Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cytoskeleton associated protein, putative

Species:

Leishmania major

UniProt:

Q4QBS4_LEIMA

TriTrypDb:

LmjF.22.0730 , LMJLV39_220012800 , LMJSD75_220012800

Length:

439

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005856	cytoskeleton	5	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QBS4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBS4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	246	250	PF00656	0.560
CLV_C14_Caspase3-7	260	264	PF00656	0.462
CLV_NRD_NRD_1	106	108	PF00675	0.645
CLV_NRD_NRD_1	170	172	PF00675	0.455
CLV_NRD_NRD_1	32	34	PF00675	0.663
CLV_NRD_NRD_1	384	386	PF00675	0.506
CLV_NRD_NRD_1	92	94	PF00675	0.615
CLV_PCSK_KEX2_1	106	108	PF00082	0.644
CLV_PCSK_KEX2_1	31	33	PF00082	0.664
CLV_PCSK_KEX2_1	333	335	PF00082	0.526
CLV_PCSK_KEX2_1	370	372	PF00082	0.495
CLV_PCSK_KEX2_1	383	385	PF00082	0.415
CLV_PCSK_KEX2_1	91	93	PF00082	0.619
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.623
CLV_PCSK_PC1ET2_1	370	372	PF00082	0.605
CLV_PCSK_PC1ET2_1	383	385	PF00082	0.434
CLV_PCSK_PC1ET2_1	91	93	PF00082	0.674
CLV_PCSK_PC7_1	102	108	PF00082	0.628
CLV_PCSK_SKI1_1	253	257	PF00082	0.516
CLV_PCSK_SKI1_1	367	371	PF00082	0.465
CLV_PCSK_SKI1_1	377	381	PF00082	0.450
CLV_PCSK_SKI1_1	402	406	PF00082	0.540
CLV_PCSK_SKI1_1	416	420	PF00082	0.421
CLV_PCSK_SKI1_1	56	60	PF00082	0.644
DEG_APCC_DBOX_1	170	178	PF00400	0.424
DOC_CKS1_1	130	135	PF01111	0.617
DOC_MAPK_gen_1	106	114	PF00069	0.581
DOC_MAPK_gen_1	171	177	PF00069	0.533
DOC_MAPK_gen_1	337	346	PF00069	0.520
DOC_USP7_MATH_1	117	121	PF00917	0.632
DOC_USP7_MATH_1	213	217	PF00917	0.451
DOC_USP7_MATH_1	396	400	PF00917	0.448
DOC_USP7_MATH_1	85	89	PF00917	0.643
DOC_USP7_MATH_2	7	13	PF00917	0.528
DOC_WW_Pin1_4	129	134	PF00397	0.663
DOC_WW_Pin1_4	42	47	PF00397	0.640
DOC_WW_Pin1_4	48	53	PF00397	0.623
LIG_14-3-3_CanoR_1	31	36	PF00244	0.663
LIG_14-3-3_CanoR_1	62	67	PF00244	0.658
LIG_14-3-3_CanoR_1	92	97	PF00244	0.729
LIG_APCC_ABBA_1	161	166	PF00400	0.436
LIG_APCC_ABBA_1	206	211	PF00400	0.499
LIG_APCC_ABBAyCdc20_2	160	166	PF00400	0.438
LIG_BIR_II_1	1	5	PF00653	0.631
LIG_CaM_IQ_9	326	341	PF13499	0.457
LIG_EABR_CEP55_1	112	122	PF12180	0.570
LIG_FHA_1	189	195	PF00498	0.527
LIG_FHA_1	347	353	PF00498	0.461
LIG_FHA_2	130	136	PF00498	0.615
LIG_FHA_2	18	24	PF00498	0.476
LIG_LIR_Gen_1	146	155	PF02991	0.564
LIG_LIR_Gen_1	233	244	PF02991	0.508
LIG_LIR_Nem_3	146	150	PF02991	0.569
LIG_LIR_Nem_3	233	239	PF02991	0.534
LIG_PCNA_PIPBox_1	215	224	PF02747	0.497
LIG_RPA_C_Fungi	14	26	PF08784	0.563
LIG_SH2_STAP1	136	140	PF00017	0.568
LIG_SH2_STAP1	147	151	PF00017	0.501
LIG_SH2_STAP1	164	168	PF00017	0.396
LIG_SH2_STAP1	209	213	PF00017	0.454
LIG_SH2_STAP1	387	391	PF00017	0.524
LIG_SH2_STAT3	266	269	PF00017	0.520
LIG_SH2_STAT5	266	269	PF00017	0.496
LIG_SH2_STAT5	428	431	PF00017	0.474
LIG_SH3_3	111	117	PF00018	0.569
LIG_SH3_3	127	133	PF00018	0.637
LIG_SUMO_SIM_anti_2	173	181	PF11976	0.481
LIG_SUMO_SIM_par_1	173	181	PF11976	0.429
LIG_SUMO_SIM_par_1	324	329	PF11976	0.583
LIG_TRAF2_1	132	135	PF00917	0.630
LIG_TRAF2_1	139	142	PF00917	0.580
LIG_TRAF2_1	58	61	PF00917	0.639
LIG_TRAF2_1	7	10	PF00917	0.543
MOD_CDK_SPxK_1	50	56	PF00069	0.675
MOD_CK1_1	198	204	PF00069	0.644
MOD_CK1_1	34	40	PF00069	0.667
MOD_CK2_1	129	135	PF00069	0.657
MOD_CK2_1	17	23	PF00069	0.477
MOD_DYRK1A_RPxSP_1	42	46	PF00069	0.663
MOD_GlcNHglycan	1	4	PF01048	0.722
MOD_GlcNHglycan	108	111	PF01048	0.754
MOD_GlcNHglycan	121	124	PF01048	0.631
MOD_GlcNHglycan	79	82	PF01048	0.794
MOD_GSK3_1	102	109	PF00069	0.723
MOD_GSK3_1	117	124	PF00069	0.659
MOD_GSK3_1	194	201	PF00069	0.589
MOD_GSK3_1	373	380	PF00069	0.519
MOD_GSK3_1	5	12	PF00069	0.543
MOD_GSK3_1	56	63	PF00069	0.747
MOD_N-GLC_1	117	122	PF02516	0.648
MOD_N-GLC_1	273	278	PF02516	0.501
MOD_N-GLC_1	85	90	PF02516	0.714
MOD_NEK2_1	261	266	PF00069	0.398
MOD_NEK2_1	346	351	PF00069	0.513
MOD_NEK2_1	373	378	PF00069	0.518
MOD_NEK2_2	387	392	PF00069	0.525
MOD_PIKK_1	326	332	PF00454	0.554
MOD_PIKK_1	56	62	PF00454	0.712
MOD_PK_1	62	68	PF00069	0.664
MOD_PKA_1	106	112	PF00069	0.636
MOD_PKA_1	253	259	PF00069	0.449
MOD_PKA_1	31	37	PF00069	0.674
MOD_PKA_1	332	338	PF00069	0.519
MOD_PKA_1	91	97	PF00069	0.609
MOD_PKA_2	106	112	PF00069	0.677
MOD_PKA_2	31	37	PF00069	0.674
MOD_PKA_2	317	323	PF00069	0.530
MOD_PKA_2	333	339	PF00069	0.484
MOD_PKA_2	61	67	PF00069	0.667
MOD_PKA_2	91	97	PF00069	0.649
MOD_Plk_1	117	123	PF00069	0.699
MOD_Plk_1	387	393	PF00069	0.524
MOD_Plk_1	85	91	PF00069	0.713
MOD_Plk_4	213	219	PF00069	0.464
MOD_Plk_4	261	267	PF00069	0.442
MOD_Plk_4	85	91	PF00069	0.599
MOD_ProDKin_1	129	135	PF00069	0.659
MOD_ProDKin_1	42	48	PF00069	0.641
MOD_ProDKin_1	50	56	PF00069	0.613
MOD_SUMO_for_1	355	358	PF00179	0.526
MOD_SUMO_for_1	409	412	PF00179	0.516
MOD_SUMO_rev_2	411	420	PF00179	0.508
TRG_DiLeu_BaEn_1	358	363	PF01217	0.516
TRG_DiLeu_BaEn_4	158	164	PF01217	0.466
TRG_DiLeu_BaEn_4	413	419	PF01217	0.512
TRG_ENDOCYTIC_2	147	150	PF00928	0.606
TRG_ENDOCYTIC_2	164	167	PF00928	0.360
TRG_ER_diArg_1	31	33	PF00400	0.604
TRG_Pf-PMV_PEXEL_1	371	375	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I875	Leptomonas seymouri	68%	97%
A0A1X0NT91	Trypanosomatidae	35%	95%
A0A3Q8IFG4	Leishmania donovani	90%	100%
A4HCB9	Leishmania braziliensis	69%	100%
E9AVQ7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%