Putative proteasome regulatory ATPase subunit 5

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome regulatory ATPase subunit 5, putative

Species:

Leishmania major

UniProt:

Q4QBT5_LEIMA

TriTrypDb:

LmjF.22.0620 , LMJLV39_220011300 , LMJSD75_220011400

Length:

444

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	7
GO:0005737	cytoplasm	2	12
GO:0008540	proteasome regulatory particle, base subcomplex	2	2
GO:0032991	protein-containing complex	1	12
GO:0043226	organelle	2	7
GO:0043227	membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043231	intracellular membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	12
GO:0000502	proteasome complex	3	10
GO:0140535	intracellular protein-containing complex	2	10
GO:1902494	catalytic complex	2	10
GO:1905368	peptidase complex	3	10
GO:1905369	endopeptidase complex	4	10

Expansion

Sequence features

Q4QBT5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBT5

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0009987	cellular process	1	2
GO:0010498	proteasomal protein catabolic process	5	2
GO:0019538	protein metabolic process	3	12
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0030163	protein catabolic process	4	12
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	12
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	12
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901565	organonitrogen compound catabolic process	4	12
GO:1901575	organic substance catabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0016887	ATP hydrolysis activity	7	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0036402	proteasome-activating activity	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	291	295	PF00656	0.332
CLV_C14_Caspase3-7	320	324	PF00656	0.332
CLV_NRD_NRD_1	116	118	PF00675	0.305
CLV_NRD_NRD_1	121	123	PF00675	0.303
CLV_NRD_NRD_1	23	25	PF00675	0.708
CLV_NRD_NRD_1	354	356	PF00675	0.332
CLV_NRD_NRD_1	376	378	PF00675	0.458
CLV_NRD_NRD_1	434	436	PF00675	0.491
CLV_PCSK_KEX2_1	23	25	PF00082	0.731
CLV_PCSK_KEX2_1	299	301	PF00082	0.321
CLV_PCSK_KEX2_1	376	378	PF00082	0.458
CLV_PCSK_KEX2_1	74	76	PF00082	0.521
CLV_PCSK_KEX2_1	82	84	PF00082	0.480
CLV_PCSK_PC1ET2_1	23	25	PF00082	0.731
CLV_PCSK_PC1ET2_1	299	301	PF00082	0.453
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.530
CLV_PCSK_PC1ET2_1	82	84	PF00082	0.472
CLV_PCSK_SKI1_1	226	230	PF00082	0.332
CLV_PCSK_SKI1_1	238	242	PF00082	0.332
CLV_PCSK_SKI1_1	274	278	PF00082	0.332
CLV_PCSK_SKI1_1	313	317	PF00082	0.327
CLV_PCSK_SKI1_1	82	86	PF00082	0.556
DEG_APCC_DBOX_1	312	320	PF00400	0.332
DEG_APCC_KENBOX_2	84	88	PF00400	0.610
DOC_MAPK_gen_1	281	290	PF00069	0.332
DOC_MAPK_gen_1	349	359	PF00069	0.321
DOC_MAPK_gen_1	65	73	PF00069	0.588
DOC_MAPK_MEF2A_6	134	141	PF00069	0.480
DOC_MAPK_MEF2A_6	281	289	PF00069	0.332
DOC_MAPK_RevD_3	285	300	PF00069	0.332
DOC_PIKK_1	105	113	PF02985	0.492
DOC_PP1_RVXF_1	353	360	PF00149	0.332
DOC_PP1_RVXF_1	380	387	PF00149	0.417
DOC_PP4_FxxP_1	359	362	PF00568	0.438
DOC_USP7_MATH_1	295	299	PF00917	0.331
DOC_USP7_MATH_1	366	370	PF00917	0.563
DOC_USP7_UBL2_3	119	123	PF12436	0.492
DOC_USP7_UBL2_3	185	189	PF12436	0.510
DOC_USP7_UBL2_3	81	85	PF12436	0.542
DOC_WW_Pin1_4	148	153	PF00397	0.521
DOC_WW_Pin1_4	230	235	PF00397	0.348
LIG_14-3-3_CanoR_1	134	138	PF00244	0.480
LIG_Actin_WH2_2	336	351	PF00022	0.332
LIG_BIR_III_4	294	298	PF00653	0.332
LIG_BRCT_BRCA1_1	285	289	PF00533	0.453
LIG_CtBP_PxDLS_1	152	156	PF00389	0.566
LIG_FHA_1	134	140	PF00498	0.480
LIG_FHA_1	160	166	PF00498	0.480
LIG_FHA_1	335	341	PF00498	0.342
LIG_FHA_1	54	60	PF00498	0.622
LIG_FHA_2	210	216	PF00498	0.479
LIG_FHA_2	312	318	PF00498	0.332
LIG_GBD_Chelix_1	93	101	PF00786	0.348
LIG_LIR_Apic_2	358	362	PF02991	0.332
LIG_LIR_Gen_1	132	142	PF02991	0.585
LIG_LIR_Gen_1	161	171	PF02991	0.480
LIG_LIR_Gen_1	188	196	PF02991	0.453
LIG_LIR_Gen_1	215	225	PF02991	0.495
LIG_LIR_Nem_3	132	138	PF02991	0.490
LIG_LIR_Nem_3	161	166	PF02991	0.477
LIG_LIR_Nem_3	188	193	PF02991	0.464
LIG_LIR_Nem_3	215	220	PF02991	0.501
LIG_LIR_Nem_3	383	389	PF02991	0.320
LIG_PCNA_yPIPBox_3	198	208	PF02747	0.416
LIG_PCNA_yPIPBox_3	305	319	PF02747	0.335
LIG_PDZ_Class_2	439	444	PF00595	0.559
LIG_SH2_CRK	231	235	PF00017	0.343
LIG_SH2_NCK_1	13	17	PF00017	0.665
LIG_SH2_NCK_1	190	194	PF00017	0.451
LIG_SH2_STAP1	135	139	PF00017	0.585
LIG_SH2_STAP1	173	177	PF00017	0.445
LIG_SH2_STAT5	135	138	PF00017	0.548
LIG_SH2_STAT5	190	193	PF00017	0.445
LIG_SH2_STAT5	419	422	PF00017	0.332
LIG_SH2_STAT5	92	95	PF00017	0.423
LIG_SH3_3	134	140	PF00018	0.470
LIG_SH3_3	204	210	PF00018	0.414
LIG_SH3_3	339	345	PF00018	0.332
LIG_SH3_3	354	360	PF00018	0.417
LIG_SH3_4	119	126	PF00018	0.566
LIG_SH3_4	185	192	PF00018	0.500
LIG_SUMO_SIM_anti_2	314	320	PF11976	0.332
LIG_SUMO_SIM_par_1	314	320	PF11976	0.332
LIG_SUMO_SIM_par_1	369	375	PF11976	0.438
LIG_SUMO_SIM_par_1	99	109	PF11976	0.505
LIG_TRAF2_1	16	19	PF00917	0.643
LIG_TRAF2_1	362	365	PF00917	0.458
LIG_TRAF2_1	66	69	PF00917	0.614
LIG_WRC_WIRS_1	59	64	PF05994	0.637
LIG_WW_1	170	173	PF00397	0.481
MOD_CK1_1	233	239	PF00069	0.348
MOD_CK1_1	298	304	PF00069	0.330
MOD_CK2_1	101	107	PF00069	0.491
MOD_CK2_1	209	215	PF00069	0.475
MOD_CK2_1	27	33	PF00069	0.595
MOD_CK2_1	311	317	PF00069	0.332
MOD_CK2_1	366	372	PF00069	0.540
MOD_CK2_1	63	69	PF00069	0.537
MOD_CK2_1	93	99	PF00069	0.348
MOD_Cter_Amidation	115	118	PF01082	0.280
MOD_Cter_Amidation	79	82	PF01082	0.606
MOD_GlcNHglycan	125	128	PF01048	0.279
MOD_GlcNHglycan	2	5	PF01048	0.628
MOD_GlcNHglycan	349	352	PF01048	0.322
MOD_GSK3_1	129	136	PF00069	0.480
MOD_N-GLC_1	27	32	PF02516	0.632
MOD_N-GLC_1	63	68	PF02516	0.590
MOD_NEK2_1	347	352	PF00069	0.319
MOD_NEK2_1	93	98	PF00069	0.348
MOD_PIKK_1	317	323	PF00454	0.348
MOD_PIKK_1	53	59	PF00454	0.595
MOD_PK_1	283	289	PF00069	0.453
MOD_PKA_1	435	441	PF00069	0.517
MOD_PKA_2	133	139	PF00069	0.490
MOD_PKA_2	366	372	PF00069	0.509
MOD_PKA_2	390	396	PF00069	0.343
MOD_Plk_1	415	421	PF00069	0.417
MOD_Plk_4	133	139	PF00069	0.480
MOD_Plk_4	159	165	PF00069	0.480
MOD_Plk_4	236	242	PF00069	0.332
MOD_Plk_4	283	289	PF00069	0.348
MOD_Plk_4	366	372	PF00069	0.540
MOD_ProDKin_1	148	154	PF00069	0.521
MOD_ProDKin_1	230	236	PF00069	0.348
MOD_SUMO_rev_2	181	186	PF00179	0.536
MOD_SUMO_rev_2	327	334	PF00179	0.332
MOD_SUMO_rev_2	350	357	PF00179	0.332
TRG_ENDOCYTIC_2	135	138	PF00928	0.570
TRG_ENDOCYTIC_2	190	193	PF00928	0.457
TRG_ER_diArg_1	376	378	PF00400	0.489
TRG_ER_diArg_1	45	48	PF00400	0.508
TRG_NLS_MonoExtC_3	280	285	PF00514	0.348
TRG_NLS_MonoExtC_3	80	85	PF00514	0.614
TRG_Pf-PMV_PEXEL_1	50	54	PF00026	0.520

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5B8	Leptomonas seymouri	95%	100%
A0A0N1IGY9	Leptomonas seymouri	45%	100%
A0A0N1IM81	Leptomonas seymouri	50%	100%
A0A0S4ITX1	Bodo saltans	77%	100%
A0A0S4JSD8	Bodo saltans	40%	100%
A0A1X0NMZ3	Trypanosomatidae	50%	100%
A0A1X0NNS1	Trypanosomatidae	46%	100%
A0A1X0NT86	Trypanosomatidae	79%	100%
A0A1X0P1T5	Trypanosomatidae	42%	100%
A0A3Q8IJS0	Leishmania donovani	53%	100%
A0A3R7LUG9	Trypanosoma rangeli	77%	100%
A0A3R7N4Y5	Trypanosoma rangeli	49%	100%
A0A3S5H547	Leishmania donovani	46%	100%
A0A3S7WRY0	Leishmania donovani	39%	100%
A0A3S7WSK7	Leishmania donovani	51%	100%
A0A3S7WX14	Leishmania donovani	99%	100%
A0A3S7WX46	Leishmania donovani	49%	100%
A0A422NDS9	Trypanosoma rangeli	45%	100%
A0A422NLD8	Trypanosoma rangeli	49%	100%
A0A422NUD9	Trypanosoma rangeli	41%	100%
A0PQT9	Mycobacterium ulcerans (strain Agy99)	34%	73%
A0QZ54	Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155)	34%	72%
A1KKF8	Mycobacterium bovis (strain BCG / Pasteur 1173P2)	34%	73%
A1TAQ3	Mycolicibacterium vanbaalenii (strain DSM 7251 / JCM 13017 / BCRC 16820 / KCTC 9966 / NRRL B-24157 / PYR-1)	33%	72%
A1UHT0	Mycobacterium sp. (strain KMS)	34%	72%
A3CV35	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	42%	100%
A3Q196	Mycobacterium sp. (strain JLS)	34%	72%
A4G0S4	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	50%	100%
A4H3L6	Leishmania braziliensis	46%	100%
A4H6T6	Leishmania braziliensis	45%	100%
A4H795	Leishmania braziliensis	51%	100%
A4HCA3	Leishmania braziliensis	49%	100%
A4HCA7	Leishmania braziliensis	98%	100%
A4HPV3	Leishmania braziliensis	52%	100%
A4HVN7	Leishmania infantum	51%	100%
A4HZT4	Leishmania infantum	49%	100%
A4HZT9	Leishmania infantum	99%	100%
A4IE38	Leishmania infantum	53%	100%
A4TB65	Mycolicibacterium gilvum (strain PYR-GCK)	33%	72%
A5U4E1	Mycobacterium tuberculosis (strain ATCC 25177 / H37Ra)	34%	73%
A5WP89	Mycobacterium tuberculosis (strain F11)	34%	73%
A6UQT3	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	49%	100%
A6VHR1	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	50%	100%
A7I8B8	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	40%	100%
A9A916	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	50%	100%
B1MAH2	Mycobacteroides abscessus (strain ATCC 19977 / DSM 44196 / CIP 104536 / JCM 13569 / NCTC 13031 / TMC 1543)	34%	74%
B2GIP2	Kocuria rhizophila (strain ATCC 9341 / DSM 348 / NBRC 103217 / DC2201)	34%	78%
B2HFW2	Mycobacterium marinum (strain ATCC BAA-535 / M)	34%	73%
B6YXR2	Thermococcus onnurineus (strain NA1)	43%	100%
B8GGN4	Methanosphaerula palustris (strain ATCC BAA-1556 / DSM 19958 / E1-9c)	41%	100%
B8ZRF0	Mycobacterium leprae (strain Br4923)	34%	73%
C0ZZV2	Rhodococcus erythropolis (strain PR4 / NBRC 100887)	34%	75%
C1AQ31	Mycobacterium bovis (strain BCG / Tokyo 172 / ATCC 35737 / TMC 1019)	34%	73%
C1ASQ2	Rhodococcus opacus (strain B4)	32%	75%
C3MRF1	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	46%	100%
C3MY47	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	46%	100%
C3MZI6	Sulfolobus islandicus (strain M.16.27)	46%	100%
C3N7K8	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	46%	100%
C3NFW6	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	46%	100%
C4KIR6	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	46%	100%
C5A6P8	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	44%	100%
C5CES8	Kosmotoga olearia (strain ATCC BAA-1733 / DSM 21960 / TBF 19.5.1)	39%	69%
C6DPU6	Mycobacterium tuberculosis (strain KZN 1435 / MDR)	34%	73%
C9ZQC1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
C9ZRM8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	73%	100%
D0A4A2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	49%	100%
D0A6K9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
D0LDS6	Gordonia bronchialis (strain ATCC 25592 / DSM 43247 / BCRC 13721 / JCM 3198 / KCTC 3076 / NBRC 16047 / NCTC 10667)	34%	73%
D1BHU2	Sanguibacter keddieii (strain ATCC 51767 / DSM 10542 / NCFB 3025 / ST-74)	29%	76%
E9ACJ9	Leishmania major	46%	100%
E9AG43	Leishmania infantum	46%	100%
E9AGB0	Leishmania infantum	39%	100%
E9AJT7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	46%	100%
E9ANU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	100%
E9APD3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	51%	100%
E9ATM0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	100%
E9AVN9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E9AVP4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	99%	100%
O04019	Arabidopsis thaliana	64%	100%
O14126	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	58%	100%
O16368	Caenorhabditis elegans	50%	100%
O17071	Caenorhabditis elegans	43%	100%
O23894	Brassica campestris	62%	100%
O26824	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	42%	100%
O28303	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	45%	100%
O42586	Xenopus laevis	63%	100%
O42587	Xenopus laevis	64%	100%
O42931	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	42%	100%
O50202	Rhodococcus erythropolis	34%	75%
O57940	Pyrococcus horikoshii (strain ATCC 700860 / DSM 12428 / JCM 9974 / NBRC 100139 / OT-3)	43%	100%
O64982	Prunus persica	50%	100%
O74894	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	100%
O76371	Caenorhabditis elegans	63%	100%
O88685	Mus musculus	64%	100%
P0DKJ9	Oryza sativa subsp. japonica	50%	100%
P0DKK0	Oryza sativa subsp. japonica	50%	100%
P17980	Homo sapiens	64%	100%
P33297	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	59%	100%
P33298	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	39%	100%
P33299	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	49%	95%
P34123	Dictyostelium discoideum	40%	100%
P36612	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	45%	99%
P40327	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	49%	100%
P43686	Homo sapiens	40%	100%
P46465	Oryza sativa subsp. japonica	63%	100%
P46466	Oryza sativa subsp. japonica	49%	99%
P46502	Caenorhabditis elegans	40%	100%
P46507	Manduca sexta	39%	100%
P46509	Mycobacterium leprae (strain TN)	34%	73%
P48601	Drosophila melanogaster	51%	100%
P53549	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	41%	100%
P54775	Mus musculus	40%	100%
P54776	Solanum lycopersicum	62%	100%
P54778	Solanum tuberosum	38%	100%
P62191	Homo sapiens	51%	100%
P62192	Mus musculus	51%	100%
P62193	Rattus norvegicus	51%	100%
P62194	Bos taurus	50%	100%
P62195	Homo sapiens	50%	100%
P62196	Mus musculus	50%	100%
P62197	Sus scrofa	50%	100%
P62198	Rattus norvegicus	50%	100%
P62333	Homo sapiens	42%	100%
P62334	Mus musculus	42%	100%
P62335	Ictidomys tridecemlineatus	42%	100%
P63346	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	34%	73%
P78578	Aspergillus niger	38%	100%
P85200	Helianthus annuus	39%	100%
P9WQN4	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	34%	73%
P9WQN5	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	34%	73%
Q01939	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	47%	100%
Q0W257	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	41%	100%
Q1B795	Mycobacterium sp. (strain MCS)	34%	72%
Q25544	Naegleria fowleri	50%	100%
Q2FQ56	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	44%	100%
Q2KIW6	Bos taurus	42%	100%
Q3T030	Bos taurus	40%	100%
Q41365	Spinacia oleracea	50%	100%
Q4Q0X8	Leishmania major	53%	100%
Q4QBU0	Leishmania major	49%	100%
Q4QG45	Leishmania major	51%	100%
Q4QGS2	Leishmania major	39%	100%
Q4R7L3	Macaca fascicularis	40%	100%
Q54PJ1	Dictyostelium discoideum	40%	100%
Q54PN7	Dictyostelium discoideum	61%	100%
Q55BV5	Dictyostelium discoideum	49%	100%
Q58576	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	51%	100%
Q5JHS5	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	43%	100%
Q5YUW4	Nocardia farcinica (strain IFM 10152)	35%	76%
Q63569	Rattus norvegicus	64%	100%
Q63570	Rattus norvegicus	40%	100%
Q6LWR0	Methanococcus maripaludis (strain S2 / LL)	50%	100%
Q8PY58	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	45%	100%
Q8SQI9	Encephalitozoon cuniculi (strain GB-M1)	38%	100%
Q8SQK0	Encephalitozoon cuniculi (strain GB-M1)	46%	100%
Q8SR13	Encephalitozoon cuniculi (strain GB-M1)	53%	100%
Q8SRH0	Encephalitozoon cuniculi (strain GB-M1)	46%	100%
Q8TI88	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	45%	100%
Q8TX03	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	45%	100%
Q8U4H3	Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)	43%	100%
Q90732	Gallus gallus	51%	100%
Q975U2	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	40%	100%
Q980M1	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	46%	100%
Q9SEI2	Arabidopsis thaliana	62%	100%
Q9SEI4	Arabidopsis thaliana	38%	100%
Q9SL67	Arabidopsis thaliana	48%	100%
Q9SSB4	Arabidopsis thaliana	46%	96%
Q9SSB5	Arabidopsis thaliana	50%	100%
Q9SZD4	Arabidopsis thaliana	48%	100%
Q9V287	Pyrococcus abyssi (strain GE5 / Orsay)	43%	100%
Q9XTT9	Caenorhabditis elegans	49%	100%
Q9YAC7	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	46%	100%
V5AV12	Trypanosoma cruzi	50%	100%
V5B5X1	Trypanosoma cruzi	45%	100%
V5B5X6	Trypanosoma cruzi	78%	100%
V5BKL6	Trypanosoma cruzi	49%	100%