Mitochondrial guide RNA binding complex subunit 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

guide RNA associated protein, GAP2, putative

Species:

Leishmania major

UniProt:

Q4QBT2_LEIMA

TriTrypDb:

LmjF.22.0650 , LMJLV39_220011600 , LMJSD75_220011700

Length:

500

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0110165	cellular anatomical entity	1	4
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QBT2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBT2

Function

Biological processes
Term	Name	Level	Count
GO:0000959	mitochondrial RNA metabolic process	6	3
GO:0000963	mitochondrial RNA processing	6	3
GO:0006139	nucleobase-containing compound metabolic process	3	3
GO:0006396	RNA processing	6	3
GO:0006725	cellular aromatic compound metabolic process	3	3
GO:0006807	nitrogen compound metabolic process	2	3
GO:0008152	metabolic process	1	3
GO:0009987	cellular process	1	3
GO:0010467	gene expression	4	3
GO:0016070	RNA metabolic process	5	3
GO:0034641	cellular nitrogen compound metabolic process	3	3
GO:0043170	macromolecule metabolic process	3	3
GO:0044237	cellular metabolic process	2	3
GO:0044238	primary metabolic process	2	3
GO:0046483	heterocycle metabolic process	3	3
GO:0071704	organic substance metabolic process	2	3
GO:0090304	nucleic acid metabolic process	4	3
GO:0140053	mitochondrial gene expression	5	3
GO:1901360	organic cyclic compound metabolic process	3	3
GO:0009451	RNA modification	5	1
GO:0016071	mRNA metabolic process	6	1
GO:0016556	mRNA modification	6	1
GO:0043412	macromolecule modification	4	1

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003723	RNA binding	4	3
GO:0003729	mRNA binding	5	3
GO:0005488	binding	1	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	209	213	PF00656	0.536
CLV_NRD_NRD_1	105	107	PF00675	0.526
CLV_PCSK_KEX2_1	105	107	PF00082	0.577
CLV_PCSK_KEX2_1	316	318	PF00082	0.436
CLV_PCSK_KEX2_1	424	426	PF00082	0.373
CLV_PCSK_PC1ET2_1	316	318	PF00082	0.435
CLV_PCSK_PC1ET2_1	424	426	PF00082	0.326
CLV_PCSK_SKI1_1	16	20	PF00082	0.694
CLV_PCSK_SKI1_1	247	251	PF00082	0.433
CLV_PCSK_SKI1_1	316	320	PF00082	0.517
CLV_PCSK_SKI1_1	356	360	PF00082	0.362
CLV_PCSK_SKI1_1	57	61	PF00082	0.500
CLV_PCSK_SKI1_1	84	88	PF00082	0.549
DEG_APCC_DBOX_1	424	432	PF00400	0.403
DEG_Nend_UBRbox_1	1	4	PF02207	0.470
DOC_CDC14_PxL_1	485	493	PF14671	0.457
DOC_CKS1_1	249	254	PF01111	0.388
DOC_CYCLIN_RxL_1	244	251	PF00134	0.381
DOC_CYCLIN_yCln2_LP_2	249	255	PF00134	0.388
DOC_MAPK_gen_1	316	326	PF00069	0.393
DOC_MAPK_gen_1	421	431	PF00069	0.385
DOC_MAPK_MEF2A_6	236	245	PF00069	0.477
DOC_MAPK_MEF2A_6	317	326	PF00069	0.391
DOC_MAPK_MEF2A_6	424	431	PF00069	0.386
DOC_MAPK_MEF2A_6	439	448	PF00069	0.321
DOC_MAPK_MEF2A_6	46	54	PF00069	0.575
DOC_PP1_RVXF_1	221	228	PF00149	0.409
DOC_USP7_MATH_1	186	190	PF00917	0.528
DOC_USP7_MATH_1	260	264	PF00917	0.412
DOC_USP7_MATH_1	363	367	PF00917	0.583
DOC_USP7_MATH_1	53	57	PF00917	0.549
DOC_WW_Pin1_4	248	253	PF00397	0.424
LIG_14-3-3_CanoR_1	190	200	PF00244	0.459
LIG_14-3-3_CanoR_1	308	312	PF00244	0.489
LIG_14-3-3_CanoR_1	33	42	PF00244	0.660
LIG_14-3-3_CanoR_1	7	11	PF00244	0.756
LIG_BIR_III_4	212	216	PF00653	0.546
LIG_deltaCOP1_diTrp_1	338	346	PF00928	0.494
LIG_deltaCOP1_diTrp_1	64	70	PF00928	0.463
LIG_FHA_1	121	127	PF00498	0.473
LIG_FHA_1	240	246	PF00498	0.476
LIG_FHA_1	43	49	PF00498	0.728
LIG_FHA_1	491	497	PF00498	0.519
LIG_FHA_1	56	62	PF00498	0.661
LIG_FHA_2	148	154	PF00498	0.517
LIG_FHA_2	346	352	PF00498	0.511
LIG_FHA_2	39	45	PF00498	0.589
LIG_LIR_Gen_1	219	229	PF02991	0.368
LIG_LIR_Gen_1	274	284	PF02991	0.466
LIG_LIR_Gen_1	338	346	PF02991	0.365
LIG_LIR_Gen_1	371	381	PF02991	0.426
LIG_LIR_Gen_1	405	416	PF02991	0.410
LIG_LIR_Nem_3	193	199	PF02991	0.456
LIG_LIR_Nem_3	219	224	PF02991	0.414
LIG_LIR_Nem_3	274	280	PF02991	0.484
LIG_LIR_Nem_3	297	303	PF02991	0.395
LIG_LIR_Nem_3	338	342	PF02991	0.398
LIG_LIR_Nem_3	371	376	PF02991	0.474
LIG_LIR_Nem_3	405	411	PF02991	0.390
LIG_NRBOX	472	478	PF00104	0.332
LIG_SH2_CRK	221	225	PF00017	0.375
LIG_SH2_CRK	373	377	PF00017	0.420
LIG_SH2_NCK_1	373	377	PF00017	0.407
LIG_SH2_SRC	110	113	PF00017	0.486
LIG_SH2_SRC	63	66	PF00017	0.413
LIG_SH2_STAP1	221	225	PF00017	0.427
LIG_SH2_STAP1	277	281	PF00017	0.395
LIG_SH2_STAP1	63	67	PF00017	0.554
LIG_SH2_STAT3	265	268	PF00017	0.402
LIG_SH2_STAT5	110	113	PF00017	0.480
LIG_SH2_STAT5	206	209	PF00017	0.496
LIG_SH2_STAT5	265	268	PF00017	0.430
LIG_SH2_STAT5	277	280	PF00017	0.444
LIG_SH2_STAT5	373	376	PF00017	0.474
LIG_SH2_STAT5	399	402	PF00017	0.386
LIG_SH3_3	146	152	PF00018	0.540
LIG_SH3_3	194	200	PF00018	0.482
LIG_SH3_3	347	353	PF00018	0.553
LIG_SH3_3	386	392	PF00018	0.440
LIG_SH3_3	443	449	PF00018	0.393
LIG_SUMO_SIM_anti_2	320	326	PF11976	0.503
LIG_SUMO_SIM_par_1	377	385	PF11976	0.525
LIG_SUMO_SIM_par_1	427	437	PF11976	0.452
LIG_SUMO_SIM_par_1	465	472	PF11976	0.470
LIG_TYR_ITIM	61	66	PF00017	0.561
LIG_TYR_ITSM	217	224	PF00017	0.367
MOD_CK1_1	113	119	PF00069	0.542
MOD_CK1_1	263	269	PF00069	0.403
MOD_CK1_1	451	457	PF00069	0.641
MOD_CK1_1	55	61	PF00069	0.579
MOD_CK1_1	9	15	PF00069	0.753
MOD_CK2_1	147	153	PF00069	0.612
MOD_CK2_1	179	185	PF00069	0.577
MOD_CK2_1	345	351	PF00069	0.507
MOD_CK2_1	398	404	PF00069	0.379
MOD_CMANNOS	67	70	PF00535	0.409
MOD_GlcNHglycan	115	118	PF01048	0.575
MOD_GlcNHglycan	193	196	PF01048	0.580
MOD_GlcNHglycan	2	5	PF01048	0.520
MOD_GlcNHglycan	262	265	PF01048	0.508
MOD_GlcNHglycan	285	288	PF01048	0.487
MOD_GlcNHglycan	365	368	PF01048	0.564
MOD_GlcNHglycan	450	453	PF01048	0.579
MOD_GSK3_1	186	193	PF00069	0.420
MOD_GSK3_1	200	207	PF00069	0.423
MOD_GSK3_1	271	278	PF00069	0.421
MOD_GSK3_1	34	41	PF00069	0.624
MOD_GSK3_1	341	348	PF00069	0.381
MOD_GSK3_1	398	405	PF00069	0.391
MOD_GSK3_1	444	451	PF00069	0.536
MOD_GSK3_1	467	474	PF00069	0.495
MOD_GSK3_1	492	499	PF00069	0.650
MOD_GSK3_1	6	13	PF00069	0.647
MOD_N-GLC_1	191	196	PF02516	0.456
MOD_N-GLC_1	402	407	PF02516	0.513
MOD_NEK2_1	10	15	PF00069	0.734
MOD_NEK2_1	177	182	PF00069	0.443
MOD_NEK2_1	271	276	PF00069	0.485
MOD_NEK2_1	28	33	PF00069	0.708
MOD_NEK2_1	358	363	PF00069	0.391
MOD_NEK2_1	444	449	PF00069	0.360
MOD_PIKK_1	147	153	PF00454	0.595
MOD_PKA_2	219	225	PF00069	0.378
MOD_PKA_2	307	313	PF00069	0.480
MOD_PKA_2	34	40	PF00069	0.516
MOD_PKA_2	369	375	PF00069	0.490
MOD_PKA_2	420	426	PF00069	0.487
MOD_PKA_2	6	12	PF00069	0.756
MOD_PKB_1	33	41	PF00069	0.476
MOD_Plk_1	191	197	PF00069	0.489
MOD_Plk_1	239	245	PF00069	0.470
MOD_Plk_1	471	477	PF00069	0.343
MOD_Plk_4	275	281	PF00069	0.384
MOD_Plk_4	472	478	PF00069	0.498
MOD_ProDKin_1	248	254	PF00069	0.416
MOD_SUMO_for_1	330	333	PF00179	0.372
MOD_SUMO_for_1	61	64	PF00179	0.586
TRG_DiLeu_BaEn_1	244	249	PF01217	0.486
TRG_DiLeu_BaEn_1	393	398	PF01217	0.419
TRG_DiLeu_BaEn_1	472	477	PF01217	0.337
TRG_DiLeu_BaEn_4	435	441	PF01217	0.458
TRG_DiLeu_BaEn_4	64	70	PF01217	0.404
TRG_DiLeu_BaLyEn_6	424	429	PF01217	0.383
TRG_ENDOCYTIC_2	221	224	PF00928	0.381
TRG_ENDOCYTIC_2	277	280	PF00928	0.392
TRG_ENDOCYTIC_2	373	376	PF00928	0.550
TRG_ENDOCYTIC_2	63	66	PF00928	0.558
TRG_ER_diArg_1	104	106	PF00400	0.549
TRG_ER_diArg_1	359	362	PF00400	0.385
TRG_Pf-PMV_PEXEL_1	46	51	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IK37	Leptomonas seymouri	73%	100%
A0A0N1IKX3	Leptomonas seymouri	28%	92%
A0A0S4IN88	Bodo saltans	44%	93%
A0A0S4JQR1	Bodo saltans	30%	93%
A0A1X0NRA1	Trypanosomatidae	28%	98%
A0A1X0NTQ0	Trypanosomatidae	57%	100%
A0A3Q8II17	Leishmania donovani	28%	100%
A0A3S7WX47	Leishmania donovani	95%	100%
A0A422NDT8	Trypanosoma rangeli	57%	100%
A0A422NKD3	Trypanosoma rangeli	28%	100%
A4HCA9	Leishmania braziliensis	87%	100%
A4HLY4	Leishmania braziliensis	29%	100%
A4HZU2	Leishmania infantum	95%	100%
A4I9B3	Leishmania infantum	28%	100%
C9ZJB1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
C9ZRN1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9AVP7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9B4B3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
Q4Q3R2	Leishmania major	28%	100%
V5BAI0	Trypanosoma cruzi	28%	100%
V5BVS4	Trypanosoma cruzi	56%	100%