AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

mitochondrial chaperone, putative

Species:

Leishmania major

UniProt:

Q4QBQ3_LEIMA

TriTrypDb:

LmjF.22.0940 , LMJLV39_220014700 , LMJSD75_220015000

Length:

731

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 17
NetGPI	no	yes: 0, no: 17

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	8
GO:0110165	cellular anatomical entity	1	8

Expansion

Sequence features

Q4QBQ3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBQ3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	18
GO:0003824	catalytic activity	1	18
GO:0005488	binding	1	18
GO:0005524	ATP binding	5	18
GO:0016462	pyrophosphatase activity	5	18
GO:0016787	hydrolase activity	2	18
GO:0016817	hydrolase activity, acting on acid anhydrides	3	18
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	18
GO:0016887	ATP hydrolysis activity	7	18
GO:0017076	purine nucleotide binding	4	18
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	18
GO:0030554	adenyl nucleotide binding	5	18
GO:0032553	ribonucleotide binding	3	18
GO:0032555	purine ribonucleotide binding	4	18
GO:0032559	adenyl ribonucleotide binding	5	18
GO:0035639	purine ribonucleoside triphosphate binding	4	18
GO:0036094	small molecule binding	2	18
GO:0043167	ion binding	2	18
GO:0043168	anion binding	3	18
GO:0097159	organic cyclic compound binding	2	18
GO:0097367	carbohydrate derivative binding	2	18
GO:1901265	nucleoside phosphate binding	3	18
GO:1901363	heterocyclic compound binding	2	18

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	182	186	PF00656	0.749
CLV_C14_Caspase3-7	392	396	PF00656	0.495
CLV_C14_Caspase3-7	410	414	PF00656	0.504
CLV_C14_Caspase3-7	484	488	PF00656	0.775
CLV_NRD_NRD_1	260	262	PF00675	0.357
CLV_NRD_NRD_1	326	328	PF00675	0.418
CLV_NRD_NRD_1	425	427	PF00675	0.312
CLV_NRD_NRD_1	430	432	PF00675	0.320
CLV_NRD_NRD_1	503	505	PF00675	0.617
CLV_NRD_NRD_1	610	612	PF00675	0.586
CLV_PCSK_KEX2_1	229	231	PF00082	0.410
CLV_PCSK_KEX2_1	26	28	PF00082	0.601
CLV_PCSK_KEX2_1	260	262	PF00082	0.340
CLV_PCSK_KEX2_1	326	328	PF00082	0.462
CLV_PCSK_KEX2_1	425	427	PF00082	0.328
CLV_PCSK_KEX2_1	430	432	PF00082	0.332
CLV_PCSK_KEX2_1	503	505	PF00082	0.604
CLV_PCSK_KEX2_1	610	612	PF00082	0.586
CLV_PCSK_PC1ET2_1	229	231	PF00082	0.344
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.601
CLV_PCSK_PC7_1	426	432	PF00082	0.339
CLV_PCSK_SKI1_1	158	162	PF00082	0.385
CLV_PCSK_SKI1_1	201	205	PF00082	0.373
CLV_PCSK_SKI1_1	260	264	PF00082	0.314
CLV_PCSK_SKI1_1	279	283	PF00082	0.308
CLV_PCSK_SKI1_1	291	295	PF00082	0.307
CLV_PCSK_SKI1_1	313	317	PF00082	0.377
CLV_PCSK_SKI1_1	351	355	PF00082	0.391
DEG_APCC_DBOX_1	583	591	PF00400	0.571
DEG_Nend_UBRbox_3	1	3	PF02207	0.448
DEG_SPOP_SBC_1	9	13	PF00917	0.399
DOC_ANK_TNKS_1	328	335	PF00023	0.597
DOC_CKS1_1	698	703	PF01111	0.638
DOC_CYCLIN_yClb1_LxF_4	336	341	PF00134	0.548
DOC_CYCLIN_yCln2_LP_2	74	80	PF00134	0.308
DOC_MAPK_gen_1	199	207	PF00069	0.594
DOC_MAPK_gen_1	235	243	PF00069	0.627
DOC_MAPK_gen_1	300	310	PF00069	0.584
DOC_MAPK_gen_1	399	408	PF00069	0.543
DOC_MAPK_gen_1	577	587	PF00069	0.583
DOC_MAPK_MEF2A_6	201	209	PF00069	0.562
DOC_MAPK_MEF2A_6	364	371	PF00069	0.504
DOC_MAPK_MEF2A_6	580	587	PF00069	0.588
DOC_PIKK_1	120	128	PF02985	0.554
DOC_PP1_RVXF_1	289	295	PF00149	0.605
DOC_PP1_RVXF_1	336	342	PF00149	0.536
DOC_SPAK_OSR1_1	329	333	PF12202	0.606
DOC_SPAK_OSR1_1	580	584	PF12202	0.631
DOC_SPAK_OSR1_1	696	700	PF12202	0.563
DOC_USP7_MATH_1	15	19	PF00917	0.569
DOC_USP7_MATH_1	414	418	PF00917	0.524
DOC_USP7_MATH_1	483	487	PF00917	0.733
DOC_USP7_MATH_1	7	11	PF00917	0.404
DOC_WW_Pin1_4	172	177	PF00397	0.617
DOC_WW_Pin1_4	697	702	PF00397	0.558
LIG_14-3-3_CanoR_1	166	172	PF00244	0.607
LIG_14-3-3_CanoR_1	238	244	PF00244	0.612
LIG_14-3-3_CanoR_1	364	370	PF00244	0.491
LIG_14-3-3_CanoR_1	435	442	PF00244	0.527
LIG_14-3-3_CanoR_1	580	584	PF00244	0.582
LIG_APCC_ABBA_1	116	121	PF00400	0.578
LIG_APCC_ABBA_1	211	216	PF00400	0.445
LIG_APCC_ABBA_1	263	268	PF00400	0.603
LIG_APCC_ABBA_1	406	411	PF00400	0.515
LIG_deltaCOP1_diTrp_1	62	71	PF00928	0.476
LIG_eIF4E_1	105	111	PF01652	0.512
LIG_EVH1_1	65	69	PF00568	0.343
LIG_FHA_1	192	198	PF00498	0.618
LIG_FHA_1	314	320	PF00498	0.567
LIG_FHA_1	446	452	PF00498	0.725
LIG_FHA_1	68	74	PF00498	0.295
LIG_FHA_1	9	15	PF00498	0.530
LIG_FHA_2	251	257	PF00498	0.529
LIG_FHA_2	698	704	PF00498	0.613
LIG_LIR_Apic_2	170	176	PF02991	0.635
LIG_LIR_Apic_2	569	573	PF02991	0.607
LIG_LIR_Apic_2	62	66	PF02991	0.473
LIG_LIR_Gen_1	127	137	PF02991	0.608
LIG_LIR_Gen_1	29	38	PF02991	0.547
LIG_LIR_Gen_1	588	596	PF02991	0.549
LIG_LIR_Gen_1	70	79	PF02991	0.335
LIG_LIR_Gen_1	91	101	PF02991	0.566
LIG_LIR_Nem_3	127	133	PF02991	0.627
LIG_LIR_Nem_3	163	168	PF02991	0.633
LIG_LIR_Nem_3	208	213	PF02991	0.556
LIG_LIR_Nem_3	29	35	PF02991	0.555
LIG_LIR_Nem_3	62	67	PF02991	0.482
LIG_LIR_Nem_3	70	74	PF02991	0.341
LIG_LIR_Nem_3	91	96	PF02991	0.553
LIG_NRBOX	542	548	PF00104	0.571
LIG_PCNA_PIPBox_1	711	720	PF02747	0.576
LIG_PCNA_TLS_4	204	211	PF02747	0.484
LIG_PDZ_Class_2	726	731	PF00595	0.591
LIG_Pex14_1	280	284	PF04695	0.559
LIG_Pex14_2	305	309	PF04695	0.540
LIG_Pex14_2	385	389	PF04695	0.469
LIG_Pex14_2	67	71	PF04695	0.457
LIG_Pex3_1	46	57	PF04882	0.314
LIG_Rb_pABgroove_1	403	411	PF01858	0.515
LIG_REV1ctd_RIR_1	382	391	PF16727	0.488
LIG_RPA_C_Fungi	420	432	PF08784	0.345
LIG_SH2_CRK	173	177	PF00017	0.505
LIG_SH2_CRK	344	348	PF00017	0.332
LIG_SH2_CRK	98	102	PF00017	0.409
LIG_SH2_NCK_1	119	123	PF00017	0.464
LIG_SH2_NCK_1	173	177	PF00017	0.491
LIG_SH2_SRC	119	122	PF00017	0.560
LIG_SH2_SRC	210	213	PF00017	0.332
LIG_SH2_STAP1	105	109	PF00017	0.585
LIG_SH2_STAP1	381	385	PF00017	0.352
LIG_SH2_STAT3	695	698	PF00017	0.489
LIG_SH2_STAT5	136	139	PF00017	0.393
LIG_SH2_STAT5	210	213	PF00017	0.415
LIG_SH2_STAT5	222	225	PF00017	0.558
LIG_SH2_STAT5	297	300	PF00017	0.566
LIG_SH3_1	63	69	PF00018	0.446
LIG_SH3_3	200	206	PF00018	0.411
LIG_SH3_3	340	346	PF00018	0.372
LIG_SH3_3	364	370	PF00018	0.471
LIG_SH3_3	551	557	PF00018	0.442
LIG_SH3_3	63	69	PF00018	0.573
LIG_SUMO_SIM_anti_2	316	321	PF11976	0.436
LIG_SUMO_SIM_anti_2	70	76	PF11976	0.346
LIG_SUMO_SIM_par_1	560	566	PF11976	0.424
LIG_TYR_ITIM	601	606	PF00017	0.593
LIG_TYR_ITIM	96	101	PF00017	0.404
LIG_WRC_WIRS_1	168	173	PF05994	0.386
MOD_CDC14_SPxK_1	175	178	PF00782	0.472
MOD_CDK_SPxK_1	172	178	PF00069	0.475
MOD_CK1_1	10	16	PF00069	0.695
MOD_CK1_1	20	26	PF00069	0.569
MOD_CK1_1	36	42	PF00069	0.378
MOD_CK1_1	687	693	PF00069	0.727
MOD_CK1_1	92	98	PF00069	0.493
MOD_CK2_1	121	127	PF00069	0.403
MOD_CK2_1	697	703	PF00069	0.414
MOD_Cter_Amidation	501	504	PF01082	0.829
MOD_GlcNHglycan	35	38	PF01048	0.566
MOD_GlcNHglycan	54	57	PF01048	0.598
MOD_GlcNHglycan	542	546	PF01048	0.378
MOD_GlcNHglycan	612	615	PF01048	0.633
MOD_GlcNHglycan	687	690	PF01048	0.767
MOD_GlcNHglycan	98	101	PF01048	0.516
MOD_GSK3_1	191	198	PF00069	0.452
MOD_GSK3_1	246	253	PF00069	0.475
MOD_GSK3_1	365	372	PF00069	0.442
MOD_GSK3_1	507	514	PF00069	0.704
MOD_GSK3_1	606	613	PF00069	0.654
MOD_GSK3_1	680	687	PF00069	0.698
MOD_GSK3_1	88	95	PF00069	0.546
MOD_GSK3_1	9	16	PF00069	0.752
MOD_LATS_1	608	614	PF00433	0.590
MOD_N-GLC_1	1	6	PF02516	0.672
MOD_N-GLC_1	239	244	PF02516	0.329
MOD_N-GLC_1	246	251	PF02516	0.344
MOD_NEK2_1	1	6	PF00069	0.708
MOD_NEK2_1	454	459	PF00069	0.756
MOD_NEK2_1	49	54	PF00069	0.648
MOD_NEK2_1	541	546	PF00069	0.487
MOD_NEK2_1	79	84	PF00069	0.313
MOD_NEK2_2	304	309	PF00069	0.449
MOD_NEK2_2	579	584	PF00069	0.462
MOD_PIKK_1	716	722	PF00454	0.435
MOD_PKA_1	610	616	PF00069	0.614
MOD_PKA_2	234	240	PF00069	0.505
MOD_PKA_2	434	440	PF00069	0.399
MOD_PKA_2	579	585	PF00069	0.481
MOD_PKA_2	610	616	PF00069	0.711
MOD_PKA_2	725	731	PF00069	0.530
MOD_Plk_1	223	229	PF00069	0.438
MOD_Plk_1	239	245	PF00069	0.292
MOD_Plk_1	313	319	PF00069	0.525
MOD_Plk_2-3	121	127	PF00069	0.403
MOD_Plk_4	137	143	PF00069	0.412
MOD_Plk_4	17	23	PF00069	0.696
MOD_Plk_4	304	310	PF00069	0.426
MOD_Plk_4	315	321	PF00069	0.408
MOD_Plk_4	414	420	PF00069	0.376
MOD_Plk_4	591	597	PF00069	0.510
MOD_Plk_4	67	73	PF00069	0.566
MOD_Plk_4	89	95	PF00069	0.560
MOD_ProDKin_1	172	178	PF00069	0.518
MOD_ProDKin_1	697	703	PF00069	0.430
MOD_SUMO_for_1	192	195	PF00179	0.495
TRG_DiLeu_BaEn_1	591	596	PF01217	0.531
TRG_DiLeu_BaEn_2	402	408	PF01217	0.358
TRG_DiLeu_BaLyEn_6	148	153	PF01217	0.375
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.460
TRG_ENDOCYTIC_2	119	122	PF00928	0.662
TRG_ENDOCYTIC_2	168	171	PF00928	0.465
TRG_ENDOCYTIC_2	210	213	PF00928	0.426
TRG_ENDOCYTIC_2	381	384	PF00928	0.332
TRG_ENDOCYTIC_2	589	592	PF00928	0.420
TRG_ENDOCYTIC_2	603	606	PF00928	0.419
TRG_ENDOCYTIC_2	98	101	PF00928	0.672
TRG_ER_diArg_1	199	202	PF00400	0.513
TRG_ER_diArg_1	259	261	PF00400	0.433
TRG_ER_diArg_1	326	329	PF00400	0.558
TRG_ER_diArg_1	425	427	PF00400	0.371
TRG_ER_diArg_1	583	586	PF00400	0.457
TRG_NES_CRM1_1	591	605	PF08389	0.444
TRG_Pf-PMV_PEXEL_1	108	113	PF00026	0.363
TRG_Pf-PMV_PEXEL_1	145	149	PF00026	0.440
TRG_Pf-PMV_PEXEL_1	653	657	PF00026	0.483

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P906	Leptomonas seymouri	31%	99%
A0A1X0NTT2	Trypanosomatidae	35%	100%
A0A3Q8IC80	Leishmania donovani	91%	99%
A0A3Q8IC95	Leishmania donovani	75%	100%
A0A3Q8IHZ0	Leishmania donovani	29%	100%
A0A422NUH1	Trypanosoma rangeli	34%	100%
A4HCE5	Leishmania braziliensis	75%	100%
A4HZW7	Leishmania infantum	75%	100%
A4IDZ9	Leishmania infantum	29%	100%
C9ZSJ9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AU21	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9AVS5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
E9AVS6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q0H4	Leishmania major	28%	100%
Q4QBQ4	Leishmania major	80%	100%
V5DMJ8	Trypanosoma cruzi	33%	100%