Putative UDP-galactose transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

UDP-galactose transporter, putative

Species:

Leishmania major

UniProt:

Q4QBP6_LEIMA

TriTrypDb:

LmjF.22.1010 , LMJLV39_220015600 , LMJSD75_220015800

Length:

580

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	9
GO:0016020	membrane	2	7

Expansion

Sequence features

Q4QBP6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBP6

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	9
GO:0006811	monoatomic ion transport	4	2
GO:0006820	monoatomic anion transport	5	2
GO:0009987	cellular process	1	9
GO:0015711	organic anion transport	5	2
GO:0015780	nucleotide-sugar transmembrane transport	3	2
GO:0015931	nucleobase-containing compound transport	5	2
GO:0034220	monoatomic ion transmembrane transport	3	2
GO:0051179	localization	1	9
GO:0051234	establishment of localization	2	9
GO:0055085	transmembrane transport	2	9
GO:0071702	organic substance transport	4	2
GO:0071705	nitrogen compound transport	4	2
GO:0072334	UDP-galactose transmembrane transport	5	2
GO:0090481	pyrimidine nucleotide-sugar transmembrane transport	4	2
GO:0098656	monoatomic anion transmembrane transport	4	2
GO:1901264	carbohydrate derivative transport	5	2

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	2
GO:0005338	nucleotide-sugar transmembrane transporter activity	4	2
GO:0005459	UDP-galactose transmembrane transporter activity	6	2
GO:0005460	UDP-glucose transmembrane transporter activity	6	2
GO:0008509	monoatomic anion transmembrane transporter activity	4	2
GO:0008514	organic anion transmembrane transporter activity	5	2
GO:0015075	monoatomic ion transmembrane transporter activity	3	2
GO:0015165	pyrimidine nucleotide-sugar transmembrane transporter activity	5	2
GO:0015932	nucleobase-containing compound transmembrane transporter activity	3	2
GO:0022857	transmembrane transporter activity	2	2
GO:1901505	carbohydrate derivative transmembrane transporter activity	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	140	142	PF00675	0.438
CLV_NRD_NRD_1	174	176	PF00675	0.436
CLV_NRD_NRD_1	199	201	PF00675	0.275
CLV_NRD_NRD_1	451	453	PF00675	0.331
CLV_NRD_NRD_1	89	91	PF00675	0.734
CLV_PCSK_KEX2_1	140	142	PF00082	0.438
CLV_PCSK_KEX2_1	174	176	PF00082	0.438
CLV_PCSK_KEX2_1	199	201	PF00082	0.275
CLV_PCSK_KEX2_1	317	319	PF00082	0.277
CLV_PCSK_KEX2_1	386	388	PF00082	0.405
CLV_PCSK_KEX2_1	89	91	PF00082	0.734
CLV_PCSK_PC1ET2_1	317	319	PF00082	0.277
CLV_PCSK_PC1ET2_1	386	388	PF00082	0.405
CLV_PCSK_SKI1_1	154	158	PF00082	0.519
CLV_PCSK_SKI1_1	34	38	PF00082	0.330
CLV_PCSK_SKI1_1	61	65	PF00082	0.537
DEG_APCC_DBOX_1	328	336	PF00400	0.468
DEG_SCF_FBW7_1	16	22	PF00400	0.592
DEG_SPOP_SBC_1	263	267	PF00917	0.305
DEG_SPOP_SBC_1	285	289	PF00917	0.251
DEG_SPOP_SBC_1	517	521	PF00917	0.755
DOC_CKS1_1	16	21	PF01111	0.708
DOC_CYCLIN_yClb5_NLxxxL_5	327	336	PF00134	0.405
DOC_MAPK_gen_1	199	207	PF00069	0.475
DOC_MAPK_gen_1	210	220	PF00069	0.475
DOC_MAPK_gen_1	232	240	PF00069	0.516
DOC_MAPK_gen_1	317	326	PF00069	0.506
DOC_MAPK_gen_1	452	459	PF00069	0.275
DOC_MAPK_HePTP_8	207	219	PF00069	0.475
DOC_MAPK_MEF2A_6	210	219	PF00069	0.475
DOC_MAPK_MEF2A_6	320	328	PF00069	0.512
DOC_MAPK_MEF2A_6	452	461	PF00069	0.275
DOC_USP7_MATH_1	158	162	PF00917	0.743
DOC_USP7_MATH_1	285	289	PF00917	0.260
DOC_USP7_MATH_1	362	366	PF00917	0.327
DOC_USP7_MATH_1	515	519	PF00917	0.759
DOC_USP7_MATH_1	535	539	PF00917	0.724
DOC_USP7_MATH_1	96	100	PF00917	0.502
DOC_WW_Pin1_4	15	20	PF00397	0.682
DOC_WW_Pin1_4	513	518	PF00397	0.702
DOC_WW_Pin1_4	526	531	PF00397	0.768
DOC_WW_Pin1_4	569	574	PF00397	0.763
LIG_14-3-3_CanoR_1	11	17	PF00244	0.703
LIG_14-3-3_CanoR_1	140	144	PF00244	0.598
LIG_14-3-3_CanoR_1	199	204	PF00244	0.513
LIG_14-3-3_CanoR_1	389	398	PF00244	0.205
LIG_Actin_WH2_2	125	142	PF00022	0.309
LIG_Actin_WH2_2	436	454	PF00022	0.331
LIG_Actin_WH2_2	482	499	PF00022	0.488
LIG_APCC_ABBA_1	396	401	PF00400	0.288
LIG_BIR_II_1	1	5	PF00653	0.745
LIG_BRCT_BRCA1_1	185	189	PF00533	0.572
LIG_BRCT_BRCA1_1	339	343	PF00533	0.389
LIG_Clathr_ClatBox_1	342	346	PF01394	0.364
LIG_deltaCOP1_diTrp_1	349	358	PF00928	0.333
LIG_EVH1_1	16	20	PF00568	0.667
LIG_FHA_1	11	17	PF00498	0.747
LIG_FHA_1	118	124	PF00498	0.377
LIG_FHA_1	239	245	PF00498	0.325
LIG_FHA_1	263	269	PF00498	0.340
LIG_FHA_1	309	315	PF00498	0.460
LIG_FHA_1	361	367	PF00498	0.293
LIG_FHA_1	392	398	PF00498	0.344
LIG_FHA_1	434	440	PF00498	0.478
LIG_FHA_2	542	548	PF00498	0.614
LIG_GBD_Chelix_1	38	46	PF00786	0.350
LIG_LIR_Gen_1	192	203	PF02991	0.491
LIG_LIR_Gen_1	349	358	PF02991	0.304
LIG_LIR_Gen_1	403	413	PF02991	0.294
LIG_LIR_Gen_1	470	481	PF02991	0.462
LIG_LIR_Gen_1	486	496	PF02991	0.416
LIG_LIR_Nem_3	349	355	PF02991	0.304
LIG_LIR_Nem_3	403	408	PF02991	0.270
LIG_LIR_Nem_3	438	443	PF02991	0.331
LIG_LIR_Nem_3	470	476	PF02991	0.430
LIG_LIR_Nem_3	486	491	PF02991	0.440
LIG_NRBOX	298	304	PF00104	0.389
LIG_NRBOX	420	426	PF00104	0.466
LIG_Pex14_1	354	358	PF04695	0.333
LIG_Pex14_2	185	189	PF04695	0.499
LIG_RPA_C_Fungi	84	96	PF08784	0.456
LIG_SH2_CRK	534	538	PF00017	0.552
LIG_SH2_GRB2like	307	310	PF00017	0.396
LIG_SH2_GRB2like	488	491	PF00017	0.496
LIG_SH2_NCK_1	534	538	PF00017	0.591
LIG_SH2_PTP2	488	491	PF00017	0.496
LIG_SH2_SRC	488	491	PF00017	0.496
LIG_SH2_STAT5	110	113	PF00017	0.532
LIG_SH2_STAT5	307	310	PF00017	0.396
LIG_SH2_STAT5	488	491	PF00017	0.496
LIG_SH2_STAT5	67	70	PF00017	0.565
LIG_SH3_1	14	20	PF00018	0.610
LIG_SH3_3	100	106	PF00018	0.700
LIG_SH3_3	14	20	PF00018	0.665
LIG_SH3_3	553	559	PF00018	0.715
LIG_SUMO_SIM_anti_2	32	39	PF11976	0.425
LIG_SUMO_SIM_par_1	202	208	PF11976	0.334
LIG_SUMO_SIM_par_1	296	301	PF11976	0.233
LIG_SUMO_SIM_par_1	343	349	PF11976	0.309
LIG_SUMO_SIM_par_1	441	446	PF11976	0.355
LIG_TRAF2_1	507	510	PF00917	0.545
LIG_ULM_U2AF65_1	317	322	PF00076	0.405
LIG_WRC_WIRS_1	355	360	PF05994	0.412
LIG_WW_3	18	22	PF00397	0.476
MOD_CDC14_SPxK_1	572	575	PF00782	0.709
MOD_CDK_SPxK_1	15	21	PF00069	0.603
MOD_CDK_SPxK_1	569	575	PF00069	0.709
MOD_CK1_1	15	21	PF00069	0.652
MOD_CK1_1	254	260	PF00069	0.365
MOD_CK1_1	261	267	PF00069	0.335
MOD_CK1_1	276	282	PF00069	0.380
MOD_CK1_1	287	293	PF00069	0.390
MOD_CK1_1	392	398	PF00069	0.357
MOD_CK1_1	423	429	PF00069	0.412
MOD_CK1_1	516	522	PF00069	0.684
MOD_CK1_1	542	548	PF00069	0.676
MOD_GlcNHglycan	128	131	PF01048	0.391
MOD_GlcNHglycan	21	24	PF01048	0.648
MOD_GlcNHglycan	261	264	PF01048	0.326
MOD_GlcNHglycan	276	279	PF01048	0.190
MOD_GlcNHglycan	391	394	PF01048	0.376
MOD_GlcNHglycan	425	428	PF01048	0.412
MOD_GlcNHglycan	453	456	PF01048	0.280
MOD_GlcNHglycan	469	472	PF01048	0.417
MOD_GlcNHglycan	537	540	PF01048	0.671
MOD_GlcNHglycan	546	550	PF01048	0.680
MOD_GlcNHglycan	71	74	PF01048	0.490
MOD_GlcNHglycan	83	86	PF01048	0.447
MOD_GSK3_1	115	122	PF00069	0.410
MOD_GSK3_1	15	22	PF00069	0.721
MOD_GSK3_1	254	261	PF00069	0.317
MOD_GSK3_1	262	269	PF00069	0.279
MOD_GSK3_1	272	279	PF00069	0.284
MOD_GSK3_1	284	291	PF00069	0.351
MOD_GSK3_1	327	334	PF00069	0.350
MOD_GSK3_1	350	357	PF00069	0.374
MOD_GSK3_1	362	369	PF00069	0.237
MOD_GSK3_1	435	442	PF00069	0.327
MOD_GSK3_1	453	460	PF00069	0.331
MOD_GSK3_1	511	518	PF00069	0.714
MOD_GSK3_1	535	542	PF00069	0.776
MOD_GSK3_1	74	81	PF00069	0.586
MOD_N-GLC_1	158	163	PF02516	0.636
MOD_N-GLC_1	254	259	PF02516	0.410
MOD_N-GLC_1	308	313	PF02516	0.331
MOD_N-GLC_1	526	531	PF02516	0.695
MOD_N-GLC_2	167	169	PF02516	0.594
MOD_N-GLC_2	49	51	PF02516	0.412
MOD_NEK2_1	119	124	PF00069	0.438
MOD_NEK2_1	139	144	PF00069	0.557
MOD_NEK2_1	183	188	PF00069	0.364
MOD_NEK2_1	189	194	PF00069	0.349
MOD_NEK2_1	238	243	PF00069	0.438
MOD_NEK2_1	298	303	PF00069	0.343
MOD_NEK2_1	327	332	PF00069	0.366
MOD_NEK2_1	420	425	PF00069	0.361
MOD_NEK2_1	443	448	PF00069	0.350
MOD_NEK2_1	451	456	PF00069	0.364
MOD_NEK2_1	74	79	PF00069	0.574
MOD_NEK2_2	110	115	PF00069	0.526
MOD_NEK2_2	53	58	PF00069	0.379
MOD_PIKK_1	117	123	PF00454	0.466
MOD_PIKK_1	308	314	PF00454	0.331
MOD_PK_1	453	459	PF00069	0.364
MOD_PKA_1	199	205	PF00069	0.412
MOD_PKA_2	10	16	PF00069	0.633
MOD_PKA_2	139	145	PF00069	0.490
MOD_PKA_2	199	205	PF00069	0.386
MOD_PKA_2	273	279	PF00069	0.233
MOD_PKA_2	451	457	PF00069	0.255
MOD_PKB_1	387	395	PF00069	0.233
MOD_Plk_1	400	406	PF00069	0.466
MOD_Plk_1	492	498	PF00069	0.525
MOD_Plk_4	110	116	PF00069	0.428
MOD_Plk_4	134	140	PF00069	0.587
MOD_Plk_4	167	173	PF00069	0.572
MOD_Plk_4	288	294	PF00069	0.412
MOD_Plk_4	298	304	PF00069	0.382
MOD_Plk_4	322	328	PF00069	0.371
MOD_Plk_4	331	337	PF00069	0.345
MOD_Plk_4	362	368	PF00069	0.294
MOD_Plk_4	392	398	PF00069	0.303
MOD_Plk_4	420	426	PF00069	0.348
MOD_Plk_4	446	452	PF00069	0.331
MOD_Plk_4	453	459	PF00069	0.331
MOD_ProDKin_1	15	21	PF00069	0.620
MOD_ProDKin_1	513	519	PF00069	0.648
MOD_ProDKin_1	526	532	PF00069	0.738
MOD_ProDKin_1	569	575	PF00069	0.738
MOD_SUMO_for_1	57	60	PF00179	0.372
TRG_ENDOCYTIC_2	195	198	PF00928	0.331
TRG_ENDOCYTIC_2	488	491	PF00928	0.496
TRG_ENDOCYTIC_2	534	537	PF00928	0.709
TRG_ER_diArg_1	139	141	PF00400	0.554
TRG_ER_diArg_1	198	200	PF00400	0.331
TRG_ER_diArg_1	225	228	PF00400	0.466
TRG_ER_diArg_1	318	321	PF00400	0.466
TRG_ER_diLys_1	575	580	PF00400	0.796

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7F6	Leptomonas seymouri	50%	100%
A0A1X0NV21	Trypanosomatidae	38%	100%
A0A3Q8IBG5	Leishmania donovani	88%	99%
A0A422N3L8	Trypanosoma rangeli	36%	100%
A4HCB7	Leishmania braziliensis	69%	100%
A4HZX4	Leishmania infantum	88%	99%
E9AVT3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
P0CP32	Cryptococcus neoformans var. neoformans serotype D (strain JEC21 / ATCC MYA-565)	26%	100%
P0CP33	Cryptococcus neoformans var. neoformans serotype D (strain B-3501A)	26%	100%