Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBV9_LEIMA

TriTrypDb:

LmjF.22.0360 , LMJLV39_220008800 , LMJSD75_220008900

Length:

343

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBV9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBV9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	145	147	PF00675	0.614
CLV_NRD_NRD_1	157	159	PF00675	0.454
CLV_NRD_NRD_1	187	189	PF00675	0.549
CLV_NRD_NRD_1	292	294	PF00675	0.807
CLV_NRD_NRD_1	93	95	PF00675	0.523
CLV_PCSK_KEX2_1	144	146	PF00082	0.612
CLV_PCSK_KEX2_1	157	159	PF00082	0.466
CLV_PCSK_KEX2_1	187	189	PF00082	0.549
CLV_PCSK_KEX2_1	269	271	PF00082	0.682
CLV_PCSK_KEX2_1	292	294	PF00082	0.807
CLV_PCSK_KEX2_1	93	95	PF00082	0.523
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.585
CLV_PCSK_PC1ET2_1	269	271	PF00082	0.682
CLV_PCSK_PC7_1	265	271	PF00082	0.662
CLV_PCSK_SKI1_1	174	178	PF00082	0.599
CLV_PCSK_SKI1_1	188	192	PF00082	0.513
CLV_PCSK_SKI1_1	77	81	PF00082	0.633
CLV_Separin_Metazoa	53	57	PF03568	0.603
DEG_APCC_DBOX_1	156	164	PF00400	0.627
DEG_APCC_DBOX_1	55	63	PF00400	0.578
DOC_CYCLIN_RxL_1	72	83	PF00134	0.626
DOC_MAPK_gen_1	157	163	PF00069	0.439
DOC_MAPK_gen_1	306	314	PF00069	0.653
DOC_MAPK_gen_1	72	81	PF00069	0.456
DOC_MAPK_gen_1	93	101	PF00069	0.520
DOC_USP7_MATH_1	211	215	PF00917	0.736
DOC_USP7_MATH_1	231	235	PF00917	0.439
DOC_USP7_MATH_1	274	278	PF00917	0.580
DOC_USP7_UBL2_3	228	232	PF12436	0.753
DOC_WW_Pin1_4	293	298	PF00397	0.725
DOC_WW_Pin1_4	46	51	PF00397	0.627
LIG_14-3-3_CanoR_1	157	161	PF00244	0.455
LIG_14-3-3_CanoR_1	16	24	PF00244	0.719
LIG_14-3-3_CanoR_1	187	191	PF00244	0.539
LIG_14-3-3_CanoR_1	282	290	PF00244	0.793
LIG_14-3-3_CanoR_1	292	300	PF00244	0.637
LIG_14-3-3_CanoR_1	75	80	PF00244	0.538
LIG_Actin_WH2_2	52	69	PF00022	0.581
LIG_APCC_ABBAyCdc20_2	188	194	PF00400	0.628
LIG_FHA_1	24	30	PF00498	0.694
LIG_FHA_1	262	268	PF00498	0.558
LIG_FHA_1	49	55	PF00498	0.626
LIG_FHA_1	76	82	PF00498	0.634
LIG_FHA_2	136	142	PF00498	0.620
LIG_FHA_2	34	40	PF00498	0.571
LIG_LIR_Gen_1	206	215	PF02991	0.634
LIG_LIR_Nem_3	175	180	PF02991	0.530
LIG_LIR_Nem_3	206	210	PF02991	0.622
LIG_PDZ_Class_2	338	343	PF00595	0.658
LIG_REV1ctd_RIR_1	175	183	PF16727	0.640
LIG_SH2_SRC	98	101	PF00017	0.524
LIG_SH2_STAP1	331	335	PF00017	0.682
LIG_SH2_STAT3	259	262	PF00017	0.680
LIG_SH2_STAT3	65	68	PF00017	0.416
LIG_SH2_STAT5	65	68	PF00017	0.416
LIG_SH2_STAT5	98	101	PF00017	0.524
LIG_SH3_3	297	303	PF00018	0.682
LIG_SUMO_SIM_anti_2	239	245	PF11976	0.598
LIG_SUMO_SIM_par_1	169	175	PF11976	0.558
LIG_SUMO_SIM_par_1	234	239	PF11976	0.508
LIG_SUMO_SIM_par_1	77	83	PF11976	0.588
LIG_TRAF2_1	140	143	PF00917	0.564
LIG_TRAF2_1	50	53	PF00917	0.664
LIG_TYR_ITIM	96	101	PF00017	0.519
LIG_WRC_WIRS_1	204	209	PF05994	0.657
MOD_CDK_SPxxK_3	295	302	PF00069	0.685
MOD_CK1_1	20	26	PF00069	0.751
MOD_CK1_1	206	212	PF00069	0.667
MOD_CK1_1	298	304	PF00069	0.717
MOD_CK1_1	48	54	PF00069	0.623
MOD_CK2_1	135	141	PF00069	0.634
MOD_CK2_1	231	237	PF00069	0.529
MOD_CK2_1	46	52	PF00069	0.693
MOD_Cter_Amidation	267	270	PF01082	0.663
MOD_Cter_Amidation	290	293	PF01082	0.693
MOD_GlcNHglycan	17	20	PF01048	0.723
MOD_GlcNHglycan	213	216	PF01048	0.696
MOD_GlcNHglycan	276	279	PF01048	0.638
MOD_GlcNHglycan	309	312	PF01048	0.529
MOD_GlcNHglycan	331	334	PF01048	0.714
MOD_GSK3_1	152	159	PF00069	0.629
MOD_GSK3_1	20	27	PF00069	0.735
MOD_GSK3_1	274	281	PF00069	0.655
MOD_GSK3_1	291	298	PF00069	0.587
MOD_GSK3_1	41	48	PF00069	0.688
MOD_GSK3_1	71	78	PF00069	0.574
MOD_NEK2_1	108	113	PF00069	0.605
MOD_NEK2_1	135	140	PF00069	0.527
MOD_NEK2_1	24	29	PF00069	0.676
MOD_NEK2_1	261	266	PF00069	0.483
MOD_NEK2_1	40	45	PF00069	0.704
MOD_NEK2_1	66	71	PF00069	0.560
MOD_NEK2_2	152	157	PF00069	0.630
MOD_PIKK_1	301	307	PF00454	0.713
MOD_PIKK_1	66	72	PF00454	0.560
MOD_PKA_2	135	141	PF00069	0.560
MOD_PKA_2	15	21	PF00069	0.749
MOD_PKA_2	156	162	PF00069	0.593
MOD_PKA_2	186	192	PF00069	0.543
MOD_PKA_2	281	287	PF00069	0.677
MOD_PKA_2	291	297	PF00069	0.695
MOD_PKA_2	301	307	PF00069	0.460
MOD_PKA_2	55	61	PF00069	0.662
MOD_PKA_2	66	72	PF00069	0.357
MOD_Plk_1	152	158	PF00069	0.565
MOD_Plk_1	24	30	PF00069	0.702
MOD_Plk_1	41	47	PF00069	0.619
MOD_Plk_4	203	209	PF00069	0.622
MOD_Plk_4	231	237	PF00069	0.567
MOD_Plk_4	24	30	PF00069	0.683
MOD_Plk_4	41	47	PF00069	0.544
MOD_ProDKin_1	293	299	PF00069	0.723
MOD_ProDKin_1	46	52	PF00069	0.623
TRG_ENDOCYTIC_2	98	101	PF00928	0.418
TRG_ER_diArg_1	156	158	PF00400	0.635
TRG_ER_diArg_1	186	188	PF00400	0.545
TRG_ER_diArg_1	92	94	PF00400	0.525
TRG_Pf-PMV_PEXEL_1	158	162	PF00026	0.626
TRG_Pf-PMV_PEXEL_1	77	82	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVH6	Leptomonas seymouri	42%	98%
A0A3S7WX10	Leishmania donovani	90%	100%
A4HC85	Leishmania braziliensis	69%	89%
A4HZR4	Leishmania infantum	91%	100%
E9AVM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%