Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBV5_LEIMA

TriTrypDb:

LmjF.22.0400 , LMJLV39_220009200 , LMJSD75_220009300

Length:

726

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBV5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBV5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	178	182	PF00656	0.454
CLV_NRD_NRD_1	128	130	PF00675	0.702
CLV_NRD_NRD_1	187	189	PF00675	0.459
CLV_NRD_NRD_1	292	294	PF00675	0.755
CLV_NRD_NRD_1	413	415	PF00675	0.562
CLV_NRD_NRD_1	417	419	PF00675	0.506
CLV_NRD_NRD_1	428	430	PF00675	0.446
CLV_NRD_NRD_1	529	531	PF00675	0.480
CLV_NRD_NRD_1	575	577	PF00675	0.523
CLV_NRD_NRD_1	648	650	PF00675	0.521
CLV_NRD_NRD_1	70	72	PF00675	0.704
CLV_PCSK_FUR_1	411	415	PF00082	0.572
CLV_PCSK_KEX2_1	128	130	PF00082	0.731
CLV_PCSK_KEX2_1	292	294	PF00082	0.778
CLV_PCSK_KEX2_1	413	415	PF00082	0.511
CLV_PCSK_KEX2_1	417	419	PF00082	0.450
CLV_PCSK_KEX2_1	428	430	PF00082	0.379
CLV_PCSK_KEX2_1	529	531	PF00082	0.480
CLV_PCSK_KEX2_1	575	577	PF00082	0.523
CLV_PCSK_KEX2_1	648	650	PF00082	0.521
CLV_PCSK_KEX2_1	70	72	PF00082	0.814
CLV_PCSK_PC7_1	413	419	PF00082	0.556
CLV_PCSK_SKI1_1	184	188	PF00082	0.490
CLV_PCSK_SKI1_1	428	432	PF00082	0.533
CLV_PCSK_SKI1_1	548	552	PF00082	0.542
CLV_PCSK_SKI1_1	694	698	PF00082	0.596
CLV_PCSK_SKI1_1	705	709	PF00082	0.416
DEG_COP1_1	473	482	PF00400	0.643
DEG_ODPH_VHL_1	509	521	PF01847	0.342
DEG_SCF_FBW7_1	67	72	PF00400	0.634
DEG_SPOP_SBC_1	97	101	PF00917	0.622
DOC_CKS1_1	112	117	PF01111	0.688
DOC_CYCLIN_yCln2_LP_2	134	140	PF00134	0.656
DOC_CYCLIN_yCln2_LP_2	435	441	PF00134	0.373
DOC_CYCLIN_yCln2_LP_2	74	80	PF00134	0.623
DOC_MAPK_DCC_7	488	498	PF00069	0.396
DOC_MAPK_gen_1	128	138	PF00069	0.746
DOC_MAPK_gen_1	488	498	PF00069	0.396
DOC_MAPK_HePTP_8	138	150	PF00069	0.566
DOC_MAPK_MEF2A_6	129	138	PF00069	0.718
DOC_MAPK_MEF2A_6	141	150	PF00069	0.440
DOC_MAPK_MEF2A_6	491	498	PF00069	0.491
DOC_MAPK_NFAT4_5	131	139	PF00069	0.673
DOC_MAPK_RevD_3	174	189	PF00069	0.538
DOC_PP1_RVXF_1	341	347	PF00149	0.456
DOC_PP2B_LxvP_1	134	137	PF13499	0.664
DOC_PP2B_LxvP_1	158	161	PF13499	0.630
DOC_PP2B_LxvP_1	224	227	PF13499	0.732
DOC_PP2B_LxvP_1	435	438	PF13499	0.497
DOC_PP2B_LxvP_1	439	442	PF13499	0.462
DOC_PP2B_LxvP_1	74	77	PF13499	0.691
DOC_PP2B_LxvP_1	93	96	PF13499	0.727
DOC_USP7_MATH_1	110	114	PF00917	0.533
DOC_USP7_MATH_1	361	365	PF00917	0.441
DOC_USP7_MATH_1	478	482	PF00917	0.520
DOC_USP7_MATH_1	489	493	PF00917	0.442
DOC_USP7_MATH_1	565	569	PF00917	0.506
DOC_USP7_MATH_1	58	62	PF00917	0.686
DOC_USP7_MATH_1	642	646	PF00917	0.616
DOC_USP7_MATH_1	96	100	PF00917	0.805
DOC_USP7_UBL2_3	36	40	PF12436	0.753
DOC_WW_Pin1_4	111	116	PF00397	0.652
DOC_WW_Pin1_4	357	362	PF00397	0.593
DOC_WW_Pin1_4	548	553	PF00397	0.567
DOC_WW_Pin1_4	558	563	PF00397	0.582
DOC_WW_Pin1_4	65	70	PF00397	0.776
LIG_14-3-3_CanoR_1	129	135	PF00244	0.642
LIG_14-3-3_CanoR_1	151	157	PF00244	0.532
LIG_14-3-3_CanoR_1	216	222	PF00244	0.725
LIG_14-3-3_CanoR_1	488	494	PF00244	0.355
LIG_14-3-3_CanoR_1	529	539	PF00244	0.507
LIG_14-3-3_CanoR_1	649	655	PF00244	0.471
LIG_Actin_WH2_2	562	577	PF00022	0.391
LIG_APCC_ABBAyCdc20_2	683	689	PF00400	0.550
LIG_APCC_ABBAyCdc20_2	705	711	PF00400	0.496
LIG_BIR_III_2	281	285	PF00653	0.695
LIG_BIR_III_4	371	375	PF00653	0.509
LIG_BRCT_BRCA1_1	643	647	PF00533	0.705
LIG_Clathr_ClatBox_1	22	26	PF01394	0.653
LIG_deltaCOP1_diTrp_1	597	605	PF00928	0.608
LIG_eIF4E_1	147	153	PF01652	0.385
LIG_FHA_1	119	125	PF00498	0.658
LIG_FHA_1	171	177	PF00498	0.641
LIG_FHA_1	269	275	PF00498	0.731
LIG_FHA_1	301	307	PF00498	0.760
LIG_FHA_1	314	320	PF00498	0.727
LIG_FHA_1	33	39	PF00498	0.597
LIG_FHA_1	330	336	PF00498	0.419
LIG_FHA_1	391	397	PF00498	0.554
LIG_FHA_1	498	504	PF00498	0.611
LIG_FHA_1	673	679	PF00498	0.536
LIG_FHA_2	167	173	PF00498	0.491
LIG_FHA_2	471	477	PF00498	0.726
LIG_FHA_2	6	12	PF00498	0.632
LIG_Integrin_RGD_1	576	578	PF01839	0.504
LIG_LIR_Gen_1	144	153	PF02991	0.396
LIG_LIR_Gen_1	330	338	PF02991	0.545
LIG_LIR_Gen_1	660	670	PF02991	0.478
LIG_LIR_Gen_1	699	708	PF02991	0.502
LIG_LIR_LC3C_4	395	399	PF02991	0.389
LIG_LIR_Nem_3	125	130	PF02991	0.631
LIG_LIR_Nem_3	144	150	PF02991	0.399
LIG_LIR_Nem_3	157	162	PF02991	0.373
LIG_LIR_Nem_3	330	336	PF02991	0.550
LIG_LIR_Nem_3	360	365	PF02991	0.581
LIG_LIR_Nem_3	660	666	PF02991	0.469
LIG_LIR_Nem_3	689	693	PF02991	0.498
LIG_LIR_Nem_3	699	703	PF02991	0.418
LIG_MYND_1	558	562	PF01753	0.579
LIG_NRBOX	220	226	PF00104	0.731
LIG_Pex14_1	600	604	PF04695	0.599
LIG_SH2_GRB2like	585	588	PF00017	0.604
LIG_SH2_PTP2	663	666	PF00017	0.467
LIG_SH2_STAP1	375	379	PF00017	0.593
LIG_SH2_STAP1	700	704	PF00017	0.454
LIG_SH2_STAT3	365	368	PF00017	0.542
LIG_SH2_STAT5	147	150	PF00017	0.383
LIG_SH2_STAT5	302	305	PF00017	0.628
LIG_SH2_STAT5	388	391	PF00017	0.493
LIG_SH2_STAT5	518	521	PF00017	0.442
LIG_SH2_STAT5	579	582	PF00017	0.462
LIG_SH2_STAT5	585	588	PF00017	0.502
LIG_SH2_STAT5	663	666	PF00017	0.467
LIG_SH3_1	109	115	PF00018	0.584
LIG_SH3_3	109	115	PF00018	0.654
LIG_SH3_3	261	267	PF00018	0.677
LIG_SH3_3	493	499	PF00018	0.357
LIG_SH3_3	556	562	PF00018	0.688
LIG_SH3_3	661	667	PF00018	0.472
LIG_SUMO_SIM_anti_2	390	398	PF11976	0.625
LIG_SUMO_SIM_par_1	164	173	PF11976	0.517
LIG_SUMO_SIM_par_1	217	222	PF11976	0.723
LIG_SUMO_SIM_par_1	284	291	PF11976	0.656
LIG_SUMO_SIM_par_1	334	339	PF11976	0.521
LIG_SUMO_SIM_par_1	390	402	PF11976	0.633
LIG_SxIP_EBH_1	488	500	PF03271	0.362
LIG_TRAF2_1	142	145	PF00917	0.444
LIG_TRAF2_1	460	463	PF00917	0.747
LIG_TRFH_1	365	369	PF08558	0.642
LIG_TRFH_1	663	667	PF08558	0.469
MOD_CDK_SPK_2	65	70	PF00069	0.733
MOD_CDK_SPxK_1	65	71	PF00069	0.734
MOD_CK1_1	101	107	PF00069	0.649
MOD_CK1_1	199	205	PF00069	0.695
MOD_CK1_1	265	271	PF00069	0.789
MOD_CK1_1	481	487	PF00069	0.446
MOD_CK1_1	5	11	PF00069	0.669
MOD_CK1_1	53	59	PF00069	0.704
MOD_CK1_1	60	66	PF00069	0.711
MOD_CK1_1	715	721	PF00069	0.428
MOD_CK2_1	166	172	PF00069	0.487
MOD_CK2_1	295	301	PF00069	0.724
MOD_CK2_1	470	476	PF00069	0.731
MOD_CK2_1	5	11	PF00069	0.638
MOD_DYRK1A_RPxSP_1	548	552	PF00069	0.655
MOD_GlcNHglycan	100	103	PF01048	0.716
MOD_GlcNHglycan	338	341	PF01048	0.528
MOD_GlcNHglycan	637	640	PF01048	0.663
MOD_GlcNHglycan	64	67	PF01048	0.812
MOD_GSK3_1	118	125	PF00069	0.626
MOD_GSK3_1	166	173	PF00069	0.534
MOD_GSK3_1	284	291	PF00069	0.727
MOD_GSK3_1	300	307	PF00069	0.764
MOD_GSK3_1	309	316	PF00069	0.664
MOD_GSK3_1	357	364	PF00069	0.517
MOD_GSK3_1	388	395	PF00069	0.611
MOD_GSK3_1	442	449	PF00069	0.590
MOD_GSK3_1	499	506	PF00069	0.388
MOD_GSK3_1	53	60	PF00069	0.663
MOD_GSK3_1	610	617	PF00069	0.743
MOD_GSK3_1	65	72	PF00069	0.720
MOD_GSK3_1	97	104	PF00069	0.615
MOD_NEK2_1	152	157	PF00069	0.527
MOD_NEK2_1	170	175	PF00069	0.528
MOD_NEK2_1	198	203	PF00069	0.594
MOD_NEK2_2	642	647	PF00069	0.713
MOD_PIKK_1	17	23	PF00454	0.665
MOD_PIKK_1	292	298	PF00454	0.719
MOD_PIKK_1	530	536	PF00454	0.513
MOD_PIKK_1	58	64	PF00454	0.578
MOD_PIKK_1	614	620	PF00454	0.713
MOD_PIKK_1	715	721	PF00454	0.584
MOD_PKA_1	292	298	PF00069	0.662
MOD_PKA_2	130	136	PF00069	0.687
MOD_PKA_2	291	297	PF00069	0.746
MOD_PKA_2	447	453	PF00069	0.678
MOD_PKA_2	614	620	PF00069	0.713
MOD_PKA_2	622	628	PF00069	0.525
MOD_Plk_1	104	110	PF00069	0.621
MOD_Plk_1	300	306	PF00069	0.596
MOD_Plk_1	323	329	PF00069	0.650
MOD_Plk_2-3	166	172	PF00069	0.487
MOD_Plk_4	154	160	PF00069	0.474
MOD_Plk_4	481	487	PF00069	0.561
MOD_Plk_4	499	505	PF00069	0.521
MOD_Plk_4	642	648	PF00069	0.596
MOD_Plk_4	650	656	PF00069	0.478
MOD_Plk_4	658	664	PF00069	0.489
MOD_ProDKin_1	111	117	PF00069	0.649
MOD_ProDKin_1	357	363	PF00069	0.585
MOD_ProDKin_1	548	554	PF00069	0.574
MOD_ProDKin_1	558	564	PF00069	0.576
MOD_ProDKin_1	65	71	PF00069	0.777
TRG_DiLeu_BaEn_1	392	397	PF01217	0.632
TRG_DiLeu_BaEn_1	542	547	PF01217	0.623
TRG_DiLeu_BaEn_4	143	149	PF01217	0.605
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.510
TRG_DiLeu_BaLyEn_6	158	163	PF01217	0.524
TRG_DiLeu_BaLyEn_6	225	230	PF01217	0.699
TRG_ENDOCYTIC_2	147	150	PF00928	0.383
TRG_ENDOCYTIC_2	375	378	PF00928	0.536
TRG_ENDOCYTIC_2	518	521	PF00928	0.434
TRG_ENDOCYTIC_2	663	666	PF00928	0.467
TRG_ENDOCYTIC_2	693	696	PF00928	0.498
TRG_ENDOCYTIC_2	700	703	PF00928	0.485
TRG_ER_diArg_1	127	129	PF00400	0.743
TRG_ER_diArg_1	411	414	PF00400	0.578
TRG_ER_diArg_1	428	430	PF00400	0.405
TRG_ER_diArg_1	528	530	PF00400	0.485
TRG_ER_diArg_1	574	576	PF00400	0.528
TRG_ER_diArg_1	647	649	PF00400	0.538
TRG_ER_diArg_1	69	71	PF00400	0.829
TRG_NES_CRM1_1	165	178	PF08389	0.527
TRG_Pf-PMV_PEXEL_1	350	354	PF00026	0.653
TRG_Pf-PMV_PEXEL_1	429	434	PF00026	0.517
TRG_Pf-PMV_PEXEL_1	712	716	PF00026	0.521

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4U6	Leptomonas seymouri	43%	97%
A0A3Q8ILF7	Leishmania donovani	89%	100%
A4HC89	Leishmania braziliensis	63%	99%
A4HZR8	Leishmania infantum	89%	100%
E9AVM4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%