LeishMANIAdb
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RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
RING-type domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QBQ7_LEIMA
TriTrypDb:
LmjF.22.0900 , LMJLV39_220014200 * , LMJSD75_220014700 *
Length:
930

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBQ7
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBQ7

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 124 128 PF00656 0.626
CLV_C14_Caspase3-7 157 161 PF00656 0.640
CLV_C14_Caspase3-7 171 175 PF00656 0.654
CLV_C14_Caspase3-7 268 272 PF00656 0.605
CLV_C14_Caspase3-7 43 47 PF00656 0.645
CLV_C14_Caspase3-7 453 457 PF00656 0.656
CLV_NRD_NRD_1 213 215 PF00675 0.590
CLV_NRD_NRD_1 424 426 PF00675 0.587
CLV_NRD_NRD_1 598 600 PF00675 0.433
CLV_NRD_NRD_1 636 638 PF00675 0.625
CLV_NRD_NRD_1 697 699 PF00675 0.557
CLV_NRD_NRD_1 866 868 PF00675 0.478
CLV_NRD_NRD_1 921 923 PF00675 0.536
CLV_PCSK_FUR_1 491 495 PF00082 0.523
CLV_PCSK_KEX2_1 213 215 PF00082 0.590
CLV_PCSK_KEX2_1 306 308 PF00082 0.510
CLV_PCSK_KEX2_1 424 426 PF00082 0.587
CLV_PCSK_KEX2_1 493 495 PF00082 0.548
CLV_PCSK_KEX2_1 598 600 PF00082 0.433
CLV_PCSK_KEX2_1 636 638 PF00082 0.625
CLV_PCSK_KEX2_1 696 698 PF00082 0.462
CLV_PCSK_PC1ET2_1 306 308 PF00082 0.510
CLV_PCSK_PC1ET2_1 493 495 PF00082 0.535
CLV_PCSK_SKI1_1 214 218 PF00082 0.575
CLV_PCSK_SKI1_1 235 239 PF00082 0.620
CLV_PCSK_SKI1_1 282 286 PF00082 0.435
CLV_PCSK_SKI1_1 676 680 PF00082 0.524
DEG_APCC_DBOX_1 675 683 PF00400 0.448
DEG_SCF_FBW7_2 727 733 PF00400 0.390
DEG_SPOP_SBC_1 760 764 PF00917 0.530
DEG_SPOP_SBC_1 790 794 PF00917 0.564
DEG_SPOP_SBC_1 90 94 PF00917 0.671
DOC_CKS1_1 201 206 PF01111 0.583
DOC_CKS1_1 479 484 PF01111 0.490
DOC_CKS1_1 549 554 PF01111 0.466
DOC_CKS1_1 727 732 PF01111 0.452
DOC_CYCLIN_RxL_1 300 313 PF00134 0.511
DOC_MAPK_DCC_7 412 421 PF00069 0.522
DOC_MAPK_gen_1 306 316 PF00069 0.524
DOC_MAPK_gen_1 407 415 PF00069 0.559
DOC_MAPK_gen_1 491 501 PF00069 0.517
DOC_MAPK_gen_1 527 537 PF00069 0.635
DOC_MAPK_gen_1 702 710 PF00069 0.380
DOC_MAPK_gen_1 876 883 PF00069 0.307
DOC_MAPK_JIP1_4 409 415 PF00069 0.552
DOC_MAPK_MEF2A_6 235 244 PF00069 0.528
DOC_MAPK_MEF2A_6 412 421 PF00069 0.532
DOC_MAPK_MEF2A_6 581 588 PF00069 0.397
DOC_MAPK_MEF2A_6 828 835 PF00069 0.358
DOC_MAPK_MEF2A_6 876 883 PF00069 0.307
DOC_MAPK_NFAT4_5 828 836 PF00069 0.358
DOC_MAPK_NFAT4_5 876 884 PF00069 0.306
DOC_PP1_RVXF_1 304 311 PF00149 0.510
DOC_PP1_RVXF_1 832 838 PF00149 0.386
DOC_PP2B_LxvP_1 240 243 PF13499 0.614
DOC_PP2B_LxvP_1 413 416 PF13499 0.523
DOC_PP2B_PxIxI_1 416 422 PF00149 0.411
DOC_USP7_MATH_1 184 188 PF00917 0.703
DOC_USP7_MATH_1 212 216 PF00917 0.595
DOC_USP7_MATH_1 325 329 PF00917 0.633
DOC_USP7_MATH_1 382 386 PF00917 0.590
DOC_USP7_MATH_1 758 762 PF00917 0.674
DOC_USP7_MATH_1 803 807 PF00917 0.693
DOC_USP7_MATH_1 90 94 PF00917 0.671
DOC_WW_Pin1_4 104 109 PF00397 0.675
DOC_WW_Pin1_4 127 132 PF00397 0.720
DOC_WW_Pin1_4 200 205 PF00397 0.584
DOC_WW_Pin1_4 478 483 PF00397 0.501
DOC_WW_Pin1_4 512 517 PF00397 0.566
DOC_WW_Pin1_4 548 553 PF00397 0.466
DOC_WW_Pin1_4 668 673 PF00397 0.535
DOC_WW_Pin1_4 726 731 PF00397 0.467
DOC_WW_Pin1_4 786 791 PF00397 0.690
DOC_WW_Pin1_4 808 813 PF00397 0.545
LIG_14-3-3_CanoR_1 213 217 PF00244 0.607
LIG_14-3-3_CanoR_1 239 243 PF00244 0.489
LIG_14-3-3_CanoR_1 425 431 PF00244 0.480
LIG_14-3-3_CanoR_1 530 536 PF00244 0.553
LIG_14-3-3_CanoR_1 539 549 PF00244 0.504
LIG_14-3-3_CanoR_1 569 577 PF00244 0.419
LIG_14-3-3_CanoR_1 744 753 PF00244 0.541
LIG_14-3-3_CanoR_1 834 840 PF00244 0.468
LIG_14-3-3_CanoR_1 89 97 PF00244 0.683
LIG_14-3-3_CanoR_1 922 930 PF00244 0.570
LIG_BIR_II_1 1 5 PF00653 0.720
LIG_CaM_IQ_9 585 601 PF13499 0.407
LIG_CtBP_PxDLS_1 28 32 PF00389 0.570
LIG_deltaCOP1_diTrp_1 346 354 PF00928 0.516
LIG_Dynein_DLC8_1 528 534 PF01221 0.557
LIG_EH1_1 468 476 PF00400 0.507
LIG_FHA_1 222 228 PF00498 0.513
LIG_FHA_1 239 245 PF00498 0.488
LIG_FHA_1 311 317 PF00498 0.743
LIG_FHA_1 351 357 PF00498 0.521
LIG_FHA_1 530 536 PF00498 0.576
LIG_FHA_1 549 555 PF00498 0.419
LIG_FHA_1 722 728 PF00498 0.534
LIG_FHA_1 799 805 PF00498 0.662
LIG_FHA_1 847 853 PF00498 0.419
LIG_FHA_2 155 161 PF00498 0.650
LIG_FHA_2 255 261 PF00498 0.583
LIG_FHA_2 373 379 PF00498 0.563
LIG_FHA_2 541 547 PF00498 0.479
LIG_FHA_2 571 577 PF00498 0.480
LIG_FHA_2 681 687 PF00498 0.397
LIG_FHA_2 701 707 PF00498 0.332
LIG_FHA_2 71 77 PF00498 0.595
LIG_FHA_2 836 842 PF00498 0.391
LIG_FHA_2 900 906 PF00498 0.574
LIG_LIR_Gen_1 107 116 PF02991 0.650
LIG_LIR_Gen_1 429 437 PF02991 0.480
LIG_LIR_Gen_1 563 572 PF02991 0.444
LIG_LIR_Gen_1 645 654 PF02991 0.412
LIG_LIR_Gen_1 740 747 PF02991 0.403
LIG_LIR_Nem_3 107 113 PF02991 0.629
LIG_LIR_Nem_3 283 288 PF02991 0.503
LIG_LIR_Nem_3 298 302 PF02991 0.440
LIG_LIR_Nem_3 429 433 PF02991 0.444
LIG_LIR_Nem_3 511 517 PF02991 0.538
LIG_LIR_Nem_3 563 567 PF02991 0.446
LIG_LIR_Nem_3 645 649 PF02991 0.418
LIG_LIR_Nem_3 740 745 PF02991 0.396
LIG_LIR_Nem_3 889 895 PF02991 0.461
LIG_MYND_1 668 672 PF01753 0.538
LIG_NRBOX 828 834 PF00104 0.362
LIG_RPA_C_Fungi 899 911 PF08784 0.466
LIG_SH2_CRK 892 896 PF00017 0.472
LIG_SH2_NCK_1 110 114 PF00017 0.635
LIG_SH2_NCK_1 892 896 PF00017 0.472
LIG_SH2_SRC 104 107 PF00017 0.648
LIG_SH2_SRC 110 113 PF00017 0.618
LIG_SH2_SRC 430 433 PF00017 0.451
LIG_SH2_STAP1 430 434 PF00017 0.502
LIG_SH2_STAT3 67 70 PF00017 0.605
LIG_SH2_STAT5 401 404 PF00017 0.516
LIG_SH2_STAT5 486 489 PF00017 0.547
LIG_SH2_STAT5 571 574 PF00017 0.409
LIG_SH3_1 205 211 PF00018 0.685
LIG_SH3_2 208 213 PF14604 0.661
LIG_SH3_2 479 484 PF14604 0.539
LIG_SH3_3 198 204 PF00018 0.641
LIG_SH3_3 205 211 PF00018 0.688
LIG_SH3_3 215 221 PF00018 0.594
LIG_SH3_3 241 247 PF00018 0.493
LIG_SH3_3 476 482 PF00018 0.538
LIG_SH3_3 50 56 PF00018 0.772
LIG_SH3_3 546 552 PF00018 0.469
LIG_SH3_3 564 570 PF00018 0.609
LIG_SH3_3 724 730 PF00018 0.485
LIG_SH3_3 784 790 PF00018 0.763
LIG_SH3_3 9 15 PF00018 0.651
LIG_SH3_CIN85_PxpxPR_1 208 213 PF14604 0.661
LIG_SUMO_SIM_anti_2 228 233 PF11976 0.536
LIG_SUMO_SIM_par_1 223 228 PF11976 0.543
LIG_SUMO_SIM_par_1 277 283 PF11976 0.500
LIG_SUMO_SIM_par_1 678 686 PF11976 0.401
LIG_TRAF2_1 620 623 PF00917 0.411
LIG_TRAF2_1 703 706 PF00917 0.467
LIG_TRAF2_1 73 76 PF00917 0.669
LIG_UBA3_1 587 596 PF00899 0.485
LIG_WW_3 210 214 PF00397 0.662
LIG_WW_3 54 58 PF00397 0.716
MOD_CDC14_SPxK_1 130 133 PF00782 0.714
MOD_CDK_SPK_2 200 205 PF00069 0.584
MOD_CDK_SPK_2 548 553 PF00069 0.466
MOD_CDK_SPxK_1 127 133 PF00069 0.721
MOD_CDK_SPxK_1 478 484 PF00069 0.488
MOD_CDK_SPxxK_3 791 798 PF00069 0.561
MOD_CK1_1 143 149 PF00069 0.776
MOD_CK1_1 17 23 PF00069 0.723
MOD_CK1_1 187 193 PF00069 0.695
MOD_CK1_1 540 546 PF00069 0.546
MOD_CK1_1 759 765 PF00069 0.630
MOD_CK1_1 774 780 PF00069 0.770
MOD_CK1_1 789 795 PF00069 0.611
MOD_CK1_1 796 802 PF00069 0.639
MOD_CK1_1 846 852 PF00069 0.462
MOD_CK1_1 871 877 PF00069 0.488
MOD_CK2_1 1 7 PF00069 0.670
MOD_CK2_1 133 139 PF00069 0.676
MOD_CK2_1 17 23 PF00069 0.626
MOD_CK2_1 254 260 PF00069 0.551
MOD_CK2_1 372 378 PF00069 0.614
MOD_CK2_1 426 432 PF00069 0.538
MOD_CK2_1 540 546 PF00069 0.502
MOD_CK2_1 570 576 PF00069 0.492
MOD_CK2_1 617 623 PF00069 0.413
MOD_CK2_1 668 674 PF00069 0.531
MOD_CK2_1 680 686 PF00069 0.335
MOD_CK2_1 70 76 PF00069 0.597
MOD_CK2_1 700 706 PF00069 0.325
MOD_CK2_1 835 841 PF00069 0.421
MOD_Cter_Amidation 422 425 PF01082 0.444
MOD_Cter_Amidation 865 868 PF01082 0.475
MOD_GlcNHglycan 118 122 PF01048 0.808
MOD_GlcNHglycan 18 22 PF01048 0.643
MOD_GlcNHglycan 197 200 PF01048 0.651
MOD_GlcNHglycan 262 265 PF01048 0.720
MOD_GlcNHglycan 267 270 PF01048 0.499
MOD_GlcNHglycan 3 6 PF01048 0.710
MOD_GlcNHglycan 321 324 PF01048 0.656
MOD_GlcNHglycan 327 330 PF01048 0.773
MOD_GlcNHglycan 41 45 PF01048 0.818
MOD_GlcNHglycan 452 455 PF01048 0.750
MOD_GlcNHglycan 46 49 PF01048 0.735
MOD_GlcNHglycan 462 465 PF01048 0.603
MOD_GlcNHglycan 641 644 PF01048 0.453
MOD_GlcNHglycan 749 752 PF01048 0.491
MOD_GlcNHglycan 758 761 PF01048 0.608
MOD_GlcNHglycan 805 808 PF01048 0.760
MOD_GlcNHglycan 822 825 PF01048 0.461
MOD_GlcNHglycan 98 101 PF01048 0.664
MOD_GSK3_1 143 150 PF00069 0.797
MOD_GSK3_1 221 228 PF00069 0.512
MOD_GSK3_1 250 257 PF00069 0.630
MOD_GSK3_1 40 47 PF00069 0.649
MOD_GSK3_1 446 453 PF00069 0.632
MOD_GSK3_1 517 524 PF00069 0.644
MOD_GSK3_1 531 538 PF00069 0.503
MOD_GSK3_1 756 763 PF00069 0.700
MOD_GSK3_1 770 777 PF00069 0.623
MOD_GSK3_1 786 793 PF00069 0.629
MOD_GSK3_1 842 849 PF00069 0.539
MOD_N-GLC_1 195 200 PF02516 0.711
MOD_N-GLC_2 526 528 PF02516 0.567
MOD_NEK2_1 265 270 PF00069 0.625
MOD_NEK2_1 310 315 PF00069 0.696
MOD_NEK2_1 517 522 PF00069 0.534
MOD_NEK2_1 535 540 PF00069 0.511
MOD_NEK2_1 709 714 PF00069 0.513
MOD_NEK2_1 745 750 PF00069 0.451
MOD_NEK2_1 770 775 PF00069 0.632
MOD_NEK2_1 842 847 PF00069 0.471
MOD_NEK2_1 899 904 PF00069 0.480
MOD_NEK2_2 91 96 PF00069 0.677
MOD_PIKK_1 151 157 PF00454 0.660
MOD_PIKK_1 187 193 PF00454 0.694
MOD_PIKK_1 502 508 PF00454 0.525
MOD_PIKK_1 529 535 PF00454 0.557
MOD_PIKK_1 793 799 PF00454 0.557
MOD_PIKK_1 846 852 PF00454 0.519
MOD_PK_1 133 139 PF00069 0.653
MOD_PKA_2 212 218 PF00069 0.603
MOD_PKA_2 238 244 PF00069 0.500
MOD_PKA_2 250 256 PF00069 0.635
MOD_PKA_2 44 50 PF00069 0.651
MOD_PKA_2 526 532 PF00069 0.560
MOD_PKA_2 617 623 PF00069 0.413
MOD_PKB_1 87 95 PF00069 0.723
MOD_Plk_1 225 231 PF00069 0.598
MOD_Plk_1 868 874 PF00069 0.445
MOD_Plk_4 227 233 PF00069 0.500
MOD_Plk_4 245 251 PF00069 0.578
MOD_Plk_4 310 316 PF00069 0.689
MOD_Plk_4 382 388 PF00069 0.623
MOD_Plk_4 843 849 PF00069 0.483
MOD_ProDKin_1 104 110 PF00069 0.678
MOD_ProDKin_1 127 133 PF00069 0.721
MOD_ProDKin_1 200 206 PF00069 0.584
MOD_ProDKin_1 478 484 PF00069 0.503
MOD_ProDKin_1 512 518 PF00069 0.563
MOD_ProDKin_1 548 554 PF00069 0.468
MOD_ProDKin_1 668 674 PF00069 0.533
MOD_ProDKin_1 726 732 PF00069 0.457
MOD_ProDKin_1 786 792 PF00069 0.690
MOD_ProDKin_1 808 814 PF00069 0.545
MOD_SUMO_rev_2 248 258 PF00179 0.598
TRG_DiLeu_BaEn_1 851 856 PF01217 0.389
TRG_ENDOCYTIC_2 110 113 PF00928 0.660
TRG_ENDOCYTIC_2 430 433 PF00928 0.484
TRG_ENDOCYTIC_2 514 517 PF00928 0.528
TRG_ENDOCYTIC_2 68 71 PF00928 0.725
TRG_ENDOCYTIC_2 742 745 PF00928 0.396
TRG_ENDOCYTIC_2 892 895 PF00928 0.470
TRG_ER_diArg_1 212 214 PF00400 0.593
TRG_ER_diArg_1 307 310 PF00400 0.486
TRG_ER_diArg_1 406 409 PF00400 0.537
TRG_ER_diArg_1 598 601 PF00400 0.433
TRG_ER_diArg_1 635 637 PF00400 0.634
TRG_ER_diArg_1 696 698 PF00400 0.462
TRG_ER_diArg_1 86 89 PF00400 0.639
TRG_ER_diArg_1 875 878 PF00400 0.390
TRG_ER_diArg_1 906 909 PF00400 0.497
TRG_NES_CRM1_1 283 297 PF08389 0.462
TRG_NES_CRM1_1 576 589 PF08389 0.478
TRG_Pf-PMV_PEXEL_1 214 219 PF00026 0.571
TRG_Pf-PMV_PEXEL_1 282 286 PF00026 0.435
TRG_Pf-PMV_PEXEL_1 739 743 PF00026 0.399

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1ILI1 Leptomonas seymouri 51% 99%
A0A3S5H7A9 Leishmania donovani 90% 100%
A4HCD9 Leishmania braziliensis 71% 100%
A4HZW4 Leishmania infantum 90% 100%
E9AVS2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS