Ubiquitin-conjugating enzyme-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin-conjugating enzyme-like protein

Species:

Leishmania major

UniProt:

Q4QBT6_LEIMA

TriTrypDb:

LmjF.22.0610 , LMJLV39_220011200 , LMJSD75_220011300

Length:

260

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBT6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBT6

Function

Biological processes
Term	Name	Level	Count
GO:0000209	protein polyubiquitination	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	2
GO:0006281	DNA repair	5	2
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0006950	response to stress	2	2
GO:0006974	DNA damage response	4	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0010498	proteasomal protein catabolic process	5	2
GO:0016567	protein ubiquitination	7	2
GO:0016570	histone modification	5	2
GO:0016574	histone ubiquitination	6	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0030163	protein catabolic process	4	2
GO:0032446	protein modification by small protein conjugation	6	2
GO:0033554	cellular response to stress	3	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0046483	heterocycle metabolic process	3	2
GO:0050896	response to stimulus	1	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0051716	cellular response to stimulus	2	2
GO:0070647	protein modification by small protein conjugation or removal	5	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901565	organonitrogen compound catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0004842	ubiquitin-protein transferase activity	4	3
GO:0016740	transferase activity	2	3
GO:0019787	ubiquitin-like protein transferase activity	3	3
GO:0061631	ubiquitin conjugating enzyme activity	5	3
GO:0061650	ubiquitin-like protein conjugating enzyme activity	4	3
GO:0140096	catalytic activity, acting on a protein	2	3
GO:0000166	nucleotide binding	3	1
GO:0005488	binding	1	1
GO:0005524	ATP binding	5	1
GO:0016746	acyltransferase activity	3	1
GO:0016874	ligase activity	2	1
GO:0017076	purine nucleotide binding	4	1
GO:0030554	adenyl nucleotide binding	5	1
GO:0032553	ribonucleotide binding	3	1
GO:0032555	purine ribonucleotide binding	4	1
GO:0032559	adenyl ribonucleotide binding	5	1
GO:0035639	purine ribonucleoside triphosphate binding	4	1
GO:0036094	small molecule binding	2	1
GO:0043167	ion binding	2	1
GO:0043168	anion binding	3	1
GO:0097159	organic cyclic compound binding	2	1
GO:0097367	carbohydrate derivative binding	2	1
GO:1901265	nucleoside phosphate binding	3	1
GO:1901363	heterocyclic compound binding	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	93	95	PF00675	0.306
CLV_PCSK_KEX2_1	93	95	PF00082	0.294
CLV_PCSK_SKI1_1	165	169	PF00082	0.277
CLV_PCSK_SKI1_1	219	223	PF00082	0.331
CLV_PCSK_SKI1_1	9	13	PF00082	0.649
DEG_Nend_UBRbox_3	1	3	PF02207	0.666
DEG_SCF_FBW7_1	27	33	PF00400	0.552
DOC_CKS1_1	19	24	PF01111	0.521
DOC_CKS1_1	27	32	PF01111	0.546
DOC_MAPK_MEF2A_6	165	174	PF00069	0.266
DOC_PP1_RVXF_1	157	163	PF00149	0.331
DOC_PP4_FxxP_1	155	158	PF00568	0.334
DOC_PP4_FxxP_1	57	60	PF00568	0.701
DOC_WW_Pin1_4	133	138	PF00397	0.334
DOC_WW_Pin1_4	153	158	PF00397	0.252
DOC_WW_Pin1_4	18	23	PF00397	0.602
DOC_WW_Pin1_4	26	31	PF00397	0.622
DOC_WW_Pin1_4	47	52	PF00397	0.680
LIG_14-3-3_CanoR_1	219	228	PF00244	0.331
LIG_14-3-3_CanoR_1	71	79	PF00244	0.653
LIG_Actin_WH2_2	171	186	PF00022	0.297
LIG_Clathr_ClatBox_1	142	146	PF01394	0.331
LIG_deltaCOP1_diTrp_1	135	143	PF00928	0.336
LIG_FHA_1	162	168	PF00498	0.313
LIG_FHA_1	19	25	PF00498	0.536
LIG_FHA_2	134	140	PF00498	0.272
LIG_FHA_2	48	54	PF00498	0.652
LIG_IRF3_LxIS_1	193	199	PF10401	0.331
LIG_LIR_Apic_2	152	158	PF02991	0.331
LIG_LIR_Nem_3	98	102	PF02991	0.331
LIG_NRBOX	192	198	PF00104	0.349
LIG_PDZ_Class_3	255	260	PF00595	0.549
LIG_SH2_SRC	173	176	PF00017	0.272
LIG_SH2_STAP1	228	232	PF00017	0.272
LIG_SH2_STAT5	173	176	PF00017	0.266
LIG_SH3_2	154	159	PF14604	0.331
LIG_SH3_3	151	157	PF00018	0.278
LIG_SH3_3	16	22	PF00018	0.653
LIG_SH3_3	164	170	PF00018	0.325
LIG_SH3_3	24	30	PF00018	0.686
LIG_SUMO_SIM_par_1	196	202	PF11976	0.288
LIG_WRC_WIRS_1	99	104	PF05994	0.349
MOD_CDC14_SPxK_1	156	159	PF00782	0.349
MOD_CDK_SPxK_1	153	159	PF00069	0.349
MOD_CDK_SPxxK_3	47	54	PF00069	0.650
MOD_CK1_1	112	118	PF00069	0.336
MOD_CK1_1	186	192	PF00069	0.297
MOD_CK1_1	199	205	PF00069	0.249
MOD_CK1_1	70	76	PF00069	0.644
MOD_CK2_1	133	139	PF00069	0.272
MOD_GlcNHglycan	130	133	PF01048	0.326
MOD_GlcNHglycan	210	213	PF01048	0.301
MOD_GlcNHglycan	225	228	PF01048	0.349
MOD_GlcNHglycan	60	63	PF01048	0.651
MOD_GlcNHglycan	72	75	PF01048	0.674
MOD_GSK3_1	108	115	PF00069	0.310
MOD_GSK3_1	179	186	PF00069	0.417
MOD_GSK3_1	219	226	PF00069	0.348
MOD_GSK3_1	236	243	PF00069	0.411
MOD_GSK3_1	26	33	PF00069	0.658
MOD_GSK3_1	5	12	PF00069	0.697
MOD_N-GLC_1	112	117	PF02516	0.310
MOD_N-GLC_1	223	228	PF02516	0.331
MOD_N-GLC_2	177	179	PF02516	0.272
MOD_NEK2_1	183	188	PF00069	0.386
MOD_NEK2_1	196	201	PF00069	0.281
MOD_NEK2_1	240	245	PF00069	0.427
MOD_NEK2_2	179	184	PF00069	0.282
MOD_PKA_2	67	73	PF00069	0.649
MOD_PKB_1	84	92	PF00069	0.505
MOD_Plk_1	112	118	PF00069	0.349
MOD_Plk_1	223	229	PF00069	0.331
MOD_Plk_1	236	242	PF00069	0.397
MOD_Plk_2-3	247	253	PF00069	0.608
MOD_Plk_4	199	205	PF00069	0.292
MOD_ProDKin_1	133	139	PF00069	0.334
MOD_ProDKin_1	153	159	PF00069	0.252
MOD_ProDKin_1	18	24	PF00069	0.605
MOD_ProDKin_1	26	32	PF00069	0.623
MOD_ProDKin_1	47	53	PF00069	0.679
MOD_SUMO_rev_2	223	232	PF00179	0.331
TRG_DiLeu_BaLyEn_6	216	221	PF01217	0.331
TRG_ENDOCYTIC_2	99	102	PF00928	0.331
TRG_ER_diArg_1	93	95	PF00400	0.272
TRG_Pf-PMV_PEXEL_1	219	223	PF00026	0.331
TRG_Pf-PMV_PEXEL_1	233	237	PF00026	0.364
TRG_Pf-PMV_PEXEL_1	93	97	PF00026	0.272

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HXA7	Leptomonas seymouri	65%	97%
A0A3Q8IFB8	Leishmania donovani	29%	100%
A0A3S7WX16	Leishmania donovani	97%	100%
A0A3S7WYH9	Leishmania donovani	26%	100%
A0A422NDI3	Trypanosoma rangeli	54%	100%
A4HCA6	Leishmania braziliensis	83%	100%
A4HDN1	Leishmania braziliensis	28%	100%
A4HK50	Leishmania braziliensis	30%	100%
A4HZT8	Leishmania infantum	97%	100%
A4I7L2	Leishmania infantum	29%	100%
E9AH78	Leishmania infantum	26%	100%
E9AVP3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AX16	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	100%
E9B2J3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
O60015	Pichia angusta	31%	100%
P0C8G3	African swine fever virus (isolate Pig/Kenya/KEN-50/1950)	30%	100%
P49428	Komagataella pastoris	29%	100%
P52478	Caenorhabditis elegans	42%	100%
P56616	Xenopus laevis	34%	100%
Q32PA5	Bos taurus	34%	100%
Q4Q5L3	Leishmania major	31%	100%
Q4QAG0	Leishmania major	27%	100%
Q5VVX9	Homo sapiens	32%	81%
Q6PCF7	Xenopus laevis	31%	83%
Q95LM1	Macaca fascicularis	32%	81%
Q9D1C1	Mus musculus	34%	100%