Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBU5_LEIMA

TriTrypDb:

LmjF.22.0510 , LMJLV39_220010300 , LMJSD75_220010400

Length:

581

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBU5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBU5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	232	236	PF00656	0.721
CLV_NRD_NRD_1	153	155	PF00675	0.494
CLV_NRD_NRD_1	315	317	PF00675	0.441
CLV_NRD_NRD_1	550	552	PF00675	0.682
CLV_NRD_NRD_1	86	88	PF00675	0.616
CLV_PCSK_KEX2_1	153	155	PF00082	0.494
CLV_PCSK_KEX2_1	315	317	PF00082	0.441
CLV_PCSK_KEX2_1	550	552	PF00082	0.682
CLV_PCSK_KEX2_1	86	88	PF00082	0.616
CLV_PCSK_SKI1_1	146	150	PF00082	0.561
CLV_PCSK_SKI1_1	315	319	PF00082	0.556
CLV_PCSK_SKI1_1	55	59	PF00082	0.400
DEG_APCC_DBOX_1	145	153	PF00400	0.561
DEG_MDM2_SWIB_1	501	509	PF02201	0.494
DEG_Nend_UBRbox_3	1	3	PF02207	0.508
DEG_SCF_TRCP1_1	235	240	PF00400	0.694
DEG_SPOP_SBC_1	266	270	PF00917	0.737
DEG_SPOP_SBC_1	288	292	PF00917	0.428
DEG_SPOP_SBC_1	343	347	PF00917	0.711
DOC_CYCLIN_yCln2_LP_2	373	379	PF00134	0.578
DOC_CYCLIN_yCln2_LP_2	497	503	PF00134	0.633
DOC_MAPK_gen_1	315	324	PF00069	0.424
DOC_MAPK_MEF2A_6	493	501	PF00069	0.580
DOC_MAPK_RevD_3	72	87	PF00069	0.532
DOC_PP1_RVXF_1	53	59	PF00149	0.449
DOC_PP2B_LxvP_1	497	500	PF13499	0.666
DOC_PP2B_LxvP_1	542	545	PF13499	0.763
DOC_PP2B_LxvP_1	59	62	PF13499	0.462
DOC_PP4_FxxP_1	285	288	PF00568	0.396
DOC_SPAK_OSR1_1	71	75	PF12202	0.531
DOC_USP7_MATH_1	159	163	PF00917	0.454
DOC_USP7_MATH_1	185	189	PF00917	0.713
DOC_USP7_MATH_1	213	217	PF00917	0.771
DOC_USP7_MATH_1	249	253	PF00917	0.601
DOC_USP7_MATH_1	258	262	PF00917	0.630
DOC_USP7_MATH_1	266	270	PF00917	0.783
DOC_USP7_MATH_1	326	330	PF00917	0.568
DOC_USP7_MATH_1	343	347	PF00917	0.734
DOC_USP7_MATH_1	348	352	PF00917	0.676
DOC_USP7_MATH_1	439	443	PF00917	0.650
DOC_USP7_MATH_2	413	419	PF00917	0.554
DOC_WW_Pin1_4	116	121	PF00397	0.644
DOC_WW_Pin1_4	13	18	PF00397	0.616
DOC_WW_Pin1_4	193	198	PF00397	0.632
DOC_WW_Pin1_4	259	264	PF00397	0.710
DOC_WW_Pin1_4	267	272	PF00397	0.611
DOC_WW_Pin1_4	344	349	PF00397	0.692
DOC_WW_Pin1_4	372	377	PF00397	0.500
DOC_WW_Pin1_4	388	393	PF00397	0.584
DOC_WW_Pin1_4	394	399	PF00397	0.592
DOC_WW_Pin1_4	559	564	PF00397	0.698
LIG_14-3-3_CanoR_1	115	120	PF00244	0.741
LIG_14-3-3_CanoR_1	124	130	PF00244	0.579
LIG_14-3-3_CanoR_1	267	271	PF00244	0.691
LIG_14-3-3_CanoR_1	444	453	PF00244	0.751
LIG_14-3-3_CanoR_1	487	497	PF00244	0.609
LIG_14-3-3_CanoR_1	550	556	PF00244	0.571
LIG_Actin_WH2_2	302	320	PF00022	0.547
LIG_Actin_WH2_2	38	54	PF00022	0.527
LIG_BRCT_BRCA1_1	229	233	PF00533	0.666
LIG_BRCT_BRCA1_1	63	67	PF00533	0.451
LIG_CSL_BTD_1	542	545	PF09270	0.763
LIG_deltaCOP1_diTrp_1	466	471	PF00928	0.478
LIG_EH1_1	306	314	PF00400	0.532
LIG_FHA_1	175	181	PF00498	0.656
LIG_FHA_1	289	295	PF00498	0.528
LIG_FHA_1	300	306	PF00498	0.419
LIG_FHA_1	525	531	PF00498	0.727
LIG_FHA_1	96	102	PF00498	0.483
LIG_FHA_2	159	165	PF00498	0.558
LIG_FHA_2	177	183	PF00498	0.655
LIG_FHA_2	268	274	PF00498	0.663
LIG_FHA_2	513	519	PF00498	0.561
LIG_LIR_Apic_2	283	288	PF02991	0.394
LIG_LIR_Gen_1	415	424	PF02991	0.661
LIG_LIR_Gen_1	466	474	PF02991	0.523
LIG_LIR_Gen_1	77	85	PF02991	0.572
LIG_LIR_Nem_3	164	169	PF02991	0.525
LIG_LIR_Nem_3	174	178	PF02991	0.450
LIG_LIR_Nem_3	415	420	PF02991	0.656
LIG_LIR_Nem_3	466	470	PF02991	0.577
LIG_LIR_Nem_3	575	581	PF02991	0.461
LIG_LIR_Nem_3	77	83	PF02991	0.560
LIG_Pex14_2	501	505	PF04695	0.516
LIG_SH2_CRK	173	177	PF00017	0.589
LIG_SH2_NCK_1	43	47	PF00017	0.526
LIG_SH2_STAP1	43	47	PF00017	0.434
LIG_SH2_STAT5	173	176	PF00017	0.452
LIG_SH2_STAT5	308	311	PF00017	0.413
LIG_SH2_STAT5	464	467	PF00017	0.407
LIG_SH2_STAT5	568	571	PF00017	0.548
LIG_SH3_3	191	197	PF00018	0.755
LIG_SH3_3	395	401	PF00018	0.622
LIG_SH3_3	467	473	PF00018	0.654
LIG_SH3_3	535	541	PF00018	0.755
LIG_SUMO_SIM_par_1	176	183	PF11976	0.641
LIG_SUMO_SIM_par_1	451	457	PF11976	0.652
MOD_CDC14_SPxK_1	16	19	PF00782	0.636
MOD_CDK_SPxK_1	13	19	PF00069	0.617
MOD_CK1_1	119	125	PF00069	0.651
MOD_CK1_1	134	140	PF00069	0.603
MOD_CK1_1	196	202	PF00069	0.745
MOD_CK1_1	207	213	PF00069	0.626
MOD_CK1_1	229	235	PF00069	0.710
MOD_CK1_1	261	267	PF00069	0.721
MOD_CK1_1	299	305	PF00069	0.455
MOD_CK1_1	31	37	PF00069	0.536
MOD_CK1_1	333	339	PF00069	0.626
MOD_CK1_1	344	350	PF00069	0.706
MOD_CK1_1	351	357	PF00069	0.584
MOD_CK1_1	418	424	PF00069	0.639
MOD_CK1_1	442	448	PF00069	0.655
MOD_CK1_1	536	542	PF00069	0.638
MOD_CK1_1	546	552	PF00069	0.557
MOD_CK1_1	559	565	PF00069	0.556
MOD_CK1_1	60	66	PF00069	0.451
MOD_CK2_1	158	164	PF00069	0.457
MOD_CK2_1	267	273	PF00069	0.678
MOD_CK2_1	344	350	PF00069	0.738
MOD_CK2_1	512	518	PF00069	0.447
MOD_GlcNHglycan	121	124	PF01048	0.723
MOD_GlcNHglycan	187	190	PF01048	0.814
MOD_GlcNHglycan	20	23	PF01048	0.691
MOD_GlcNHglycan	235	238	PF01048	0.690
MOD_GlcNHglycan	256	259	PF01048	0.685
MOD_GlcNHglycan	291	294	PF01048	0.582
MOD_GlcNHglycan	298	301	PF01048	0.523
MOD_GlcNHglycan	334	338	PF01048	0.657
MOD_GlcNHglycan	358	361	PF01048	0.624
MOD_GlcNHglycan	419	423	PF01048	0.620
MOD_GlcNHglycan	440	444	PF01048	0.649
MOD_GlcNHglycan	538	541	PF01048	0.668
MOD_GlcNHglycan	552	555	PF01048	0.736
MOD_GlcNHglycan	559	562	PF01048	0.678
MOD_GlcNHglycan	59	62	PF01048	0.333
MOD_GlcNHglycan	91	94	PF01048	0.534
MOD_GSK3_1	115	122	PF00069	0.658
MOD_GSK3_1	227	234	PF00069	0.603
MOD_GSK3_1	254	261	PF00069	0.612
MOD_GSK3_1	27	34	PF00069	0.601
MOD_GSK3_1	326	333	PF00069	0.521
MOD_GSK3_1	342	349	PF00069	0.715
MOD_GSK3_1	350	357	PF00069	0.778
MOD_GSK3_1	546	553	PF00069	0.627
MOD_GSK3_1	568	575	PF00069	0.426
MOD_GSK3_1	57	64	PF00069	0.426
MOD_N-GLC_1	105	110	PF02516	0.637
MOD_N-GLC_2	368	370	PF02516	0.586
MOD_NEK2_1	233	238	PF00069	0.715
MOD_NEK2_1	28	33	PF00069	0.640
MOD_NEK2_1	511	516	PF00069	0.424
MOD_NEK2_1	556	561	PF00069	0.714
MOD_NEK2_1	57	62	PF00069	0.385
MOD_NEK2_1	6	11	PF00069	0.414
MOD_PIKK_1	105	111	PF00454	0.612
MOD_PIKK_1	31	37	PF00454	0.409
MOD_PIKK_1	445	451	PF00454	0.704
MOD_PIKK_1	61	67	PF00454	0.563
MOD_PKA_1	550	556	PF00069	0.745
MOD_PKA_2	18	24	PF00069	0.756
MOD_PKA_2	207	213	PF00069	0.746
MOD_PKA_2	266	272	PF00069	0.689
MOD_PKA_2	296	302	PF00069	0.496
MOD_PKA_2	415	421	PF00069	0.654
MOD_PKA_2	533	539	PF00069	0.795
MOD_PKA_2	546	552	PF00069	0.652
MOD_PKB_1	362	370	PF00069	0.540
MOD_Plk_1	105	111	PF00069	0.672
MOD_Plk_4	196	202	PF00069	0.629
MOD_Plk_4	568	574	PF00069	0.422
MOD_ProDKin_1	116	122	PF00069	0.645
MOD_ProDKin_1	13	19	PF00069	0.617
MOD_ProDKin_1	193	199	PF00069	0.633
MOD_ProDKin_1	259	265	PF00069	0.711
MOD_ProDKin_1	267	273	PF00069	0.602
MOD_ProDKin_1	344	350	PF00069	0.694
MOD_ProDKin_1	372	378	PF00069	0.495
MOD_ProDKin_1	388	394	PF00069	0.598
MOD_ProDKin_1	559	565	PF00069	0.689
TRG_DiLeu_BaLyEn_6	301	306	PF01217	0.510
TRG_ER_diArg_1	141	144	PF00400	0.475
TRG_ER_diArg_1	152	154	PF00400	0.447
TRG_ER_diArg_1	315	317	PF00400	0.441
TRG_ER_diArg_1	363	366	PF00400	0.602
TRG_ER_diArg_1	85	87	PF00400	0.607

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZL6	Leptomonas seymouri	33%	100%
A0A3Q8IFE8	Leishmania donovani	85%	100%
A4HC97	Leishmania braziliensis	65%	89%
A4HZS9	Leishmania infantum	85%	100%
E9AVN4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%