Kinesin-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kinesin, putative

Species:

Leishmania major

UniProt:

Q4QBU1_LEIMA

TriTrypDb:

LmjF.22.0560 , LMJLV39_220010700 , LMJSD75_220010800

Length:

891

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 14
NetGPI	no	yes: 0, no: 14

Cellular components
Term	Name	Level	Count
GO:0005874	microtubule	6	11
GO:0099080	supramolecular complex	2	11
GO:0099081	supramolecular polymer	3	11
GO:0099512	supramolecular fiber	4	11
GO:0099513	polymeric cytoskeletal fiber	5	11
GO:0110165	cellular anatomical entity	1	11
GO:0005737	cytoplasm	2	1
GO:0005871	kinesin complex	3	1
GO:0005875	microtubule associated complex	2	1
GO:0032991	protein-containing complex	1	1

Expansion

Sequence features

Q4QBU1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBU1

Function

Biological processes
Term	Name	Level	Count
GO:0007017	microtubule-based process	2	15
GO:0007018	microtubule-based movement	3	15
GO:0009987	cellular process	1	15
GO:0006810	transport	3	1
GO:0030705	cytoskeleton-dependent intracellular transport	4	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	15
GO:0003774	cytoskeletal motor activity	1	15
GO:0003777	microtubule motor activity	2	15
GO:0003824	catalytic activity	1	9
GO:0005488	binding	1	15
GO:0005515	protein binding	2	15
GO:0005524	ATP binding	5	15
GO:0008017	microtubule binding	5	15
GO:0008092	cytoskeletal protein binding	3	15
GO:0015631	tubulin binding	4	15
GO:0016787	hydrolase activity	2	9
GO:0017076	purine nucleotide binding	4	15
GO:0030554	adenyl nucleotide binding	5	15
GO:0032553	ribonucleotide binding	3	15
GO:0032555	purine ribonucleotide binding	4	15
GO:0032559	adenyl ribonucleotide binding	5	15
GO:0035639	purine ribonucleoside triphosphate binding	4	15
GO:0036094	small molecule binding	2	15
GO:0043167	ion binding	2	15
GO:0043168	anion binding	3	15
GO:0097159	organic cyclic compound binding	2	15
GO:0097367	carbohydrate derivative binding	2	15
GO:0140657	ATP-dependent activity	1	15
GO:1901265	nucleoside phosphate binding	3	15
GO:1901363	heterocyclic compound binding	2	15
GO:0008574	plus-end-directed microtubule motor activity	3	1
GO:0016462	pyrophosphatase activity	5	1
GO:0016817	hydrolase activity, acting on acid anhydrides	3	1
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	1
GO:0016887	ATP hydrolysis activity	7	1
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.586
CLV_NRD_NRD_1	300	302	PF00675	0.568
CLV_NRD_NRD_1	458	460	PF00675	0.494
CLV_NRD_NRD_1	619	621	PF00675	0.411
CLV_NRD_NRD_1	775	777	PF00675	0.518
CLV_PCSK_FUR_1	428	432	PF00082	0.404
CLV_PCSK_KEX2_1	300	302	PF00082	0.622
CLV_PCSK_KEX2_1	430	432	PF00082	0.404
CLV_PCSK_KEX2_1	619	621	PF00082	0.528
CLV_PCSK_KEX2_1	775	777	PF00082	0.677
CLV_PCSK_KEX2_1	817	819	PF00082	0.418
CLV_PCSK_PC1ET2_1	430	432	PF00082	0.366
CLV_PCSK_PC1ET2_1	817	819	PF00082	0.418
CLV_PCSK_SKI1_1	147	151	PF00082	0.277
CLV_PCSK_SKI1_1	313	317	PF00082	0.313
CLV_PCSK_SKI1_1	335	339	PF00082	0.255
CLV_PCSK_SKI1_1	354	358	PF00082	0.233
CLV_PCSK_SKI1_1	430	434	PF00082	0.306
CLV_PCSK_SKI1_1	459	463	PF00082	0.468
CLV_PCSK_SKI1_1	472	476	PF00082	0.408
CLV_PCSK_SKI1_1	532	536	PF00082	0.473
CLV_PCSK_SKI1_1	582	586	PF00082	0.379
CLV_PCSK_SKI1_1	764	768	PF00082	0.478
DEG_Nend_Nbox_1	1	3	PF02207	0.435
DEG_SCF_FBW7_2	409	414	PF00400	0.366
DOC_CKS1_1	741	746	PF01111	0.439
DOC_CYCLIN_RxL_1	456	466	PF00134	0.470
DOC_MAPK_gen_1	428	438	PF00069	0.354
DOC_MAPK_gen_1	532	540	PF00069	0.390
DOC_MAPK_gen_1	815	824	PF00069	0.416
DOC_MAPK_MEF2A_6	104	113	PF00069	0.361
DOC_MAPK_MEF2A_6	240	249	PF00069	0.233
DOC_MAPK_MEF2A_6	817	826	PF00069	0.410
DOC_MIT_MIM_1	696	704	PF04212	0.552
DOC_USP7_MATH_1	173	177	PF00917	0.383
DOC_USP7_MATH_1	412	416	PF00917	0.366
DOC_USP7_MATH_1	498	502	PF00917	0.720
DOC_USP7_MATH_1	762	766	PF00917	0.544
DOC_USP7_MATH_1	783	787	PF00917	0.540
DOC_USP7_UBL2_3	316	320	PF12436	0.253
DOC_USP7_UBL2_3	856	860	PF12436	0.426
DOC_WW_Pin1_4	102	107	PF00397	0.345
DOC_WW_Pin1_4	174	179	PF00397	0.373
DOC_WW_Pin1_4	184	189	PF00397	0.354
DOC_WW_Pin1_4	407	412	PF00397	0.296
DOC_WW_Pin1_4	488	493	PF00397	0.549
DOC_WW_Pin1_4	494	499	PF00397	0.653
DOC_WW_Pin1_4	740	745	PF00397	0.430
LIG_14-3-3_CanoR_1	227	234	PF00244	0.267
LIG_14-3-3_CanoR_1	246	250	PF00244	0.349
LIG_14-3-3_CanoR_1	284	292	PF00244	0.670
LIG_14-3-3_CanoR_1	420	424	PF00244	0.238
LIG_14-3-3_CanoR_1	569	573	PF00244	0.509
LIG_14-3-3_CanoR_1	619	628	PF00244	0.523
LIG_14-3-3_CanoR_1	703	711	PF00244	0.594
LIG_14-3-3_CanoR_1	731	739	PF00244	0.436
LIG_14-3-3_CanoR_1	825	830	PF00244	0.357
LIG_14-3-3_CanoR_1	877	883	PF00244	0.431
LIG_Actin_WH2_2	441	458	PF00022	0.497
LIG_APCC_ABBA_1	139	144	PF00400	0.277
LIG_APCC_ABBA_1	381	386	PF00400	0.249
LIG_APCC_ABBAyCdc20_2	127	133	PF00400	0.366
LIG_BIR_III_4	154	158	PF00653	0.253
LIG_FHA_1	179	185	PF00498	0.268
LIG_FHA_1	215	221	PF00498	0.254
LIG_FHA_1	388	394	PF00498	0.277
LIG_FHA_1	401	407	PF00498	0.277
LIG_FHA_1	408	414	PF00498	0.243
LIG_FHA_1	456	462	PF00498	0.488
LIG_FHA_1	464	470	PF00498	0.456
LIG_FHA_1	57	63	PF00498	0.233
LIG_FHA_1	573	579	PF00498	0.487
LIG_FHA_1	669	675	PF00498	0.616
LIG_FHA_2	272	278	PF00498	0.680
LIG_FHA_2	359	365	PF00498	0.383
LIG_FHA_2	534	540	PF00498	0.408
LIG_FHA_2	56	62	PF00498	0.356
LIG_FHA_2	708	714	PF00498	0.674
LIG_FHA_2	751	757	PF00498	0.732
LIG_Integrin_RGD_1	661	663	PF01839	0.445
LIG_LIR_Gen_1	115	122	PF02991	0.263
LIG_LIR_Gen_1	132	142	PF02991	0.252
LIG_LIR_Gen_1	401	409	PF02991	0.238
LIG_LIR_Gen_1	48	57	PF02991	0.304
LIG_LIR_Gen_1	682	690	PF02991	0.503
LIG_LIR_Gen_1	94	102	PF02991	0.308
LIG_LIR_Nem_3	115	120	PF02991	0.259
LIG_LIR_Nem_3	132	138	PF02991	0.309
LIG_LIR_Nem_3	195	201	PF02991	0.307
LIG_LIR_Nem_3	380	384	PF02991	0.255
LIG_LIR_Nem_3	401	405	PF02991	0.238
LIG_LIR_Nem_3	48	52	PF02991	0.304
LIG_LIR_Nem_3	682	686	PF02991	0.473
LIG_LIR_Nem_3	727	733	PF02991	0.445
LIG_LIR_Nem_3	94	98	PF02991	0.289
LIG_NRBOX	145	151	PF00104	0.233
LIG_NRBOX	388	394	PF00104	0.277
LIG_NRBOX	728	734	PF00104	0.434
LIG_PCNA_yPIPBox_3	143	151	PF02747	0.407
LIG_SH2_CRK	683	687	PF00017	0.557
LIG_SH2_NCK_1	221	225	PF00017	0.366
LIG_SH2_NCK_1	53	57	PF00017	0.253
LIG_SH2_SRC	53	56	PF00017	0.302
LIG_SH2_STAP1	221	225	PF00017	0.268
LIG_SH2_STAP1	479	483	PF00017	0.628
LIG_SH2_STAP1	53	57	PF00017	0.335
LIG_SH2_STAP1	63	67	PF00017	0.268
LIG_SH2_STAT3	142	145	PF00017	0.216
LIG_SH2_STAT3	479	482	PF00017	0.609
LIG_SH2_STAT5	201	204	PF00017	0.259
LIG_SH2_STAT5	221	224	PF00017	0.169
LIG_SH2_STAT5	254	257	PF00017	0.613
LIG_SH2_STAT5	468	471	PF00017	0.421
LIG_SH2_STAT5	665	668	PF00017	0.471
LIG_SH2_STAT5	95	98	PF00017	0.249
LIG_SH3_3	881	887	PF00018	0.466
LIG_SUMO_SIM_par_1	189	195	PF11976	0.250
LIG_SUMO_SIM_par_1	830	836	PF11976	0.326
LIG_SxIP_EBH_1	375	385	PF03271	0.238
LIG_TRAF2_1	212	215	PF00917	0.309
LIG_TRAF2_1	273	276	PF00917	0.655
LIG_TRAF2_1	526	529	PF00917	0.359
LIG_TRAF2_1	630	633	PF00917	0.510
LIG_TRAF2_2	744	749	PF00917	0.505
LIG_UBA3_1	846	853	PF00899	0.487
MOD_CK1_1	165	171	PF00069	0.451
MOD_CK1_1	174	180	PF00069	0.367
MOD_CK1_1	226	232	PF00069	0.280
MOD_CK1_1	238	244	PF00069	0.275
MOD_CK1_1	287	293	PF00069	0.728
MOD_CK1_1	3	9	PF00069	0.389
MOD_CK1_1	355	361	PF00069	0.262
MOD_CK1_1	387	393	PF00069	0.310
MOD_CK1_1	419	425	PF00069	0.257
MOD_CK1_1	491	497	PF00069	0.596
MOD_CK1_1	571	577	PF00069	0.492
MOD_CK1_1	707	713	PF00069	0.525
MOD_CK1_1	91	97	PF00069	0.277
MOD_CK2_1	134	140	PF00069	0.277
MOD_CK2_1	189	195	PF00069	0.249
MOD_CK2_1	209	215	PF00069	0.139
MOD_CK2_1	271	277	PF00069	0.690
MOD_CK2_1	33	39	PF00069	0.249
MOD_CK2_1	412	418	PF00069	0.373
MOD_CK2_1	5	11	PF00069	0.397
MOD_CK2_1	533	539	PF00069	0.464
MOD_CK2_1	55	61	PF00069	0.334
MOD_CK2_1	589	595	PF00069	0.531
MOD_CK2_1	619	625	PF00069	0.480
MOD_CK2_1	783	789	PF00069	0.494
MOD_Cter_Amidation	298	301	PF01082	0.545
MOD_GlcNHglycan	164	167	PF01048	0.438
MOD_GlcNHglycan	173	176	PF01048	0.227
MOD_GlcNHglycan	184	187	PF01048	0.153
MOD_GlcNHglycan	228	231	PF01048	0.295
MOD_GlcNHglycan	292	295	PF01048	0.640
MOD_GlcNHglycan	313	316	PF01048	0.266
MOD_GlcNHglycan	414	417	PF01048	0.268
MOD_GlcNHglycan	500	503	PF01048	0.677
MOD_GlcNHglycan	733	736	PF01048	0.506
MOD_GlcNHglycan	90	93	PF01048	0.277
MOD_GSK3_1	1	8	PF00069	0.387
MOD_GSK3_1	173	180	PF00069	0.480
MOD_GSK3_1	215	222	PF00069	0.300
MOD_GSK3_1	245	252	PF00069	0.355
MOD_GSK3_1	283	290	PF00069	0.703
MOD_GSK3_1	354	361	PF00069	0.288
MOD_GSK3_1	368	375	PF00069	0.249
MOD_GSK3_1	412	419	PF00069	0.372
MOD_GSK3_1	494	501	PF00069	0.694
MOD_GSK3_1	564	571	PF00069	0.529
MOD_GSK3_1	582	589	PF00069	0.589
MOD_GSK3_1	720	727	PF00069	0.494
MOD_GSK3_1	750	757	PF00069	0.595
MOD_GSK3_1	98	105	PF00069	0.277
MOD_N-GLC_1	352	357	PF02516	0.277
MOD_N-GLC_1	707	712	PF02516	0.498
MOD_N-GLC_1	79	84	PF02516	0.292
MOD_NEK2_1	1	6	PF00069	0.476
MOD_NEK2_1	292	297	PF00069	0.538
MOD_NEK2_1	392	397	PF00069	0.233
MOD_NEK2_1	455	460	PF00069	0.519
MOD_NEK2_1	572	577	PF00069	0.527
MOD_NEK2_1	586	591	PF00069	0.630
MOD_NEK2_1	644	649	PF00069	0.424
MOD_NEK2_1	679	684	PF00069	0.550
MOD_NEK2_1	704	709	PF00069	0.485
MOD_NEK2_1	724	729	PF00069	0.433
MOD_NEK2_1	852	857	PF00069	0.492
MOD_NEK2_1	98	103	PF00069	0.272
MOD_NEK2_2	189	194	PF00069	0.366
MOD_NEK2_2	750	755	PF00069	0.535
MOD_NEK2_2	79	84	PF00069	0.326
MOD_NEK2_2	864	869	PF00069	0.460
MOD_PIKK_1	1	7	PF00454	0.415
MOD_PIKK_1	271	277	PF00454	0.697
MOD_PIKK_1	285	291	PF00454	0.704
MOD_PIKK_1	572	578	PF00454	0.518
MOD_PIKK_1	586	592	PF00454	0.571
MOD_PIKK_1	644	650	PF00454	0.457
MOD_PIKK_1	737	743	PF00454	0.586
MOD_PIKK_1	754	760	PF00454	0.453
MOD_PIKK_1	854	860	PF00454	0.603
MOD_PIKK_1	878	884	PF00454	0.592
MOD_PK_1	825	831	PF00069	0.411
MOD_PKA_1	619	625	PF00069	0.395
MOD_PKA_1	775	781	PF00069	0.521
MOD_PKA_2	226	232	PF00069	0.278
MOD_PKA_2	23	29	PF00069	0.404
MOD_PKA_2	245	251	PF00069	0.327
MOD_PKA_2	283	289	PF00069	0.703
MOD_PKA_2	384	390	PF00069	0.277
MOD_PKA_2	419	425	PF00069	0.259
MOD_PKA_2	455	461	PF00069	0.558
MOD_PKA_2	568	574	PF00069	0.506
MOD_PKA_2	619	625	PF00069	0.426
MOD_PKA_2	699	705	PF00069	0.615
MOD_PKA_2	720	726	PF00069	0.454
MOD_PKA_2	754	760	PF00069	0.612
MOD_PKA_2	775	781	PF00069	0.521
MOD_PKA_2	878	884	PF00069	0.423
MOD_Plk_1	214	220	PF00069	0.312
MOD_Plk_1	249	255	PF00069	0.305
MOD_Plk_1	32	38	PF00069	0.405
MOD_Plk_1	352	358	PF00069	0.268
MOD_Plk_1	582	588	PF00069	0.556
MOD_Plk_1	667	673	PF00069	0.422
MOD_Plk_1	707	713	PF00069	0.493
MOD_Plk_2-3	257	263	PF00069	0.586
MOD_Plk_2-3	33	39	PF00069	0.366
MOD_Plk_4	134	140	PF00069	0.268
MOD_Plk_4	215	221	PF00069	0.436
MOD_Plk_4	358	364	PF00069	0.243
MOD_Plk_4	377	383	PF00069	0.251
MOD_Plk_4	463	469	PF00069	0.440
MOD_Plk_4	511	517	PF00069	0.559
MOD_Plk_4	720	726	PF00069	0.480
MOD_Plk_4	79	85	PF00069	0.329
MOD_Plk_4	93	99	PF00069	0.349
MOD_ProDKin_1	102	108	PF00069	0.345
MOD_ProDKin_1	174	180	PF00069	0.373
MOD_ProDKin_1	184	190	PF00069	0.354
MOD_ProDKin_1	407	413	PF00069	0.296
MOD_ProDKin_1	488	494	PF00069	0.552
MOD_ProDKin_1	740	746	PF00069	0.435
MOD_SUMO_rev_2	529	536	PF00179	0.486
MOD_SUMO_rev_2	602	609	PF00179	0.617
MOD_SUMO_rev_2	809	816	PF00179	0.432
TRG_DiLeu_BaEn_1	623	628	PF01217	0.455
TRG_DiLeu_BaEn_1	693	698	PF01217	0.598
TRG_DiLeu_BaEn_4	529	535	PF01217	0.515
TRG_DiLeu_BaEn_4	633	639	PF01217	0.499
TRG_DiLeu_BaLyEn_6	501	506	PF01217	0.490
TRG_DiLeu_BaLyEn_6	652	657	PF01217	0.438
TRG_DiLeu_BaLyEn_6	728	733	PF01217	0.421
TRG_DiLeu_BaLyEn_6	792	797	PF01217	0.399
TRG_ENDOCYTIC_2	683	686	PF00928	0.553
TRG_ENDOCYTIC_2	95	98	PF00928	0.249
TRG_ER_diArg_1	14	17	PF00400	0.341
TRG_ER_diArg_1	790	793	PF00400	0.536
TRG_ER_diArg_1	877	880	PF00400	0.595
TRG_NES_CRM1_1	124	140	PF08389	0.271
TRG_NES_CRM1_1	529	543	PF08389	0.493
TRG_NES_CRM1_1	664	677	PF08389	0.402
TRG_NES_CRM1_1	820	835	PF08389	0.422
TRG_NLS_Bipartite_1	300	322	PF00514	0.508
TRG_NLS_MonoExtN_4	316	322	PF00514	0.253
TRG_NLS_MonoExtN_4	428	434	PF00514	0.366
TRG_Pf-PMV_PEXEL_1	601	606	PF00026	0.447
TRG_Pf-PMV_PEXEL_1	795	799	PF00026	0.479

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A068FIK2	Gossypium hirsutum	28%	86%
A0A0N1HVM1	Leptomonas seymouri	63%	96%
A0A0S4INA4	Bodo saltans	41%	100%
A0A1X0NUN6	Trypanosomatidae	41%	95%
A0A3Q8IG88	Leishmania donovani	31%	100%
A0A3S7WX05	Leishmania donovani	92%	100%
A0A422N2N4	Trypanosoma rangeli	42%	100%
A4H4I4	Leishmania braziliensis	24%	100%
A4HCA1	Leishmania braziliensis	78%	100%
A4HZT3	Leishmania infantum	92%	100%
A4IBA7	Leishmania infantum	31%	100%
E9AF32	Leishmania major	31%	100%
E9AVN8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9B687	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
O35787	Rattus norvegicus	29%	81%
Q9LPC6	Arabidopsis thaliana	25%	100%
V5BLH7	Trypanosoma cruzi	43%	100%