EngB-type G domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

50S ribosome-binding GTPase, putative

Species:

Leishmania major

UniProt:

Q4QBR5_LEIMA

TriTrypDb:

LmjF.22.0820 , LMJLV39_220012600 , LMJSD75_220013800

Length:

975

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBR5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBR5

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	14
GO:0005488	binding	1	14
GO:0005525	GTP binding	5	14
GO:0017076	purine nucleotide binding	4	14
GO:0019001	guanyl nucleotide binding	5	14
GO:0032553	ribonucleotide binding	3	14
GO:0032555	purine ribonucleotide binding	4	14
GO:0032561	guanyl ribonucleotide binding	5	14
GO:0035639	purine ribonucleoside triphosphate binding	4	14
GO:0036094	small molecule binding	2	14
GO:0043167	ion binding	2	14
GO:0043168	anion binding	3	14
GO:0097159	organic cyclic compound binding	2	14
GO:0097367	carbohydrate derivative binding	2	14
GO:1901265	nucleoside phosphate binding	3	14
GO:1901363	heterocyclic compound binding	2	14
GO:0003676	nucleic acid binding	3	2
GO:0003746	translation elongation factor activity	4	2
GO:0008135	translation factor activity, RNA binding	3	2
GO:0045182	translation regulator activity	1	2
GO:0090079	translation regulator activity, nucleic acid binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	309	313	PF00656	0.524
CLV_C14_Caspase3-7	396	400	PF00656	0.441
CLV_C14_Caspase3-7	443	447	PF00656	0.582
CLV_C14_Caspase3-7	559	563	PF00656	0.720
CLV_C14_Caspase3-7	642	646	PF00656	0.646
CLV_NRD_NRD_1	22	24	PF00675	0.803
CLV_NRD_NRD_1	250	252	PF00675	0.345
CLV_NRD_NRD_1	318	320	PF00675	0.290
CLV_NRD_NRD_1	382	384	PF00675	0.479
CLV_NRD_NRD_1	385	387	PF00675	0.462
CLV_NRD_NRD_1	488	490	PF00675	0.813
CLV_NRD_NRD_1	535	537	PF00675	0.698
CLV_NRD_NRD_1	588	590	PF00675	0.589
CLV_NRD_NRD_1	596	598	PF00675	0.577
CLV_NRD_NRD_1	74	76	PF00675	0.606
CLV_NRD_NRD_1	784	786	PF00675	0.646
CLV_NRD_NRD_1	791	793	PF00675	0.661
CLV_NRD_NRD_1	840	842	PF00675	0.571
CLV_NRD_NRD_1	870	872	PF00675	0.543
CLV_NRD_NRD_1	885	887	PF00675	0.532
CLV_PCSK_FUR_1	533	537	PF00082	0.601
CLV_PCSK_FUR_1	788	792	PF00082	0.698
CLV_PCSK_KEX2_1	22	24	PF00082	0.824
CLV_PCSK_KEX2_1	318	320	PF00082	0.293
CLV_PCSK_KEX2_1	382	384	PF00082	0.447
CLV_PCSK_KEX2_1	429	431	PF00082	0.599
CLV_PCSK_KEX2_1	488	490	PF00082	0.800
CLV_PCSK_KEX2_1	535	537	PF00082	0.715
CLV_PCSK_KEX2_1	588	590	PF00082	0.575
CLV_PCSK_KEX2_1	596	598	PF00082	0.569
CLV_PCSK_KEX2_1	73	75	PF00082	0.599
CLV_PCSK_KEX2_1	783	785	PF00082	0.624
CLV_PCSK_KEX2_1	790	792	PF00082	0.648
CLV_PCSK_KEX2_1	840	842	PF00082	0.557
CLV_PCSK_KEX2_1	870	872	PF00082	0.561
CLV_PCSK_KEX2_1	951	953	PF00082	0.613
CLV_PCSK_PC1ET2_1	429	431	PF00082	0.667
CLV_PCSK_PC1ET2_1	73	75	PF00082	0.649
CLV_PCSK_PC1ET2_1	783	785	PF00082	0.644
CLV_PCSK_PC1ET2_1	951	953	PF00082	0.613
CLV_PCSK_PC7_1	484	490	PF00082	0.706
CLV_PCSK_SKI1_1	116	120	PF00082	0.497
CLV_PCSK_SKI1_1	178	182	PF00082	0.783
CLV_PCSK_SKI1_1	332	336	PF00082	0.293
CLV_PCSK_SKI1_1	386	390	PF00082	0.450
CLV_PCSK_SKI1_1	423	427	PF00082	0.564
CLV_PCSK_SKI1_1	430	434	PF00082	0.535
CLV_PCSK_SKI1_1	435	439	PF00082	0.512
CLV_PCSK_SKI1_1	508	512	PF00082	0.675
CLV_PCSK_SKI1_1	536	540	PF00082	0.621
CLV_PCSK_SKI1_1	75	79	PF00082	0.577
CLV_PCSK_SKI1_1	851	855	PF00082	0.596
CLV_Separin_Metazoa	404	408	PF03568	0.477
DEG_APCC_DBOX_1	74	82	PF00400	0.585
DEG_APCC_KENBOX_2	855	859	PF00400	0.618
DEG_SPOP_SBC_1	241	245	PF00917	0.493
DOC_ANK_TNKS_1	717	724	PF00023	0.733
DOC_ANK_TNKS_1	942	949	PF00023	0.666
DOC_CDC14_PxL_1	920	928	PF14671	0.650
DOC_CYCLIN_RxL_1	846	857	PF00134	0.644
DOC_CYCLIN_yCln2_LP_2	95	98	PF00134	0.574
DOC_MAPK_DCC_7	94	103	PF00069	0.613
DOC_MAPK_gen_1	302	310	PF00069	0.573
DOC_MAPK_gen_1	533	541	PF00069	0.653
DOC_MAPK_gen_1	715	724	PF00069	0.683
DOC_MAPK_MEF2A_6	94	103	PF00069	0.594
DOC_PP1_RVXF_1	249	256	PF00149	0.493
DOC_PP1_RVXF_1	338	345	PF00149	0.593
DOC_PP1_RVXF_1	589	596	PF00149	0.587
DOC_PP2B_LxvP_1	168	171	PF13499	0.761
DOC_PP2B_LxvP_1	95	98	PF13499	0.574
DOC_PP4_FxxP_1	391	394	PF00568	0.419
DOC_SPAK_OSR1_1	718	722	PF12202	0.650
DOC_USP7_MATH_1	160	164	PF00917	0.758
DOC_USP7_MATH_1	191	195	PF00917	0.717
DOC_USP7_MATH_1	226	230	PF00917	0.493
DOC_USP7_MATH_1	241	245	PF00917	0.493
DOC_USP7_MATH_1	440	444	PF00917	0.577
DOC_USP7_MATH_1	479	483	PF00917	0.737
DOC_USP7_MATH_1	529	533	PF00917	0.783
DOC_USP7_MATH_1	572	576	PF00917	0.780
DOC_USP7_MATH_1	6	10	PF00917	0.656
DOC_USP7_MATH_1	623	627	PF00917	0.575
DOC_USP7_MATH_1	660	664	PF00917	0.785
DOC_USP7_MATH_1	686	690	PF00917	0.772
DOC_USP7_MATH_1	737	741	PF00917	0.783
DOC_USP7_MATH_1	748	752	PF00917	0.669
DOC_USP7_MATH_1	830	834	PF00917	0.651
DOC_USP7_UBL2_3	336	340	PF12436	0.573
DOC_USP7_UBL2_3	380	384	PF12436	0.462
DOC_WW_Pin1_4	156	161	PF00397	0.747
DOC_WW_Pin1_4	243	248	PF00397	0.498
DOC_WW_Pin1_4	257	262	PF00397	0.475
DOC_WW_Pin1_4	521	526	PF00397	0.695
DOC_WW_Pin1_4	602	607	PF00397	0.757
DOC_WW_Pin1_4	700	705	PF00397	0.739
LIG_14-3-3_CanoR_1	132	140	PF00244	0.736
LIG_14-3-3_CanoR_1	251	256	PF00244	0.493
LIG_14-3-3_CanoR_1	318	322	PF00244	0.493
LIG_14-3-3_CanoR_1	366	371	PF00244	0.414
LIG_14-3-3_CanoR_1	4	11	PF00244	0.733
LIG_14-3-3_CanoR_1	407	417	PF00244	0.567
LIG_14-3-3_CanoR_1	508	513	PF00244	0.678
LIG_14-3-3_CanoR_1	690	696	PF00244	0.575
LIG_14-3-3_CanoR_1	718	722	PF00244	0.699
LIG_14-3-3_CanoR_1	753	760	PF00244	0.692
LIG_14-3-3_CanoR_1	899	905	PF00244	0.677
LIG_APCC_ABBA_1	654	659	PF00400	0.688
LIG_APCC_Cbox_1	590	596	PF00515	0.658
LIG_BIR_II_1	1	5	PF00653	0.614
LIG_BIR_III_4	562	566	PF00653	0.670
LIG_BIR_III_4	668	672	PF00653	0.639
LIG_BIR_III_4	813	817	PF00653	0.652
LIG_DLG_GKlike_1	251	259	PF00625	0.493
LIG_EVH1_2	99	103	PF00568	0.622
LIG_FHA_1	120	126	PF00498	0.612
LIG_FHA_1	248	254	PF00498	0.493
LIG_FHA_1	411	417	PF00498	0.501
LIG_FHA_1	434	440	PF00498	0.611
LIG_FHA_1	6	12	PF00498	0.679
LIG_FHA_1	935	941	PF00498	0.582
LIG_FHA_1	960	966	PF00498	0.634
LIG_FHA_2	285	291	PF00498	0.493
LIG_FHA_2	333	339	PF00498	0.493
LIG_FHA_2	355	361	PF00498	0.513
LIG_FHA_2	399	405	PF00498	0.436
LIG_FHA_2	502	508	PF00498	0.734
LIG_FHA_2	640	646	PF00498	0.630
LIG_FHA_2	832	838	PF00498	0.657
LIG_HCF-1_HBM_1	204	207	PF13415	0.655
LIG_LIR_Gen_1	122	129	PF02991	0.642
LIG_LIR_Gen_1	136	145	PF02991	0.547
LIG_LIR_Gen_1	213	221	PF02991	0.344
LIG_LIR_Gen_1	254	264	PF02991	0.493
LIG_LIR_Gen_1	287	296	PF02991	0.493
LIG_LIR_Gen_1	717	727	PF02991	0.488
LIG_LIR_Gen_1	761	770	PF02991	0.637
LIG_LIR_Gen_1	860	869	PF02991	0.516
LIG_LIR_Gen_1	901	911	PF02991	0.568
LIG_LIR_Nem_3	102	106	PF02991	0.591
LIG_LIR_Nem_3	122	126	PF02991	0.311
LIG_LIR_Nem_3	136	141	PF02991	0.548
LIG_LIR_Nem_3	213	218	PF02991	0.459
LIG_LIR_Nem_3	254	259	PF02991	0.493
LIG_LIR_Nem_3	287	291	PF02991	0.507
LIG_LIR_Nem_3	311	317	PF02991	0.493
LIG_LIR_Nem_3	717	722	PF02991	0.484
LIG_LIR_Nem_3	761	766	PF02991	0.589
LIG_LIR_Nem_3	860	866	PF02991	0.529
LIG_LIR_Nem_3	901	907	PF02991	0.572
LIG_NRBOX	231	237	PF00104	0.493
LIG_NRBOX	421	427	PF00104	0.632
LIG_NRBOX	849	855	PF00104	0.639
LIG_OCRL_FandH_1	529	541	PF00620	0.553
LIG_SH2_CRK	123	127	PF00017	0.512
LIG_SH2_CRK	256	260	PF00017	0.493
LIG_SH2_CRK	375	379	PF00017	0.420
LIG_SH2_CRK	385	389	PF00017	0.454
LIG_SH2_GRB2like	916	919	PF00017	0.585
LIG_SH2_NCK_1	375	379	PF00017	0.420
LIG_SH2_PTP2	537	540	PF00017	0.748
LIG_SH2_SRC	215	218	PF00017	0.447
LIG_SH2_STAT3	770	773	PF00017	0.718
LIG_SH2_STAT5	207	210	PF00017	0.612
LIG_SH2_STAT5	314	317	PF00017	0.493
LIG_SH2_STAT5	326	329	PF00017	0.493
LIG_SH2_STAT5	341	344	PF00017	0.423
LIG_SH2_STAT5	459	462	PF00017	0.607
LIG_SH2_STAT5	537	540	PF00017	0.666
LIG_SH2_STAT5	89	92	PF00017	0.587
LIG_SH2_STAT5	893	896	PF00017	0.535
LIG_SH3_1	856	862	PF00018	0.629
LIG_SH3_1	94	100	PF00018	0.582
LIG_SH3_3	274	280	PF00018	0.493
LIG_SH3_3	286	292	PF00018	0.493
LIG_SH3_3	616	622	PF00018	0.563
LIG_SH3_3	703	709	PF00018	0.682
LIG_SH3_3	823	829	PF00018	0.684
LIG_SH3_3	856	862	PF00018	0.517
LIG_SH3_3	93	99	PF00018	0.594
LIG_SUMO_SIM_anti_2	401	407	PF11976	0.538
LIG_SUMO_SIM_anti_2	54	61	PF11976	0.539
LIG_SUMO_SIM_par_1	54	61	PF11976	0.539
LIG_TRAF2_1	875	878	PF00917	0.626
LIG_WRC_WIRS_1	172	177	PF05994	0.701
MOD_CK1_1	143	149	PF00069	0.695
MOD_CK1_1	159	165	PF00069	0.652
MOD_CK1_1	173	179	PF00069	0.741
MOD_CK1_1	320	326	PF00069	0.493
MOD_CK1_1	482	488	PF00069	0.595
MOD_CK1_1	689	695	PF00069	0.807
MOD_CK1_1	717	723	PF00069	0.530
MOD_CK1_1	751	757	PF00069	0.751
MOD_CK1_1	833	839	PF00069	0.620
MOD_CK2_1	159	165	PF00069	0.769
MOD_CK2_1	398	404	PF00069	0.442
MOD_CK2_1	4	10	PF00069	0.680
MOD_CK2_1	501	507	PF00069	0.749
MOD_CK2_1	660	666	PF00069	0.743
MOD_CK2_1	966	972	PF00069	0.786
MOD_GlcNHglycan	133	136	PF01048	0.681
MOD_GlcNHglycan	143	146	PF01048	0.666
MOD_GlcNHglycan	23	26	PF01048	0.704
MOD_GlcNHglycan	395	398	PF01048	0.415
MOD_GlcNHglycan	469	472	PF01048	0.768
MOD_GlcNHglycan	483	487	PF01048	0.716
MOD_GlcNHglycan	492	496	PF01048	0.821
MOD_GlcNHglycan	504	507	PF01048	0.583
MOD_GlcNHglycan	554	557	PF01048	0.714
MOD_GlcNHglycan	608	611	PF01048	0.729
MOD_GlcNHglycan	634	637	PF01048	0.789
MOD_GlcNHglycan	739	742	PF01048	0.768
MOD_GlcNHglycan	753	756	PF01048	0.620
MOD_GlcNHglycan	778	781	PF01048	0.713
MOD_GlcNHglycan	812	817	PF01048	0.641
MOD_GlcNHglycan	818	821	PF01048	0.640
MOD_GSK3_1	140	147	PF00069	0.673
MOD_GSK3_1	156	163	PF00069	0.789
MOD_GSK3_1	170	177	PF00069	0.759
MOD_GSK3_1	242	249	PF00069	0.507
MOD_GSK3_1	251	258	PF00069	0.508
MOD_GSK3_1	354	361	PF00069	0.493
MOD_GSK3_1	362	369	PF00069	0.438
MOD_GSK3_1	460	467	PF00069	0.660
MOD_GSK3_1	552	559	PF00069	0.718
MOD_GSK3_1	57	64	PF00069	0.632
MOD_GSK3_1	600	607	PF00069	0.712
MOD_GSK3_1	722	729	PF00069	0.699
MOD_GSK3_1	812	819	PF00069	0.610
MOD_GSK3_1	955	962	PF00069	0.601
MOD_GSK3_1	966	973	PF00069	0.646
MOD_LATS_1	364	370	PF00433	0.433
MOD_N-GLC_1	247	252	PF02516	0.293
MOD_N-GLC_1	934	939	PF02516	0.576
MOD_NEK2_1	119	124	PF00069	0.594
MOD_NEK2_1	255	260	PF00069	0.506
MOD_NEK2_1	284	289	PF00069	0.524
MOD_NEK2_1	354	359	PF00069	0.549
MOD_NEK2_1	433	438	PF00069	0.593
MOD_NEK2_1	831	836	PF00069	0.585
MOD_NEK2_1	869	874	PF00069	0.496
MOD_NEK2_1	934	939	PF00069	0.576
MOD_NEK2_2	748	753	PF00069	0.765
MOD_PIKK_1	925	931	PF00454	0.593
MOD_PIKK_1	960	966	PF00454	0.599
MOD_PK_1	358	364	PF00069	0.430
MOD_PK_1	366	372	PF00069	0.419
MOD_PKA_1	251	257	PF00069	0.545
MOD_PKA_2	131	137	PF00069	0.724
MOD_PKA_2	21	27	PF00069	0.798
MOD_PKA_2	317	323	PF00069	0.493
MOD_PKA_2	479	485	PF00069	0.752
MOD_PKA_2	689	695	PF00069	0.785
MOD_PKA_2	714	720	PF00069	0.687
MOD_PKA_2	816	822	PF00069	0.652
MOD_PKA_2	869	875	PF00069	0.557
MOD_PKA_2	898	904	PF00069	0.646
MOD_PKB_1	489	497	PF00069	0.807
MOD_PKB_1	637	645	PF00069	0.754
MOD_Plk_1	164	170	PF00069	0.662
MOD_Plk_1	440	446	PF00069	0.596
MOD_Plk_1	573	579	PF00069	0.731
MOD_Plk_1	87	93	PF00069	0.591
MOD_Plk_1	877	883	PF00069	0.680
MOD_Plk_4	121	127	PF00069	0.512
MOD_Plk_4	227	233	PF00069	0.493
MOD_Plk_4	284	290	PF00069	0.493
MOD_Plk_4	320	326	PF00069	0.493
MOD_Plk_4	366	372	PF00069	0.436
MOD_Plk_4	508	514	PF00069	0.561
MOD_Plk_4	849	855	PF00069	0.618
MOD_Plk_4	955	961	PF00069	0.597
MOD_ProDKin_1	156	162	PF00069	0.745
MOD_ProDKin_1	243	249	PF00069	0.498
MOD_ProDKin_1	257	263	PF00069	0.475
MOD_ProDKin_1	521	527	PF00069	0.698
MOD_ProDKin_1	602	608	PF00069	0.761
MOD_ProDKin_1	700	706	PF00069	0.738
TRG_DiLeu_BaEn_4	108	114	PF01217	0.534
TRG_DiLeu_BaEn_4	877	883	PF01217	0.618
TRG_ENDOCYTIC_2	123	126	PF00928	0.505
TRG_ENDOCYTIC_2	215	218	PF00928	0.422
TRG_ENDOCYTIC_2	256	259	PF00928	0.493
TRG_ENDOCYTIC_2	314	317	PF00928	0.493
TRG_ENDOCYTIC_2	375	378	PF00928	0.403
TRG_ENDOCYTIC_2	385	388	PF00928	0.427
TRG_ENDOCYTIC_2	459	462	PF00928	0.625
TRG_ENDOCYTIC_2	942	945	PF00928	0.564
TRG_ER_diArg_1	192	195	PF00400	0.662
TRG_ER_diArg_1	317	319	PF00400	0.493
TRG_ER_diArg_1	533	536	PF00400	0.761
TRG_ER_diArg_1	595	597	PF00400	0.647
TRG_ER_diArg_1	789	792	PF00400	0.670
TRG_ER_diArg_1	869	871	PF00400	0.602
TRG_NLS_MonoExtC_3	382	387	PF00514	0.434
TRG_NLS_MonoExtN_4	380	387	PF00514	0.433
TRG_Pf-PMV_PEXEL_1	407	412	PF00026	0.435
TRG_Pf-PMV_PEXEL_1	423	427	PF00026	0.676

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILH8	Leptomonas seymouri	55%	83%
A0A1X0NT82	Trypanosomatidae	45%	100%
A0A3Q8IC70	Leishmania donovani	94%	100%
A0A3R7NJM0	Trypanosoma rangeli	45%	100%
A0A3S7WX68	Leishmania donovani	93%	83%
A4HCB6	Leishmania braziliensis	80%	98%
A4HZV0	Leishmania infantum	94%	100%
C9ZSF9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AVQ6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	86%
E9AVR6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4QBS5	Leishmania major	99%	84%
V5BVT0	Trypanosoma cruzi	44%	100%