Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBQ9_LEIMA

TriTrypDb:

LmjF.22.0880 , LMJLV39_220014000 , LMJSD75_220014500

Length:

704

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBQ9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBQ9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	370	374	PF00656	0.472
CLV_C14_Caspase3-7	555	559	PF00656	0.507
CLV_C14_Caspase3-7	600	604	PF00656	0.548
CLV_NRD_NRD_1	114	116	PF00675	0.571
CLV_NRD_NRD_1	331	333	PF00675	0.449
CLV_NRD_NRD_1	375	377	PF00675	0.450
CLV_NRD_NRD_1	4	6	PF00675	0.569
CLV_NRD_NRD_1	528	530	PF00675	0.534
CLV_NRD_NRD_1	590	592	PF00675	0.664
CLV_NRD_NRD_1	612	614	PF00675	0.617
CLV_NRD_NRD_1	630	632	PF00675	0.590
CLV_NRD_NRD_1	691	693	PF00675	0.510
CLV_PCSK_FUR_1	610	614	PF00082	0.628
CLV_PCSK_KEX2_1	114	116	PF00082	0.571
CLV_PCSK_KEX2_1	331	333	PF00082	0.449
CLV_PCSK_KEX2_1	375	377	PF00082	0.450
CLV_PCSK_KEX2_1	527	529	PF00082	0.554
CLV_PCSK_KEX2_1	590	592	PF00082	0.664
CLV_PCSK_KEX2_1	6	8	PF00082	0.560
CLV_PCSK_KEX2_1	612	614	PF00082	0.621
CLV_PCSK_KEX2_1	691	693	PF00082	0.510
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.560
CLV_PCSK_SKI1_1	115	119	PF00082	0.609
CLV_PCSK_SKI1_1	17	21	PF00082	0.568
CLV_PCSK_SKI1_1	454	458	PF00082	0.600
CLV_PCSK_SKI1_1	632	636	PF00082	0.654
CLV_PCSK_SKI1_1	657	661	PF00082	0.551
DEG_APCC_DBOX_1	23	31	PF00400	0.545
DEG_COP1_1	210	220	PF00400	0.621
DEG_SCF_FBW7_1	395	402	PF00400	0.591
DEG_SPOP_SBC_1	107	111	PF00917	0.626
DEG_SPOP_SBC_1	408	412	PF00917	0.652
DEG_SPOP_SBC_1	490	494	PF00917	0.571
DOC_CKS1_1	396	401	PF01111	0.593
DOC_CYCLIN_RxL_1	654	663	PF00134	0.551
DOC_MAPK_gen_1	114	120	PF00069	0.624
DOC_MAPK_gen_1	567	575	PF00069	0.614
DOC_PP2B_LxvP_1	155	158	PF13499	0.524
DOC_PP2B_LxvP_1	237	240	PF13499	0.590
DOC_PP2B_LxvP_1	96	99	PF13499	0.596
DOC_PP2B_PxIxI_1	219	225	PF00149	0.633
DOC_PP4_FxxP_1	129	132	PF00568	0.589
DOC_PP4_FxxP_1	38	41	PF00568	0.559
DOC_USP7_MATH_1	10	14	PF00917	0.475
DOC_USP7_MATH_1	108	112	PF00917	0.611
DOC_USP7_MATH_1	196	200	PF00917	0.620
DOC_USP7_MATH_1	212	216	PF00917	0.650
DOC_USP7_MATH_1	218	222	PF00917	0.629
DOC_USP7_MATH_1	288	292	PF00917	0.622
DOC_USP7_MATH_1	367	371	PF00917	0.563
DOC_USP7_MATH_1	404	408	PF00917	0.644
DOC_USP7_MATH_1	426	430	PF00917	0.541
DOC_USP7_MATH_1	445	449	PF00917	0.486
DOC_USP7_MATH_1	496	500	PF00917	0.596
DOC_USP7_MATH_1	523	527	PF00917	0.576
DOC_USP7_MATH_1	54	58	PF00917	0.521
DOC_WW_Pin1_4	119	124	PF00397	0.552
DOC_WW_Pin1_4	210	215	PF00397	0.664
DOC_WW_Pin1_4	216	221	PF00397	0.621
DOC_WW_Pin1_4	395	400	PF00397	0.594
DOC_WW_Pin1_4	439	444	PF00397	0.592
DOC_WW_Pin1_4	508	513	PF00397	0.538
LIG_14-3-3_CanoR_1	17	22	PF00244	0.578
LIG_14-3-3_CanoR_1	358	363	PF00244	0.471
LIG_14-3-3_CanoR_1	380	384	PF00244	0.422
LIG_14-3-3_CanoR_1	529	535	PF00244	0.499
LIG_14-3-3_CanoR_1	631	639	PF00244	0.548
LIG_BIR_II_1	1	5	PF00653	0.646
LIG_BIR_III_4	116	120	PF00653	0.536
LIG_BRCT_BRCA1_1	34	38	PF00533	0.558
LIG_Clathr_ClatBox_1	27	31	PF01394	0.549
LIG_deltaCOP1_diTrp_1	342	346	PF00928	0.458
LIG_deltaCOP1_diTrp_1	695	700	PF00928	0.406
LIG_DLG_GKlike_1	358	366	PF00625	0.481
LIG_EVH1_1	395	399	PF00568	0.591
LIG_FHA_1	122	128	PF00498	0.512
LIG_FHA_1	195	201	PF00498	0.577
LIG_FHA_1	44	50	PF00498	0.507
LIG_FHA_1	495	501	PF00498	0.559
LIG_FHA_1	516	522	PF00498	0.554
LIG_FHA_1	633	639	PF00498	0.761
LIG_FHA_1	664	670	PF00498	0.641
LIG_FHA_2	143	149	PF00498	0.555
LIG_FHA_2	18	24	PF00498	0.584
LIG_FHA_2	410	416	PF00498	0.551
LIG_FHA_2	479	485	PF00498	0.596
LIG_FHA_2	598	604	PF00498	0.545
LIG_FHA_2	668	674	PF00498	0.672
LIG_FHA_2	678	684	PF00498	0.520
LIG_LIR_Apic_2	126	132	PF02991	0.584
LIG_LIR_Apic_2	35	41	PF02991	0.557
LIG_LIR_Gen_1	484	491	PF02991	0.558
LIG_LIR_Gen_1	52	63	PF02991	0.520
LIG_LIR_Gen_1	531	539	PF02991	0.535
LIG_LIR_Nem_3	484	489	PF02991	0.556
LIG_LIR_Nem_3	52	58	PF02991	0.574
LIG_LIR_Nem_3	531	535	PF02991	0.555
LIG_PDZ_Class_1	699	704	PF00595	0.417
LIG_SH2_CRK	532	536	PF00017	0.480
LIG_SH2_CRK	55	59	PF00017	0.490
LIG_SH2_GRB2like	62	65	PF00017	0.582
LIG_SH2_STAP1	542	546	PF00017	0.460
LIG_SH2_STAP1	55	59	PF00017	0.490
LIG_SH2_STAP1	621	625	PF00017	0.598
LIG_SH2_STAT3	542	545	PF00017	0.453
LIG_SH2_STAT5	36	39	PF00017	0.566
LIG_SH2_STAT5	477	480	PF00017	0.683
LIG_SH2_STAT5	485	488	PF00017	0.562
LIG_SH3_2	236	241	PF14604	0.595
LIG_SH3_2	396	401	PF14604	0.637
LIG_SH3_3	129	135	PF00018	0.607
LIG_SH3_3	214	220	PF00018	0.730
LIG_SH3_3	230	236	PF00018	0.504
LIG_SH3_3	38	44	PF00018	0.525
LIG_SH3_3	393	399	PF00018	0.586
LIG_SH3_3	461	467	PF00018	0.685
LIG_SH3_CIN85_PxpxPR_1	236	241	PF14604	0.595
LIG_TRAF2_1	13	16	PF00917	0.486
LIG_TRAF2_1	553	556	PF00917	0.541
LIG_TYR_ITIM	53	58	PF00017	0.486
LIG_UBA3_1	359	363	PF00899	0.401
LIG_WW_3	238	242	PF00397	0.595
MOD_CDK_SPxK_1	395	401	PF00069	0.587
MOD_CK1_1	194	200	PF00069	0.578
MOD_CK1_1	213	219	PF00069	0.636
MOD_CK1_1	249	255	PF00069	0.534
MOD_CK1_1	291	297	PF00069	0.645
MOD_CK1_1	349	355	PF00069	0.453
MOD_CK1_1	407	413	PF00069	0.644
MOD_CK1_1	422	428	PF00069	0.537
MOD_CK1_1	431	437	PF00069	0.548
MOD_CK1_1	492	498	PF00069	0.598
MOD_CK1_1	508	514	PF00069	0.503
MOD_CK1_1	547	553	PF00069	0.546
MOD_CK1_1	626	632	PF00069	0.557
MOD_CK2_1	10	16	PF00069	0.483
MOD_CK2_1	160	166	PF00069	0.772
MOD_CK2_1	17	23	PF00069	0.524
MOD_CK2_1	241	247	PF00069	0.643
MOD_CK2_1	36	42	PF00069	0.450
MOD_CK2_1	667	673	PF00069	0.753
MOD_CK2_1	677	683	PF00069	0.545
MOD_CMANNOS	343	346	PF00535	0.458
MOD_CMANNOS	387	390	PF00535	0.393
MOD_CMANNOS	697	700	PF00535	0.402
MOD_Cter_Amidation	112	115	PF01082	0.573
MOD_Cter_Amidation	629	632	PF01082	0.650
MOD_GlcNHglycan	110	113	PF01048	0.746
MOD_GlcNHglycan	12	15	PF01048	0.474
MOD_GlcNHglycan	129	132	PF01048	0.567
MOD_GlcNHglycan	152	155	PF01048	0.554
MOD_GlcNHglycan	162	165	PF01048	0.629
MOD_GlcNHglycan	170	173	PF01048	0.664
MOD_GlcNHglycan	253	256	PF01048	0.538
MOD_GlcNHglycan	271	274	PF01048	0.461
MOD_GlcNHglycan	294	297	PF01048	0.673
MOD_GlcNHglycan	300	303	PF01048	0.721
MOD_GlcNHglycan	315	318	PF01048	0.466
MOD_GlcNHglycan	328	331	PF01048	0.447
MOD_GlcNHglycan	369	373	PF01048	0.522
MOD_GlcNHglycan	402	405	PF01048	0.642
MOD_GlcNHglycan	406	409	PF01048	0.640
MOD_GlcNHglycan	421	424	PF01048	0.543
MOD_GlcNHglycan	447	450	PF01048	0.552
MOD_GlcNHglycan	494	497	PF01048	0.607
MOD_GlcNHglycan	507	510	PF01048	0.688
MOD_GlcNHglycan	582	585	PF01048	0.655
MOD_GlcNHglycan	640	643	PF01048	0.734
MOD_GlcNHglycan	83	86	PF01048	0.667
MOD_GlcNHglycan	92	95	PF01048	0.640
MOD_GSK3_1	119	126	PF00069	0.517
MOD_GSK3_1	196	203	PF00069	0.597
MOD_GSK3_1	212	219	PF00069	0.625
MOD_GSK3_1	249	256	PF00069	0.543
MOD_GSK3_1	275	282	PF00069	0.682
MOD_GSK3_1	287	294	PF00069	0.576
MOD_GSK3_1	32	39	PF00069	0.553
MOD_GSK3_1	342	349	PF00069	0.454
MOD_GSK3_1	395	402	PF00069	0.620
MOD_GSK3_1	404	411	PF00069	0.566
MOD_GSK3_1	422	429	PF00069	0.537
MOD_GSK3_1	437	444	PF00069	0.501
MOD_GSK3_1	485	492	PF00069	0.575
MOD_GSK3_1	513	520	PF00069	0.621
MOD_GSK3_1	634	641	PF00069	0.782
MOD_GSK3_1	663	670	PF00069	0.700
MOD_N-GLC_1	431	436	PF02516	0.593
MOD_N-GLC_1	513	518	PF02516	0.621
MOD_N-GLC_1	580	585	PF02516	0.656
MOD_N-GLC_1	80	85	PF02516	0.532
MOD_NEK2_1	1	6	PF00069	0.577
MOD_NEK2_1	106	111	PF00069	0.632
MOD_NEK2_1	160	165	PF00069	0.622
MOD_NEK2_1	251	256	PF00069	0.504
MOD_NEK2_1	269	274	PF00069	0.508
MOD_NEK2_1	326	331	PF00069	0.462
MOD_NEK2_1	437	442	PF00069	0.573
MOD_NEK2_1	478	483	PF00069	0.591
MOD_NEK2_1	513	518	PF00069	0.621
MOD_NEK2_1	546	551	PF00069	0.626
MOD_NEK2_1	660	665	PF00069	0.533
MOD_NEK2_2	379	384	PF00069	0.426
MOD_NEK2_2	54	59	PF00069	0.489
MOD_PIKK_1	253	259	PF00454	0.454
MOD_PIKK_1	275	281	PF00454	0.630
MOD_PIKK_1	344	350	PF00454	0.453
MOD_PIKK_1	43	49	PF00454	0.510
MOD_PIKK_1	663	669	PF00454	0.556
MOD_PK_1	191	197	PF00069	0.580
MOD_PK_1	241	247	PF00069	0.665
MOD_PKA_1	528	534	PF00069	0.574
MOD_PKA_1	590	596	PF00069	0.658
MOD_PKA_1	691	697	PF00069	0.490
MOD_PKA_2	379	385	PF00069	0.425
MOD_PKA_2	400	406	PF00069	0.537
MOD_PKA_2	528	534	PF00069	0.574
MOD_PKA_2	547	553	PF00069	0.413
MOD_PKA_2	590	596	PF00069	0.651
MOD_PKA_2	626	632	PF00069	0.560
MOD_PKA_2	691	697	PF00069	0.490
MOD_Plk_1	246	252	PF00069	0.568
MOD_Plk_1	32	38	PF00069	0.554
MOD_Plk_2-3	677	683	PF00069	0.602
MOD_Plk_4	196	202	PF00069	0.626
MOD_Plk_4	218	224	PF00069	0.612
MOD_Plk_4	246	252	PF00069	0.568
MOD_Plk_4	379	385	PF00069	0.425
MOD_Plk_4	517	523	PF00069	0.596
MOD_Plk_4	530	536	PF00069	0.486
MOD_Plk_4	54	60	PF00069	0.492
MOD_Plk_4	634	640	PF00069	0.569
MOD_Plk_4	660	666	PF00069	0.628
MOD_Plk_4	677	683	PF00069	0.537
MOD_ProDKin_1	119	125	PF00069	0.552
MOD_ProDKin_1	210	216	PF00069	0.665
MOD_ProDKin_1	395	401	PF00069	0.602
MOD_ProDKin_1	439	445	PF00069	0.588
MOD_ProDKin_1	508	514	PF00069	0.538
MOD_SUMO_for_1	201	204	PF00179	0.635
TRG_DiLeu_BaEn_1	23	28	PF01217	0.611
TRG_DiLeu_BaLyEn_6	178	183	PF01217	0.506
TRG_DiLeu_BaLyEn_6	468	473	PF01217	0.541
TRG_ENDOCYTIC_2	532	535	PF00928	0.487
TRG_ENDOCYTIC_2	55	58	PF00928	0.486
TRG_ENDOCYTIC_2	8	11	PF00928	0.518
TRG_ER_diArg_1	5	8	PF00400	0.564
TRG_ER_diArg_1	527	529	PF00400	0.554
TRG_ER_diArg_1	589	591	PF00400	0.653
TRG_ER_diArg_1	610	613	PF00400	0.681
TRG_ER_diArg_1	690	692	PF00400	0.536
TRG_NLS_MonoExtC_3	4	9	PF00514	0.556
TRG_NLS_MonoExtN_4	5	10	PF00514	0.547

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IL70	Leptomonas seymouri	41%	94%
A0A3Q8IBF7	Leishmania donovani	89%	100%
A4HCD8	Leishmania braziliensis	74%	100%
A4HZW2	Leishmania infantum	89%	100%
E9AVS0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%