AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial chaperone, putative

Species:

Leishmania major

UniProt:

Q4QBQ4_LEIMA

TriTrypDb:

LmjF.22.0930 , LMJLV39_220014500 , LMJLV39_220014600 , LMJSD75_220015000

Length:

718

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

Q4QBQ4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBQ4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	18
GO:0003824	catalytic activity	1	18
GO:0005488	binding	1	18
GO:0005524	ATP binding	5	18
GO:0016462	pyrophosphatase activity	5	18
GO:0016787	hydrolase activity	2	18
GO:0016817	hydrolase activity, acting on acid anhydrides	3	18
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	18
GO:0016887	ATP hydrolysis activity	7	18
GO:0017076	purine nucleotide binding	4	18
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	18
GO:0030554	adenyl nucleotide binding	5	18
GO:0032553	ribonucleotide binding	3	18
GO:0032555	purine ribonucleotide binding	4	18
GO:0032559	adenyl ribonucleotide binding	5	18
GO:0035639	purine ribonucleoside triphosphate binding	4	18
GO:0036094	small molecule binding	2	18
GO:0043167	ion binding	2	18
GO:0043168	anion binding	3	18
GO:0097159	organic cyclic compound binding	2	18
GO:0097367	carbohydrate derivative binding	2	18
GO:1901265	nucleoside phosphate binding	3	18
GO:1901363	heterocyclic compound binding	2	18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	36	40	PF00656	0.434
CLV_C14_Caspase3-7	379	383	PF00656	0.594
CLV_C14_Caspase3-7	397	401	PF00656	0.414
CLV_C14_Caspase3-7	471	475	PF00656	0.701
CLV_C14_Caspase3-7	9	13	PF00656	0.379
CLV_NRD_NRD_1	225	227	PF00675	0.379
CLV_NRD_NRD_1	247	249	PF00675	0.346
CLV_NRD_NRD_1	313	315	PF00675	0.405
CLV_NRD_NRD_1	412	414	PF00675	0.301
CLV_NRD_NRD_1	417	419	PF00675	0.309
CLV_NRD_NRD_1	490	492	PF00675	0.556
CLV_NRD_NRD_1	597	599	PF00675	0.584
CLV_PCSK_KEX2_1	225	227	PF00082	0.371
CLV_PCSK_KEX2_1	247	249	PF00082	0.330
CLV_PCSK_KEX2_1	313	315	PF00082	0.452
CLV_PCSK_KEX2_1	412	414	PF00082	0.317
CLV_PCSK_KEX2_1	417	419	PF00082	0.321
CLV_PCSK_KEX2_1	490	492	PF00082	0.634
CLV_PCSK_KEX2_1	597	599	PF00082	0.584
CLV_PCSK_PC7_1	413	419	PF00082	0.329
CLV_PCSK_SKI1_1	188	192	PF00082	0.355
CLV_PCSK_SKI1_1	247	251	PF00082	0.332
CLV_PCSK_SKI1_1	266	270	PF00082	0.311
CLV_PCSK_SKI1_1	278	282	PF00082	0.405
CLV_PCSK_SKI1_1	300	304	PF00082	0.368
CLV_PCSK_SKI1_1	338	342	PF00082	0.315
CLV_PCSK_SKI1_1	68	72	PF00082	0.450
DEG_APCC_DBOX_1	185	193	PF00400	0.508
DEG_APCC_DBOX_1	570	578	PF00400	0.564
DOC_ANK_TNKS_1	315	322	PF00023	0.594
DOC_CKS1_1	685	690	PF01111	0.629
DOC_CYCLIN_RxL_1	65	73	PF00134	0.664
DOC_CYCLIN_yClb1_LxF_4	323	328	PF00134	0.533
DOC_CYCLIN_yCln2_LP_2	55	61	PF00134	0.308
DOC_MAPK_gen_1	287	297	PF00069	0.666
DOC_MAPK_gen_1	386	395	PF00069	0.543
DOC_MAPK_gen_1	564	574	PF00069	0.564
DOC_MAPK_MEF2A_6	351	358	PF00069	0.492
DOC_MAPK_MEF2A_6	567	574	PF00069	0.573
DOC_PP1_RVXF_1	276	282	PF00149	0.599
DOC_PP1_RVXF_1	323	329	PF00149	0.531
DOC_SPAK_OSR1_1	316	320	PF12202	0.603
DOC_SPAK_OSR1_1	567	571	PF12202	0.618
DOC_SPAK_OSR1_1	683	687	PF12202	0.555
DOC_USP7_MATH_1	13	17	PF00917	0.448
DOC_USP7_MATH_1	131	135	PF00917	0.570
DOC_USP7_MATH_1	149	153	PF00917	0.480
DOC_USP7_MATH_1	199	203	PF00917	0.486
DOC_USP7_MATH_1	401	405	PF00917	0.524
DOC_USP7_MATH_1	470	474	PF00917	0.623
DOC_USP7_UBL2_3	191	195	PF12436	0.488
DOC_WW_Pin1_4	158	163	PF00397	0.589
DOC_WW_Pin1_4	684	689	PF00397	0.541
LIG_14-3-3_CanoR_1	225	231	PF00244	0.583
LIG_14-3-3_CanoR_1	351	357	PF00244	0.480
LIG_14-3-3_CanoR_1	422	429	PF00244	0.526
LIG_14-3-3_CanoR_1	567	571	PF00244	0.566
LIG_APCC_ABBA_1	250	255	PF00400	0.602
LIG_APCC_ABBA_1	393	398	PF00400	0.515
LIG_BRCT_BRCA1_1	133	137	PF00533	0.507
LIG_CSL_BTD_1	196	199	PF09270	0.433
LIG_EVH1_2	100	104	PF00568	0.545
LIG_FHA_1	139	145	PF00498	0.590
LIG_FHA_1	225	231	PF00498	0.478
LIG_FHA_1	301	307	PF00498	0.564
LIG_FHA_1	433	439	PF00498	0.630
LIG_FHA_2	143	149	PF00498	0.620
LIG_FHA_2	213	219	PF00498	0.517
LIG_FHA_2	4	10	PF00498	0.383
LIG_FHA_2	685	691	PF00498	0.602
LIG_LIR_Apic_2	161	167	PF02991	0.610
LIG_LIR_Apic_2	218	222	PF02991	0.512
LIG_LIR_Apic_2	556	560	PF02991	0.583
LIG_LIR_Gen_1	12	22	PF02991	0.402
LIG_LIR_Gen_1	48	59	PF02991	0.317
LIG_LIR_Gen_1	575	583	PF02991	0.532
LIG_LIR_Nem_3	12	17	PF02991	0.402
LIG_LIR_Nem_3	48	54	PF02991	0.335
LIG_MLH1_MIPbox_1	133	137	PF16413	0.507
LIG_NRBOX	529	535	PF00104	0.557
LIG_PCNA_PIPBox_1	698	707	PF02747	0.572
LIG_PDZ_Class_2	713	718	PF00595	0.587
LIG_Pex14_1	267	271	PF04695	0.566
LIG_Pex14_2	292	296	PF04695	0.531
LIG_Pex14_2	372	376	PF04695	0.469
LIG_Rb_pABgroove_1	390	398	PF01858	0.515
LIG_REV1ctd_RIR_1	369	378	PF16727	0.488
LIG_RPA_C_Fungi	407	419	PF08784	0.345
LIG_SH2_CRK	331	335	PF00017	0.317
LIG_SH2_GRB2like	138	141	PF00017	0.505
LIG_SH2_PTP2	164	167	PF00017	0.412
LIG_SH2_PTP2	51	54	PF00017	0.348
LIG_SH2_STAP1	29	33	PF00017	0.427
LIG_SH2_STAP1	368	372	PF00017	0.342
LIG_SH2_STAT3	29	32	PF00017	0.577
LIG_SH2_STAT3	682	685	PF00017	0.479
LIG_SH2_STAT5	121	124	PF00017	0.374
LIG_SH2_STAT5	164	167	PF00017	0.421
LIG_SH2_STAT5	208	211	PF00017	0.564
LIG_SH2_STAT5	284	287	PF00017	0.485
LIG_SH2_STAT5	33	36	PF00017	0.435
LIG_SH2_STAT5	51	54	PF00017	0.227
LIG_SH2_STAT5	90	93	PF00017	0.456
LIG_SH3_3	102	108	PF00018	0.433
LIG_SH3_3	156	162	PF00018	0.488
LIG_SH3_3	327	333	PF00018	0.372
LIG_SH3_3	351	357	PF00018	0.463
LIG_SH3_3	538	544	PF00018	0.440
LIG_SH3_3	63	69	PF00018	0.484
LIG_SH3_3	83	89	PF00018	0.423
LIG_SH3_3	94	100	PF00018	0.335
LIG_SUMO_SIM_anti_2	303	308	PF11976	0.432
LIG_SUMO_SIM_par_1	141	148	PF11976	0.385
LIG_SUMO_SIM_par_1	211	218	PF11976	0.327
LIG_SUMO_SIM_par_1	547	553	PF11976	0.405
LIG_TYR_ITIM	588	593	PF00017	0.593
LIG_UBA3_1	189	195	PF00899	0.336
MOD_CK1_1	3	9	PF00069	0.511
MOD_CK1_1	674	680	PF00069	0.633
MOD_CK1_1	78	84	PF00069	0.546
MOD_CK2_1	684	690	PF00069	0.391
MOD_Cter_Amidation	488	491	PF01082	0.824
MOD_GlcNHglycan	237	240	PF01048	0.522
MOD_GlcNHglycan	529	533	PF01048	0.373
MOD_GlcNHglycan	599	602	PF01048	0.651
MOD_GlcNHglycan	674	677	PF01048	0.718
MOD_GSK3_1	138	145	PF00069	0.371
MOD_GSK3_1	149	156	PF00069	0.485
MOD_GSK3_1	33	40	PF00069	0.563
MOD_GSK3_1	352	359	PF00069	0.493
MOD_GSK3_1	41	48	PF00069	0.635
MOD_GSK3_1	494	501	PF00069	0.691
MOD_GSK3_1	593	600	PF00069	0.662
MOD_GSK3_1	667	674	PF00069	0.686
MOD_LATS_1	595	601	PF00433	0.594
MOD_N-GLC_1	170	175	PF02516	0.506
MOD_NEK2_1	41	46	PF00069	0.581
MOD_NEK2_1	441	446	PF00069	0.696
MOD_NEK2_1	528	533	PF00069	0.479
MOD_NEK2_1	70	75	PF00069	0.535
MOD_NEK2_1	76	81	PF00069	0.478
MOD_NEK2_2	291	296	PF00069	0.450
MOD_NEK2_2	566	571	PF00069	0.435
MOD_PIKK_1	703	709	PF00454	0.431
MOD_PKA_1	597	603	PF00069	0.611
MOD_PKA_2	224	230	PF00069	0.439
MOD_PKA_2	421	427	PF00069	0.377
MOD_PKA_2	566	572	PF00069	0.456
MOD_PKA_2	597	603	PF00069	0.698
MOD_PKA_2	712	718	PF00069	0.511
MOD_Plk_1	217	223	PF00069	0.500
MOD_Plk_1	300	306	PF00069	0.484
MOD_Plk_2-3	212	218	PF00069	0.335
MOD_Plk_4	142	148	PF00069	0.404
MOD_Plk_4	291	297	PF00069	0.412
MOD_Plk_4	302	308	PF00069	0.405
MOD_Plk_4	37	43	PF00069	0.530
MOD_Plk_4	401	407	PF00069	0.488
MOD_Plk_4	45	51	PF00069	0.580
MOD_Plk_4	578	584	PF00069	0.372
MOD_Plk_4	70	76	PF00069	0.644
MOD_ProDKin_1	158	164	PF00069	0.473
MOD_ProDKin_1	684	690	PF00069	0.407
MOD_SUMO_for_1	209	212	PF00179	0.321
TRG_DiLeu_BaEn_1	185	190	PF01217	0.359
TRG_DiLeu_BaEn_1	578	583	PF01217	0.516
TRG_DiLeu_BaEn_2	389	395	PF01217	0.342
TRG_DiLeu_BaLyEn_6	66	71	PF01217	0.578
TRG_DiLeu_LyEn_5	185	190	PF01217	0.341
TRG_ENDOCYTIC_2	368	371	PF00928	0.317
TRG_ENDOCYTIC_2	51	54	PF00928	0.445
TRG_ENDOCYTIC_2	57	60	PF00928	0.264
TRG_ENDOCYTIC_2	576	579	PF00928	0.398
TRG_ENDOCYTIC_2	590	593	PF00928	0.444
TRG_ER_diArg_1	186	189	PF00400	0.467
TRG_ER_diArg_1	224	226	PF00400	0.418
TRG_ER_diArg_1	230	233	PF00400	0.472
TRG_ER_diArg_1	246	248	PF00400	0.416
TRG_ER_diArg_1	313	316	PF00400	0.541
TRG_ER_diArg_1	412	414	PF00400	0.369
TRG_ER_diArg_1	570	573	PF00400	0.449
TRG_NES_CRM1_1	578	592	PF08389	0.443
TRG_Pf-PMV_PEXEL_1	640	644	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	68	72	PF00026	0.516

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P906	Leptomonas seymouri	31%	98%
A0A1X0NTT2	Trypanosomatidae	36%	100%
A0A3Q8IC80	Leishmania donovani	74%	98%
A0A3Q8IC95	Leishmania donovani	90%	99%
A0A3Q8IHZ0	Leishmania donovani	29%	100%
A0A422NUH1	Trypanosoma rangeli	34%	100%
A4HCE5	Leishmania braziliensis	65%	100%
A4HZW7	Leishmania infantum	91%	100%
A4IDZ9	Leishmania infantum	29%	100%
C9ZSJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AU21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AVS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	99%
E9AVS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	98%
Q4Q0H4	Leishmania major	28%	100%
Q4QBQ3	Leishmania major	80%	100%
V5DMJ8	Trypanosoma cruzi	33%	100%