TFIIS N-terminal domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBU6_LEIMA

TriTrypDb:

LmjF.22.0500 , LMJLV39_220010200 , LMJSD75_220010300

Length:

512

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	5
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4QBU6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBU6

Function

Biological processes
Term	Name	Level	Count
GO:0006405	RNA export from nucleus	5	2
GO:0006406	mRNA export from nucleus	6	2
GO:0006810	transport	3	2
GO:0006913	nucleocytoplasmic transport	5	2
GO:0009987	cellular process	1	2
GO:0015931	nucleobase-containing compound transport	5	2
GO:0016973	poly(A)+ mRNA export from nucleus	7	2
GO:0046907	intracellular transport	3	2
GO:0050657	nucleic acid transport	6	2
GO:0050658	RNA transport	4	2
GO:0051028	mRNA transport	5	2
GO:0051168	nuclear export	6	2
GO:0051169	nuclear transport	4	2
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051236	establishment of RNA localization	3	2
GO:0051641	cellular localization	2	2
GO:0051649	establishment of localization in cell	3	2
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	101	105	PF00656	0.612
CLV_C14_Caspase3-7	230	234	PF00656	0.545
CLV_C14_Caspase3-7	405	409	PF00656	0.521
CLV_C14_Caspase3-7	84	88	PF00656	0.700
CLV_NRD_NRD_1	192	194	PF00675	0.678
CLV_NRD_NRD_1	201	203	PF00675	0.552
CLV_NRD_NRD_1	263	265	PF00675	0.667
CLV_NRD_NRD_1	400	402	PF00675	0.552
CLV_PCSK_KEX2_1	146	148	PF00082	0.502
CLV_PCSK_KEX2_1	150	152	PF00082	0.417
CLV_PCSK_KEX2_1	167	169	PF00082	0.664
CLV_PCSK_KEX2_1	201	203	PF00082	0.767
CLV_PCSK_KEX2_1	400	402	PF00082	0.590
CLV_PCSK_PC1ET2_1	146	148	PF00082	0.482
CLV_PCSK_PC1ET2_1	150	152	PF00082	0.417
CLV_PCSK_PC1ET2_1	167	169	PF00082	0.664
CLV_PCSK_SKI1_1	139	143	PF00082	0.541
CLV_PCSK_SKI1_1	244	248	PF00082	0.571
CLV_PCSK_SKI1_1	256	260	PF00082	0.617
CLV_PCSK_SKI1_1	307	311	PF00082	0.488
DEG_APCC_DBOX_1	306	314	PF00400	0.440
DEG_Kelch_Keap1_1	206	211	PF01344	0.540
DEG_Nend_UBRbox_2	1	3	PF02207	0.722
DOC_CYCLIN_yCln2_LP_2	225	231	PF00134	0.639
DOC_MAPK_MEF2A_6	354	362	PF00069	0.370
DOC_PP4_FxxP_1	468	471	PF00568	0.640
DOC_USP7_MATH_1	189	193	PF00917	0.736
DOC_USP7_MATH_1	309	313	PF00917	0.447
DOC_USP7_UBL2_3	138	142	PF12436	0.467
DOC_USP7_UBL2_3	146	150	PF12436	0.459
DOC_USP7_UBL2_3	153	157	PF12436	0.427
DOC_USP7_UBL2_3	163	167	PF12436	0.539
DOC_USP7_UBL2_3	171	175	PF12436	0.528
DOC_USP7_UBL2_3	176	180	PF12436	0.602
DOC_USP7_UBL2_3	195	199	PF12436	0.726
DOC_USP7_UBL2_3	439	443	PF12436	0.671
DOC_WW_Pin1_4	34	39	PF00397	0.627
DOC_WW_Pin1_4	449	454	PF00397	0.647
LIG_14-3-3_CanoR_1	264	274	PF00244	0.597
LIG_14-3-3_CanoR_1	294	300	PF00244	0.565
LIG_14-3-3_CanoR_1	354	362	PF00244	0.449
LIG_Actin_WH2_2	235	250	PF00022	0.588
LIG_APCC_ABBA_1	15	20	PF00400	0.670
LIG_BRCT_BRCA1_1	460	464	PF00533	0.648
LIG_BRCT_BRCA1_2	460	466	PF00533	0.573
LIG_eIF4E_1	322	328	PF01652	0.508
LIG_FHA_1	125	131	PF00498	0.481
LIG_FHA_1	353	359	PF00498	0.427
LIG_FHA_1	371	377	PF00498	0.618
LIG_FHA_2	354	360	PF00498	0.511
LIG_FHA_2	457	463	PF00498	0.519
LIG_GBD_Chelix_1	274	282	PF00786	0.497
LIG_LIR_Apic_2	467	471	PF02991	0.623
LIG_LIR_Gen_1	213	223	PF02991	0.638
LIG_LIR_Gen_1	418	427	PF02991	0.553
LIG_LIR_Gen_1	452	458	PF02991	0.656
LIG_LIR_Gen_1	52	61	PF02991	0.532
LIG_LIR_Nem_3	335	341	PF02991	0.429
LIG_LIR_Nem_3	377	382	PF02991	0.524
LIG_LIR_Nem_3	418	423	PF02991	0.524
LIG_LIR_Nem_3	452	457	PF02991	0.659
LIG_LIR_Nem_3	477	482	PF02991	0.564
LIG_LIR_Nem_3	52	56	PF02991	0.527
LIG_NRP_CendR_1	511	512	PF00754	0.720
LIG_Pex14_2	464	468	PF04695	0.658
LIG_SH2_CRK	479	483	PF00017	0.662
LIG_SH2_STAT5	502	505	PF00017	0.615
LIG_SH3_1	470	476	PF00018	0.557
LIG_SH3_3	359	365	PF00018	0.526
LIG_SH3_3	447	453	PF00018	0.527
LIG_SH3_3	470	476	PF00018	0.532
LIG_SH3_3	481	487	PF00018	0.554
LIG_SUMO_SIM_anti_2	127	134	PF11976	0.506
LIG_SUMO_SIM_anti_2	355	363	PF11976	0.415
LIG_SUMO_SIM_par_1	131	137	PF11976	0.594
LIG_TYR_ITSM	475	482	PF00017	0.668
LIG_UBA3_1	131	139	PF00899	0.539
LIG_WRC_WIRS_1	417	422	PF05994	0.520
MOD_CK1_1	174	180	PF00069	0.702
MOD_CK1_1	21	27	PF00069	0.668
MOD_CK1_1	425	431	PF00069	0.700
MOD_CK1_1	446	452	PF00069	0.593
MOD_CK1_1	49	55	PF00069	0.720
MOD_CK2_1	106	112	PF00069	0.776
MOD_CK2_1	264	270	PF00069	0.596
MOD_CK2_1	449	455	PF00069	0.560
MOD_CK2_1	456	462	PF00069	0.499
MOD_Cter_Amidation	144	147	PF01082	0.585
MOD_GlcNHglycan	108	111	PF01048	0.718
MOD_GlcNHglycan	189	192	PF01048	0.738
MOD_GlcNHglycan	267	270	PF01048	0.571
MOD_GlcNHglycan	27	30	PF01048	0.733
MOD_GlcNHglycan	279	282	PF01048	0.481
MOD_GlcNHglycan	34	37	PF01048	0.623
MOD_GlcNHglycan	424	427	PF01048	0.527
MOD_GlcNHglycan	46	51	PF01048	0.748
MOD_GlcNHglycan	495	498	PF01048	0.664
MOD_GSK3_1	158	165	PF00069	0.584
MOD_GSK3_1	21	28	PF00069	0.670
MOD_GSK3_1	366	373	PF00069	0.606
MOD_GSK3_1	418	425	PF00069	0.528
MOD_GSK3_1	42	49	PF00069	0.781
MOD_N-GLC_1	493	498	PF02516	0.667
MOD_NEK2_1	131	136	PF00069	0.570
MOD_NEK2_1	155	160	PF00069	0.457
MOD_NEK2_1	353	358	PF00069	0.496
MOD_NEK2_1	366	371	PF00069	0.495
MOD_NEK2_1	416	421	PF00069	0.485
MOD_NEK2_1	464	469	PF00069	0.634
MOD_NEK2_2	210	215	PF00069	0.656
MOD_PKA_1	162	168	PF00069	0.592
MOD_PKA_1	195	201	PF00069	0.750
MOD_PKA_1	264	270	PF00069	0.533
MOD_PKA_2	263	269	PF00069	0.634
MOD_PKA_2	295	301	PF00069	0.572
MOD_PKA_2	353	359	PF00069	0.447
MOD_Plk_1	3	9	PF00069	0.738
MOD_Plk_1	334	340	PF00069	0.346
MOD_Plk_1	374	380	PF00069	0.635
MOD_Plk_1	403	409	PF00069	0.539
MOD_Plk_4	21	27	PF00069	0.476
MOD_Plk_4	210	216	PF00069	0.654
MOD_Plk_4	3	9	PF00069	0.738
MOD_Plk_4	309	315	PF00069	0.472
MOD_Plk_4	334	340	PF00069	0.358
MOD_Plk_4	464	470	PF00069	0.549
MOD_ProDKin_1	34	40	PF00069	0.631
MOD_ProDKin_1	449	455	PF00069	0.649
MOD_SUMO_rev_2	134	141	PF00179	0.543
MOD_SUMO_rev_2	429	438	PF00179	0.678
TRG_DiLeu_BaEn_2	210	216	PF01217	0.654
TRG_DiLeu_BaEn_3	2	8	PF01217	0.711
TRG_DiLeu_BaEn_4	3	9	PF01217	0.713
TRG_ENDOCYTIC_2	479	482	PF00928	0.574
TRG_ER_diArg_1	293	296	PF00400	0.480
TRG_ER_diArg_1	399	401	PF00400	0.573
TRG_ER_diArg_1	510	512	PF00400	0.723
TRG_NLS_Bipartite_1	138	154	PF00514	0.506
TRG_NLS_Bipartite_1	162	179	PF00514	0.607
TRG_NLS_MonoCore_2	192	197	PF00514	0.631
TRG_NLS_MonoExtC_3	149	154	PF00514	0.427
TRG_NLS_MonoExtC_3	166	171	PF00514	0.595
TRG_NLS_MonoExtN_4	147	154	PF00514	0.497
TRG_NLS_MonoExtN_4	193	198	PF00514	0.654
TRG_Pf-PMV_PEXEL_1	286	290	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PAB7	Leptomonas seymouri	58%	100%
A0A3Q8IAL9	Leishmania donovani	90%	99%
A0A422N2J9	Trypanosoma rangeli	35%	100%
A4HC96	Leishmania braziliensis	75%	100%
A4HZS8	Leishmania infantum	90%	99%
C9ZRL3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AVN3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	99%
V5BLH2	Trypanosoma cruzi	34%	100%