EngB-type G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

50S ribosome-binding GTPase, putative

Species:

Leishmania major

UniProt:

Q4QBR5_LEIMA

TriTrypDb:

LmjF.22.0820 , LMJLV39_220012600 , LMJSD75_220013800

Length:

975

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBR5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBR5

Function

Could not find GO biological_process term for this entry.

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	14
GO:0003676	nucleic acid binding	3	2
GO:0003746	translation elongation factor activity	4	2
GO:0005488	binding	1	14
GO:0005525	GTP binding	5	14
GO:0008135	translation factor activity, RNA binding	3	2
GO:0017076	purine nucleotide binding	4	14
GO:0019001	guanyl nucleotide binding	5	14
GO:0032553	ribonucleotide binding	3	14
GO:0032555	purine ribonucleotide binding	4	14

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	309	313	PF00656	0.524
CLV_C14_Caspase3-7	396	400	PF00656	0.441
CLV_C14_Caspase3-7	443	447	PF00656	0.582
CLV_C14_Caspase3-7	559	563	PF00656	0.720
CLV_C14_Caspase3-7	642	646	PF00656	0.646
CLV_NRD_NRD_1	22	24	PF00675	0.803
CLV_NRD_NRD_1	250	252	PF00675	0.345
CLV_NRD_NRD_1	318	320	PF00675	0.290
CLV_NRD_NRD_1	382	384	PF00675	0.479
CLV_NRD_NRD_1	385	387	PF00675	0.462

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILH8	Leptomonas seymouri	55%	83%
A0A1X0NT82	Trypanosomatidae	45%	100%
A0A3Q8IC70	Leishmania donovani	94%	100%
A0A3R7NJM0	Trypanosoma rangeli	45%	100%
A0A3S7WX68	Leishmania donovani	93%	83%
A4HCB6	Leishmania braziliensis	80%	98%
A4HZV0	Leishmania infantum	94%	100%
C9ZSF9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AVQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	86%
E9AVR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%

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