LeishMANIAdb
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3'a2rel-related protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
3'a2rel-related protein
Gene product:
3'a2rel-related protein
Species:
Leishmania major
UniProt:
Q4QBS8_LEIMA
TriTrypDb:
LmjF.22.0690 , LMJLV39_220012200 , LMJSD75_220012200
Length:
599

Annotations

LeishMANIAdb annotations

A very special family of kinetoplastid proteins, carrying multiply amyloid-like segments on their disordered extracellular domain, alongside with RGD motifs. Duplicated in Leishmaniids

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 4, no: 5
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0016020 membrane 2 8
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

Q4QBS8
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBS8

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 539 543 PF00656 0.780
CLV_NRD_NRD_1 176 178 PF00675 0.723
CLV_NRD_NRD_1 247 249 PF00675 0.448
CLV_NRD_NRD_1 252 254 PF00675 0.459
CLV_NRD_NRD_1 332 334 PF00675 0.506
CLV_NRD_NRD_1 337 339 PF00675 0.472
CLV_PCSK_FUR_1 250 254 PF00082 0.435
CLV_PCSK_FUR_1 335 339 PF00082 0.511
CLV_PCSK_KEX2_1 176 178 PF00082 0.709
CLV_PCSK_KEX2_1 247 249 PF00082 0.448
CLV_PCSK_KEX2_1 252 254 PF00082 0.459
CLV_PCSK_KEX2_1 334 336 PF00082 0.507
CLV_PCSK_KEX2_1 337 339 PF00082 0.488
CLV_PCSK_PC1ET2_1 252 254 PF00082 0.445
CLV_PCSK_PC1ET2_1 334 336 PF00082 0.507
CLV_PCSK_PC7_1 248 254 PF00082 0.427
CLV_PCSK_PC7_1 333 339 PF00082 0.522
CLV_PCSK_SKI1_1 222 226 PF00082 0.575
CLV_PCSK_SKI1_1 25 29 PF00082 0.396
CLV_PCSK_SKI1_1 253 257 PF00082 0.467
CLV_PCSK_SKI1_1 462 466 PF00082 0.594
CLV_PCSK_SKI1_1 514 518 PF00082 0.481
DEG_APCC_DBOX_1 221 229 PF00400 0.364
DEG_APCC_DBOX_1 24 32 PF00400 0.473
DEG_Nend_UBRbox_4 1 3 PF02207 0.716
DEG_SPOP_SBC_1 128 132 PF00917 0.546
DEG_SPOP_SBC_1 155 159 PF00917 0.516
DEG_SPOP_SBC_1 202 206 PF00917 0.520
DEG_SPOP_SBC_1 438 442 PF00917 0.774
DOC_CKS1_1 43 48 PF01111 0.500
DOC_CYCLIN_RxL_1 250 263 PF00134 0.710
DOC_CYCLIN_yCln2_LP_2 231 237 PF00134 0.430
DOC_CYCLIN_yCln2_LP_2 80 86 PF00134 0.541
DOC_MAPK_gen_1 250 260 PF00069 0.760
DOC_MAPK_gen_1 300 307 PF00069 0.653
DOC_MAPK_gen_1 331 341 PF00069 0.736
DOC_MAPK_gen_1 69 78 PF00069 0.501
DOC_MAPK_MEF2A_6 21 30 PF00069 0.535
DOC_MAPK_MEF2A_6 216 225 PF00069 0.438
DOC_MAPK_MEF2A_6 69 78 PF00069 0.542
DOC_PP2B_LxvP_1 231 234 PF13499 0.430
DOC_PP2B_LxvP_1 556 559 PF13499 0.778
DOC_PP2B_LxvP_1 71 74 PF13499 0.520
DOC_SPAK_OSR1_1 302 306 PF12202 0.716
DOC_USP7_MATH_1 124 128 PF00917 0.604
DOC_USP7_MATH_1 129 133 PF00917 0.566
DOC_USP7_MATH_1 138 142 PF00917 0.482
DOC_USP7_MATH_1 15 19 PF00917 0.667
DOC_USP7_MATH_1 155 159 PF00917 0.516
DOC_USP7_MATH_1 171 175 PF00917 0.543
DOC_USP7_MATH_1 203 207 PF00917 0.532
DOC_USP7_MATH_1 372 376 PF00917 0.745
DOC_USP7_MATH_1 403 407 PF00917 0.788
DOC_USP7_MATH_1 411 415 PF00917 0.658
DOC_USP7_MATH_1 424 428 PF00917 0.685
DOC_USP7_MATH_1 446 450 PF00917 0.694
DOC_USP7_MATH_1 491 495 PF00917 0.804
DOC_USP7_MATH_1 503 507 PF00917 0.724
DOC_USP7_UBL2_3 252 256 PF12436 0.657
DOC_WW_Pin1_4 11 16 PF00397 0.751
DOC_WW_Pin1_4 134 139 PF00397 0.556
DOC_WW_Pin1_4 361 366 PF00397 0.753
DOC_WW_Pin1_4 42 47 PF00397 0.524
LIG_14-3-3_CanoR_1 176 181 PF00244 0.469
LIG_14-3-3_CanoR_1 569 576 PF00244 0.803
LIG_Clathr_ClatBox_1 117 121 PF01394 0.457
LIG_EVH1_2 209 213 PF00568 0.521
LIG_FHA_1 17 23 PF00498 0.604
LIG_FHA_1 38 44 PF00498 0.531
LIG_FHA_1 410 416 PF00498 0.812
LIG_FHA_1 438 444 PF00498 0.757
LIG_FHA_1 458 464 PF00498 0.774
LIG_FHA_1 490 496 PF00498 0.730
LIG_FHA_1 75 81 PF00498 0.522
LIG_FHA_2 420 426 PF00498 0.673
LIG_FHA_2 43 49 PF00498 0.440
LIG_FHA_2 569 575 PF00498 0.758
LIG_Integrin_RGD_1 537 539 PF01839 0.584
LIG_LIR_Gen_1 282 291 PF02991 0.744
LIG_LIR_Gen_1 301 311 PF02991 0.587
LIG_LIR_Gen_1 35 43 PF02991 0.375
LIG_LIR_Gen_1 515 525 PF02991 0.710
LIG_LIR_Nem_3 282 286 PF02991 0.735
LIG_LIR_Nem_3 301 306 PF02991 0.591
LIG_LIR_Nem_3 317 323 PF02991 0.718
LIG_LIR_Nem_3 515 520 PF02991 0.706
LIG_NRBOX 28 34 PF00104 0.412
LIG_SH2_GRB2like 456 459 PF00017 0.734
LIG_SH2_STAP1 34 38 PF00017 0.263
LIG_SH2_STAT5 456 459 PF00017 0.734
LIG_SH3_3 40 46 PF00018 0.574
LIG_SH3_3 474 480 PF00018 0.803
LIG_SH3_3 507 513 PF00018 0.738
LIG_SH3_3 81 87 PF00018 0.575
LIG_SH3_CIN85_PxpxPR_1 83 88 PF14604 0.439
LIG_SUMO_SIM_anti_2 186 192 PF11976 0.549
LIG_SUMO_SIM_anti_2 77 82 PF11976 0.464
LIG_SUMO_SIM_par_1 188 194 PF11976 0.556
LIG_SUMO_SIM_par_1 29 35 PF11976 0.327
LIG_SUMO_SIM_par_1 74 79 PF11976 0.455
LIG_TRAF2_1 119 122 PF00917 0.524
LIG_TRAF2_1 380 383 PF00917 0.781
LIG_WRC_WIRS_1 108 113 PF05994 0.499
LIG_WRC_WIRS_1 33 38 PF05994 0.375
LIG_WRC_WIRS_1 520 525 PF05994 0.681
MOD_CK1_1 127 133 PF00069 0.604
MOD_CK1_1 134 140 PF00069 0.567
MOD_CK1_1 156 162 PF00069 0.636
MOD_CK1_1 166 172 PF00069 0.514
MOD_CK1_1 364 370 PF00069 0.724
MOD_CK1_1 37 43 PF00069 0.350
MOD_CK1_1 442 448 PF00069 0.762
MOD_CK2_1 376 382 PF00069 0.787
MOD_CK2_1 419 425 PF00069 0.674
MOD_CK2_1 496 502 PF00069 0.758
MOD_CK2_1 512 518 PF00069 0.633
MOD_CK2_1 568 574 PF00069 0.759
MOD_GlcNHglycan 121 125 PF01048 0.777
MOD_GlcNHglycan 133 136 PF01048 0.751
MOD_GlcNHglycan 140 143 PF01048 0.742
MOD_GlcNHglycan 168 172 PF01048 0.749
MOD_GlcNHglycan 182 185 PF01048 0.684
MOD_GlcNHglycan 205 208 PF01048 0.739
MOD_GlcNHglycan 366 369 PF01048 0.549
MOD_GlcNHglycan 395 398 PF01048 0.610
MOD_GlcNHglycan 405 408 PF01048 0.470
MOD_GlcNHglycan 427 430 PF01048 0.595
MOD_GlcNHglycan 434 437 PF01048 0.528
MOD_GlcNHglycan 471 474 PF01048 0.625
MOD_GlcNHglycan 481 484 PF01048 0.557
MOD_GlcNHglycan 498 501 PF01048 0.573
MOD_GlcNHglycan 514 517 PF01048 0.479
MOD_GlcNHglycan 542 545 PF01048 0.592
MOD_GlcNHglycan 548 551 PF01048 0.594
MOD_GlcNHglycan 57 60 PF01048 0.750
MOD_GlcNHglycan 91 94 PF01048 0.726
MOD_GSK3_1 11 18 PF00069 0.705
MOD_GSK3_1 120 127 PF00069 0.517
MOD_GSK3_1 130 137 PF00069 0.555
MOD_GSK3_1 150 157 PF00069 0.569
MOD_GSK3_1 163 170 PF00069 0.566
MOD_GSK3_1 171 178 PF00069 0.557
MOD_GSK3_1 37 44 PF00069 0.577
MOD_GSK3_1 372 379 PF00069 0.754
MOD_GSK3_1 383 390 PF00069 0.729
MOD_GSK3_1 438 445 PF00069 0.769
MOD_GSK3_1 446 453 PF00069 0.691
MOD_N-GLC_1 11 16 PF02516 0.500
MOD_N-GLC_1 260 265 PF02516 0.542
MOD_N-GLC_1 457 462 PF02516 0.525
MOD_NEK2_1 120 125 PF00069 0.564
MOD_NEK2_1 175 180 PF00069 0.530
MOD_NEK2_1 260 265 PF00069 0.742
MOD_NEK2_1 32 37 PF00069 0.414
MOD_NEK2_1 450 455 PF00069 0.709
MOD_NEK2_1 457 462 PF00069 0.747
MOD_NEK2_1 55 60 PF00069 0.495
MOD_NEK2_1 76 81 PF00069 0.463
MOD_NEK2_2 171 176 PF00069 0.512
MOD_NEK2_2 491 496 PF00069 0.730
MOD_PIKK_1 109 115 PF00454 0.499
MOD_PIKK_1 489 495 PF00454 0.728
MOD_PKA_1 176 182 PF00069 0.456
MOD_PKA_2 166 172 PF00069 0.534
MOD_PKA_2 175 181 PF00069 0.461
MOD_PKA_2 246 252 PF00069 0.701
MOD_PKA_2 301 307 PF00069 0.738
MOD_PKA_2 419 425 PF00069 0.674
MOD_PKA_2 568 574 PF00069 0.759
MOD_PKA_2 87 93 PF00069 0.449
MOD_Plk_1 167 173 PF00069 0.466
MOD_Plk_1 316 322 PF00069 0.693
MOD_Plk_1 450 456 PF00069 0.650
MOD_Plk_1 458 464 PF00069 0.634
MOD_Plk_2-3 568 574 PF00069 0.759
MOD_Plk_4 176 182 PF00069 0.456
MOD_Plk_4 411 417 PF00069 0.786
MOD_Plk_4 439 445 PF00069 0.762
MOD_Plk_4 76 82 PF00069 0.473
MOD_ProDKin_1 11 17 PF00069 0.747
MOD_ProDKin_1 134 140 PF00069 0.556
MOD_ProDKin_1 361 367 PF00069 0.753
MOD_ProDKin_1 42 48 PF00069 0.526
TRG_ER_diArg_1 175 177 PF00400 0.518
TRG_ER_diArg_1 247 250 PF00400 0.712
TRG_ER_diArg_1 300 303 PF00400 0.690
TRG_ER_diArg_1 335 338 PF00400 0.712
TRG_NLS_MonoExtC_3 251 256 PF00514 0.651
TRG_NLS_MonoExtC_3 332 337 PF00514 0.708
TRG_NLS_MonoExtN_4 250 257 PF00514 0.651
TRG_NLS_MonoExtN_4 331 338 PF00514 0.709

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8ILH2 Leishmania donovani 88% 97%
A0A3S7WX43 Leishmania donovani 89% 97%
A4HCB1 Leishmania braziliensis 63% 100%
A4HDA2 Leishmania braziliensis 57% 96%
E9AGZ2 Leishmania infantum 89% 97%
E9AGZ3 Leishmania infantum 89% 97%
E9AVQ1 Leishmania mexicana (strain MHOM/GT/2001/U1103) 83% 100%
Q4QBR2 Leishmania major 100% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS