WD_REPEATS_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

F-box and WD40 domain containing protein

Species:

Leishmania major

UniProt:

Q4QBP9_LEIMA

TriTrypDb:

LmjF.22.0980 , LMJLV39_220015300 , LMJSD75_220015500

Length:

706

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005681	spliceosomal complex	3	2
GO:0010494	cytoplasmic stress granule	5	2
GO:0032991	protein-containing complex	1	4
GO:0035770	ribonucleoprotein granule	3	2
GO:0036464	cytoplasmic ribonucleoprotein granule	4	2
GO:0043226	organelle	2	4
GO:0043228	non-membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043232	intracellular non-membrane-bounded organelle	4	4
GO:0071013	catalytic step 2 spliceosome	3	2
GO:0099080	supramolecular complex	2	2
GO:0110165	cellular anatomical entity	1	4
GO:0140513	nuclear protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1990904	ribonucleoprotein complex	2	4
GO:0005840	ribosome	5	2

Expansion

Sequence features

Q4QBP9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBP9

Function

Biological processes
Term	Name	Level	Count
GO:0000375	RNA splicing, via transesterification reactions	8	2
GO:0000377	RNA splicing, via transesterification reactions with bulged adenosine as nucleophile	9	2
GO:0000398	mRNA splicing, via spliceosome	8	2
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006396	RNA processing	6	2
GO:0006397	mRNA processing	7	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0008380	RNA splicing	7	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016071	mRNA metabolic process	6	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.406
CLV_C14_Caspase3-7	309	313	PF00656	0.537
CLV_C14_Caspase3-7	68	72	PF00656	0.650
CLV_NRD_NRD_1	253	255	PF00675	0.525
CLV_NRD_NRD_1	270	272	PF00675	0.302
CLV_NRD_NRD_1	400	402	PF00675	0.522
CLV_PCSK_KEX2_1	253	255	PF00082	0.525
CLV_PCSK_KEX2_1	270	272	PF00082	0.533
CLV_PCSK_KEX2_1	631	633	PF00082	0.462
CLV_PCSK_PC1ET2_1	631	633	PF00082	0.386
CLV_PCSK_SKI1_1	151	155	PF00082	0.389
CLV_PCSK_SKI1_1	187	191	PF00082	0.543
CLV_PCSK_SKI1_1	259	263	PF00082	0.543
CLV_PCSK_SKI1_1	649	653	PF00082	0.409
DEG_APCC_DBOX_1	150	158	PF00400	0.351
DEG_APCC_DBOX_1	186	194	PF00400	0.358
DEG_Nend_Nbox_1	1	3	PF02207	0.741
DEG_SPOP_SBC_1	415	419	PF00917	0.557
DOC_CYCLIN_yClb1_LxF_4	523	528	PF00134	0.422
DOC_MAPK_DCC_7	365	374	PF00069	0.462
DOC_MAPK_FxFP_2	635	638	PF00069	0.394
DOC_MAPK_gen_1	117	125	PF00069	0.298
DOC_MAPK_gen_1	251	258	PF00069	0.418
DOC_MAPK_gen_1	365	372	PF00069	0.464
DOC_MAPK_gen_1	469	477	PF00069	0.362
DOC_MAPK_HePTP_8	362	374	PF00069	0.452
DOC_MAPK_MEF2A_6	182	190	PF00069	0.362
DOC_MAPK_MEF2A_6	205	213	PF00069	0.358
DOC_MAPK_MEF2A_6	281	288	PF00069	0.372
DOC_MAPK_MEF2A_6	365	374	PF00069	0.427
DOC_MAPK_MEF2A_6	656	663	PF00069	0.403
DOC_PP1_RVXF_1	523	529	PF00149	0.419
DOC_PP2B_LxvP_1	477	480	PF13499	0.289
DOC_PP4_FxxP_1	61	64	PF00568	0.620
DOC_PP4_FxxP_1	635	638	PF00568	0.394
DOC_SPAK_OSR1_1	281	285	PF12202	0.333
DOC_USP7_MATH_1	140	144	PF00917	0.434
DOC_USP7_MATH_1	22	26	PF00917	0.588
DOC_USP7_MATH_1	345	349	PF00917	0.611
DOC_USP7_MATH_1	35	39	PF00917	0.591
DOC_USP7_MATH_1	360	364	PF00917	0.506
DOC_USP7_MATH_1	397	401	PF00917	0.485
DOC_USP7_UBL2_3	402	406	PF12436	0.512
DOC_WW_Pin1_4	293	298	PF00397	0.558
DOC_WW_Pin1_4	38	43	PF00397	0.650
DOC_WW_Pin1_4	45	50	PF00397	0.766
DOC_WW_Pin1_4	578	583	PF00397	0.502
LIG_14-3-3_CanoR_1	525	529	PF00244	0.411
LIG_14-3-3_CanoR_1	656	662	PF00244	0.405
LIG_BIR_III_4	76	80	PF00653	0.561
LIG_deltaCOP1_diTrp_1	120	124	PF00928	0.365
LIG_EH1_1	182	190	PF00400	0.362
LIG_FHA_1	225	231	PF00498	0.529
LIG_FHA_1	39	45	PF00498	0.501
LIG_FHA_1	579	585	PF00498	0.426
LIG_FHA_1	588	594	PF00498	0.502
LIG_FHA_1	609	615	PF00498	0.335
LIG_FHA_1	653	659	PF00498	0.440
LIG_FHA_1	677	683	PF00498	0.554
LIG_FHA_1	92	98	PF00498	0.459
LIG_FHA_2	144	150	PF00498	0.437
LIG_FHA_2	460	466	PF00498	0.376
LIG_FHA_2	550	556	PF00498	0.411
LIG_FHA_2	63	69	PF00498	0.617
LIG_FHA_2	97	103	PF00498	0.474
LIG_GBD_Chelix_1	184	192	PF00786	0.404
LIG_LIR_Apic_2	340	345	PF02991	0.511
LIG_LIR_Apic_2	58	64	PF02991	0.620
LIG_LIR_Gen_1	120	126	PF02991	0.363
LIG_LIR_Gen_1	166	175	PF02991	0.494
LIG_LIR_Gen_1	204	214	PF02991	0.444
LIG_LIR_Gen_1	299	306	PF02991	0.580
LIG_LIR_Gen_1	387	398	PF02991	0.393
LIG_LIR_Gen_1	527	536	PF02991	0.427
LIG_LIR_Gen_1	604	615	PF02991	0.440
LIG_LIR_Nem_3	120	125	PF02991	0.415
LIG_LIR_Nem_3	166	170	PF02991	0.494
LIG_LIR_Nem_3	204	209	PF02991	0.435
LIG_LIR_Nem_3	299	304	PF02991	0.581
LIG_LIR_Nem_3	387	393	PF02991	0.399
LIG_LIR_Nem_3	527	531	PF02991	0.399
LIG_LIR_Nem_3	556	562	PF02991	0.376
LIG_LIR_Nem_3	604	610	PF02991	0.450
LIG_LYPXL_SIV_4	636	644	PF13949	0.400
LIG_PDZ_Class_1	701	706	PF00595	0.402
LIG_RPA_C_Fungi	248	260	PF08784	0.313
LIG_SH2_CRK	301	305	PF00017	0.586
LIG_SH2_CRK	607	611	PF00017	0.402
LIG_SH2_GRB2like	163	166	PF00017	0.380
LIG_SH2_NCK_1	607	611	PF00017	0.402
LIG_SH2_PTP2	122	125	PF00017	0.256
LIG_SH2_PTP2	206	209	PF00017	0.356
LIG_SH2_PTP2	559	562	PF00017	0.385
LIG_SH2_STAP1	88	92	PF00017	0.387
LIG_SH2_STAT5	122	125	PF00017	0.331
LIG_SH2_STAT5	206	209	PF00017	0.523
LIG_SH2_STAT5	301	304	PF00017	0.471
LIG_SH2_STAT5	323	326	PF00017	0.392
LIG_SH2_STAT5	390	393	PF00017	0.376
LIG_SH2_STAT5	407	410	PF00017	0.541
LIG_SH2_STAT5	547	550	PF00017	0.331
LIG_SH2_STAT5	559	562	PF00017	0.321
LIG_SH2_STAT5	603	606	PF00017	0.352
LIG_SH3_2	42	47	PF14604	0.510
LIG_SH3_3	367	373	PF00018	0.507
LIG_SH3_3	39	45	PF00018	0.615
LIG_SH3_3	473	479	PF00018	0.529
LIG_SH3_3	517	523	PF00018	0.419
LIG_SH3_4	402	409	PF00018	0.511
LIG_SUMO_SIM_anti_2	285	290	PF11976	0.393
LIG_SUMO_SIM_anti_2	527	533	PF11976	0.436
LIG_SUMO_SIM_anti_2	549	558	PF11976	0.449
LIG_SUMO_SIM_par_1	457	462	PF11976	0.419
LIG_SUMO_SIM_par_1	493	500	PF11976	0.379
LIG_SUMO_SIM_par_1	659	665	PF11976	0.358
LIG_TYR_ITSM	297	304	PF00017	0.433
LIG_TYR_ITSM	603	610	PF00017	0.338
LIG_UBA3_1	97	101	PF00899	0.444
MOD_CK1_1	143	149	PF00069	0.393
MOD_CK1_1	38	44	PF00069	0.567
MOD_CK1_1	416	422	PF00069	0.755
MOD_CK1_1	443	449	PF00069	0.512
MOD_CK1_1	500	506	PF00069	0.470
MOD_CK1_1	601	607	PF00069	0.473
MOD_CK2_1	1	7	PF00069	0.572
MOD_CK2_1	143	149	PF00069	0.379
MOD_CK2_1	459	465	PF00069	0.358
MOD_CK2_1	52	58	PF00069	0.608
MOD_CK2_1	549	555	PF00069	0.378
MOD_CK2_1	62	68	PF00069	0.621
MOD_GlcNHglycan	127	130	PF01048	0.403
MOD_GlcNHglycan	158	161	PF01048	0.329
MOD_GlcNHglycan	334	338	PF01048	0.431
MOD_GlcNHglycan	351	354	PF01048	0.542
MOD_GlcNHglycan	418	421	PF01048	0.659
MOD_GlcNHglycan	453	456	PF01048	0.493
MOD_GlcNHglycan	499	502	PF01048	0.414
MOD_GlcNHglycan	520	523	PF01048	0.481
MOD_GlcNHglycan	532	535	PF01048	0.454
MOD_GlcNHglycan	562	565	PF01048	0.332
MOD_GSK3_1	18	25	PF00069	0.604
MOD_GSK3_1	217	224	PF00069	0.433
MOD_GSK3_1	245	252	PF00069	0.487
MOD_GSK3_1	296	303	PF00069	0.503
MOD_GSK3_1	306	313	PF00069	0.434
MOD_GSK3_1	329	336	PF00069	0.436
MOD_GSK3_1	345	352	PF00069	0.462
MOD_GSK3_1	416	423	PF00069	0.685
MOD_GSK3_1	574	581	PF00069	0.458
MOD_GSK3_1	583	590	PF00069	0.408
MOD_GSK3_1	59	66	PF00069	0.598
MOD_GSK3_1	594	601	PF00069	0.359
MOD_N-GLC_1	518	523	PF02516	0.518
MOD_NEK2_1	1	6	PF00069	0.690
MOD_NEK2_1	249	254	PF00069	0.479
MOD_NEK2_1	306	311	PF00069	0.592
MOD_NEK2_1	314	319	PF00069	0.511
MOD_NEK2_1	490	495	PF00069	0.436
MOD_NEK2_1	532	537	PF00069	0.579
MOD_NEK2_1	554	559	PF00069	0.459
MOD_NEK2_1	652	657	PF00069	0.360
MOD_NEK2_1	701	706	PF00069	0.365
MOD_NEK2_2	217	222	PF00069	0.341
MOD_NEK2_2	360	365	PF00069	0.455
MOD_PIKK_1	140	146	PF00454	0.553
MOD_PIKK_1	306	312	PF00454	0.549
MOD_PIKK_1	91	97	PF00454	0.520
MOD_PKA_2	413	419	PF00069	0.634
MOD_PKA_2	490	496	PF00069	0.422
MOD_PKA_2	524	530	PF00069	0.457
MOD_Plk_1	245	251	PF00069	0.347
MOD_Plk_1	464	470	PF00069	0.465
MOD_Plk_1	554	560	PF00069	0.511
MOD_Plk_1	595	601	PF00069	0.442
MOD_Plk_1	640	646	PF00069	0.375
MOD_Plk_2-3	81	87	PF00069	0.513
MOD_Plk_4	296	302	PF00069	0.425
MOD_Plk_4	337	343	PF00069	0.455
MOD_Plk_4	490	496	PF00069	0.400
MOD_Plk_4	524	530	PF00069	0.395
MOD_Plk_4	532	538	PF00069	0.431
MOD_Plk_4	549	555	PF00069	0.256
MOD_Plk_4	598	604	PF00069	0.400
MOD_Plk_4	640	646	PF00069	0.375
MOD_ProDKin_1	293	299	PF00069	0.553
MOD_ProDKin_1	38	44	PF00069	0.650
MOD_ProDKin_1	45	51	PF00069	0.765
MOD_ProDKin_1	578	584	PF00069	0.496
TRG_DiLeu_BaEn_2	119	125	PF01217	0.364
TRG_DiLeu_BaLyEn_6	677	682	PF01217	0.382
TRG_ENDOCYTIC_2	122	125	PF00928	0.369
TRG_ENDOCYTIC_2	206	209	PF00928	0.380
TRG_ENDOCYTIC_2	301	304	PF00928	0.589
TRG_ENDOCYTIC_2	323	326	PF00928	0.450
TRG_ENDOCYTIC_2	390	393	PF00928	0.343
TRG_ENDOCYTIC_2	559	562	PF00928	0.363
TRG_ENDOCYTIC_2	607	610	PF00928	0.409
TRG_ENDOCYTIC_2	615	618	PF00928	0.398
TRG_ER_diArg_1	253	255	PF00400	0.430
TRG_ER_diArg_1	265	268	PF00400	0.314
TRG_ER_diArg_1	270	272	PF00400	0.310
TRG_ER_diArg_1	364	367	PF00400	0.493
TRG_ER_diArg_1	575	578	PF00400	0.556
TRG_ER_FFAT_2	545	552	PF00635	0.363
TRG_Pf-PMV_PEXEL_1	270	274	PF00026	0.420
TRG_Pf-PMV_PEXEL_1	680	685	PF00026	0.364

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E7	Leptomonas seymouri	44%	72%
A0A3S7WX75	Leishmania donovani	95%	100%
A4HCB8	Leishmania braziliensis	75%	100%
A4HZX1	Leishmania infantum	95%	100%
C9ZSK5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	26%	100%
E9AVT0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
V5DMK2	Trypanosoma cruzi	26%	100%