tRNA-binding domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Putative tRNA binding domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QBU9_LEIMA

TriTrypDb:

LmjF.22.0470 , LMJLV39_220009900 , LMJSD75_220010000

Length:

426

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	yes	yes: 3
Pissara et al.	yes	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QBU9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBU9

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000049	tRNA binding	5	11
GO:0003676	nucleic acid binding	3	11
GO:0003723	RNA binding	4	11
GO:0005488	binding	1	11
GO:0097159	organic cyclic compound binding	2	11
GO:1901363	heterocyclic compound binding	2	11
GO:0003824	catalytic activity	1	3
GO:0004812	aminoacyl-tRNA ligase activity	4	3
GO:0016874	ligase activity	2	3
GO:0016875	ligase activity, forming carbon-oxygen bonds	3	3
GO:0140098	catalytic activity, acting on RNA	3	3
GO:0140101	catalytic activity, acting on a tRNA	4	3
GO:0140640	catalytic activity, acting on a nucleic acid	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	394	398	PF00656	0.599
CLV_MEL_PAP_1	266	272	PF00089	0.411
CLV_NRD_NRD_1	215	217	PF00675	0.592
CLV_NRD_NRD_1	277	279	PF00675	0.383
CLV_NRD_NRD_1	58	60	PF00675	0.588
CLV_PCSK_KEX2_1	214	216	PF00082	0.599
CLV_PCSK_KEX2_1	254	256	PF00082	0.718
CLV_PCSK_KEX2_1	277	279	PF00082	0.372
CLV_PCSK_KEX2_1	341	343	PF00082	0.443
CLV_PCSK_KEX2_1	58	60	PF00082	0.646
CLV_PCSK_PC1ET2_1	254	256	PF00082	0.707
CLV_PCSK_PC1ET2_1	341	343	PF00082	0.392
CLV_PCSK_SKI1_1	126	130	PF00082	0.644
CLV_PCSK_SKI1_1	254	258	PF00082	0.814
CLV_PCSK_SKI1_1	360	364	PF00082	0.480
CLV_PCSK_SKI1_1	67	71	PF00082	0.575
CLV_Separin_Metazoa	211	215	PF03568	0.619
DEG_Nend_UBRbox_3	1	3	PF02207	0.548
DOC_MAPK_gen_1	324	331	PF00069	0.610
DOC_MAPK_gen_1	341	348	PF00069	0.554
DOC_PP1_RVXF_1	358	364	PF00149	0.594
DOC_PP2B_LxvP_1	23	26	PF13499	0.588
DOC_USP7_MATH_1	101	105	PF00917	0.647
DOC_USP7_MATH_1	173	177	PF00917	0.652
DOC_USP7_MATH_1	18	22	PF00917	0.587
DOC_USP7_MATH_1	193	197	PF00917	0.749
DOC_USP7_MATH_1	200	204	PF00917	0.707
DOC_USP7_MATH_1	205	209	PF00917	0.615
DOC_USP7_MATH_1	379	383	PF00917	0.594
DOC_USP7_UBL2_3	219	223	PF12436	0.582
DOC_USP7_UBL2_3	254	258	PF12436	0.847
DOC_WW_Pin1_4	60	65	PF00397	0.598
LIG_14-3-3_CanoR_1	133	137	PF00244	0.486
LIG_14-3-3_CanoR_1	58	64	PF00244	0.463
LIG_Actin_WH2_2	43	60	PF00022	0.541
LIG_FHA_1	150	156	PF00498	0.568
LIG_FHA_1	294	300	PF00498	0.582
LIG_FHA_1	313	319	PF00498	0.575
LIG_FHA_2	127	133	PF00498	0.536
LIG_FHA_2	235	241	PF00498	0.743
LIG_FHA_2	255	261	PF00498	0.806
LIG_FHA_2	392	398	PF00498	0.507
LIG_KLC1_Yacidic_2	283	288	PF13176	0.583
LIG_LIR_Apic_2	167	173	PF02991	0.543
LIG_LIR_Apic_2	203	207	PF02991	0.746
LIG_LIR_Gen_1	264	273	PF02991	0.495
LIG_LIR_LC3C_4	315	320	PF02991	0.629
LIG_LIR_Nem_3	264	270	PF02991	0.537
LIG_LIR_Nem_3	46	50	PF02991	0.575
LIG_PCNA_PIPBox_1	385	394	PF02747	0.529
LIG_SH2_CRK	204	208	PF00017	0.692
LIG_SH2_NCK_1	110	114	PF00017	0.615
LIG_SH2_NCK_1	142	146	PF00017	0.569
LIG_SH2_NCK_1	204	208	PF00017	0.692
LIG_SH2_PTP2	267	270	PF00017	0.495
LIG_SH2_STAP1	142	146	PF00017	0.569
LIG_SH2_STAP1	367	371	PF00017	0.621
LIG_SH2_STAT5	127	130	PF00017	0.599
LIG_SH2_STAT5	170	173	PF00017	0.525
LIG_SH2_STAT5	267	270	PF00017	0.495
LIG_SH2_STAT5	286	289	PF00017	0.583
LIG_SH3_3	373	379	PF00018	0.537
LIG_SUMO_SIM_anti_2	72	81	PF11976	0.616
LIG_SUMO_SIM_par_1	21	27	PF11976	0.393
LIG_TRAF2_1	207	210	PF00917	0.621
LIG_TRAF2_1	308	311	PF00917	0.614
MOD_CAAXbox	423	426	PF01239	0.581
MOD_CDK_SPxxK_3	60	67	PF00069	0.597
MOD_CK1_1	149	155	PF00069	0.586
MOD_CK1_1	21	27	PF00069	0.557
MOD_CK2_1	108	114	PF00069	0.633
MOD_CK2_1	126	132	PF00069	0.358
MOD_CK2_1	205	211	PF00069	0.567
MOD_CK2_1	21	27	PF00069	0.509
MOD_CK2_1	234	240	PF00069	0.779
MOD_CK2_1	254	260	PF00069	0.721
MOD_Cter_Amidation	252	255	PF01082	0.778
MOD_GlcNHglycan	148	151	PF01048	0.601
MOD_GlcNHglycan	176	179	PF01048	0.646
MOD_GlcNHglycan	185	188	PF01048	0.710
MOD_GlcNHglycan	195	198	PF01048	0.770
MOD_GlcNHglycan	242	245	PF01048	0.755
MOD_GlcNHglycan	246	249	PF01048	0.775
MOD_GlcNHglycan	300	303	PF01048	0.351
MOD_GlcNHglycan	410	413	PF01048	0.666
MOD_GSK3_1	118	125	PF00069	0.636
MOD_GSK3_1	128	135	PF00069	0.457
MOD_GSK3_1	174	181	PF00069	0.627
MOD_GSK3_1	240	247	PF00069	0.764
MOD_GSK3_1	256	263	PF00069	0.612
MOD_GSK3_1	379	386	PF00069	0.607
MOD_GSK3_1	387	394	PF00069	0.503
MOD_N-GLC_1	146	151	PF02516	0.577
MOD_N-GLC_1	5	10	PF02516	0.520
MOD_NEK2_1	117	122	PF00069	0.555
MOD_NEK2_1	146	151	PF00069	0.574
MOD_NEK2_1	261	266	PF00069	0.623
MOD_NEK2_1	303	308	PF00069	0.589
MOD_NEK2_1	312	317	PF00069	0.565
MOD_NEK2_1	329	334	PF00069	0.585
MOD_NEK2_1	4	9	PF00069	0.364
MOD_NEK2_1	57	62	PF00069	0.545
MOD_NEK2_2	262	267	PF00069	0.407
MOD_PIKK_1	181	187	PF00454	0.694
MOD_PIKK_1	312	318	PF00454	0.648
MOD_PIKK_1	330	336	PF00454	0.629
MOD_PKA_1	254	260	PF00069	0.781
MOD_PKA_1	341	347	PF00069	0.638
MOD_PKA_2	132	138	PF00069	0.481
MOD_PKA_2	174	180	PF00069	0.746
MOD_PKA_2	254	260	PF00069	0.679
MOD_PKA_2	341	347	PF00069	0.481
MOD_PKA_2	38	44	PF00069	0.601
MOD_PKA_2	57	63	PF00069	0.307
MOD_Plk_1	5	11	PF00069	0.515
MOD_Plk_2-3	132	138	PF00069	0.613
MOD_Plk_4	18	24	PF00069	0.508
MOD_Plk_4	262	268	PF00069	0.587
MOD_Plk_4	324	330	PF00069	0.633
MOD_Plk_4	395	401	PF00069	0.520
MOD_Plk_4	6	12	PF00069	0.551
MOD_Plk_4	75	81	PF00069	0.613
MOD_ProDKin_1	60	66	PF00069	0.593
MOD_SUMO_for_1	222	225	PF00179	0.694
MOD_SUMO_rev_2	247	256	PF00179	0.827
MOD_SUMO_rev_2	343	349	PF00179	0.592
TRG_DiLeu_BaEn_1	75	80	PF01217	0.600
TRG_DiLeu_BaEn_2	64	70	PF01217	0.590
TRG_ENDOCYTIC_2	110	113	PF00928	0.591
TRG_ENDOCYTIC_2	267	270	PF00928	0.495
TRG_ER_diArg_1	213	216	PF00400	0.608
TRG_ER_diArg_1	276	278	PF00400	0.591
TRG_ER_diArg_1	57	59	PF00400	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P301	Leptomonas seymouri	66%	100%
A0A0S4IJF4	Bodo saltans	39%	100%
A0A1X0NUW2	Trypanosomatidae	45%	100%
A0A3R7KNR3	Trypanosoma rangeli	44%	100%
A0A3S7WX09	Leishmania donovani	86%	100%
A4HC93	Leishmania braziliensis	78%	100%
A4HZS5	Leishmania infantum	86%	100%
C9ZRK5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9AVN0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
V5B5W2	Trypanosoma cruzi	37%	100%