Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QBV8_LEIMA

TriTrypDb:

LmjF.22.0370 , LMJLV39_220008900 , LMJSD75_220009000

Length:

274

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBV8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBV8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	170	172	PF00675	0.594
CLV_NRD_NRD_1	79	81	PF00675	0.474
CLV_NRD_NRD_1	99	101	PF00675	0.672
CLV_PCSK_KEX2_1	170	172	PF00082	0.594
CLV_PCSK_KEX2_1	71	73	PF00082	0.492
CLV_PCSK_KEX2_1	79	81	PF00082	0.512
CLV_PCSK_KEX2_1	99	101	PF00082	0.672
CLV_PCSK_PC1ET2_1	71	73	PF00082	0.538
CLV_PCSK_SKI1_1	188	192	PF00082	0.570
CLV_PCSK_SKI1_1	40	44	PF00082	0.474
DEG_APCC_DBOX_1	39	47	PF00400	0.474
DEG_APCC_DBOX_1	98	106	PF00400	0.522
DEG_Nend_UBRbox_1	1	4	PF02207	0.654
DEG_SPOP_SBC_1	48	52	PF00917	0.409
DOC_CKS1_1	160	165	PF01111	0.715
DOC_CYCLIN_RxL_1	37	45	PF00134	0.487
DOC_CYCLIN_yCln2_LP_2	22	28	PF00134	0.491
DOC_CYCLIN_yCln2_LP_2	89	95	PF00134	0.525
DOC_MAPK_gen_1	99	107	PF00069	0.507
DOC_PP1_RVXF_1	186	192	PF00149	0.539
DOC_PP1_RVXF_1	225	231	PF00149	0.522
DOC_PP2B_LxvP_1	89	92	PF13499	0.579
DOC_USP7_MATH_1	48	52	PF00917	0.616
DOC_USP7_MATH_1	73	77	PF00917	0.498
DOC_USP7_MATH_1	95	99	PF00917	0.672
DOC_USP7_MATH_2	139	145	PF00917	0.538
DOC_WW_Pin1_4	159	164	PF00397	0.748
DOC_WW_Pin1_4	206	211	PF00397	0.642
LIG_14-3-3_CanoR_1	170	178	PF00244	0.583
LIG_BIR_III_4	29	33	PF00653	0.394
LIG_FHA_1	156	162	PF00498	0.790
LIG_FHA_1	163	169	PF00498	0.682
LIG_FHA_1	200	206	PF00498	0.416
LIG_FHA_1	215	221	PF00498	0.577
LIG_FHA_2	108	114	PF00498	0.417
LIG_FHA_2	124	130	PF00498	0.675
LIG_FHA_2	252	258	PF00498	0.698
LIG_LIR_Apic_2	103	109	PF02991	0.579
LIG_LIR_Gen_1	265	271	PF02991	0.483
LIG_LIR_Gen_1	5	14	PF02991	0.347
LIG_LIR_Nem_3	197	203	PF02991	0.467
LIG_LIR_Nem_3	265	270	PF02991	0.479
LIG_LIR_Nem_3	5	10	PF02991	0.354
LIG_NRBOX	244	250	PF00104	0.509
LIG_NRBOX	7	13	PF00104	0.575
LIG_SH2_NCK_1	74	78	PF00017	0.465
LIG_SH2_STAT5	106	109	PF00017	0.483
LIG_SH3_3	157	163	PF00018	0.718
LIG_SH3_3	175	181	PF00018	0.532
LIG_SH3_3	207	213	PF00018	0.541
LIG_SUMO_SIM_anti_2	5	12	PF11976	0.345
LIG_TRAF2_1	195	198	PF00917	0.440
LIG_WRC_WIRS_1	200	205	PF05994	0.434
MOD_CK1_1	155	161	PF00069	0.747
MOD_CK1_1	49	55	PF00069	0.607
MOD_CK1_1	87	93	PF00069	0.607
MOD_CK2_1	107	113	PF00069	0.427
MOD_CK2_1	123	129	PF00069	0.622
MOD_CK2_1	192	198	PF00069	0.480
MOD_CK2_1	206	212	PF00069	0.496
MOD_CK2_1	251	257	PF00069	0.517
MOD_Cter_Amidation	168	171	PF01082	0.589
MOD_GlcNHglycan	59	62	PF01048	0.727
MOD_GlcNHglycan	93	96	PF01048	0.688
MOD_GSK3_1	155	162	PF00069	0.724
MOD_GSK3_1	42	49	PF00069	0.590
MOD_GSK3_1	87	94	PF00069	0.608
MOD_NEK2_1	205	210	PF00069	0.399
MOD_NEK2_1	249	254	PF00069	0.500
MOD_NEK2_1	42	47	PF00069	0.475
MOD_NEK2_1	65	70	PF00069	0.536
MOD_PIKK_1	123	129	PF00454	0.669
MOD_PIKK_1	51	57	PF00454	0.606
MOD_PIKK_1	65	71	PF00454	0.542
MOD_PKA_2	152	158	PF00069	0.734
MOD_PKA_2	169	175	PF00069	0.586
MOD_PKB_1	151	159	PF00069	0.733
MOD_Plk_1	141	147	PF00069	0.747
MOD_Plk_1	2	8	PF00069	0.525
MOD_Plk_2-3	3	9	PF00069	0.546
MOD_Plk_4	142	148	PF00069	0.733
MOD_Plk_4	3	9	PF00069	0.570
MOD_Plk_4	84	90	PF00069	0.617
MOD_ProDKin_1	159	165	PF00069	0.745
MOD_ProDKin_1	206	212	PF00069	0.646
TRG_DiLeu_BaLyEn_6	38	43	PF01217	0.468
TRG_ENDOCYTIC_2	193	196	PF00928	0.487
TRG_ENDOCYTIC_2	200	203	PF00928	0.438
TRG_ENDOCYTIC_2	74	77	PF00928	0.444
TRG_ER_diArg_1	151	154	PF00400	0.722
TRG_ER_diArg_1	79	81	PF00400	0.481
TRG_Pf-PMV_PEXEL_1	243	247	PF00026	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB35	Leptomonas seymouri	41%	99%
A0A3S7WWY3	Leishmania donovani	87%	100%
A4HC86	Leishmania braziliensis	61%	92%
A4HZR5	Leishmania infantum	87%	100%
E9AVM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%