Carnitine palmitoyltransferase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

carnitine palmitoyltransferase-like protein

Species:

Leishmania major

UniProt:

Q4QBW4_LEIMA

TriTrypDb:

LmjF.22.0310 , LMJLV39_220008200 , LMJSD75_220008300

Length:

676

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QBW4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBW4

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	7
GO:0006629	lipid metabolic process	3	7
GO:0006631	fatty acid metabolic process	4	7
GO:0006635	fatty acid beta-oxidation	6	2
GO:0008152	metabolic process	1	7
GO:0009056	catabolic process	2	2
GO:0009062	fatty acid catabolic process	5	2
GO:0009987	cellular process	1	7
GO:0016042	lipid catabolic process	4	2
GO:0016054	organic acid catabolic process	4	2
GO:0019395	fatty acid oxidation	5	2
GO:0019752	carboxylic acid metabolic process	5	7
GO:0030258	lipid modification	4	2
GO:0032787	monocarboxylic acid metabolic process	6	7
GO:0034440	lipid oxidation	5	2
GO:0043436	oxoacid metabolic process	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044242	cellular lipid catabolic process	4	2
GO:0044248	cellular catabolic process	3	2
GO:0044255	cellular lipid metabolic process	3	7
GO:0044281	small molecule metabolic process	2	7
GO:0044282	small molecule catabolic process	3	2
GO:0046395	carboxylic acid catabolic process	5	2
GO:0071704	organic substance metabolic process	2	7
GO:0072329	monocarboxylic acid catabolic process	6	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0004095	carnitine O-palmitoyltransferase activity	7	8
GO:0008374	O-acyltransferase activity	5	8
GO:0016406	carnitine O-acyltransferase activity	6	8
GO:0016409	palmitoyltransferase activity	5	8
GO:0016416	O-palmitoyltransferase activity	6	8
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	275	279	PF00656	0.312
CLV_C14_Caspase3-7	352	356	PF00656	0.346
CLV_C14_Caspase3-7	401	405	PF00656	0.287
CLV_MEL_PAP_1	455	461	PF00089	0.213
CLV_NRD_NRD_1	112	114	PF00675	0.419
CLV_NRD_NRD_1	409	411	PF00675	0.401
CLV_NRD_NRD_1	427	429	PF00675	0.123
CLV_NRD_NRD_1	457	459	PF00675	0.322
CLV_NRD_NRD_1	516	518	PF00675	0.417
CLV_NRD_NRD_1	554	556	PF00675	0.187
CLV_PCSK_FUR_1	514	518	PF00082	0.376
CLV_PCSK_KEX2_1	112	114	PF00082	0.419
CLV_PCSK_KEX2_1	195	197	PF00082	0.436
CLV_PCSK_KEX2_1	409	411	PF00082	0.368
CLV_PCSK_KEX2_1	457	459	PF00082	0.324
CLV_PCSK_KEX2_1	516	518	PF00082	0.418
CLV_PCSK_KEX2_1	554	556	PF00082	0.246
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.422
CLV_PCSK_SKI1_1	136	140	PF00082	0.420
CLV_PCSK_SKI1_1	323	327	PF00082	0.387
DEG_APCC_DBOX_1	521	529	PF00400	0.187
DEG_Nend_UBRbox_3	1	3	PF02207	0.435
DEG_SCF_FBW7_2	479	484	PF00400	0.327
DEG_SPOP_SBC_1	651	655	PF00917	0.530
DOC_ANK_TNKS_1	14	21	PF00023	0.433
DOC_ANK_TNKS_1	185	192	PF00023	0.330
DOC_CKS1_1	216	221	PF01111	0.396
DOC_CKS1_1	46	51	PF01111	0.421
DOC_CKS1_1	83	88	PF01111	0.315
DOC_CYCLIN_yCln2_LP_2	357	363	PF00134	0.187
DOC_CYCLIN_yCln2_LP_2	64	70	PF00134	0.278
DOC_MAPK_gen_1	134	141	PF00069	0.405
DOC_MAPK_gen_1	457	468	PF00069	0.363
DOC_MAPK_gen_1	516	525	PF00069	0.377
DOC_MAPK_MEF2A_6	59	66	PF00069	0.488
DOC_PP1_RVXF_1	253	260	PF00149	0.396
DOC_PP1_RVXF_1	436	443	PF00149	0.268
DOC_PP2B_LxvP_1	64	67	PF13499	0.253
DOC_PP2B_LxvP_1	672	675	PF13499	0.371
DOC_USP7_MATH_1	119	123	PF00917	0.336
DOC_USP7_MATH_1	140	144	PF00917	0.396
DOC_USP7_MATH_1	398	402	PF00917	0.396
DOC_USP7_MATH_1	421	425	PF00917	0.415
DOC_USP7_MATH_1	652	656	PF00917	0.427
DOC_USP7_MATH_1	90	94	PF00917	0.388
DOC_WW_Pin1_4	215	220	PF00397	0.319
DOC_WW_Pin1_4	35	40	PF00397	0.632
DOC_WW_Pin1_4	359	364	PF00397	0.422
DOC_WW_Pin1_4	367	372	PF00397	0.361
DOC_WW_Pin1_4	45	50	PF00397	0.523
DOC_WW_Pin1_4	475	480	PF00397	0.325
DOC_WW_Pin1_4	640	645	PF00397	0.490
DOC_WW_Pin1_4	82	87	PF00397	0.284
LIG_14-3-3_CanoR_1	112	119	PF00244	0.362
LIG_14-3-3_CanoR_1	142	148	PF00244	0.449
LIG_14-3-3_CanoR_1	40	44	PF00244	0.434
LIG_14-3-3_CanoR_1	516	525	PF00244	0.342
LIG_14-3-3_CanoR_1	538	542	PF00244	0.343
LIG_14-3-3_CanoR_1	565	574	PF00244	0.426
LIG_14-3-3_CanoR_1	577	584	PF00244	0.280
LIG_14-3-3_CanoR_1	632	638	PF00244	0.406
LIG_Actin_WH2_2	279	296	PF00022	0.396
LIG_BRCT_BRCA1_1	125	129	PF00533	0.396
LIG_BRCT_BRCA1_1	168	172	PF00533	0.253
LIG_BRCT_BRCA1_1	201	205	PF00533	0.299
LIG_BRCT_BRCA1_1	216	220	PF00533	0.362
LIG_BRCT_BRCA1_1	529	533	PF00533	0.242
LIG_BRCT_BRCA1_1	654	658	PF00533	0.473
LIG_BRCT_BRCA1_2	168	174	PF00533	0.347
LIG_CtBP_PxDLS_1	231	235	PF00389	0.253
LIG_eIF4E_1	123	129	PF01652	0.396
LIG_FHA_1	119	125	PF00498	0.257
LIG_FHA_1	144	150	PF00498	0.347
LIG_FHA_1	206	212	PF00498	0.244
LIG_FHA_1	216	222	PF00498	0.271
LIG_FHA_1	322	328	PF00498	0.287
LIG_FHA_1	432	438	PF00498	0.253
LIG_FHA_1	454	460	PF00498	0.376
LIG_FHA_1	46	52	PF00498	0.394
LIG_FHA_1	478	484	PF00498	0.371
LIG_FHA_1	529	535	PF00498	0.322
LIG_FHA_2	273	279	PF00498	0.262
LIG_FHA_2	40	46	PF00498	0.557
LIG_FHA_2	524	530	PF00498	0.291
LIG_Integrin_RGD_1	391	393	PF01839	0.330
LIG_LIR_Apic_2	589	594	PF02991	0.347
LIG_LIR_Gen_1	235	241	PF02991	0.305
LIG_LIR_Gen_1	25	36	PF02991	0.483
LIG_LIR_Gen_1	287	297	PF02991	0.253
LIG_LIR_Gen_1	309	315	PF02991	0.332
LIG_LIR_Nem_3	169	175	PF02991	0.351
LIG_LIR_Nem_3	235	240	PF02991	0.305
LIG_LIR_Nem_3	25	31	PF02991	0.415
LIG_LIR_Nem_3	287	293	PF02991	0.253
LIG_LIR_Nem_3	309	314	PF02991	0.307
LIG_LIR_Nem_3	317	322	PF02991	0.220
LIG_MYND_1	49	53	PF01753	0.432
LIG_PCNA_yPIPBox_3	586	599	PF02747	0.252
LIG_Pex14_2	237	241	PF04695	0.369
LIG_Pex14_2	658	662	PF04695	0.441
LIG_PTB_Apo_2	410	417	PF02174	0.330
LIG_PTB_Phospho_1	410	416	PF10480	0.330
LIG_SH2_CRK	290	294	PF00017	0.253
LIG_SH2_CRK	550	554	PF00017	0.187
LIG_SH2_GRB2like	411	414	PF00017	0.330
LIG_SH2_STAT5	123	126	PF00017	0.268
LIG_SH2_STAT5	176	179	PF00017	0.253
LIG_SH2_STAT5	199	202	PF00017	0.318
LIG_SH2_STAT5	215	218	PF00017	0.384
LIG_SH2_STAT5	411	414	PF00017	0.253
LIG_SH2_STAT5	619	622	PF00017	0.265
LIG_SH2_STAT5	76	79	PF00017	0.253
LIG_SH3_1	59	65	PF00018	0.490
LIG_SH3_3	213	219	PF00018	0.406
LIG_SH3_3	225	231	PF00018	0.228
LIG_SH3_3	357	363	PF00018	0.351
LIG_SH3_3	59	65	PF00018	0.490
LIG_SH3_3	596	602	PF00018	0.330
LIG_SH3_3	638	644	PF00018	0.402
LIG_SUMO_SIM_par_1	282	288	PF11976	0.347
LIG_SUMO_SIM_par_1	471	478	PF11976	0.304
LIG_SUMO_SIM_par_1	593	601	PF11976	0.187
LIG_TRAF2_1	338	341	PF00917	0.377
LIG_TRAF2_1	42	45	PF00917	0.468
LIG_TRAF2_1	665	668	PF00917	0.477
LIG_TRFH_1	619	623	PF08558	0.330
MOD_CDK_SPK_2	35	40	PF00069	0.502
MOD_CDK_SPxxK_3	367	374	PF00069	0.396
MOD_CK1_1	122	128	PF00069	0.288
MOD_CK1_1	143	149	PF00069	0.375
MOD_CK1_1	309	315	PF00069	0.407
MOD_CK1_1	387	393	PF00069	0.438
MOD_CK1_1	397	403	PF00069	0.319
MOD_CK1_1	536	542	PF00069	0.314
MOD_CK1_1	564	570	PF00069	0.278
MOD_CK1_1	597	603	PF00069	0.281
MOD_CK1_1	654	660	PF00069	0.524
MOD_CK2_1	282	288	PF00069	0.330
MOD_CK2_1	39	45	PF00069	0.486
MOD_CK2_1	523	529	PF00069	0.291
MOD_CK2_1	537	543	PF00069	0.150
MOD_GlcNHglycan	136	139	PF01048	0.395
MOD_GlcNHglycan	161	164	PF01048	0.340
MOD_GlcNHglycan	196	199	PF01048	0.427
MOD_GlcNHglycan	24	27	PF01048	0.589
MOD_GlcNHglycan	396	399	PF01048	0.391
MOD_GlcNHglycan	654	657	PF01048	0.389
MOD_GlcNHglycan	668	672	PF01048	0.360
MOD_GlcNHglycan	92	95	PF01048	0.388
MOD_GSK3_1	118	125	PF00069	0.289
MOD_GSK3_1	194	201	PF00069	0.422
MOD_GSK3_1	35	42	PF00069	0.555
MOD_GSK3_1	380	387	PF00069	0.283
MOD_GSK3_1	394	401	PF00069	0.292
MOD_GSK3_1	453	460	PF00069	0.381
MOD_GSK3_1	47	54	PF00069	0.335
MOD_GSK3_1	523	530	PF00069	0.275
MOD_GSK3_1	533	540	PF00069	0.260
MOD_GSK3_1	561	568	PF00069	0.330
MOD_GSK3_1	622	629	PF00069	0.412
MOD_GSK3_1	640	647	PF00069	0.501
MOD_GSK3_1	650	657	PF00069	0.529
MOD_GSK3_1	88	95	PF00069	0.414
MOD_N-GLC_1	241	246	PF02516	0.267
MOD_NEK2_1	129	134	PF00069	0.381
MOD_NEK2_1	159	164	PF00069	0.292
MOD_NEK2_1	166	171	PF00069	0.246
MOD_NEK2_1	205	210	PF00069	0.273
MOD_NEK2_1	22	27	PF00069	0.610
MOD_NEK2_1	232	237	PF00069	0.235
MOD_NEK2_1	240	245	PF00069	0.259
MOD_NEK2_1	272	277	PF00069	0.396
MOD_NEK2_1	384	389	PF00069	0.341
MOD_NEK2_1	448	453	PF00069	0.350
MOD_NEK2_1	528	533	PF00069	0.408
MOD_NEK2_1	537	542	PF00069	0.453
MOD_NEK2_1	628	633	PF00069	0.396
MOD_NEK2_1	69	74	PF00069	0.402
MOD_NEK2_1	89	94	PF00069	0.332
MOD_NEK2_2	617	622	PF00069	0.265
MOD_OFUCOSY	624	630	PF10250	0.187
MOD_PIKK_1	232	238	PF00454	0.282
MOD_PIKK_1	541	547	PF00454	0.429
MOD_PK_1	369	375	PF00069	0.343
MOD_PK_1	382	388	PF00069	0.183
MOD_PKA_1	457	463	PF00069	0.278
MOD_PKA_2	111	117	PF00069	0.362
MOD_PKA_2	39	45	PF00069	0.550
MOD_PKA_2	453	459	PF00069	0.326
MOD_PKA_2	537	543	PF00069	0.402
MOD_PKA_2	564	570	PF00069	0.427
MOD_PKA_2	576	582	PF00069	0.357
MOD_Plk_1	129	135	PF00069	0.289
MOD_Plk_1	232	238	PF00069	0.278
MOD_Plk_1	241	247	PF00069	0.234
MOD_Plk_1	306	312	PF00069	0.348
MOD_Plk_1	339	345	PF00069	0.371
MOD_Plk_1	380	386	PF00069	0.253
MOD_Plk_1	398	404	PF00069	0.253
MOD_Plk_1	483	489	PF00069	0.396
MOD_Plk_1	528	534	PF00069	0.330
MOD_Plk_1	611	617	PF00069	0.265
MOD_Plk_1	667	673	PF00069	0.493
MOD_Plk_4	119	125	PF00069	0.262
MOD_Plk_4	306	312	PF00069	0.454
MOD_Plk_4	339	345	PF00069	0.380
MOD_Plk_4	47	53	PF00069	0.412
MOD_Plk_4	594	600	PF00069	0.364
MOD_Plk_4	633	639	PF00069	0.471
MOD_ProDKin_1	215	221	PF00069	0.319
MOD_ProDKin_1	35	41	PF00069	0.620
MOD_ProDKin_1	359	365	PF00069	0.422
MOD_ProDKin_1	367	373	PF00069	0.361
MOD_ProDKin_1	45	51	PF00069	0.523
MOD_ProDKin_1	475	481	PF00069	0.325
MOD_ProDKin_1	640	646	PF00069	0.506
MOD_ProDKin_1	82	88	PF00069	0.284
MOD_SUMO_rev_2	252	257	PF00179	0.353
TRG_DiLeu_BaEn_1	340	345	PF01217	0.415
TRG_DiLeu_BaEn_1	353	358	PF01217	0.459
TRG_DiLeu_BaEn_1	668	673	PF01217	0.380
TRG_DiLeu_BaEn_2	528	534	PF01217	0.330
TRG_ENDOCYTIC_2	290	293	PF00928	0.253
TRG_ENDOCYTIC_2	550	553	PF00928	0.187
TRG_ER_diArg_1	111	113	PF00400	0.418
TRG_ER_diArg_1	408	410	PF00400	0.408
TRG_ER_diArg_1	457	459	PF00400	0.278
TRG_ER_diArg_1	5	8	PF00400	0.532
TRG_ER_diArg_1	515	517	PF00400	0.328
TRG_ER_diArg_1	553	555	PF00400	0.187
TRG_Pf-PMV_PEXEL_1	410	414	PF00026	0.396

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK11	Leptomonas seymouri	61%	100%
A0A0S4JAG1	Bodo saltans	23%	93%
A0A0S4JRH6	Bodo saltans	37%	99%
A0A0S4JRL8	Bodo saltans	24%	84%
A0A0S4KE24	Bodo saltans	22%	82%
A0A1X0NT60	Trypanosomatidae	39%	99%
A0A1X0P523	Trypanosomatidae	21%	89%
A0A1X0P5Y2	Trypanosomatidae	27%	85%
A0A3S5IQT1	Trypanosoma rangeli	22%	90%
A0A3S7WX31	Leishmania donovani	92%	100%
A0A422NSK2	Trypanosoma rangeli	36%	100%
A4HC81	Leishmania braziliensis	82%	100%
A4HHE2	Leishmania braziliensis	23%	100%
A4HZQ9	Leishmania infantum	92%	100%
B2ZGJ1	Danio rerio	25%	100%
C9ZRI9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AVL5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
F1LN46	Rattus norvegicus	23%	84%
O19094	Bos taurus	25%	100%
P07668	Drosophila melanogaster	24%	94%
P11466	Rattus norvegicus	25%	100%
P13222	Sus scrofa	25%	100%
P18886	Rattus norvegicus	29%	100%
P23786	Homo sapiens	30%	100%
P28329	Homo sapiens	25%	90%
P32198	Rattus norvegicus	24%	87%
P32738	Rattus norvegicus	24%	100%
P43155	Homo sapiens	22%	100%
P47934	Mus musculus	22%	100%
P50416	Homo sapiens	24%	87%
P52825	Mus musculus	30%	100%
P52826	Columba livia	25%	100%
P80235	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	98%
P97742	Mus musculus	26%	87%
Q03059	Mus musculus	26%	100%
Q2KJB7	Bos taurus	29%	100%
Q58DK1	Bos taurus	23%	88%
Q5U3U3	Danio rerio	29%	100%
Q60HG9	Macaca fascicularis	30%	100%
Q63704	Rattus norvegicus	23%	88%
Q68Y62	Equus caballus	25%	87%
Q6P4X5	Xenopus tropicalis	28%	100%
Q704S8	Rattus norvegicus	23%	100%
Q7ZXE1	Xenopus laevis	29%	100%
Q8BGD5	Mus musculus	23%	85%
Q8HY46	Sus scrofa	23%	88%
Q8TCG5	Homo sapiens	25%	84%
Q90YJ9	Gallus gallus	25%	100%
Q924X2	Mus musculus	23%	88%
Q92523	Homo sapiens	24%	88%
Q9DC50	Mus musculus	26%	100%
Q9UKG9	Homo sapiens	24%	100%
V5BQH8	Trypanosoma cruzi	22%	85%
V5DBT5	Trypanosoma cruzi	39%	100%