SEP domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

SEP domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QBW3_LEIMA

TriTrypDb:

LmjF.22.0320 , LMJLV39_220008300 , LMJSD75_220008400

Length:

357

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005829	cytosol	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QBW3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBW3

Function

Biological processes
Term	Name	Level	Count
GO:0000045	autophagosome assembly	6	2
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006996	organelle organization	4	2
GO:0007030	Golgi organization	5	2
GO:0007033	vacuole organization	5	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0010498	proteasomal protein catabolic process	5	2
GO:0016043	cellular component organization	3	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0022607	cellular component assembly	4	2
GO:0030163	protein catabolic process	4	2
GO:0031468	nuclear membrane reassembly	6	2
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0061024	membrane organization	4	2
GO:0061025	membrane fusion	5	2
GO:0070925	organelle assembly	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0071709	membrane assembly	5	2
GO:0071763	nuclear membrane organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2
GO:1905037	autophagosome organization	6	2

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0032182	ubiquitin-like protein binding	3	2
GO:0043130	ubiquitin binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	116	120	PF00656	0.695
CLV_C14_Caspase3-7	26	30	PF00656	0.582
CLV_C14_Caspase3-7	56	60	PF00656	0.464
CLV_NRD_NRD_1	105	107	PF00675	0.579
CLV_NRD_NRD_1	292	294	PF00675	0.490
CLV_NRD_NRD_1	331	333	PF00675	0.566
CLV_PCSK_KEX2_1	292	294	PF00082	0.561
CLV_PCSK_KEX2_1	331	333	PF00082	0.540
CLV_PCSK_SKI1_1	31	35	PF00082	0.534
DEG_Nend_UBRbox_2	1	3	PF02207	0.695
DEG_SPOP_SBC_1	237	241	PF00917	0.626
DOC_ANK_TNKS_1	3	10	PF00023	0.431
DOC_MAPK_gen_1	154	163	PF00069	0.448
DOC_MAPK_gen_1	19	27	PF00069	0.544
DOC_MAPK_gen_1	289	297	PF00069	0.605
DOC_MAPK_gen_1	346	354	PF00069	0.495
DOC_MAPK_MEF2A_6	154	163	PF00069	0.447
DOC_MAPK_MEF2A_6	19	27	PF00069	0.566
DOC_PP2B_LxvP_1	235	238	PF13499	0.691
DOC_USP7_MATH_1	113	117	PF00917	0.722
DOC_USP7_MATH_1	155	159	PF00917	0.572
DOC_USP7_MATH_1	177	181	PF00917	0.499
DOC_USP7_MATH_1	236	240	PF00917	0.623
DOC_USP7_MATH_1	242	246	PF00917	0.633
DOC_USP7_MATH_1	258	262	PF00917	0.555
DOC_USP7_MATH_1	92	96	PF00917	0.569
DOC_WW_Pin1_4	143	148	PF00397	0.495
DOC_WW_Pin1_4	251	256	PF00397	0.677
DOC_WW_Pin1_4	260	265	PF00397	0.660
LIG_14-3-3_CanoR_1	13	19	PF00244	0.348
LIG_14-3-3_CanoR_1	138	148	PF00244	0.520
LIG_14-3-3_CanoR_1	301	305	PF00244	0.418
LIG_APCC_ABBA_1	161	166	PF00400	0.426
LIG_BRCT_BRCA1_1	171	175	PF00533	0.549
LIG_CaM_NSCaTE_8	39	46	PF13499	0.559
LIG_CtBP_PxDLS_1	196	200	PF00389	0.560
LIG_FHA_1	207	213	PF00498	0.536
LIG_FHA_1	269	275	PF00498	0.564
LIG_FHA_1	278	284	PF00498	0.490
LIG_FHA_2	24	30	PF00498	0.548
LIG_FHA_2	286	292	PF00498	0.519
LIG_FHA_2	301	307	PF00498	0.311
LIG_FHA_2	54	60	PF00498	0.462
LIG_LIR_Apic_2	191	197	PF02991	0.560
LIG_LIR_Apic_2	219	223	PF02991	0.518
LIG_LIR_Gen_1	224	231	PF02991	0.398
LIG_LIR_Gen_1	280	286	PF02991	0.513
LIG_LIR_Nem_3	10	15	PF02991	0.577
LIG_LIR_Nem_3	172	178	PF02991	0.499
LIG_LIR_Nem_3	20	25	PF02991	0.561
LIG_LIR_Nem_3	224	228	PF02991	0.529
LIG_LIR_Nem_3	280	285	PF02991	0.513
LIG_PCNA_yPIPBox_3	315	326	PF02747	0.514
LIG_SH2_PTP2	194	197	PF00017	0.515
LIG_SH2_PTP2	220	223	PF00017	0.515
LIG_SH2_SRC	194	197	PF00017	0.515
LIG_SH2_SRC	220	223	PF00017	0.515
LIG_SH2_SRC	266	269	PF00017	0.582
LIG_SH2_STAT5	141	144	PF00017	0.580
LIG_SH2_STAT5	148	151	PF00017	0.596
LIG_SH2_STAT5	194	197	PF00017	0.535
LIG_SH2_STAT5	220	223	PF00017	0.512
LIG_SH2_STAT5	225	228	PF00017	0.521
LIG_SH2_STAT5	63	66	PF00017	0.547
LIG_SH3_3	73	79	PF00018	0.607
LIG_SUMO_SIM_anti_2	280	288	PF11976	0.449
LIG_SUMO_SIM_par_1	269	278	PF11976	0.635
LIG_SUMO_SIM_par_1	280	288	PF11976	0.512
LIG_UBA3_1	100	107	PF00899	0.544
LIG_WW_1	222	225	PF00397	0.516
LIG_WW_3	328	332	PF00397	0.481
MOD_CK1_1	14	20	PF00069	0.510
MOD_CK1_1	254	260	PF00069	0.729
MOD_CK1_1	336	342	PF00069	0.519
MOD_CK1_1	80	86	PF00069	0.703
MOD_CK2_1	119	125	PF00069	0.733
MOD_CK2_1	285	291	PF00069	0.547
MOD_DYRK1A_RPxSP_1	260	264	PF00069	0.553
MOD_GlcNHglycan	115	118	PF01048	0.685
MOD_GlcNHglycan	121	124	PF01048	0.690
MOD_GlcNHglycan	244	247	PF01048	0.694
MOD_GlcNHglycan	260	263	PF01048	0.592
MOD_GlcNHglycan	59	62	PF01048	0.564
MOD_GlcNHglycan	71	74	PF01048	0.511
MOD_GlcNHglycan	79	82	PF01048	0.517
MOD_GlcNHglycan	86	90	PF01048	0.622
MOD_GlcNHglycan	92	95	PF01048	0.604
MOD_GSK3_1	139	146	PF00069	0.490
MOD_GSK3_1	155	162	PF00069	0.363
MOD_GSK3_1	237	244	PF00069	0.582
MOD_GSK3_1	254	261	PF00069	0.616
MOD_GSK3_1	273	280	PF00069	0.525
MOD_GSK3_1	334	341	PF00069	0.557
MOD_GSK3_1	53	60	PF00069	0.554
MOD_GSK3_1	92	99	PF00069	0.573
MOD_NEK2_1	139	144	PF00069	0.499
MOD_NEK2_1	285	290	PF00069	0.543
MOD_NEK2_1	333	338	PF00069	0.593
MOD_PIKK_1	336	342	PF00454	0.495
MOD_PK_1	11	17	PF00069	0.563
MOD_PKA_2	300	306	PF00069	0.427
MOD_Plk_1	155	161	PF00069	0.420
MOD_Plk_1	206	212	PF00069	0.498
MOD_Plk_1	277	283	PF00069	0.562
MOD_Plk_2-3	273	279	PF00069	0.620
MOD_Plk_2-3	300	306	PF00069	0.573
MOD_Plk_4	221	227	PF00069	0.531
MOD_Plk_4	278	284	PF00069	0.539
MOD_Plk_4	96	102	PF00069	0.460
MOD_ProDKin_1	143	149	PF00069	0.497
MOD_ProDKin_1	251	257	PF00069	0.680
MOD_ProDKin_1	260	266	PF00069	0.644
TRG_DiLeu_BaEn_2	181	187	PF01217	0.541
TRG_DiLeu_BaEn_2	277	283	PF01217	0.551
TRG_DiLeu_BaEn_2	316	322	PF01217	0.547
TRG_ENDOCYTIC_2	225	228	PF00928	0.516
TRG_ER_diArg_1	18	21	PF00400	0.530
TRG_ER_diArg_1	330	332	PF00400	0.587
TRG_NES_CRM1_1	207	219	PF08389	0.541
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.532

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P591	Leptomonas seymouri	67%	100%
A0A0S4JV00	Bodo saltans	34%	96%
A0A1X0NTT3	Trypanosomatidae	39%	100%
A0A3Q8IAL1	Leishmania donovani	93%	100%
A0A422NSS0	Trypanosoma rangeli	37%	100%
A4HC82	Leishmania braziliensis	78%	83%
A4HZR0	Leishmania infantum	94%	100%
C9ZRJ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AVL6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O35987	Rattus norvegicus	24%	96%
P0C627	Rattus norvegicus	21%	100%
Q0KL01	Mus musculus	23%	100%
Q14CS0	Homo sapiens	21%	100%
Q3SZC4	Bos taurus	24%	96%
Q5RBG3	Pongo abelii	26%	96%
Q5ZK10	Gallus gallus	26%	97%
Q9CZ44	Mus musculus	24%	96%
Q9N2W5	Caenorhabditis elegans	21%	100%
Q9SUG6	Arabidopsis thaliana	25%	100%
Q9UNZ2	Homo sapiens	26%	96%
V5AVR5	Trypanosoma cruzi	39%	100%