Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycogen synthase kinase-3 alpha, putative

Species:

Leishmania major

UniProt:

Q4QBU7_LEIMA

TriTrypDb:

LmjF.22.0490 , LMJLV39_220010100 , LMJSD75_220010200

Length:

723

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QBU7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBU7

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0007165	signal transduction	2	2
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016310	phosphorylation	5	7
GO:0019538	protein metabolic process	3	7
GO:0035556	intracellular signal transduction	3	2
GO:0036211	protein modification process	4	7
GO:0043170	macromolecule metabolic process	3	7
GO:0043412	macromolecule modification	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	7
GO:1901564	organonitrogen compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0003824	catalytic activity	1	7
GO:0004672	protein kinase activity	3	7
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0004707	MAP kinase activity	5	2
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0016301	kinase activity	4	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:0140096	catalytic activity, acting on a protein	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.818
CLV_C14_Caspase3-7	639	643	PF00656	0.459
CLV_NRD_NRD_1	113	115	PF00675	0.562
CLV_NRD_NRD_1	4	6	PF00675	0.682
CLV_NRD_NRD_1	596	598	PF00675	0.337
CLV_PCSK_FUR_1	2	6	PF00082	0.657
CLV_PCSK_KEX2_1	113	115	PF00082	0.592
CLV_PCSK_KEX2_1	237	239	PF00082	0.450
CLV_PCSK_KEX2_1	4	6	PF00082	0.682
CLV_PCSK_KEX2_1	443	445	PF00082	0.314
CLV_PCSK_KEX2_1	596	598	PF00082	0.337
CLV_PCSK_KEX2_1	621	623	PF00082	0.290
CLV_PCSK_KEX2_1	72	74	PF00082	0.384
CLV_PCSK_PC1ET2_1	237	239	PF00082	0.310
CLV_PCSK_PC1ET2_1	443	445	PF00082	0.303
CLV_PCSK_PC1ET2_1	621	623	PF00082	0.290
CLV_PCSK_PC1ET2_1	72	74	PF00082	0.384
CLV_PCSK_PC7_1	68	74	PF00082	0.334
CLV_PCSK_SKI1_1	317	321	PF00082	0.343
CLV_PCSK_SKI1_1	341	345	PF00082	0.303
CLV_PCSK_SKI1_1	366	370	PF00082	0.311
CLV_PCSK_SKI1_1	419	423	PF00082	0.308
CLV_PCSK_SKI1_1	524	528	PF00082	0.373
CLV_PCSK_SKI1_1	596	600	PF00082	0.290
CLV_PCSK_SKI1_1	621	625	PF00082	0.337
CLV_Separin_Metazoa	412	416	PF03568	0.303
DEG_Nend_UBRbox_1	1	4	PF02207	0.585
DEG_SCF_FBW7_2	576	583	PF00400	0.337
DEG_SPOP_SBC_1	129	133	PF00917	0.609
DEG_SPOP_SBC_1	250	254	PF00917	0.524
DEG_SPOP_SBC_1	546	550	PF00917	0.307
DOC_CDC14_PxL_1	384	392	PF14671	0.303
DOC_CKS1_1	601	606	PF01111	0.241
DOC_CYCLIN_RxL_1	591	603	PF00134	0.290
DOC_MAPK_gen_1	341	350	PF00069	0.303
DOC_MAPK_gen_1	383	392	PF00069	0.303
DOC_MAPK_gen_1	482	491	PF00069	0.442
DOC_MAPK_HePTP_8	380	392	PF00069	0.303
DOC_MAPK_MEF2A_6	383	392	PF00069	0.303
DOC_MAPK_MEF2A_6	485	493	PF00069	0.370
DOC_PP1_RVXF_1	318	325	PF00149	0.345
DOC_PP1_RVXF_1	326	333	PF00149	0.266
DOC_PP2B_LxvP_1	438	441	PF13499	0.365
DOC_PP2B_LxvP_1	675	678	PF13499	0.383
DOC_PP4_FxxP_1	561	564	PF00568	0.309
DOC_USP7_MATH_1	105	109	PF00917	0.634
DOC_USP7_MATH_1	119	123	PF00917	0.705
DOC_USP7_MATH_1	129	133	PF00917	0.556
DOC_USP7_MATH_1	14	18	PF00917	0.668
DOC_USP7_MATH_1	205	209	PF00917	0.591
DOC_USP7_MATH_1	250	254	PF00917	0.600
DOC_USP7_MATH_1	33	37	PF00917	0.494
DOC_USP7_MATH_1	547	551	PF00917	0.349
DOC_USP7_MATH_1	655	659	PF00917	0.543
DOC_USP7_MATH_2	265	271	PF00917	0.578
DOC_WW_Pin1_4	253	258	PF00397	0.628
DOC_WW_Pin1_4	281	286	PF00397	0.671
DOC_WW_Pin1_4	535	540	PF00397	0.303
DOC_WW_Pin1_4	542	547	PF00397	0.303
DOC_WW_Pin1_4	576	581	PF00397	0.316
DOC_WW_Pin1_4	600	605	PF00397	0.290
DOC_WW_Pin1_4	660	665	PF00397	0.653
LIG_14-3-3_CanoR_1	120	127	PF00244	0.627
LIG_14-3-3_CanoR_1	15	22	PF00244	0.716
LIG_14-3-3_CanoR_1	35	41	PF00244	0.468
LIG_14-3-3_CanoR_1	423	431	PF00244	0.303
LIG_14-3-3_CanoR_1	465	470	PF00244	0.374
LIG_14-3-3_CanoR_1	622	629	PF00244	0.290
LIG_14-3-3_CanoR_1	695	703	PF00244	0.460
LIG_Actin_WH2_2	331	346	PF00022	0.290
LIG_Actin_WH2_2	402	417	PF00022	0.303
LIG_AP2alpha_1	634	638	PF02296	0.349
LIG_Clathr_ClatBox_1	598	602	PF01394	0.241
LIG_deltaCOP1_diTrp_1	402	406	PF00928	0.303
LIG_eIF4E_1	385	391	PF01652	0.303
LIG_FHA_1	122	128	PF00498	0.744
LIG_FHA_1	352	358	PF00498	0.324
LIG_FHA_1	37	43	PF00498	0.485
LIG_FHA_1	568	574	PF00498	0.337
LIG_FHA_1	603	609	PF00498	0.307
LIG_FHA_2	102	108	PF00498	0.800
LIG_FHA_2	133	139	PF00498	0.574
LIG_FHA_2	424	430	PF00498	0.311
LIG_FHA_2	577	583	PF00498	0.307
LIG_FHA_2	601	607	PF00498	0.290
LIG_FHA_2	622	628	PF00498	0.337
LIG_FHA_2	689	695	PF00498	0.345
LIG_Integrin_isoDGR_2	679	681	PF01839	0.404
LIG_LIR_Apic_2	382	388	PF02991	0.310
LIG_LIR_Apic_2	559	564	PF02991	0.309
LIG_LIR_Gen_1	582	593	PF02991	0.317
LIG_LIR_Nem_3	155	160	PF02991	0.388
LIG_LIR_Nem_3	389	395	PF02991	0.303
LIG_LIR_Nem_3	405	409	PF02991	0.303
LIG_LIR_Nem_3	433	438	PF02991	0.365
LIG_LIR_Nem_3	53	57	PF02991	0.408
LIG_LIR_Nem_3	579	584	PF02991	0.312
LIG_Pex14_1	595	599	PF04695	0.290
LIG_Pex14_2	634	638	PF04695	0.349
LIG_SH2_CRK	43	47	PF00017	0.418
LIG_SH2_CRK	585	589	PF00017	0.290
LIG_SH2_NCK_1	160	164	PF00017	0.435
LIG_SH2_NCK_1	698	702	PF00017	0.420
LIG_SH2_STAP1	698	702	PF00017	0.373
LIG_SH2_STAP1	76	80	PF00017	0.546
LIG_SH2_STAT5	157	160	PF00017	0.359
LIG_SH2_STAT5	221	224	PF00017	0.355
LIG_SH2_STAT5	228	231	PF00017	0.342
LIG_SH2_STAT5	235	238	PF00017	0.354
LIG_SH2_STAT5	240	243	PF00017	0.375
LIG_SH2_STAT5	379	382	PF00017	0.303
LIG_SH2_STAT5	48	51	PF00017	0.435
LIG_SH2_STAT5	698	701	PF00017	0.383
LIG_SH3_3	207	213	PF00018	0.661
LIG_SH3_3	279	285	PF00018	0.650
LIG_SH3_3	598	604	PF00018	0.241
LIG_SH3_3	626	632	PF00018	0.337
LIG_SH3_3	90	96	PF00018	0.511
LIG_SUMO_SIM_anti_2	605	613	PF11976	0.312
LIG_SUMO_SIM_anti_2	84	90	PF11976	0.394
LIG_SUMO_SIM_par_1	149	155	PF11976	0.354
LIG_SUMO_SIM_par_1	55	62	PF11976	0.381
LIG_TRAF2_1	371	374	PF00917	0.365
LIG_TRAF2_1	497	500	PF00917	0.337
LIG_TRAF2_1	580	583	PF00917	0.337
LIG_UBA3_1	434	443	PF00899	0.303
LIG_WRC_WIRS_1	403	408	PF05994	0.303
MOD_CDK_SPK_2	281	286	PF00069	0.675
MOD_CK1_1	10	16	PF00069	0.650
MOD_CK1_1	122	128	PF00069	0.745
MOD_CK1_1	130	136	PF00069	0.586
MOD_CK1_1	17	23	PF00069	0.607
MOD_CK1_1	199	205	PF00069	0.587
MOD_CK1_1	252	258	PF00069	0.608
MOD_CK1_1	298	304	PF00069	0.713
MOD_CK1_1	36	42	PF00069	0.425
MOD_CK1_1	533	539	PF00069	0.404
MOD_CK1_1	545	551	PF00069	0.224
MOD_CK1_1	658	664	PF00069	0.588
MOD_CK2_1	266	272	PF00069	0.601
MOD_CK2_1	439	445	PF00069	0.303
MOD_CK2_1	515	521	PF00069	0.382
MOD_CK2_1	576	582	PF00069	0.337
MOD_CK2_1	600	606	PF00069	0.290
MOD_CK2_1	621	627	PF00069	0.400
MOD_CK2_1	660	666	PF00069	0.565
MOD_CK2_1	688	694	PF00069	0.338
MOD_GlcNHglycan	12	15	PF01048	0.673
MOD_GlcNHglycan	127	130	PF01048	0.714
MOD_GlcNHglycan	16	19	PF01048	0.661
MOD_GlcNHglycan	198	201	PF01048	0.718
MOD_GlcNHglycan	205	208	PF01048	0.644
MOD_GlcNHglycan	269	272	PF01048	0.760
MOD_GlcNHglycan	305	308	PF01048	0.711
MOD_GlcNHglycan	363	366	PF01048	0.303
MOD_GlcNHglycan	416	419	PF01048	0.338
MOD_GlcNHglycan	474	477	PF01048	0.491
MOD_GlcNHglycan	535	538	PF01048	0.290
MOD_GlcNHglycan	561	564	PF01048	0.386
MOD_GlcNHglycan	638	641	PF01048	0.534
MOD_GlcNHglycan	657	660	PF01048	0.446
MOD_GlcNHglycan	671	674	PF01048	0.398
MOD_GlcNHglycan	7	10	PF01048	0.666
MOD_GSK3_1	10	17	PF00069	0.691
MOD_GSK3_1	101	108	PF00069	0.805
MOD_GSK3_1	121	128	PF00069	0.469
MOD_GSK3_1	199	206	PF00069	0.616
MOD_GSK3_1	23	30	PF00069	0.576
MOD_GSK3_1	245	252	PF00069	0.451
MOD_GSK3_1	253	260	PF00069	0.609
MOD_GSK3_1	263	270	PF00069	0.613
MOD_GSK3_1	294	301	PF00069	0.653
MOD_GSK3_1	31	38	PF00069	0.622
MOD_GSK3_1	375	382	PF00069	0.305
MOD_GSK3_1	529	536	PF00069	0.325
MOD_GSK3_1	542	549	PF00069	0.279
MOD_GSK3_1	559	566	PF00069	0.244
MOD_GSK3_1	651	658	PF00069	0.651
MOD_N-GLC_1	294	299	PF02516	0.654
MOD_N-GLC_1	375	380	PF02516	0.324
MOD_NEK2_1	127	132	PF00069	0.676
MOD_NEK2_1	224	229	PF00069	0.312
MOD_NEK2_1	414	419	PF00069	0.327
MOD_NEK2_1	457	462	PF00069	0.303
MOD_NEK2_1	610	615	PF00069	0.337
MOD_NEK2_1	7	12	PF00069	0.662
MOD_PIKK_1	33	39	PF00454	0.625
MOD_PIKK_1	530	536	PF00454	0.365
MOD_PKA_1	621	627	PF00069	0.290
MOD_PKA_2	10	16	PF00069	0.754
MOD_PKA_2	119	125	PF00069	0.647
MOD_PKA_2	298	304	PF00069	0.666
MOD_PKA_2	414	420	PF00069	0.303
MOD_PKA_2	50	56	PF00069	0.440
MOD_PKA_2	621	627	PF00069	0.290
MOD_Plk_1	375	381	PF00069	0.324
MOD_Plk_4	122	128	PF00069	0.680
MOD_Plk_4	224	230	PF00069	0.334
MOD_Plk_4	375	381	PF00069	0.303
MOD_Plk_4	610	616	PF00069	0.434
MOD_Plk_4	683	689	PF00069	0.461
MOD_Plk_4	87	93	PF00069	0.423
MOD_ProDKin_1	253	259	PF00069	0.633
MOD_ProDKin_1	281	287	PF00069	0.670
MOD_ProDKin_1	535	541	PF00069	0.303
MOD_ProDKin_1	542	548	PF00069	0.303
MOD_ProDKin_1	576	582	PF00069	0.316
MOD_ProDKin_1	600	606	PF00069	0.290
MOD_ProDKin_1	660	666	PF00069	0.653
MOD_SUMO_rev_2	550	560	PF00179	0.333
TRG_DiLeu_BaEn_1	606	611	PF01217	0.290
TRG_ENDOCYTIC_2	221	224	PF00928	0.369
TRG_ENDOCYTIC_2	228	231	PF00928	0.399
TRG_ENDOCYTIC_2	240	243	PF00928	0.277
TRG_ENDOCYTIC_2	43	46	PF00928	0.419
TRG_ENDOCYTIC_2	584	587	PF00928	0.290
TRG_ER_diArg_1	1	4	PF00400	0.714
TRG_ER_diArg_1	113	115	PF00400	0.562
TRG_ER_diArg_1	458	461	PF00400	0.489
TRG_ER_diArg_1	595	597	PF00400	0.337
TRG_Pf-PMV_PEXEL_1	695	700	PF00026	0.379

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HU16	Leptomonas seymouri	51%	100%
A0A3Q8IC49	Leishmania donovani	93%	99%
A4HC95	Leishmania braziliensis	76%	100%
A4HZS7	Leishmania infantum	93%	86%
E9AVN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%