SUI1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

translation initiation factor SUI1, putative

Species:

Leishmania major

UniProt:

Q4QBR8_LEIMA

TriTrypDb:

LmjF.22.0790 , LMJLV39_220013400 , LMJSD75_220013500

Length:

665

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QBR8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBR8

Function

Biological processes
Term	Name	Level	Count
GO:0001731	formation of translation preinitiation complex	7	12
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0022618	ribonucleoprotein complex assembly	6	12
GO:0043933	protein-containing complex organization	4	12
GO:0065003	protein-containing complex assembly	5	12
GO:0071826	ribonucleoprotein complex subunit organization	5	12
GO:0071840	cellular component organization or biogenesis	2	12

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	12
GO:0003743	translation initiation factor activity	4	12
GO:0005488	binding	1	12
GO:0008135	translation factor activity, RNA binding	3	12
GO:0045182	translation regulator activity	1	12
GO:0090079	translation regulator activity, nucleic acid binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	249	253	PF00656	0.552
CLV_C14_Caspase3-7	475	479	PF00656	0.471
CLV_NRD_NRD_1	152	154	PF00675	0.529
CLV_NRD_NRD_1	472	474	PF00675	0.399
CLV_PCSK_KEX2_1	560	562	PF00082	0.464
CLV_PCSK_PC1ET2_1	560	562	PF00082	0.481
CLV_PCSK_SKI1_1	136	140	PF00082	0.424
CLV_PCSK_SKI1_1	211	215	PF00082	0.552
CLV_PCSK_SKI1_1	331	335	PF00082	0.424
CLV_PCSK_SKI1_1	427	431	PF00082	0.467
CLV_PCSK_SKI1_1	439	443	PF00082	0.598
CLV_PCSK_SKI1_1	561	565	PF00082	0.516
CLV_PCSK_SKI1_1	582	586	PF00082	0.249
CLV_PCSK_SKI1_1	622	626	PF00082	0.281
DEG_APCC_DBOX_1	234	242	PF00400	0.581
DEG_APCC_KENBOX_2	245	249	PF00400	0.544
DEG_Nend_Nbox_1	1	3	PF02207	0.325
DOC_CYCLIN_RxL_1	131	140	PF00134	0.329
DOC_CYCLIN_RxL_1	424	434	PF00134	0.515
DOC_MAPK_DCC_7	497	505	PF00069	0.489
DOC_MAPK_DCC_7	564	573	PF00069	0.306
DOC_MAPK_gen_1	153	160	PF00069	0.450
DOC_MAPK_gen_1	20	29	PF00069	0.491
DOC_MAPK_gen_1	326	336	PF00069	0.484
DOC_MAPK_gen_1	497	505	PF00069	0.498
DOC_MAPK_gen_1	622	632	PF00069	0.491
DOC_MAPK_gen_1	77	87	PF00069	0.334
DOC_MAPK_MEF2A_6	187	196	PF00069	0.463
DOC_MAPK_MEF2A_6	497	505	PF00069	0.465
DOC_MAPK_MEF2A_6	516	524	PF00069	0.437
DOC_MAPK_MEF2A_6	564	573	PF00069	0.306
DOC_MAPK_MEF2A_6	625	634	PF00069	0.443
DOC_PP1_RVXF_1	330	337	PF00149	0.561
DOC_PP2B_LxvP_1	144	147	PF13499	0.376
DOC_PP2B_LxvP_1	298	301	PF13499	0.409
DOC_PP2B_LxvP_1	95	98	PF13499	0.421
DOC_USP7_MATH_1	318	322	PF00917	0.573
DOC_USP7_MATH_1	57	61	PF00917	0.515
DOC_USP7_UBL2_3	16	20	PF12436	0.443
DOC_USP7_UBL2_3	481	485	PF12436	0.559
DOC_USP7_UBL2_3	5	9	PF12436	0.458
DOC_USP7_UBL2_3	560	564	PF12436	0.509
DOC_USP7_UBL2_3	625	629	PF12436	0.469
DOC_WW_Pin1_4	153	158	PF00397	0.500
DOC_WW_Pin1_4	219	224	PF00397	0.484
DOC_WW_Pin1_4	263	268	PF00397	0.713
DOC_WW_Pin1_4	291	296	PF00397	0.516
DOC_WW_Pin1_4	347	352	PF00397	0.575
DOC_WW_Pin1_4	457	462	PF00397	0.585
LIG_14-3-3_CanoR_1	216	226	PF00244	0.525
LIG_14-3-3_CanoR_1	473	477	PF00244	0.438
LIG_BRCT_BRCA1_1	509	513	PF00533	0.384
LIG_BRCT_BRCA1_1	58	62	PF00533	0.549
LIG_BRCT_BRCA1_1	591	595	PF00533	0.547
LIG_BRCT_BRCA1_1	90	94	PF00533	0.456
LIG_deltaCOP1_diTrp_1	202	212	PF00928	0.379
LIG_eIF4E_1	471	477	PF01652	0.510
LIG_FHA_1	154	160	PF00498	0.478
LIG_FHA_1	264	270	PF00498	0.682
LIG_FHA_1	304	310	PF00498	0.501
LIG_FHA_1	318	324	PF00498	0.520
LIG_FHA_1	351	357	PF00498	0.570
LIG_FHA_1	449	455	PF00498	0.568
LIG_FHA_1	462	468	PF00498	0.530
LIG_FHA_1	484	490	PF00498	0.474
LIG_FHA_2	249	255	PF00498	0.731
LIG_FHA_2	343	349	PF00498	0.421
LIG_FHA_2	378	384	PF00498	0.425
LIG_FHA_2	458	464	PF00498	0.525
LIG_FHA_2	473	479	PF00498	0.495
LIG_FHA_2	5	11	PF00498	0.542
LIG_FHA_2	543	549	PF00498	0.543
LIG_LIR_Apic_2	412	418	PF02991	0.469
LIG_LIR_Gen_1	115	125	PF02991	0.548
LIG_LIR_Gen_1	202	213	PF02991	0.445
LIG_LIR_Gen_1	270	276	PF02991	0.535
LIG_LIR_Gen_1	303	313	PF02991	0.447
LIG_LIR_Gen_1	36	42	PF02991	0.522
LIG_LIR_Gen_1	90	100	PF02991	0.436
LIG_LIR_LC3C_4	39	42	PF02991	0.522
LIG_LIR_Nem_3	115	120	PF02991	0.516
LIG_LIR_Nem_3	202	208	PF02991	0.391
LIG_LIR_Nem_3	270	274	PF02991	0.551
LIG_LIR_Nem_3	303	308	PF02991	0.426
LIG_LIR_Nem_3	36	41	PF02991	0.522
LIG_LIR_Nem_3	401	407	PF02991	0.447
LIG_LIR_Nem_3	440	446	PF02991	0.604
LIG_LIR_Nem_3	90	95	PF02991	0.435
LIG_LIR_Nem_3	99	104	PF02991	0.273
LIG_MYND_1	295	299	PF01753	0.464
LIG_NRBOX	105	111	PF00104	0.495
LIG_NRP_CendR_1	663	665	PF00754	0.565
LIG_OCRL_FandH_1	102	114	PF00620	0.490
LIG_Pex14_1	604	608	PF04695	0.448
LIG_Pex14_2	208	212	PF04695	0.531
LIG_Pex14_2	336	340	PF04695	0.513
LIG_REV1ctd_RIR_1	99	109	PF16727	0.455
LIG_SH2_CRK	415	419	PF00017	0.512
LIG_SH2_NCK_1	271	275	PF00017	0.531
LIG_SH2_SRC	271	274	PF00017	0.488
LIG_SH2_STAP1	271	275	PF00017	0.566
LIG_SH2_STAP1	373	377	PF00017	0.419
LIG_SH2_STAT5	407	410	PF00017	0.479
LIG_SH2_STAT5	471	474	PF00017	0.461
LIG_SH2_STAT5	483	486	PF00017	0.372
LIG_SH3_3	168	174	PF00018	0.474
LIG_SH3_3	220	226	PF00018	0.466
LIG_SH3_3	517	523	PF00018	0.434
LIG_SH3_3	611	617	PF00018	0.491
LIG_SH3_4	625	632	PF00018	0.528
LIG_SH3_5	267	271	PF00018	0.601
LIG_SUMO_SIM_anti_2	162	168	PF11976	0.417
LIG_SUMO_SIM_anti_2	25	31	PF11976	0.542
LIG_SUMO_SIM_par_1	156	162	PF11976	0.500
LIG_SUMO_SIM_par_1	342	350	PF11976	0.441
LIG_SUMO_SIM_par_1	427	434	PF11976	0.523
LIG_SUMO_SIM_par_1	488	494	PF11976	0.529
LIG_TYR_ITIM	269	274	PF00017	0.561
LIG_UBA3_1	145	154	PF00899	0.410
LIG_UBA3_1	531	536	PF00899	0.500
LIG_WRC_WIRS_1	590	595	PF05994	0.540
MOD_CK1_1	217	223	PF00069	0.560
MOD_CK1_1	350	356	PF00069	0.484
MOD_CK1_1	530	536	PF00069	0.344
MOD_CK1_1	551	557	PF00069	0.547
MOD_CK1_1	575	581	PF00069	0.583
MOD_CK1_1	589	595	PF00069	0.536
MOD_CK1_1	609	615	PF00069	0.345
MOD_CK2_1	342	348	PF00069	0.430
MOD_CK2_1	377	383	PF00069	0.440
MOD_CK2_1	4	10	PF00069	0.492
MOD_CK2_1	542	548	PF00069	0.535
MOD_Cter_Amidation	42	45	PF01082	0.280
MOD_GlcNHglycan	139	142	PF01048	0.352
MOD_GlcNHglycan	150	153	PF01048	0.362
MOD_GlcNHglycan	242	245	PF01048	0.770
MOD_GlcNHglycan	320	323	PF01048	0.566
MOD_GlcNHglycan	361	364	PF01048	0.547
MOD_GlcNHglycan	409	412	PF01048	0.506
MOD_GlcNHglycan	553	556	PF01048	0.593
MOD_GlcNHglycan	59	62	PF01048	0.254
MOD_GlcNHglycan	611	614	PF01048	0.356
MOD_GSK3_1	10	17	PF00069	0.489
MOD_GSK3_1	207	214	PF00069	0.435
MOD_GSK3_1	300	307	PF00069	0.529
MOD_GSK3_1	342	349	PF00069	0.450
MOD_GSK3_1	457	464	PF00069	0.651
MOD_GSK3_1	547	554	PF00069	0.547
MOD_GSK3_1	572	579	PF00069	0.535
MOD_GSK3_1	582	589	PF00069	0.518
MOD_N-GLC_1	214	219	PF02516	0.553
MOD_N-GLC_1	359	364	PF02516	0.423
MOD_N-GLC_1	652	657	PF02516	0.431
MOD_N-GLC_2	283	285	PF02516	0.389
MOD_NEK2_1	137	142	PF00069	0.404
MOD_NEK2_1	165	170	PF00069	0.348
MOD_NEK2_1	325	330	PF00069	0.435
MOD_NEK2_1	376	381	PF00069	0.526
MOD_NEK2_1	527	532	PF00069	0.431
MOD_NEK2_1	608	613	PF00069	0.487
MOD_NEK2_1	654	659	PF00069	0.413
MOD_PIKK_1	217	223	PF00454	0.537
MOD_PIKK_1	300	306	PF00454	0.512
MOD_PIKK_1	654	660	PF00454	0.473
MOD_PK_1	499	505	PF00069	0.572
MOD_PKA_1	4	10	PF00069	0.454
MOD_PKA_1	44	50	PF00069	0.501
MOD_PKA_2	472	478	PF00069	0.508
MOD_Plk_1	214	220	PF00069	0.560
MOD_Plk_1	277	283	PF00069	0.482
MOD_Plk_1	462	468	PF00069	0.413
MOD_Plk_1	505	511	PF00069	0.455
MOD_Plk_2-3	342	348	PF00069	0.413
MOD_Plk_4	116	122	PF00069	0.476
MOD_Plk_4	25	31	PF00069	0.543
MOD_Plk_4	277	283	PF00069	0.439
MOD_Plk_4	293	299	PF00069	0.404
MOD_Plk_4	304	310	PF00069	0.418
MOD_Plk_4	462	468	PF00069	0.591
MOD_Plk_4	472	478	PF00069	0.261
MOD_Plk_4	507	513	PF00069	0.409
MOD_Plk_4	527	533	PF00069	0.540
MOD_Plk_4	644	650	PF00069	0.460
MOD_Plk_4	96	102	PF00069	0.303
MOD_ProDKin_1	153	159	PF00069	0.498
MOD_ProDKin_1	219	225	PF00069	0.474
MOD_ProDKin_1	263	269	PF00069	0.702
MOD_ProDKin_1	291	297	PF00069	0.522
MOD_ProDKin_1	347	353	PF00069	0.575
MOD_ProDKin_1	457	463	PF00069	0.581
MOD_SUMO_rev_2	13	22	PF00179	0.491
MOD_SUMO_rev_2	256	266	PF00179	0.756
TRG_DiLeu_BaEn_1	116	121	PF01217	0.460
TRG_DiLeu_BaEn_3	81	87	PF01217	0.345
TRG_DiLeu_BaLyEn_6	220	225	PF01217	0.487
TRG_ENDOCYTIC_2	271	274	PF00928	0.582
TRG_ENDOCYTIC_2	373	376	PF00928	0.399
TRG_NES_CRM1_1	525	540	PF08389	0.290
TRG_NLS_Bipartite_1	3	24	PF00514	0.522
TRG_NLS_MonoExtC_3	152	157	PF00514	0.504
TRG_NLS_MonoExtC_3	19	25	PF00514	0.501
TRG_Pf-PMV_PEXEL_1	216	221	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	419	423	PF00026	0.554

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I577	Leptomonas seymouri	57%	95%
A0A0S4INV2	Bodo saltans	25%	75%
A0A1X0NTA4	Trypanosomatidae	32%	100%
A0A3S5H7A8	Leishmania donovani	88%	100%
A0A422N4G3	Trypanosoma rangeli	33%	100%
A4HCD6	Leishmania braziliensis	76%	100%
A4HZV3	Leishmania infantum	88%	100%
C9ZSH9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AVR3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
V5BLJ1	Trypanosoma cruzi	34%	92%