Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBU2_LEIMA

TriTrypDb:

LmjF.22.0540 , LMJLV39_220010600 , LMJSD75_220010700

Length:

891

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBU2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBU2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	240	244	PF00656	0.633
CLV_C14_Caspase3-7	256	260	PF00656	0.345
CLV_C14_Caspase3-7	808	812	PF00656	0.696
CLV_NRD_NRD_1	196	198	PF00675	0.425
CLV_NRD_NRD_1	261	263	PF00675	0.536
CLV_NRD_NRD_1	270	272	PF00675	0.546
CLV_NRD_NRD_1	308	310	PF00675	0.641
CLV_NRD_NRD_1	41	43	PF00675	0.528
CLV_NRD_NRD_1	447	449	PF00675	0.382
CLV_NRD_NRD_1	47	49	PF00675	0.478
CLV_NRD_NRD_1	530	532	PF00675	0.621
CLV_NRD_NRD_1	639	641	PF00675	0.355
CLV_NRD_NRD_1	660	662	PF00675	0.530
CLV_NRD_NRD_1	775	777	PF00675	0.597
CLV_NRD_NRD_1	791	793	PF00675	0.463
CLV_NRD_NRD_1	801	803	PF00675	0.531
CLV_NRD_NRD_1	871	873	PF00675	0.653
CLV_PCSK_KEX2_1	196	198	PF00082	0.426
CLV_PCSK_KEX2_1	261	263	PF00082	0.543
CLV_PCSK_KEX2_1	270	272	PF00082	0.561
CLV_PCSK_KEX2_1	275	277	PF00082	0.599
CLV_PCSK_KEX2_1	308	310	PF00082	0.641
CLV_PCSK_KEX2_1	447	449	PF00082	0.523
CLV_PCSK_KEX2_1	47	49	PF00082	0.493
CLV_PCSK_KEX2_1	660	662	PF00082	0.526
CLV_PCSK_KEX2_1	775	777	PF00082	0.600
CLV_PCSK_KEX2_1	791	793	PF00082	0.466
CLV_PCSK_KEX2_1	800	802	PF00082	0.533
CLV_PCSK_KEX2_1	845	847	PF00082	0.548
CLV_PCSK_KEX2_1	871	873	PF00082	0.619
CLV_PCSK_PC1ET2_1	275	277	PF00082	0.517
CLV_PCSK_PC1ET2_1	845	847	PF00082	0.588
CLV_PCSK_PC7_1	271	277	PF00082	0.508
CLV_PCSK_PC7_1	796	802	PF00082	0.593
CLV_PCSK_SKI1_1	371	375	PF00082	0.414
CLV_PCSK_SKI1_1	391	395	PF00082	0.406
CLV_PCSK_SKI1_1	463	467	PF00082	0.433
CLV_PCSK_SKI1_1	48	52	PF00082	0.469
CLV_PCSK_SKI1_1	698	702	PF00082	0.554
CLV_PCSK_SKI1_1	80	84	PF00082	0.615
CLV_PCSK_SKI1_1	802	806	PF00082	0.616
CLV_Separin_Metazoa	675	679	PF03568	0.603
DEG_APCC_KENBOX_2	878	882	PF00400	0.664
DEG_SCF_TRCP1_1	704	709	PF00400	0.486
DEG_SPOP_SBC_1	478	482	PF00917	0.397
DEG_SPOP_SBC_1	535	539	PF00917	0.504
DOC_CKS1_1	132	137	PF01111	0.538
DOC_CKS1_1	347	352	PF01111	0.726
DOC_CKS1_1	753	758	PF01111	0.517
DOC_CYCLIN_yCln2_LP_2	461	467	PF00134	0.442
DOC_MAPK_gen_1	447	455	PF00069	0.432
DOC_MAPK_gen_1	47	53	PF00069	0.445
DOC_MAPK_gen_1	640	647	PF00069	0.311
DOC_MAPK_gen_1	791	797	PF00069	0.579
DOC_PP2B_LxvP_1	211	214	PF13499	0.503
DOC_PP2B_LxvP_1	49	52	PF13499	0.422
DOC_PP2B_LxvP_1	671	674	PF13499	0.450
DOC_PP2B_LxvP_1	767	770	PF13499	0.617
DOC_PP4_FxxP_1	104	107	PF00568	0.621
DOC_PP4_FxxP_1	17	20	PF00568	0.523
DOC_USP7_MATH_1	109	113	PF00917	0.593
DOC_USP7_MATH_1	139	143	PF00917	0.745
DOC_USP7_MATH_1	287	291	PF00917	0.787
DOC_USP7_MATH_1	52	56	PF00917	0.584
DOC_USP7_MATH_1	653	657	PF00917	0.398
DOC_USP7_MATH_1	708	712	PF00917	0.758
DOC_USP7_UBL2_3	884	888	PF12436	0.662
DOC_WW_Pin1_4	131	136	PF00397	0.555
DOC_WW_Pin1_4	302	307	PF00397	0.705
DOC_WW_Pin1_4	320	325	PF00397	0.502
DOC_WW_Pin1_4	346	351	PF00397	0.670
DOC_WW_Pin1_4	495	500	PF00397	0.487
DOC_WW_Pin1_4	531	536	PF00397	0.689
DOC_WW_Pin1_4	615	620	PF00397	0.389
DOC_WW_Pin1_4	654	659	PF00397	0.321
DOC_WW_Pin1_4	685	690	PF00397	0.639
DOC_WW_Pin1_4	72	77	PF00397	0.542
DOC_WW_Pin1_4	752	757	PF00397	0.767
DOC_WW_Pin1_4	844	849	PF00397	0.696
LIG_14-3-3_CanoR_1	197	205	PF00244	0.487
LIG_14-3-3_CanoR_1	309	315	PF00244	0.476
LIG_14-3-3_CanoR_1	463	468	PF00244	0.446
LIG_14-3-3_CanoR_1	529	535	PF00244	0.522
LIG_14-3-3_CanoR_1	564	574	PF00244	0.494
LIG_14-3-3_CanoR_1	737	742	PF00244	0.688
LIG_14-3-3_CanoR_1	775	782	PF00244	0.591
LIG_14-3-3_CanoR_1	871	877	PF00244	0.603
LIG_14-3-3_CanoR_1	96	100	PF00244	0.687
LIG_BIR_II_1	1	5	PF00653	0.449
LIG_BIR_III_4	241	245	PF00653	0.602
LIG_BIR_III_4	283	287	PF00653	0.494
LIG_BIR_III_4	414	418	PF00653	0.629
LIG_BRCT_BRCA1_1	100	104	PF00533	0.601
LIG_BRCT_BRCA1_1	311	315	PF00533	0.494
LIG_BRCT_BRCA1_1	557	561	PF00533	0.433
LIG_deltaCOP1_diTrp_1	273	280	PF00928	0.549
LIG_FHA_1	188	194	PF00498	0.500
LIG_FHA_1	208	214	PF00498	0.233
LIG_FHA_1	321	327	PF00498	0.713
LIG_FHA_1	464	470	PF00498	0.469
LIG_FHA_1	499	505	PF00498	0.588
LIG_FHA_1	509	515	PF00498	0.287
LIG_FHA_1	589	595	PF00498	0.441
LIG_FHA_1	705	711	PF00498	0.659
LIG_FHA_1	720	726	PF00498	0.522
LIG_FHA_1	741	747	PF00498	0.665
LIG_FHA_2	132	138	PF00498	0.634
LIG_FHA_2	236	242	PF00498	0.616
LIG_FHA_2	470	476	PF00498	0.489
LIG_FHA_2	538	544	PF00498	0.764
LIG_FHA_2	680	686	PF00498	0.643
LIG_GBD_Chelix_1	574	582	PF00786	0.366
LIG_HCF-1_HBM_1	398	401	PF13415	0.486
LIG_IBAR_NPY_1	863	865	PF08397	0.613
LIG_Integrin_RGD_1	271	273	PF01839	0.501
LIG_Integrin_RGDW_4	271	274	PF00362	0.452
LIG_LIR_Apic_2	101	107	PF02991	0.616
LIG_LIR_Apic_2	15	20	PF02991	0.481
LIG_LIR_Apic_2	750	756	PF02991	0.684
LIG_LIR_Gen_1	169	178	PF02991	0.351
LIG_LIR_Gen_1	230	236	PF02991	0.531
LIG_LIR_Gen_1	454	464	PF02991	0.424
LIG_LIR_Gen_1	609	620	PF02991	0.492
LIG_LIR_Gen_1	793	799	PF02991	0.635
LIG_LIR_LC3C_4	643	646	PF02991	0.300
LIG_LIR_Nem_3	169	174	PF02991	0.354
LIG_LIR_Nem_3	177	181	PF02991	0.355
LIG_LIR_Nem_3	226	232	PF02991	0.498
LIG_LIR_Nem_3	398	404	PF02991	0.497
LIG_LIR_Nem_3	454	459	PF02991	0.417
LIG_LIR_Nem_3	609	615	PF02991	0.480
LIG_LIR_Nem_3	77	82	PF02991	0.497
LIG_LIR_Nem_3	793	797	PF02991	0.631
LIG_LIR_Nem_3	828	833	PF02991	0.553
LIG_MYND_1	324	328	PF01753	0.614
LIG_MYND_1	669	673	PF01753	0.526
LIG_NRBOX	577	583	PF00104	0.376
LIG_PDZ_Class_1	886	891	PF00595	0.527
LIG_Pex14_1	397	401	PF04695	0.497
LIG_Pex14_2	456	460	PF04695	0.470
LIG_PTB_Apo_2	63	70	PF02174	0.508
LIG_PTB_Phospho_1	63	69	PF10480	0.509
LIG_Rb_LxCxE_1	392	412	PF01857	0.544
LIG_REV1ctd_RIR_1	830	839	PF16727	0.659
LIG_RPA_C_Fungi	257	269	PF08784	0.507
LIG_SH2_CRK	401	405	PF00017	0.513
LIG_SH2_CRK	69	73	PF00017	0.474
LIG_SH2_PTP2	794	797	PF00017	0.576
LIG_SH2_STAP1	13	17	PF00017	0.436
LIG_SH2_STAP1	229	233	PF00017	0.545
LIG_SH2_STAP1	40	44	PF00017	0.621
LIG_SH2_STAP1	649	653	PF00017	0.456
LIG_SH2_STAP1	93	97	PF00017	0.599
LIG_SH2_STAT3	13	16	PF00017	0.437
LIG_SH2_STAT5	178	181	PF00017	0.409
LIG_SH2_STAT5	232	235	PF00017	0.504
LIG_SH2_STAT5	468	471	PF00017	0.421
LIG_SH2_STAT5	632	635	PF00017	0.647
LIG_SH2_STAT5	794	797	PF00017	0.611
LIG_SH3_2	770	775	PF14604	0.622
LIG_SH3_3	103	109	PF00018	0.556
LIG_SH3_3	129	135	PF00018	0.531
LIG_SH3_3	354	360	PF00018	0.782
LIG_SH3_3	767	773	PF00018	0.775
LIG_SH3_3	94	100	PF00018	0.507
LIG_SUMO_SIM_anti_2	579	587	PF11976	0.467
LIG_SUMO_SIM_anti_2	643	648	PF11976	0.292
LIG_SUMO_SIM_anti_2	742	750	PF11976	0.494
LIG_SUMO_SIM_par_1	524	530	PF11976	0.463
LIG_SUMO_SIM_par_1	579	587	PF11976	0.467
LIG_TRAF2_1	557	560	PF00917	0.455
LIG_UBA3_1	748	752	PF00899	0.633
LIG_WRC_WIRS_1	188	193	PF05994	0.443
MOD_CDC14_SPxK_1	305	308	PF00782	0.599
MOD_CDC14_SPxK_1	657	660	PF00782	0.325
MOD_CDK_SPK_2	346	351	PF00069	0.776
MOD_CDK_SPxK_1	302	308	PF00069	0.613
MOD_CDK_SPxK_1	654	660	PF00069	0.317
MOD_CDK_SPxxK_3	302	309	PF00069	0.622
MOD_CDK_SPxxK_3	654	661	PF00069	0.315
MOD_CK1_1	12	18	PF00069	0.527
MOD_CK1_1	133	139	PF00069	0.691
MOD_CK1_1	166	172	PF00069	0.510
MOD_CK1_1	201	207	PF00069	0.404
MOD_CK1_1	289	295	PF00069	0.765
MOD_CK1_1	307	313	PF00069	0.657
MOD_CK1_1	320	326	PF00069	0.627
MOD_CK1_1	337	343	PF00069	0.774
MOD_CK1_1	480	486	PF00069	0.718
MOD_CK1_1	533	539	PF00069	0.706
MOD_CK1_1	719	725	PF00069	0.656
MOD_CK1_1	728	734	PF00069	0.552
MOD_CK1_1	778	784	PF00069	0.744
MOD_CK2_1	131	137	PF00069	0.680
MOD_CK2_1	250	256	PF00069	0.726
MOD_CK2_1	338	344	PF00069	0.807
MOD_CK2_1	537	543	PF00069	0.705
MOD_CK2_1	679	685	PF00069	0.569
MOD_Cter_Amidation	773	776	PF01082	0.669
MOD_GlcNHglycan	101	104	PF01048	0.647
MOD_GlcNHglycan	124	127	PF01048	0.760
MOD_GlcNHglycan	185	188	PF01048	0.539
MOD_GlcNHglycan	201	204	PF01048	0.403
MOD_GlcNHglycan	289	292	PF01048	0.795
MOD_GlcNHglycan	351	354	PF01048	0.726
MOD_GlcNHglycan	383	386	PF01048	0.669
MOD_GlcNHglycan	485	488	PF01048	0.537
MOD_GlcNHglycan	492	495	PF01048	0.586
MOD_GlcNHglycan	565	568	PF01048	0.470
MOD_GlcNHglycan	6	9	PF01048	0.675
MOD_GlcNHglycan	633	636	PF01048	0.488
MOD_GlcNHglycan	704	707	PF01048	0.711
MOD_GlcNHglycan	759	762	PF01048	0.654
MOD_GlcNHglycan	777	780	PF01048	0.595
MOD_GlcNHglycan	827	830	PF01048	0.576
MOD_GlcNHglycan	888	891	PF01048	0.531
MOD_GSK3_1	166	173	PF00069	0.454
MOD_GSK3_1	183	190	PF00069	0.442
MOD_GSK3_1	320	327	PF00069	0.605
MOD_GSK3_1	333	340	PF00069	0.659
MOD_GSK3_1	379	386	PF00069	0.598
MOD_GSK3_1	463	470	PF00069	0.471
MOD_GSK3_1	478	485	PF00069	0.668
MOD_GSK3_1	527	534	PF00069	0.560
MOD_GSK3_1	535	542	PF00069	0.711
MOD_GSK3_1	551	558	PF00069	0.701
MOD_GSK3_1	702	709	PF00069	0.633
MOD_GSK3_1	733	740	PF00069	0.623
MOD_GSK3_1	774	781	PF00069	0.578
MOD_GSK3_1	95	102	PF00069	0.685
MOD_LATS_1	735	741	PF00433	0.584
MOD_N-GLC_1	166	171	PF02516	0.516
MOD_N-GLC_1	702	707	PF02516	0.589
MOD_N-GLC_1	725	730	PF02516	0.622
MOD_N-GLC_1	872	877	PF02516	0.637
MOD_NEK2_1	170	175	PF00069	0.359
MOD_NEK2_1	198	203	PF00069	0.448
MOD_NEK2_1	228	233	PF00069	0.481
MOD_NEK2_1	315	320	PF00069	0.721
MOD_NEK2_1	442	447	PF00069	0.437
MOD_NEK2_1	479	484	PF00069	0.475
MOD_NEK2_1	507	512	PF00069	0.381
MOD_NEK2_1	515	520	PF00069	0.374
MOD_NEK2_1	527	532	PF00069	0.526
MOD_NEK2_1	563	568	PF00069	0.452
MOD_NEK2_1	805	810	PF00069	0.673
MOD_NEK2_2	187	192	PF00069	0.438
MOD_PIKK_1	107	113	PF00454	0.593
MOD_PIKK_1	12	18	PF00454	0.458
MOD_PIKK_1	385	391	PF00454	0.450
MOD_PIKK_1	622	628	PF00454	0.506
MOD_PKA_1	775	781	PF00069	0.613
MOD_PKA_1	871	877	PF00069	0.606
MOD_PKA_2	198	204	PF00069	0.491
MOD_PKA_2	307	313	PF00069	0.628
MOD_PKA_2	425	431	PF00069	0.535
MOD_PKA_2	530	536	PF00069	0.578
MOD_PKA_2	563	569	PF00069	0.520
MOD_PKA_2	774	780	PF00069	0.573
MOD_PKA_2	871	877	PF00069	0.606
MOD_PKA_2	95	101	PF00069	0.576
MOD_PKB_1	197	205	PF00069	0.484
MOD_Plk_1	166	172	PF00069	0.510
MOD_Plk_1	507	513	PF00069	0.481
MOD_Plk_1	719	725	PF00069	0.787
MOD_Plk_1	872	878	PF00069	0.659
MOD_Plk_4	170	176	PF00069	0.350
MOD_Plk_4	18	24	PF00069	0.388
MOD_Plk_4	207	213	PF00069	0.372
MOD_Plk_4	228	234	PF00069	0.555
MOD_Plk_4	310	316	PF00069	0.492
MOD_Plk_4	451	457	PF00069	0.403
MOD_Plk_4	463	469	PF00069	0.449
MOD_Plk_4	570	576	PF00069	0.418
MOD_Plk_4	744	750	PF00069	0.717
MOD_ProDKin_1	131	137	PF00069	0.559
MOD_ProDKin_1	302	308	PF00069	0.700
MOD_ProDKin_1	320	326	PF00069	0.503
MOD_ProDKin_1	346	352	PF00069	0.670
MOD_ProDKin_1	495	501	PF00069	0.482
MOD_ProDKin_1	531	537	PF00069	0.693
MOD_ProDKin_1	615	621	PF00069	0.385
MOD_ProDKin_1	654	660	PF00069	0.317
MOD_ProDKin_1	685	691	PF00069	0.641
MOD_ProDKin_1	72	78	PF00069	0.540
MOD_ProDKin_1	752	758	PF00069	0.770
MOD_ProDKin_1	844	850	PF00069	0.694
TRG_DiLeu_BaEn_4	223	229	PF01217	0.453
TRG_DiLeu_BaLyEn_6	522	527	PF01217	0.465
TRG_DiLeu_BaLyEn_6	573	578	PF01217	0.417
TRG_ENDOCYTIC_2	178	181	PF00928	0.350
TRG_ENDOCYTIC_2	232	235	PF00928	0.577
TRG_ENDOCYTIC_2	401	404	PF00928	0.501
TRG_ENDOCYTIC_2	649	652	PF00928	0.439
TRG_ENDOCYTIC_2	69	72	PF00928	0.470
TRG_ENDOCYTIC_2	794	797	PF00928	0.644
TRG_ER_diArg_1	196	198	PF00400	0.510
TRG_ER_diArg_1	252	255	PF00400	0.600
TRG_ER_diArg_1	261	263	PF00400	0.428
TRG_ER_diArg_1	30	33	PF00400	0.500
TRG_ER_diArg_1	447	449	PF00400	0.523
TRG_ER_diArg_1	47	49	PF00400	0.437
TRG_ER_diArg_1	528	531	PF00400	0.450
TRG_ER_diArg_1	790	792	PF00400	0.594
TRG_ER_diArg_1	800	802	PF00400	0.573
TRG_ER_diArg_1	870	872	PF00400	0.621
TRG_NES_CRM1_1	579	592	PF08389	0.428
TRG_Pf-PMV_PEXEL_1	262	266	PF00026	0.513
TRG_Pf-PMV_PEXEL_1	576	580	PF00026	0.422

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJM2	Leptomonas seymouri	50%	100%
A0A1X0NTP3	Trypanosomatidae	28%	100%
A0A3S7WX34	Leishmania donovani	90%	100%
A0A422N2K2	Trypanosoma rangeli	29%	100%
A4HCA0	Leishmania braziliensis	72%	99%
A4HZT2	Leishmania infantum	91%	100%
C9ZRL8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AVN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BVR6	Trypanosoma cruzi	31%	100%