Protein RER1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Protein RER1

Gene product:

rer1 family-like protein

Species:

Leishmania major

UniProt:

Q4QBT9_LEIMA

TriTrypDb:

LmjF.22.0580 , LMJLV39_220010900 , LMJSD75_220011000

Length:

183

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005783	endoplasmic reticulum	5	2
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:0005737	cytoplasm	2	8
GO:0016020	membrane	2	8

Expansion

Sequence features

Q4QBT9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBT9

Function

Biological processes
Term	Name	Level	Count
GO:0006621	protein retention in ER lumen	6	2
GO:0006810	transport	3	2
GO:0006890	retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum	6	2
GO:0009987	cellular process	1	2
GO:0016192	vesicle-mediated transport	4	2
GO:0032507	maintenance of protein location in cell	3	2
GO:0035437	maintenance of protein localization in endoplasmic reticulum	5	2
GO:0045185	maintenance of protein location	3	2
GO:0048193	Golgi vesicle transport	5	2
GO:0051179	localization	1	10
GO:0051234	establishment of localization	2	2
GO:0051235	maintenance of location	2	2
GO:0051651	maintenance of location in cell	2	2
GO:0072595	maintenance of protein localization in organelle	4	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	95	99	PF00656	0.504
CLV_MEL_PAP_1	8	14	PF00089	0.318
CLV_NRD_NRD_1	17	19	PF00675	0.259
CLV_PCSK_KEX2_1	25	27	PF00082	0.286
CLV_PCSK_PC1ET2_1	25	27	PF00082	0.286
CLV_PCSK_PC7_1	21	27	PF00082	0.320
CLV_PCSK_SKI1_1	116	120	PF00082	0.323
CLV_PCSK_SKI1_1	52	56	PF00082	0.348
DEG_SPOP_SBC_1	179	183	PF00917	0.683
DOC_CKS1_1	77	82	PF01111	0.295
DOC_PP1_RVXF_1	50	57	PF00149	0.336
DOC_PP2B_LxvP_1	134	137	PF13499	0.256
DOC_USP7_MATH_1	84	88	PF00917	0.494
DOC_USP7_UBL2_3	176	180	PF12436	0.625
DOC_WW_Pin1_4	76	81	PF00397	0.295
DOC_WW_Pin1_4	87	92	PF00397	0.442
LIG_14-3-3_CanoR_1	11	17	PF00244	0.604
LIG_14-3-3_CanoR_1	21	25	PF00244	0.493
LIG_14-3-3_CanoR_1	52	57	PF00244	0.368
LIG_CaM_IQ_9	150	166	PF13499	0.295
LIG_eIF4E_1	72	78	PF01652	0.338
LIG_FHA_1	61	67	PF00498	0.388
LIG_FHA_2	93	99	PF00498	0.527
LIG_LIR_Gen_1	120	131	PF02991	0.338
LIG_LIR_Gen_1	132	141	PF02991	0.240
LIG_LIR_Nem_3	120	126	PF02991	0.254
LIG_LIR_Nem_3	129	134	PF02991	0.258
LIG_LIR_Nem_3	23	27	PF02991	0.461
LIG_LIR_Nem_3	55	59	PF02991	0.368
LIG_LIR_Nem_3	99	105	PF02991	0.442
LIG_NRBOX	69	75	PF00104	0.318
LIG_Pex14_1	115	119	PF04695	0.332
LIG_Pex14_2	119	123	PF04695	0.333
LIG_Pex14_2	127	131	PF04695	0.257
LIG_Pex14_2	147	151	PF04695	0.110
LIG_SH2_SRC	27	30	PF00017	0.522
LIG_SH2_STAT5	146	149	PF00017	0.295
LIG_SH2_STAT5	167	170	PF00017	0.431
LIG_SH2_STAT5	27	30	PF00017	0.479
LIG_SH2_STAT5	49	52	PF00017	0.317
LIG_SH2_STAT5	60	63	PF00017	0.251
LIG_SH2_STAT5	72	75	PF00017	0.269
LIG_SH3_3	101	107	PF00018	0.442
LIG_SH3_3	135	141	PF00018	0.238
LIG_SUMO_SIM_par_1	73	79	PF11976	0.302
LIG_TYR_ITIM	70	75	PF00017	0.314
LIG_WRC_WIRS_1	130	135	PF05994	0.339
LIG_WRC_WIRS_1	53	58	PF05994	0.437
LIG_WRPW_2	102	105	PF00400	0.442
MOD_CK1_1	87	93	PF00069	0.524
MOD_GSK3_1	92	99	PF00069	0.525
MOD_NEK2_1	126	131	PF00069	0.303
MOD_NEK2_1	150	155	PF00069	0.314
MOD_NEK2_1	28	33	PF00069	0.461
MOD_PIKK_1	150	156	PF00454	0.314
MOD_PKA_2	20	26	PF00069	0.522
MOD_Plk_1	28	34	PF00069	0.451
MOD_Plk_4	12	18	PF00069	0.580
MOD_Plk_4	126	132	PF00069	0.328
MOD_ProDKin_1	76	82	PF00069	0.295
MOD_ProDKin_1	87	93	PF00069	0.442
TRG_DiLeu_BaEn_2	100	106	PF01217	0.494
TRG_ENDOCYTIC_2	102	105	PF00928	0.522
TRG_ENDOCYTIC_2	72	75	PF00928	0.355

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2L3	Leptomonas seymouri	79%	100%
A0A0S4INL9	Bodo saltans	57%	100%
A0A1X0NTI3	Trypanosomatidae	62%	99%
A0A3R7MCZ0	Trypanosoma rangeli	62%	99%
A0A3S7WX19	Leishmania donovani	94%	100%
A4HZT5	Leishmania infantum	94%	100%
A5PJ65	Bos taurus	34%	93%
C9ZRM1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9AVP0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
O15258	Homo sapiens	34%	93%
O48670	Arabidopsis thaliana	40%	96%
O48671	Arabidopsis thaliana	39%	94%
P25560	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	35%	97%
P52879	Caenorhabditis elegans	37%	96%
P79003	Saccharomyces pastorianus	36%	97%
Q10358	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	35%	99%
Q498C8	Rattus norvegicus	34%	93%
Q54D10	Dictyostelium discoideum	37%	97%
Q5R5U4	Pongo abelii	34%	93%
Q5ZHM5	Gallus gallus	34%	93%
Q9CQU3	Mus musculus	34%	93%
Q9ZPV7	Arabidopsis thaliana	37%	83%
Q9ZWI7	Arabidopsis thaliana	37%	86%