Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBP3_LEIMA

TriTrypDb:

LmjF.22.1040 , LMJLV39_220015900 , LMJSD75_220016100

Length:

739

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBP3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBP3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	176	180	PF00656	0.378
CLV_C14_Caspase3-7	196	200	PF00656	0.260
CLV_MEL_PAP_1	264	270	PF00089	0.512
CLV_NRD_NRD_1	109	111	PF00675	0.452
CLV_NRD_NRD_1	141	143	PF00675	0.455
CLV_NRD_NRD_1	23	25	PF00675	0.429
CLV_NRD_NRD_1	312	314	PF00675	0.448
CLV_NRD_NRD_1	354	356	PF00675	0.476
CLV_NRD_NRD_1	374	376	PF00675	0.348
CLV_NRD_NRD_1	397	399	PF00675	0.491
CLV_NRD_NRD_1	444	446	PF00675	0.784
CLV_NRD_NRD_1	516	518	PF00675	0.558
CLV_NRD_NRD_1	674	676	PF00675	0.727
CLV_NRD_NRD_1	711	713	PF00675	0.789
CLV_NRD_NRD_1	719	721	PF00675	0.740
CLV_PCSK_FUR_1	709	713	PF00082	0.533
CLV_PCSK_KEX2_1	109	111	PF00082	0.431
CLV_PCSK_KEX2_1	141	143	PF00082	0.396
CLV_PCSK_KEX2_1	17	19	PF00082	0.424
CLV_PCSK_KEX2_1	23	25	PF00082	0.425
CLV_PCSK_KEX2_1	312	314	PF00082	0.428
CLV_PCSK_KEX2_1	374	376	PF00082	0.520
CLV_PCSK_KEX2_1	397	399	PF00082	0.479
CLV_PCSK_KEX2_1	444	446	PF00082	0.681
CLV_PCSK_KEX2_1	655	657	PF00082	0.630
CLV_PCSK_KEX2_1	674	676	PF00082	0.782
CLV_PCSK_KEX2_1	709	711	PF00082	0.787
CLV_PCSK_KEX2_1	719	721	PF00082	0.706
CLV_PCSK_PC1ET2_1	141	143	PF00082	0.396
CLV_PCSK_PC1ET2_1	17	19	PF00082	0.424
CLV_PCSK_PC1ET2_1	655	657	PF00082	0.723
CLV_PCSK_SKI1_1	14	18	PF00082	0.427
CLV_PCSK_SKI1_1	142	146	PF00082	0.413
CLV_PCSK_SKI1_1	189	193	PF00082	0.513
CLV_PCSK_SKI1_1	23	27	PF00082	0.418
CLV_PCSK_SKI1_1	313	317	PF00082	0.477
CLV_PCSK_SKI1_1	407	411	PF00082	0.548
CLV_PCSK_SKI1_1	518	522	PF00082	0.618
CLV_PCSK_SKI1_1	582	586	PF00082	0.515
CLV_PCSK_SKI1_1	689	693	PF00082	0.668
CLV_PCSK_SKI1_1	719	723	PF00082	0.749
DEG_Nend_UBRbox_1	1	4	PF02207	0.418
DEG_SPOP_SBC_1	144	148	PF00917	0.361
DEG_SPOP_SBC_1	680	684	PF00917	0.732
DOC_ANK_TNKS_1	709	716	PF00023	0.522
DOC_CKS1_1	46	51	PF01111	0.418
DOC_CYCLIN_RxL_1	17	30	PF00134	0.418
DOC_MAPK_gen_1	14	22	PF00069	0.424
DOC_MAPK_gen_1	413	420	PF00069	0.476
DOC_MAPK_gen_1	70	78	PF00069	0.495
DOC_MAPK_MEF2A_6	151	160	PF00069	0.523
DOC_MAPK_MEF2A_6	249	257	PF00069	0.436
DOC_MAPK_RevD_3	8	24	PF00069	0.429
DOC_PP1_RVXF_1	165	171	PF00149	0.357
DOC_PP4_FxxP_1	221	224	PF00568	0.436
DOC_PP4_FxxP_1	644	647	PF00568	0.541
DOC_SPAK_OSR1_1	267	271	PF12202	0.522
DOC_USP7_MATH_1	144	148	PF00917	0.361
DOC_USP7_MATH_1	191	195	PF00917	0.433
DOC_USP7_MATH_1	452	456	PF00917	0.745
DOC_USP7_MATH_1	475	479	PF00917	0.665
DOC_USP7_MATH_1	501	505	PF00917	0.663
DOC_USP7_MATH_1	513	517	PF00917	0.607
DOC_USP7_MATH_1	680	684	PF00917	0.703
DOC_USP7_MATH_1	703	707	PF00917	0.648
DOC_USP7_MATH_1	713	717	PF00917	0.601
DOC_USP7_MATH_1	729	733	PF00917	0.611
DOC_USP7_UBL2_3	141	145	PF12436	0.398
DOC_USP7_UBL2_3	296	300	PF12436	0.481
DOC_USP7_UBL2_3	356	360	PF12436	0.518
DOC_USP7_UBL2_3	564	568	PF12436	0.746
DOC_WW_Pin1_4	45	50	PF00397	0.417
DOC_WW_Pin1_4	674	679	PF00397	0.683
DOC_WW_Pin1_4	691	696	PF00397	0.552
DOC_WW_Pin1_4	701	706	PF00397	0.759
LIG_14-3-3_CanoR_1	109	115	PF00244	0.350
LIG_14-3-3_CanoR_1	142	152	PF00244	0.376
LIG_14-3-3_CanoR_1	24	34	PF00244	0.410
LIG_14-3-3_CanoR_1	330	336	PF00244	0.552
LIG_14-3-3_CanoR_1	375	383	PF00244	0.574
LIG_14-3-3_CanoR_1	445	453	PF00244	0.694
LIG_14-3-3_CanoR_1	719	728	PF00244	0.586
LIG_14-3-3_CanoR_1	73	79	PF00244	0.462
LIG_14-3-3_CterR_2	737	739	PF00244	0.645
LIG_Actin_WH2_2	157	174	PF00022	0.350
LIG_Actin_WH2_2	359	376	PF00022	0.575
LIG_Actin_WH2_2	54	72	PF00022	0.546
LIG_AP2alpha_2	532	534	PF02296	0.496
LIG_BRCT_BRCA1_1	30	34	PF00533	0.405
LIG_BRCT_BRCA1_1	304	308	PF00533	0.481
LIG_EVH1_1	46	50	PF00568	0.416
LIG_FHA_1	151	157	PF00498	0.509
LIG_FHA_1	312	318	PF00498	0.515
LIG_FHA_1	5	11	PF00498	0.433
LIG_FHA_1	626	632	PF00498	0.514
LIG_FHA_1	668	674	PF00498	0.684
LIG_FHA_1	723	729	PF00498	0.738
LIG_FHA_2	241	247	PF00498	0.470
LIG_FHA_2	377	383	PF00498	0.474
LIG_LIR_Apic_2	218	224	PF02991	0.423
LIG_LIR_Apic_2	528	533	PF02991	0.505
LIG_LIR_Gen_1	113	121	PF02991	0.336
LIG_LIR_Gen_1	173	182	PF02991	0.355
LIG_LIR_Gen_1	531	542	PF02991	0.526
LIG_LIR_Gen_1	547	556	PF02991	0.544
LIG_LIR_Gen_1	85	91	PF02991	0.428
LIG_LIR_Nem_3	113	117	PF02991	0.406
LIG_LIR_Nem_3	173	178	PF02991	0.353
LIG_LIR_Nem_3	531	537	PF02991	0.553
LIG_LIR_Nem_3	547	551	PF02991	0.494
LIG_LIR_Nem_3	614	619	PF02991	0.599
LIG_LIR_Nem_3	91	96	PF02991	0.438
LIG_LIR_Nem_3	98	104	PF02991	0.358
LIG_MYND_1	52	56	PF01753	0.433
LIG_RPA_C_Fungi	190	202	PF08784	0.474
LIG_SH2_CRK	250	254	PF00017	0.464
LIG_SH2_CRK	548	552	PF00017	0.578
LIG_SH2_GRB2like	250	253	PF00017	0.438
LIG_SH2_NCK_1	530	534	PF00017	0.505
LIG_SH2_SRC	530	533	PF00017	0.502
LIG_SH2_STAP1	298	302	PF00017	0.502
LIG_SH2_STAP1	4	8	PF00017	0.428
LIG_SH2_STAP1	548	552	PF00017	0.519
LIG_SH2_STAP1	635	639	PF00017	0.606
LIG_SH2_STAT3	213	216	PF00017	0.297
LIG_SH2_STAT3	402	405	PF00017	0.574
LIG_SH2_STAT3	566	569	PF00017	0.562
LIG_SH2_STAT5	104	107	PF00017	0.410
LIG_SH2_STAT5	41	44	PF00017	0.420
LIG_SH2_STAT5	417	420	PF00017	0.557
LIG_SH2_STAT5	45	48	PF00017	0.418
LIG_SH2_STAT5	566	569	PF00017	0.702
LIG_SH2_STAT5	615	618	PF00017	0.517
LIG_SH3_3	13	19	PF00018	0.425
LIG_SH3_3	44	50	PF00018	0.420
LIG_SH3_3	620	626	PF00018	0.565
LIG_SH3_3	725	731	PF00018	0.526
LIG_SUMO_SIM_par_1	156	162	PF11976	0.482
LIG_TRAF2_1	243	246	PF00917	0.411
LIG_TRAF2_1	379	382	PF00917	0.651
LIG_UBA3_1	648	655	PF00899	0.627
LIG_WW_3	48	52	PF00397	0.419
MOD_CDC14_SPxK_1	694	697	PF00782	0.668
MOD_CDK_SPxK_1	45	51	PF00069	0.419
MOD_CDK_SPxK_1	691	697	PF00069	0.678
MOD_CK1_1	311	317	PF00069	0.422
MOD_CK1_1	376	382	PF00069	0.544
MOD_CK1_1	446	452	PF00069	0.723
MOD_CK1_1	483	489	PF00069	0.665
MOD_CK1_1	506	512	PF00069	0.667
MOD_CK1_1	669	675	PF00069	0.671
MOD_CK1_1	683	689	PF00069	0.741
MOD_CK1_1	701	707	PF00069	0.772
MOD_CK1_1	732	738	PF00069	0.574
MOD_CK1_1	74	80	PF00069	0.465
MOD_CK2_1	143	149	PF00069	0.455
MOD_CK2_1	159	165	PF00069	0.370
MOD_CK2_1	182	188	PF00069	0.435
MOD_CK2_1	232	238	PF00069	0.513
MOD_CK2_1	240	246	PF00069	0.388
MOD_CK2_1	316	322	PF00069	0.450
MOD_CK2_1	376	382	PF00069	0.484
MOD_CK2_1	85	91	PF00069	0.472
MOD_Cter_Amidation	442	445	PF01082	0.564
MOD_Cter_Amidation	562	565	PF01082	0.537
MOD_GlcNHglycan	161	164	PF01048	0.532
MOD_GlcNHglycan	233	237	PF01048	0.487
MOD_GlcNHglycan	303	307	PF01048	0.479
MOD_GlcNHglycan	375	378	PF01048	0.518
MOD_GlcNHglycan	441	444	PF01048	0.582
MOD_GlcNHglycan	454	458	PF01048	0.582
MOD_GlcNHglycan	482	485	PF01048	0.704
MOD_GlcNHglycan	495	498	PF01048	0.509
MOD_GlcNHglycan	503	506	PF01048	0.562
MOD_GlcNHglycan	510	513	PF01048	0.491
MOD_GlcNHglycan	58	61	PF01048	0.621
MOD_GlcNHglycan	65	68	PF01048	0.540
MOD_GlcNHglycan	657	660	PF01048	0.601
MOD_GlcNHglycan	662	665	PF01048	0.807
MOD_GlcNHglycan	685	688	PF01048	0.721
MOD_GlcNHglycan	705	708	PF01048	0.587
MOD_GlcNHglycan	73	76	PF01048	0.421
MOD_GSK3_1	150	157	PF00069	0.538
MOD_GSK3_1	191	198	PF00069	0.429
MOD_GSK3_1	37	44	PF00069	0.415
MOD_GSK3_1	439	446	PF00069	0.662
MOD_GSK3_1	483	490	PF00069	0.592
MOD_GSK3_1	662	669	PF00069	0.696
MOD_GSK3_1	674	681	PF00069	0.696
MOD_GSK3_1	699	706	PF00069	0.594
MOD_GSK3_1	719	726	PF00069	0.614
MOD_GSK3_1	732	739	PF00069	0.495
MOD_N-GLC_1	251	256	PF02516	0.513
MOD_NEK2_1	25	30	PF00069	0.410
MOD_NEK2_1	302	307	PF00069	0.455
MOD_NEK2_1	308	313	PF00069	0.421
MOD_NEK2_1	316	321	PF00069	0.379
MOD_NEK2_1	373	378	PF00069	0.540
MOD_NEK2_1	480	485	PF00069	0.687
MOD_NEK2_1	492	497	PF00069	0.530
MOD_NEK2_1	599	604	PF00069	0.606
MOD_NEK2_1	679	684	PF00069	0.633
MOD_NEK2_1	96	101	PF00069	0.327
MOD_NEK2_2	533	538	PF00069	0.544
MOD_NEK2_2	588	593	PF00069	0.647
MOD_PIKK_1	173	179	PF00454	0.368
MOD_PIKK_1	443	449	PF00454	0.716
MOD_PIKK_1	475	481	PF00454	0.655
MOD_PKA_1	110	116	PF00069	0.348
MOD_PKA_1	564	570	PF00069	0.570
MOD_PKA_1	655	661	PF00069	0.490
MOD_PKA_1	719	725	PF00069	0.613
MOD_PKA_2	182	188	PF00069	0.463
MOD_PKA_2	311	317	PF00069	0.446
MOD_PKA_2	373	379	PF00069	0.540
MOD_PKA_2	443	449	PF00069	0.705
MOD_PKA_2	655	661	PF00069	0.506
MOD_PKA_2	719	725	PF00069	0.559
MOD_Plk_1	251	257	PF00069	0.512
MOD_Plk_4	37	43	PF00069	0.413
MOD_Plk_4	547	553	PF00069	0.405
MOD_Plk_4	599	605	PF00069	0.659
MOD_Plk_4	723	729	PF00069	0.648
MOD_ProDKin_1	45	51	PF00069	0.419
MOD_ProDKin_1	674	680	PF00069	0.679
MOD_ProDKin_1	691	697	PF00069	0.556
MOD_ProDKin_1	701	707	PF00069	0.759
MOD_SUMO_for_1	282	285	PF00179	0.542
MOD_SUMO_for_1	424	427	PF00179	0.524
MOD_SUMO_for_1	654	657	PF00179	0.642
MOD_SUMO_rev_2	146	153	PF00179	0.565
MOD_SUMO_rev_2	630	639	PF00179	0.652
TRG_DiLeu_BaEn_1	340	345	PF01217	0.495
TRG_DiLeu_BaEn_4	381	387	PF01217	0.505
TRG_DiLeu_BaLyEn_6	644	649	PF01217	0.660
TRG_ENDOCYTIC_2	250	253	PF00928	0.414
TRG_ENDOCYTIC_2	298	301	PF00928	0.407
TRG_ENDOCYTIC_2	417	420	PF00928	0.557
TRG_ENDOCYTIC_2	548	551	PF00928	0.587
TRG_ER_diArg_1	167	170	PF00400	0.471
TRG_ER_diArg_1	22	24	PF00400	0.431
TRG_ER_diArg_1	373	375	PF00400	0.558
TRG_ER_diArg_1	673	675	PF00400	0.689
TRG_ER_diArg_1	709	712	PF00400	0.790
TRG_ER_diArg_1	719	721	PF00400	0.698
TRG_ER_diArg_1	80	83	PF00400	0.418
TRG_NES_CRM1_1	259	274	PF08389	0.525
TRG_NES_CRM1_1	419	432	PF08389	0.581
TRG_NLS_MonoExtC_3	140	145	PF00514	0.444
TRG_NLS_MonoExtN_4	141	146	PF00514	0.489
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.478
TRG_Pf-PMV_PEXEL_1	195	199	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	407	411	PF00026	0.635

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8W6	Leptomonas seymouri	66%	100%
A0A0S4KMX4	Bodo saltans	45%	100%
A0A1X0NU00	Trypanosomatidae	53%	100%
A0A3S7WXA7	Leishmania donovani	95%	100%
A0A422MU25	Trypanosoma rangeli	53%	100%
A4HCC0	Leishmania braziliensis	83%	100%
A4HZX6	Leishmania infantum	95%	100%
C9ZSL5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AVT6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%