N-acetyltransferase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Acetyltransferase (GNAT) domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QBT7_LEIMA

TriTrypDb:

LmjF.22.0600 , LMJLV39_220011100 , LMJSD75_220011200

Length:

492

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBT7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBT7

Function

Biological processes
Term	Name	Level	Count
GO:0006473	protein acetylation	6	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043543	protein acylation	5	2
GO:0044238	primary metabolic process	2	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	8
GO:0008080	N-acetyltransferase activity	6	8
GO:0016407	acetyltransferase activity	5	8
GO:0016410	N-acyltransferase activity	5	8
GO:0016740	transferase activity	2	8
GO:0016746	acyltransferase activity	3	8
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	270	274	PF00656	0.509
CLV_NRD_NRD_1	247	249	PF00675	0.516
CLV_NRD_NRD_1	335	337	PF00675	0.319
CLV_NRD_NRD_1	404	406	PF00675	0.628
CLV_NRD_NRD_1	412	414	PF00675	0.636
CLV_PCSK_KEX2_1	213	215	PF00082	0.605
CLV_PCSK_KEX2_1	247	249	PF00082	0.516
CLV_PCSK_KEX2_1	334	336	PF00082	0.317
CLV_PCSK_KEX2_1	404	406	PF00082	0.590
CLV_PCSK_KEX2_1	412	414	PF00082	0.612
CLV_PCSK_PC1ET2_1	213	215	PF00082	0.627
CLV_PCSK_SKI1_1	221	225	PF00082	0.616
CLV_PCSK_SKI1_1	247	251	PF00082	0.618
CLV_PCSK_SKI1_1	384	388	PF00082	0.467
CLV_PCSK_SKI1_1	486	490	PF00082	0.787
DEG_APCC_DBOX_1	5	13	PF00400	0.592
DEG_Nend_UBRbox_3	1	3	PF02207	0.583
DEG_ODPH_VHL_1	316	328	PF01847	0.555
DOC_CDC14_PxL_1	48	56	PF14671	0.453
DOC_CKS1_1	309	314	PF01111	0.608
DOC_CYCLIN_RxL_1	137	147	PF00134	0.546
DOC_CYCLIN_RxL_1	218	228	PF00134	0.646
DOC_CYCLIN_yCln2_LP_2	102	108	PF00134	0.521
DOC_MAPK_gen_1	384	394	PF00069	0.561
DOC_MAPK_MEF2A_6	320	328	PF00069	0.556
DOC_PP1_RVXF_1	375	381	PF00149	0.452
DOC_PP2B_LxvP_1	102	105	PF13499	0.485
DOC_PP4_FxxP_1	169	172	PF00568	0.700
DOC_USP7_MATH_1	111	115	PF00917	0.512
DOC_USP7_MATH_1	156	160	PF00917	0.711
DOC_USP7_MATH_1	162	166	PF00917	0.715
DOC_USP7_MATH_1	174	178	PF00917	0.627
DOC_USP7_MATH_1	301	305	PF00917	0.601
DOC_USP7_MATH_1	420	424	PF00917	0.642
DOC_USP7_MATH_1	441	445	PF00917	0.704
DOC_USP7_MATH_1	73	77	PF00917	0.574
DOC_USP7_MATH_2	450	456	PF00917	0.607
DOC_WW_Pin1_4	117	122	PF00397	0.578
DOC_WW_Pin1_4	158	163	PF00397	0.733
DOC_WW_Pin1_4	293	298	PF00397	0.555
DOC_WW_Pin1_4	304	309	PF00397	0.567
DOC_WW_Pin1_4	31	36	PF00397	0.452
DOC_WW_Pin1_4	4	9	PF00397	0.600
DOC_WW_Pin1_4	432	437	PF00397	0.578
DOC_WW_Pin1_4	472	477	PF00397	0.513
LIG_14-3-3_CanoR_1	11	17	PF00244	0.575
LIG_14-3-3_CanoR_1	140	145	PF00244	0.610
LIG_14-3-3_CanoR_1	201	210	PF00244	0.671
LIG_14-3-3_CanoR_1	295	303	PF00244	0.581
LIG_14-3-3_CanoR_1	418	426	PF00244	0.571
LIG_APCC_ABBA_1	371	376	PF00400	0.536
LIG_APCC_ABBA_1	380	385	PF00400	0.469
LIG_APCC_ABBA_1	386	391	PF00400	0.437
LIG_BRCT_BRCA1_1	318	322	PF00533	0.556
LIG_Clathr_ClatBox_1	262	266	PF01394	0.555
LIG_EH1_1	321	329	PF00400	0.556
LIG_FHA_1	187	193	PF00498	0.678
LIG_FHA_1	319	325	PF00498	0.556
LIG_FHA_1	355	361	PF00498	0.536
LIG_FHA_1	366	372	PF00498	0.482
LIG_FHA_1	373	379	PF00498	0.470
LIG_FHA_1	5	11	PF00498	0.484
LIG_FHA_1	97	103	PF00498	0.421
LIG_FHA_2	182	188	PF00498	0.663
LIG_FHA_2	189	195	PF00498	0.764
LIG_FHA_2	398	404	PF00498	0.540
LIG_FHA_2	72	78	PF00498	0.522
LIG_LIR_Apic_2	168	172	PF02991	0.709
LIG_LIR_Apic_2	471	476	PF02991	0.698
LIG_LIR_Gen_1	253	262	PF02991	0.306
LIG_LIR_Gen_1	99	108	PF02991	0.449
LIG_LIR_Nem_3	253	257	PF02991	0.328
LIG_LIR_Nem_3	99	103	PF02991	0.413
LIG_MYND_1	308	312	PF01753	0.529
LIG_MYND_1	52	56	PF01753	0.540
LIG_MYND_3	148	152	PF01753	0.694
LIG_SH2_PTP2	254	257	PF00017	0.411
LIG_SH2_SRC	215	218	PF00017	0.700
LIG_SH2_STAP1	188	192	PF00017	0.587
LIG_SH2_STAP1	349	353	PF00017	0.556
LIG_SH2_STAT5	188	191	PF00017	0.576
LIG_SH2_STAT5	254	257	PF00017	0.411
LIG_SH2_STAT5	53	56	PF00017	0.467
LIG_SH3_1	53	59	PF00018	0.542
LIG_SH3_3	173	179	PF00018	0.712
LIG_SH3_3	29	35	PF00018	0.538
LIG_SH3_3	306	312	PF00018	0.608
LIG_SH3_3	325	331	PF00018	0.411
LIG_SH3_3	46	52	PF00018	0.400
LIG_SH3_3	53	59	PF00018	0.459
LIG_SUMO_SIM_anti_2	323	328	PF11976	0.556
LIG_SUMO_SIM_anti_2	47	52	PF11976	0.508
LIG_SUMO_SIM_par_1	74	84	PF11976	0.543
LIG_TRAF2_1	150	153	PF00917	0.698
LIG_TRAF2_1	80	83	PF00917	0.483
LIG_UBA3_1	89	97	PF00899	0.380
LIG_WRC_WIRS_1	166	171	PF05994	0.702
MOD_CDC14_SPxK_1	120	123	PF00782	0.592
MOD_CDK_SPxK_1	117	123	PF00069	0.593
MOD_CDK_SPxxK_3	4	11	PF00069	0.596
MOD_CDK_SPxxK_3	472	479	PF00069	0.497
MOD_CK1_1	165	171	PF00069	0.723
MOD_CK1_1	181	187	PF00069	0.662
MOD_CK1_1	225	231	PF00069	0.690
MOD_CK1_1	296	302	PF00069	0.596
MOD_CK1_1	304	310	PF00069	0.549
MOD_CK1_1	397	403	PF00069	0.611
MOD_CK1_1	422	428	PF00069	0.732
MOD_CK1_1	444	450	PF00069	0.597
MOD_CK1_1	466	472	PF00069	0.622
MOD_CK2_1	188	194	PF00069	0.749
MOD_CK2_1	283	289	PF00069	0.562
MOD_CK2_1	397	403	PF00069	0.538
MOD_CK2_1	71	77	PF00069	0.510
MOD_DYRK1A_RPxSP_1	31	35	PF00069	0.434
MOD_GlcNHglycan	112	116	PF01048	0.649
MOD_GlcNHglycan	12	15	PF01048	0.576
MOD_GlcNHglycan	204	207	PF01048	0.679
MOD_GlcNHglycan	229	232	PF01048	0.729
MOD_GlcNHglycan	298	301	PF01048	0.375
MOD_GlcNHglycan	313	316	PF01048	0.217
MOD_GlcNHglycan	422	425	PF01048	0.685
MOD_GlcNHglycan	454	457	PF01048	0.833
MOD_GSK3_1	140	147	PF00069	0.617
MOD_GSK3_1	154	161	PF00069	0.675
MOD_GSK3_1	174	181	PF00069	0.640
MOD_GSK3_1	182	189	PF00069	0.598
MOD_GSK3_1	223	230	PF00069	0.669
MOD_GSK3_1	291	298	PF00069	0.582
MOD_GSK3_1	304	311	PF00069	0.535
MOD_GSK3_1	363	370	PF00069	0.504
MOD_GSK3_1	416	423	PF00069	0.547
MOD_GSK3_1	468	475	PF00069	0.584
MOD_GSK3_1	73	80	PF00069	0.517
MOD_GSK3_1	92	99	PF00069	0.451
MOD_LATS_1	138	144	PF00433	0.545
MOD_LATS_1	293	299	PF00433	0.529
MOD_NEK2_1	10	15	PF00069	0.579
MOD_NEK2_1	144	149	PF00069	0.679
MOD_NEK2_1	21	26	PF00069	0.481
MOD_NEK2_1	250	255	PF00069	0.581
MOD_NEK2_1	282	287	PF00069	0.529
MOD_NEK2_1	394	399	PF00069	0.562
MOD_NEK2_1	468	473	PF00069	0.635
MOD_PIKK_1	215	221	PF00454	0.705
MOD_PIKK_1	230	236	PF00454	0.589
MOD_PIKK_1	42	48	PF00454	0.363
MOD_PIKK_1	458	464	PF00454	0.730
MOD_PIKK_1	486	492	PF00454	0.787
MOD_PKA_2	10	16	PF00069	0.578
MOD_PKA_2	200	206	PF00069	0.685
MOD_PKA_2	411	417	PF00069	0.634
MOD_PKA_2	444	450	PF00069	0.707
MOD_PKB_1	199	207	PF00069	0.716
MOD_Plk_1	111	117	PF00069	0.543
MOD_Plk_2-3	77	83	PF00069	0.516
MOD_Plk_4	12	18	PF00069	0.571
MOD_Plk_4	178	184	PF00069	0.622
MOD_Plk_4	250	256	PF00069	0.462
MOD_Plk_4	468	474	PF00069	0.615
MOD_Plk_4	96	102	PF00069	0.410
MOD_ProDKin_1	117	123	PF00069	0.581
MOD_ProDKin_1	158	164	PF00069	0.733
MOD_ProDKin_1	293	299	PF00069	0.555
MOD_ProDKin_1	304	310	PF00069	0.567
MOD_ProDKin_1	31	37	PF00069	0.446
MOD_ProDKin_1	4	10	PF00069	0.598
MOD_ProDKin_1	432	438	PF00069	0.581
MOD_ProDKin_1	472	478	PF00069	0.515
TRG_DiLeu_BaEn_1	39	44	PF01217	0.560
TRG_DiLeu_BaLyEn_6	137	142	PF01217	0.544
TRG_DiLeu_BaLyEn_6	207	212	PF01217	0.640
TRG_DiLeu_LyEn_5	5	10	PF01217	0.597
TRG_ENDOCYTIC_2	254	257	PF00928	0.376
TRG_ER_diArg_1	333	336	PF00400	0.517
TRG_ER_diArg_1	412	415	PF00400	0.630
TRG_Pf-PMV_PEXEL_1	248	252	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	25	29	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	336	340	PF00026	0.356
TRG_Pf-PMV_PEXEL_1	344	348	PF00026	0.356
TRG_Pf-PMV_PEXEL_1	396	401	PF00026	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4Y0	Leptomonas seymouri	42%	100%
A0A3S7WX61	Leishmania donovani	89%	100%
A4HCA5	Leishmania braziliensis	67%	100%
A4HZT7	Leishmania infantum	89%	100%
E9AVP2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5BR45	Trypanosoma cruzi	33%	100%