	178	184	PF00498	0.388
LIG_FHA_1	263	269	PF00498	0.630
LIG_FHA_1	393	399	PF00498	0.516
LIG_GBD_Chelix_1	291	299	PF00786	0.514
LIG_LIR_Apic_2	308	314	PF02991	0.405
LIG_LIR_Gen_1	255	262	PF02991	0.468
LIG_LIR_Gen_1	300	311	PF02991	0.437
LIG_LIR_Gen_1	328	337	PF02991	0.487
LIG_LIR_LC3C_4	404	408	PF02991	0.348
LIG_LIR_Nem_3	13	19	PF02991	0.646
LIG_LIR_Nem_3	185	191	PF02991	0.356
LIG_LIR_Nem_3	199	204	PF02991	0.483
LIG_LIR_Nem_3	255	260	PF02991	0.467
LIG_LIR_Nem_3	300	306	PF02991	0.411
LIG_LIR_Nem_3	328	333	PF02991	0.448
LIG_LIR_Nem_3	74	80	PF02991	0.430
LIG_Pex14_1	201	205	PF04695	0.544
LIG_Pex14_2	175	179	PF04695	0.456
LIG_Pex14_2	329	333	PF04695	0.489
LIG_Pex14_2	73	77	PF04695	0.417
LIG_REV1ctd_RIR_1	172	180	PF16727	0.339
LIG_SH2_CRK	311	315	PF00017	0.409
LIG_SH2_CRK	86	90	PF00017	0.375
LIG_SH2_PTP2	322	325	PF00017	0.510
LIG_SH2_PTP2	57	60	PF00017	0.399
LIG_SH2_STAP1	330	334	PF00017	0.463
LIG_SH2_STAT3	453	456	PF00017	0.536
LIG_SH2_STAT5	305	308	PF00017	0.407
LIG_SH2_STAT5	322	325	PF00017	0.394
LIG_SH2_STAT5	330	333	PF00017	0.423
LIG_SH2_STAT5	335	338	PF00017	0.386
LIG_SH2_STAT5	343	346	PF00017	0.506
LIG_SH2_STAT5	453	456	PF00017	0.536
LIG_SH2_STAT5	458	461	PF00017	0.555
LIG_SH2_STAT5	57	60	PF00017	0.383
LIG_SH2_STAT5	94	97	PF00017	0.466
LIG_SH3_3	223	229	PF00018	0.711
LIG_TYR_ITIM	320	325	PF00017	0.484
LIG_TYR_ITIM	84	89	PF00017	0.529
LIG_WRC_WIRS_1	326	331	PF05994	0.421
MOD_CDK_SPxxK_3	398	405	PF00069	0.538
MOD_CK1_1	217	223	PF00069	0.651
MOD_CK1_1	297	303	PF00069	0.396
MOD_CK1_1	328	334	PF00069	0.490
MOD_CK1_1	362	368	PF00069	0.698
MOD_CK1_1	401	407	PF00069	0.492
MOD_CK1_1	41	47	PF00069	0.456
MOD_CK1_1	5	11	PF00069	0.630
MOD_CK2_1	247	253	PF00069	0.610
MOD_CK2_1	367	373	PF00069	0.765
MOD_CK2_1	7	13	PF00069	0.681
MOD_GlcNHglycan	198	201	PF01048	0.570
MOD_GlcNHglycan	232	235	PF01048	0.623
MOD_GlcNHglycan	249	252	PF01048	0.482
MOD_GlcNHglycan	253	257	PF01048	0.543
MOD_GlcNHglycan	33	36	PF01048	0.458
MOD_GlcNHglycan	359	362	PF01048	0.674
MOD_GlcNHglycan	369	372	PF01048	0.691
MOD_GlcNHglycan	380	383	PF01048	0.679
MOD_GlcNHglycan	4	7	PF01048	0.696
MOD_GlcNHglycan	40	43	PF01048	0.342
MOD_GlcNHglycan	9	12	PF01048	0.553
MOD_GSK3_1	1	8	PF00069	0.672
MOD_GSK3_1	154	161	PF00069	0.449
MOD_GSK3_1	214	221	PF00069	0.529
MOD_GSK3_1	230	237	PF00069	0.478
MOD_GSK3_1	294	301	PF00069	0.331
MOD_GSK3_1	357	364	PF00069	0.698
MOD_GSK3_1	392	399	PF00069	0.696
MOD_GSK3_1	423	430	PF00069	0.476
MOD_LATS_1	339	345	PF00433	0.560
MOD_N-GLC_1	262	267	PF02516	0.591
MOD_N-GLC_2	30	32	PF02516	0.544
MOD_NEK2_1	1	6	PF00069	0.682
MOD_NEK2_1	158	163	PF00069	0.377
MOD_NEK2_1	252	257	PF00069	0.706
MOD_NEK2_1	31	36	PF00069	0.446
MOD_NEK2_1	325	330	PF00069	0.402
MOD_NEK2_1	333	338	PF00069	0.389
MOD_NEK2_1	447	452	PF00069	0.454
MOD_NEK2_1	7	12	PF00069	0.566
MOD_NEK2_2	435	440	PF00069	0.416
MOD_NEK2_2	97	102	PF00069	0.415
MOD_PIKK_1	328	334	PF00454	0.507
MOD_PIKK_1	41	47	PF00454	0.484
MOD_PKA_1	196	202	PF00069	0.473
MOD_PKA_2	183	189	PF00069	0.385
MOD_PKA_2	196	202	PF00069	0.453
MOD_PKA_2	234	240	PF00069	0.684
MOD_PKA_2	396	402	PF00069	0.617
MOD_Plk_1	252	258	PF00069	0.671
MOD_Plk_1	262	268	PF00069	0.642
MOD_Plk_4	120	126	PF00069	0.423
MOD_Plk_4	154	160	PF00069	0.385
MOD_Plk_4	178	184	PF00069	0.404
MOD_Plk_4	294	300	PF00069	0.382
MOD_Plk_4	325	331	PF00069	0.431
MOD_Plk_4	447	453	PF00069	0.407
MOD_Plk_4	90	96	PF00069	0.382
MOD_ProDKin_1	115	121	PF00069	0.436
MOD_ProDKin_1	215	221	PF00069	0.584
MOD_ProDKin_1	222	228	PF00069	0.631
MOD_ProDKin_1	298	304	PF00069	0.368
MOD_ProDKin_1	310	316	PF00069	0.410
MOD_ProDKin_1	398	404	PF00069	0.542
MOD_SUMO_rev_2	253	262	PF00179	0.628
TRG_DiLeu_BaEn_1	168	173	PF01217	0.398
TRG_DiLeu_BaLyEn_6	321	326	PF01217	0.455
TRG_ENDOCYTIC_2	213	216	PF00928	0.483
TRG_ENDOCYTIC_2	322	325	PF00928	0.446
TRG_ENDOCYTIC_2	330	333	PF00928	0.433
TRG_ENDOCYTIC_2	57	60	PF00928	0.383
TRG_ENDOCYTIC_2	86	89	PF00928	0.375
TRG_ER_diArg_1	374	376	PF00400	0.734
TRG_ER_diArg_1	408	411	PF00400	0.399
TRG_ER_diArg_1	62	64	PF00400	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I563	Leptomonas seymouri	60%	100%
A0A0S4JRQ8	Bodo saltans	42%	100%
A0A1X0NUU2	Trypanosomatidae	46%	100%
A0A3Q8IC61	Leishmania donovani	92%	100%
A0A3R7L681	Trypanosoma rangeli	44%	100%
A4HC79	Leishmania braziliensis	76%	100%
A4HZQ7	Leishmania infantum	91%	100%
C9ZSF0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AVL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BK78	Trypanosoma cruzi	46%	100%