TsaA-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Uncharacterised protein family UPF0066, putative

Species:

Leishmania major

UniProt:

Q4QBT8_LEIMA

TriTrypDb:

LmjF.22.0590 , LMJLV39_220011000 , LMJSD75_220011100

Length:

488

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBT8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBT8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	461	465	PF00656	0.573
CLV_NRD_NRD_1	107	109	PF00675	0.605
CLV_NRD_NRD_1	112	114	PF00675	0.627
CLV_NRD_NRD_1	313	315	PF00675	0.691
CLV_NRD_NRD_1	374	376	PF00675	0.562
CLV_PCSK_KEX2_1	111	113	PF00082	0.651
CLV_PCSK_KEX2_1	373	375	PF00082	0.551
CLV_PCSK_KEX2_1	47	49	PF00082	0.708
CLV_PCSK_PC1ET2_1	47	49	PF00082	0.708
CLV_PCSK_PC7_1	108	114	PF00082	0.657
CLV_PCSK_SKI1_1	329	333	PF00082	0.740
CLV_PCSK_SKI1_1	397	401	PF00082	0.399
CLV_PCSK_SKI1_1	65	69	PF00082	0.534
DEG_SCF_TRCP1_1	153	158	PF00400	0.676
DEG_SPOP_SBC_1	128	132	PF00917	0.719
DOC_MAPK_gen_1	187	196	PF00069	0.645
DOC_MAPK_gen_1	201	211	PF00069	0.397
DOC_MAPK_gen_1	85	92	PF00069	0.562
DOC_MAPK_MEF2A_6	189	198	PF00069	0.636
DOC_PP2B_LxvP_1	332	335	PF13499	0.559
DOC_PP2B_LxvP_1	90	93	PF13499	0.546
DOC_PP4_FxxP_1	300	303	PF00568	0.629
DOC_USP7_MATH_1	128	132	PF00917	0.719
DOC_USP7_MATH_1	13	17	PF00917	0.761
DOC_USP7_MATH_1	303	307	PF00917	0.636
DOC_USP7_MATH_1	322	326	PF00917	0.505
DOC_USP7_UBL2_3	120	124	PF12436	0.705
DOC_USP7_UBL2_3	470	474	PF12436	0.642
DOC_WW_Pin1_4	1	6	PF00397	0.736
DOC_WW_Pin1_4	143	148	PF00397	0.619
DOC_WW_Pin1_4	15	20	PF00397	0.631
DOC_WW_Pin1_4	21	26	PF00397	0.749
DOC_WW_Pin1_4	229	234	PF00397	0.557
DOC_WW_Pin1_4	343	348	PF00397	0.753
DOC_WW_Pin1_4	401	406	PF00397	0.357
DOC_WW_Pin1_4	434	439	PF00397	0.357
LIG_14-3-3_CanoR_1	189	196	PF00244	0.596
LIG_14-3-3_CanoR_1	228	232	PF00244	0.694
LIG_14-3-3_CanoR_1	477	485	PF00244	0.686
LIG_APCC_ABBA_1	209	214	PF00400	0.549
LIG_BIR_II_1	1	5	PF00653	0.666
LIG_BIR_III_2	450	454	PF00653	0.422
LIG_BIR_III_4	464	468	PF00653	0.550
LIG_deltaCOP1_diTrp_1	290	300	PF00928	0.416
LIG_deltaCOP1_diTrp_1	393	400	PF00928	0.438
LIG_EH1_1	55	63	PF00400	0.541
LIG_FHA_1	189	195	PF00498	0.567
LIG_FHA_1	215	221	PF00498	0.534
LIG_FHA_1	268	274	PF00498	0.475
LIG_FHA_1	384	390	PF00498	0.333
LIG_FHA_1	435	441	PF00498	0.345
LIG_FHA_1	477	483	PF00498	0.641
LIG_FHA_2	132	138	PF00498	0.801
LIG_FHA_2	188	194	PF00498	0.499
LIG_FHA_2	208	214	PF00498	0.301
LIG_FHA_2	22	28	PF00498	0.731
LIG_FHA_2	275	281	PF00498	0.566
LIG_HCF-1_HBM_1	472	475	PF13415	0.575
LIG_LIR_Apic_2	299	303	PF02991	0.571
LIG_LIR_Apic_2	60	66	PF02991	0.399
LIG_LIR_Gen_1	290	301	PF02991	0.400
LIG_LIR_Nem_3	290	296	PF02991	0.370
LIG_LIR_Nem_3	393	399	PF02991	0.438
LIG_NBox_RRM_1	216	226	PF00076	0.506
LIG_Pex14_1	396	400	PF04695	0.438
LIG_Pex14_2	289	293	PF04695	0.409
LIG_Pex14_2	296	300	PF04695	0.437
LIG_REV1ctd_RIR_1	182	191	PF16727	0.502
LIG_SH2_NCK_1	212	216	PF00017	0.500
LIG_SH2_SRC	212	215	PF00017	0.535
LIG_SH2_STAP1	212	216	PF00017	0.467
LIG_SH2_STAP1	239	243	PF00017	0.554
LIG_SH2_STAT3	475	478	PF00017	0.616
LIG_SH2_STAT5	183	186	PF00017	0.525
LIG_SH2_STAT5	445	448	PF00017	0.357
LIG_SH2_STAT5	55	58	PF00017	0.490
LIG_SH3_3	14	20	PF00018	0.710
LIG_SH3_3	162	168	PF00018	0.734
LIG_SH3_3	2	8	PF00018	0.677
LIG_SH3_3	255	261	PF00018	0.515
LIG_SH3_3	402	408	PF00018	0.357
LIG_SH3_3	441	447	PF00018	0.357
LIG_SH3_3	67	73	PF00018	0.441
LIG_SH3_3	89	95	PF00018	0.567
LIG_TRAF2_1	190	193	PF00917	0.536
LIG_WRC_WIRS_1	369	374	PF05994	0.650
LIG_WW_3	389	393	PF00397	0.357
MOD_CDC14_SPxK_1	232	235	PF00782	0.540
MOD_CDC14_SPxK_1	404	407	PF00782	0.357
MOD_CDK_SPxK_1	229	235	PF00069	0.554
MOD_CDK_SPxK_1	401	407	PF00069	0.357
MOD_CK1_1	131	137	PF00069	0.723
MOD_CK1_1	18	24	PF00069	0.772
MOD_CK1_1	325	331	PF00069	0.725
MOD_CK1_1	365	371	PF00069	0.742
MOD_CK2_1	131	137	PF00069	0.800
MOD_CK2_1	187	193	PF00069	0.549
MOD_CK2_1	207	213	PF00069	0.293
MOD_CK2_1	274	280	PF00069	0.564
MOD_CK2_1	356	362	PF00069	0.785
MOD_GlcNHglycan	153	156	PF01048	0.709
MOD_GlcNHglycan	157	160	PF01048	0.652
MOD_GlcNHglycan	21	24	PF01048	0.724
MOD_GlcNHglycan	305	308	PF01048	0.675
MOD_GlcNHglycan	321	325	PF01048	0.678
MOD_GlcNHglycan	364	367	PF01048	0.719
MOD_GlcNHglycan	464	468	PF01048	0.550
MOD_GSK3_1	127	134	PF00069	0.733
MOD_GSK3_1	15	22	PF00069	0.699
MOD_GSK3_1	151	158	PF00069	0.790
MOD_GSK3_1	169	176	PF00069	0.422
MOD_GSK3_1	25	32	PF00069	0.625
MOD_GSK3_1	320	327	PF00069	0.683
MOD_GSK3_1	334	341	PF00069	0.728
MOD_NEK2_1	157	162	PF00069	0.687
MOD_NEK2_1	296	301	PF00069	0.447
MOD_NEK2_1	463	468	PF00069	0.517
MOD_NEK2_2	309	314	PF00069	0.668
MOD_PIKK_1	214	220	PF00454	0.595
MOD_PIKK_1	477	483	PF00454	0.701
MOD_PKA_2	188	194	PF00069	0.572
MOD_PKA_2	227	233	PF00069	0.680
MOD_PKA_2	356	362	PF00069	0.577
MOD_PKA_2	476	482	PF00069	0.596
MOD_Plk_1	136	142	PF00069	0.559
MOD_Plk_1	207	213	PF00069	0.552
MOD_Plk_4	136	142	PF00069	0.559
MOD_Plk_4	207	213	PF00069	0.545
MOD_Plk_4	246	252	PF00069	0.423
MOD_Plk_4	383	389	PF00069	0.339
MOD_ProDKin_1	1	7	PF00069	0.736
MOD_ProDKin_1	143	149	PF00069	0.618
MOD_ProDKin_1	15	21	PF00069	0.633
MOD_ProDKin_1	229	235	PF00069	0.554
MOD_ProDKin_1	343	349	PF00069	0.751
MOD_ProDKin_1	401	407	PF00069	0.357
MOD_ProDKin_1	434	440	PF00069	0.357
TRG_DiLeu_BaLyEn_6	86	91	PF01217	0.557
TRG_ENDOCYTIC_2	55	58	PF00928	0.572
TRG_ER_diArg_1	110	113	PF00400	0.627
TRG_ER_diArg_1	273	276	PF00400	0.482
TRG_ER_diArg_1	372	375	PF00400	0.569
TRG_ER_diArg_1	49	52	PF00400	0.621
TRG_ER_diArg_1	86	89	PF00400	0.614
TRG_NLS_MonoExtC_3	107	112	PF00514	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PB52	Leptomonas seymouri	65%	100%
A0A3S7WX66	Leishmania donovani	91%	99%
A4HCA4	Leishmania braziliensis	76%	99%
A4HZT6	Leishmania infantum	91%	99%
C9ZRM2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
E9AVP1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	99%
V5DMI0	Trypanosoma cruzi	47%	100%