Pre-mRNA-splicing factor 18

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Prp18 domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QBQ6_LEIMA

TriTrypDb:

LmjF.22.0910 , LMJLV39_220014300 , LMJSD75_220014800

Length:

549

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	7
GO:0005682	U5 snRNP	5	2
GO:0005684	U2-type spliceosomal complex	4	2
GO:0030532	small nuclear ribonucleoprotein complex	3	2
GO:0032991	protein-containing complex	1	7
GO:0046540	U4/U6 x U5 tri-snRNP complex	6	2
GO:0071020	post-spliceosomal complex	4	2
GO:0071021	U2-type post-spliceosomal complex	5	2
GO:0097525	spliceosomal snRNP complex	4	2
GO:0097526	spliceosomal tri-snRNP complex	5	2
GO:0120114	Sm-like protein family complex	2	2
GO:0140513	nuclear protein-containing complex	2	7
GO:1990904	ribonucleoprotein complex	2	7

Expansion

Sequence features

Q4QBQ6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBQ6

Function

Biological processes
Term	Name	Level	Count
GO:0000350	generation of catalytic spliceosome for second transesterification step	7	2
GO:0009987	cellular process	1	7
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0022618	ribonucleoprotein complex assembly	6	2
GO:0043933	protein-containing complex organization	4	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071826	ribonucleoprotein complex subunit organization	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0006139	nucleobase-containing compound metabolic process	3	5
GO:0006396	RNA processing	6	5
GO:0006397	mRNA processing	7	5
GO:0006725	cellular aromatic compound metabolic process	3	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0008380	RNA splicing	7	5
GO:0016070	RNA metabolic process	5	5
GO:0016071	mRNA metabolic process	6	5
GO:0034641	cellular nitrogen compound metabolic process	3	5
GO:0043170	macromolecule metabolic process	3	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0046483	heterocycle metabolic process	3	5
GO:0071704	organic substance metabolic process	2	5
GO:0090304	nucleic acid metabolic process	4	5
GO:1901360	organic cyclic compound metabolic process	3	5

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	234	238	PF00656	0.565
CLV_C14_Caspase3-7	300	304	PF00656	0.611
CLV_NRD_NRD_1	11	13	PF00675	0.497
CLV_NRD_NRD_1	444	446	PF00675	0.317
CLV_NRD_NRD_1	492	494	PF00675	0.289
CLV_PCSK_KEX2_1	11	13	PF00082	0.497
CLV_PCSK_KEX2_1	492	494	PF00082	0.290
CLV_PCSK_PC1ET2_1	11	13	PF00082	0.497
CLV_PCSK_SKI1_1	520	524	PF00082	0.255
CLV_PCSK_SKI1_1	528	532	PF00082	0.405
CLV_Separin_Metazoa	324	328	PF03568	0.289
DEG_APCC_DBOX_1	444	452	PF00400	0.469
DEG_COP1_1	156	165	PF00400	0.479
DEG_COP1_1	211	219	PF00400	0.496
DEG_ODPH_VHL_1	363	376	PF01847	0.481
DEG_SCF_FBW7_1	52	57	PF00400	0.546
DEG_SPOP_SBC_1	101	105	PF00917	0.489
DEG_SPOP_SBC_1	240	244	PF00917	0.470
DOC_CKS1_1	157	162	PF01111	0.518
DOC_CYCLIN_yCln2_LP_2	157	163	PF00134	0.579
DOC_MAPK_gen_1	406	414	PF00069	0.350
DOC_MAPK_gen_1	445	453	PF00069	0.516
DOC_MAPK_MEF2A_6	466	474	PF00069	0.551
DOC_PP2B_LxvP_1	246	249	PF13499	0.444
DOC_PP4_FxxP_1	260	263	PF00568	0.451
DOC_PP4_FxxP_1	438	441	PF00568	0.404
DOC_PP4_FxxP_1	537	540	PF00568	0.411
DOC_USP7_MATH_1	101	105	PF00917	0.444
DOC_USP7_MATH_1	125	129	PF00917	0.575
DOC_USP7_MATH_1	135	139	PF00917	0.641
DOC_USP7_MATH_1	147	151	PF00917	0.543
DOC_USP7_MATH_1	153	157	PF00917	0.482
DOC_USP7_MATH_1	161	165	PF00917	0.452
DOC_USP7_MATH_1	202	206	PF00917	0.523
DOC_USP7_MATH_1	212	216	PF00917	0.554
DOC_USP7_MATH_1	217	221	PF00917	0.530
DOC_USP7_MATH_1	240	244	PF00917	0.565
DOC_USP7_MATH_1	301	305	PF00917	0.614
DOC_USP7_MATH_1	32	36	PF00917	0.625
DOC_USP7_MATH_1	426	430	PF00917	0.515
DOC_USP7_MATH_1	85	89	PF00917	0.532
DOC_WW_Pin1_4	148	153	PF00397	0.605
DOC_WW_Pin1_4	156	161	PF00397	0.534
DOC_WW_Pin1_4	368	373	PF00397	0.454
DOC_WW_Pin1_4	427	432	PF00397	0.508
DOC_WW_Pin1_4	50	55	PF00397	0.760
DOC_WW_Pin1_4	532	537	PF00397	0.599
LIG_14-3-3_CanoR_1	144	153	PF00244	0.655
LIG_14-3-3_CanoR_1	197	203	PF00244	0.483
LIG_14-3-3_CanoR_1	349	358	PF00244	0.525
LIG_14-3-3_CanoR_1	492	496	PF00244	0.469
LIG_APCC_ABBA_1	522	527	PF00400	0.516
LIG_BIR_II_1	1	5	PF00653	0.678
LIG_BRCT_BRCA1_1	534	538	PF00533	0.585
LIG_FHA_1	152	158	PF00498	0.565
LIG_FHA_1	211	217	PF00498	0.609
LIG_FHA_1	36	42	PF00498	0.648
LIG_FHA_1	448	454	PF00498	0.500
LIG_FHA_1	511	517	PF00498	0.595
LIG_FHA_1	521	527	PF00498	0.455
LIG_FHA_2	185	191	PF00498	0.456
LIG_FHA_2	275	281	PF00498	0.481
LIG_FHA_2	432	438	PF00498	0.399
LIG_FHA_2	75	81	PF00498	0.569
LIG_Integrin_isoDGR_2	347	349	PF01839	0.590
LIG_LIR_Apic_2	437	441	PF02991	0.350
LIG_LIR_Apic_2	534	540	PF02991	0.416
LIG_LIR_Gen_1	280	291	PF02991	0.410
LIG_LIR_Gen_1	459	470	PF02991	0.469
LIG_LIR_Nem_3	2	6	PF02991	0.547
LIG_LIR_Nem_3	280	286	PF02991	0.394
LIG_LIR_Nem_3	399	404	PF02991	0.459
LIG_LIR_Nem_3	459	465	PF02991	0.469
LIG_LIR_Nem_3	468	472	PF02991	0.516
LIG_LIR_Nem_3	76	82	PF02991	0.538
LIG_MLH1_MIPbox_1	534	538	PF16413	0.461
LIG_NRBOX	321	327	PF00104	0.386
LIG_NRBOX	331	337	PF00104	0.321
LIG_NRBOX	5	11	PF00104	0.539
LIG_PCNA_yPIPBox_3	319	327	PF02747	0.311
LIG_SH2_PTP2	469	472	PF00017	0.516
LIG_SH2_SRC	469	472	PF00017	0.516
LIG_SH2_STAP1	208	212	PF00017	0.546
LIG_SH2_STAP1	422	426	PF00017	0.415
LIG_SH2_STAP1	82	86	PF00017	0.481
LIG_SH2_STAT5	255	258	PF00017	0.402
LIG_SH2_STAT5	331	334	PF00017	0.323
LIG_SH2_STAT5	375	378	PF00017	0.375
LIG_SH2_STAT5	417	420	PF00017	0.347
LIG_SH2_STAT5	469	472	PF00017	0.611
LIG_SH3_1	359	365	PF00018	0.545
LIG_SH3_3	157	163	PF00018	0.576
LIG_SH3_3	216	222	PF00018	0.682
LIG_SH3_3	359	365	PF00018	0.545
LIG_UBA3_1	285	290	PF00899	0.473
MOD_CK1_1	129	135	PF00069	0.665
MOD_CK1_1	142	148	PF00069	0.560
MOD_CK1_1	156	162	PF00069	0.526
MOD_CK1_1	164	170	PF00069	0.440
MOD_CK1_1	215	221	PF00069	0.520
MOD_CK1_1	235	241	PF00069	0.517
MOD_CK1_1	244	250	PF00069	0.415
MOD_CK1_1	35	41	PF00069	0.636
MOD_CK1_1	350	356	PF00069	0.521
MOD_CK1_1	429	435	PF00069	0.547
MOD_CK1_1	74	80	PF00069	0.642
MOD_CK2_1	130	136	PF00069	0.624
MOD_CK2_1	184	190	PF00069	0.386
MOD_CK2_1	482	488	PF00069	0.471
MOD_GlcNHglycan	132	135	PF01048	0.742
MOD_GlcNHglycan	147	150	PF01048	0.537
MOD_GlcNHglycan	227	230	PF01048	0.636
MOD_GlcNHglycan	303	306	PF01048	0.682
MOD_GlcNHglycan	34	37	PF01048	0.640
MOD_GlcNHglycan	350	353	PF01048	0.674
MOD_GlcNHglycan	423	427	PF01048	0.417
MOD_GlcNHglycan	484	487	PF01048	0.269
MOD_GlcNHglycan	73	76	PF01048	0.580
MOD_GSK3_1	125	132	PF00069	0.657
MOD_GSK3_1	135	142	PF00069	0.589
MOD_GSK3_1	147	154	PF00069	0.588
MOD_GSK3_1	202	209	PF00069	0.561
MOD_GSK3_1	235	242	PF00069	0.597
MOD_GSK3_1	303	310	PF00069	0.735
MOD_GSK3_1	347	354	PF00069	0.546
MOD_GSK3_1	41	48	PF00069	0.628
MOD_GSK3_1	413	420	PF00069	0.474
MOD_GSK3_1	422	429	PF00069	0.389
MOD_GSK3_1	50	57	PF00069	0.761
MOD_GSK3_1	71	78	PF00069	0.625
MOD_N-GLC_1	129	134	PF02516	0.659
MOD_N-GLC_1	32	37	PF02516	0.625
MOD_N-GLC_1	50	55	PF02516	0.515
MOD_NEK2_1	102	107	PF00069	0.594
MOD_NEK2_1	404	409	PF00069	0.432
MOD_NEK2_1	41	46	PF00069	0.683
MOD_NEK2_1	531	536	PF00069	0.530
MOD_PIKK_1	217	223	PF00454	0.573
MOD_PIKK_1	35	41	PF00454	0.627
MOD_PIKK_1	510	516	PF00454	0.484
MOD_PKA_2	196	202	PF00069	0.475
MOD_PKA_2	268	274	PF00069	0.532
MOD_PKA_2	348	354	PF00069	0.516
MOD_PKA_2	491	497	PF00069	0.469
MOD_Plk_1	139	145	PF00069	0.537
MOD_Plk_1	274	280	PF00069	0.490
MOD_Plk_1	470	476	PF00069	0.469
MOD_Plk_1	520	526	PF00069	0.455
MOD_Plk_4	241	247	PF00069	0.511
MOD_Plk_4	274	280	PF00069	0.545
MOD_Plk_4	303	309	PF00069	0.492
MOD_Plk_4	413	419	PF00069	0.403
MOD_Plk_4	447	453	PF00069	0.609
MOD_Plk_4	520	526	PF00069	0.458
MOD_ProDKin_1	148	154	PF00069	0.606
MOD_ProDKin_1	156	162	PF00069	0.529
MOD_ProDKin_1	368	374	PF00069	0.451
MOD_ProDKin_1	427	433	PF00069	0.506
MOD_ProDKin_1	50	56	PF00069	0.763
MOD_ProDKin_1	532	538	PF00069	0.592
MOD_SUMO_for_1	289	292	PF00179	0.497
TRG_DiLeu_BaEn_2	520	526	PF01217	0.469
TRG_DiLeu_BaEn_4	317	323	PF01217	0.406
TRG_DiLeu_BaLyEn_6	384	389	PF01217	0.393
TRG_ENDOCYTIC_2	375	378	PF00928	0.375
TRG_ENDOCYTIC_2	469	472	PF00928	0.611
TRG_ER_diArg_1	491	493	PF00400	0.487
TRG_ER_diArg_1	500	503	PF00400	0.518
TRG_NES_CRM1_1	176	190	PF08389	0.412
TRG_NES_CRM1_1	275	288	PF08389	0.472
TRG_NES_CRM1_1	324	338	PF08389	0.395
TRG_NES_CRM1_1	443	457	PF08389	0.455
TRG_NES_CRM1_1	514	527	PF08389	0.484
TRG_Pf-PMV_PEXEL_1	250	254	PF00026	0.446
TRG_Pf-PMV_PEXEL_1	320	324	PF00026	0.388
TRG_Pf-PMV_PEXEL_1	392	396	PF00026	0.456
TRG_Pf-PMV_PEXEL_1	454	458	PF00026	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I883	Leptomonas seymouri	44%	100%
A0A3Q8ICC8	Leishmania donovani	90%	99%
A4HCE1	Leishmania braziliensis	73%	100%
A4HZW5	Leishmania infantum	90%	99%
E9AVS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%