Putative peptidyl-prolyl cis-trans isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

peptidyl-prolyl cis-trans isomerase, putative

Species:

Leishmania major

UniProt:

Q4QBU3_LEIMA

TriTrypDb:

LmjF.22.0530 , LMJLV39_220010500 , LMJSD75_220010600

Length:

440

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QBU3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBU3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0003729	mRNA binding	5	2
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	10
GO:0003824	catalytic activity	1	10
GO:0005488	binding	1	2
GO:0016853	isomerase activity	2	10
GO:0016859	cis-trans isomerase activity	3	10
GO:0097159	organic cyclic compound binding	2	2
GO:0140096	catalytic activity, acting on a protein	2	10
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	238	242	PF00656	0.573
CLV_C14_Caspase3-7	292	296	PF00656	0.638
CLV_C14_Caspase3-7	345	349	PF00656	0.436
CLV_NRD_NRD_1	148	150	PF00675	0.363
CLV_NRD_NRD_1	362	364	PF00675	0.479
CLV_NRD_NRD_1	419	421	PF00675	0.369
CLV_PCSK_KEX2_1	144	146	PF00082	0.384
CLV_PCSK_KEX2_1	180	182	PF00082	0.639
CLV_PCSK_KEX2_1	362	364	PF00082	0.471
CLV_PCSK_KEX2_1	395	397	PF00082	0.375
CLV_PCSK_KEX2_1	419	421	PF00082	0.369
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.371
CLV_PCSK_PC1ET2_1	180	182	PF00082	0.639
CLV_PCSK_PC1ET2_1	395	397	PF00082	0.375
CLV_PCSK_PC7_1	140	146	PF00082	0.365
CLV_PCSK_SKI1_1	354	358	PF00082	0.528
DEG_APCC_DBOX_1	395	403	PF00400	0.469
DEG_SPOP_SBC_1	233	237	PF00917	0.623
DEG_SPOP_SBC_1	265	269	PF00917	0.588
DOC_CKS1_1	374	379	PF01111	0.453
DOC_MAPK_gen_1	149	156	PF00069	0.432
DOC_MAPK_gen_1	393	401	PF00069	0.378
DOC_MAPK_MEF2A_6	149	156	PF00069	0.403
DOC_MAPK_MEF2A_6	363	372	PF00069	0.551
DOC_MAPK_MEF2A_6	81	89	PF00069	0.542
DOC_PP4_FxxP_1	60	63	PF00568	0.410
DOC_USP7_MATH_1	155	159	PF00917	0.371
DOC_USP7_MATH_1	223	227	PF00917	0.556
DOC_USP7_MATH_1	265	269	PF00917	0.739
DOC_USP7_MATH_1	273	277	PF00917	0.678
DOC_USP7_MATH_1	305	309	PF00917	0.734
DOC_USP7_MATH_1	36	40	PF00917	0.575
DOC_WW_Pin1_4	297	302	PF00397	0.673
DOC_WW_Pin1_4	370	375	PF00397	0.532
LIG_14-3-3_CanoR_1	257	262	PF00244	0.685
LIG_14-3-3_CanoR_1	280	284	PF00244	0.571
LIG_Actin_WH2_2	404	421	PF00022	0.469
LIG_BIR_II_1	1	5	PF00653	0.611
LIG_BIR_III_4	295	299	PF00653	0.683
LIG_BRCT_BRCA1_1	69	73	PF00533	0.558
LIG_CSL_BTD_1	374	377	PF09270	0.445
LIG_eIF4E_1	313	319	PF01652	0.551
LIG_FHA_1	134	140	PF00498	0.366
LIG_FHA_1	166	172	PF00498	0.523
LIG_FHA_1	256	262	PF00498	0.649
LIG_FHA_1	273	279	PF00498	0.692
LIG_FHA_1	46	52	PF00498	0.528
LIG_FHA_2	236	242	PF00498	0.663
LIG_FHA_2	290	296	PF00498	0.721
LIG_FHA_2	374	380	PF00498	0.517
LIG_FHA_2	404	410	PF00498	0.341
LIG_FHA_2	44	50	PF00498	0.569
LIG_Integrin_RGD_1	396	398	PF01839	0.469
LIG_LIR_Apic_2	58	63	PF02991	0.410
LIG_LIR_Gen_1	385	392	PF02991	0.402
LIG_LIR_Nem_3	312	316	PF02991	0.535
LIG_LIR_Nem_3	385	390	PF02991	0.359
LIG_LYPXL_yS_3	84	87	PF13949	0.533
LIG_SH2_CRK	313	317	PF00017	0.475
LIG_SH2_SRC	313	316	PF00017	0.573
LIG_SH2_STAP1	169	173	PF00017	0.526
LIG_SH2_STAT5	105	108	PF00017	0.322
LIG_SH2_STAT5	355	358	PF00017	0.550
LIG_SH2_STAT5	387	390	PF00017	0.440
LIG_SH2_STAT5	95	98	PF00017	0.287
LIG_SH3_1	145	151	PF00018	0.469
LIG_SH3_1	362	368	PF00018	0.446
LIG_SH3_3	145	151	PF00018	0.469
LIG_SH3_3	242	248	PF00018	0.728
LIG_SH3_3	26	32	PF00018	0.678
LIG_SH3_3	325	331	PF00018	0.459
LIG_SH3_3	362	368	PF00018	0.573
LIG_SH3_3	371	377	PF00018	0.431
LIG_SH3_3	420	426	PF00018	0.328
LIG_SH3_3	66	72	PF00018	0.486
LIG_SH3_3	79	85	PF00018	0.476
LIG_SH3_5	101	105	PF00018	0.369
LIG_SUMO_SIM_par_1	129	136	PF11976	0.371
LIG_SUMO_SIM_par_1	152	158	PF11976	0.440
LIG_TRAF2_1	376	379	PF00917	0.514
LIG_TYR_ITIM	82	87	PF00017	0.543
LIG_UBA3_1	318	326	PF00899	0.527
LIG_WRC_WIRS_1	1	6	PF05994	0.694
MOD_CK1_1	111	117	PF00069	0.358
MOD_CK1_1	165	171	PF00069	0.512
MOD_CK1_1	201	207	PF00069	0.745
MOD_CK1_1	236	242	PF00069	0.654
MOD_CK1_1	373	379	PF00069	0.480
MOD_CK2_1	297	303	PF00069	0.712
MOD_CK2_1	373	379	PF00069	0.429
MOD_Cter_Amidation	142	145	PF01082	0.401
MOD_GlcNHglycan	18	21	PF01048	0.702
MOD_GlcNHglycan	196	199	PF01048	0.678
MOD_GlcNHglycan	203	206	PF01048	0.677
MOD_GlcNHglycan	214	217	PF01048	0.665
MOD_GlcNHglycan	225	228	PF01048	0.622
MOD_GlcNHglycan	230	233	PF01048	0.583
MOD_GlcNHglycan	238	241	PF01048	0.754
MOD_GlcNHglycan	268	271	PF01048	0.665
MOD_GlcNHglycan	275	278	PF01048	0.672
MOD_GlcNHglycan	307	310	PF01048	0.701
MOD_GlcNHglycan	389	393	PF01048	0.362
MOD_GlcNHglycan	422	426	PF01048	0.470
MOD_GSK3_1	194	201	PF00069	0.701
MOD_GSK3_1	219	226	PF00069	0.644
MOD_GSK3_1	228	235	PF00069	0.620
MOD_GSK3_1	251	258	PF00069	0.644
MOD_GSK3_1	285	292	PF00069	0.686
MOD_NEK2_1	133	138	PF00069	0.328
MOD_NEK2_1	162	167	PF00069	0.393
MOD_PIKK_1	426	432	PF00454	0.440
MOD_PK_1	257	263	PF00069	0.577
MOD_PK_1	55	61	PF00069	0.456
MOD_PKA_2	279	285	PF00069	0.573
MOD_Plk_2-3	403	409	PF00069	0.341
MOD_Plk_4	155	161	PF00069	0.440
MOD_Plk_4	285	291	PF00069	0.776
MOD_Plk_4	55	61	PF00069	0.509
MOD_ProDKin_1	297	303	PF00069	0.671
MOD_ProDKin_1	370	376	PF00069	0.532
MOD_SUMO_rev_2	184	192	PF00179	0.645
TRG_DiLeu_BaEn_2	123	129	PF01217	0.371
TRG_ENDOCYTIC_2	313	316	PF00928	0.481
TRG_ENDOCYTIC_2	387	390	PF00928	0.440
TRG_ENDOCYTIC_2	84	87	PF00928	0.530
TRG_ENDOCYTIC_2	94	97	PF00928	0.401
TRG_ER_diArg_1	362	364	PF00400	0.544
TRG_ER_diArg_1	418	420	PF00400	0.449
TRG_NLS_MonoCore_2	392	397	PF00514	0.469
TRG_NLS_MonoExtC_3	392	398	PF00514	0.440
TRG_Pf-PMV_PEXEL_1	180	184	PF00026	0.666

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSF6	Leptomonas seymouri	63%	100%
A0A0S4J8C1	Bodo saltans	34%	100%
A0A3Q8IE70	Leishmania donovani	93%	100%
A0A3R7K0E7	Trypanosoma rangeli	42%	100%
A4HC99	Leishmania braziliensis	78%	100%
C9ZRL7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	43%	100%
E9AVN6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BR42	Trypanosoma cruzi	43%	100%