MFS domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

major facilitator superfamily, putative

Species:

Leishmania major

UniProt:

Q4QBP2_LEIMA

TriTrypDb:

LmjF.22.1050 , LMJLV39_220016000 , LMJSD75_220016200

Length:

963

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4QBP2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBP2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	7
GO:0022857	transmembrane transporter activity	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	313	317	PF00656	0.509
CLV_C14_Caspase3-7	56	60	PF00656	0.694
CLV_C14_Caspase3-7	68	72	PF00656	0.619
CLV_NRD_NRD_1	298	300	PF00675	0.302
CLV_NRD_NRD_1	376	378	PF00675	0.284
CLV_NRD_NRD_1	474	476	PF00675	0.284
CLV_NRD_NRD_1	54	56	PF00675	0.485
CLV_PCSK_KEX2_1	179	181	PF00082	0.269
CLV_PCSK_KEX2_1	474	476	PF00082	0.274
CLV_PCSK_KEX2_1	54	56	PF00082	0.485
CLV_PCSK_PC1ET2_1	179	181	PF00082	0.269
CLV_PCSK_PC7_1	175	181	PF00082	0.269
CLV_PCSK_SKI1_1	179	183	PF00082	0.269
CLV_PCSK_SKI1_1	277	281	PF00082	0.304
CLV_PCSK_SKI1_1	475	479	PF00082	0.284
CLV_PCSK_SKI1_1	501	505	PF00082	0.516
CLV_PCSK_SKI1_1	590	594	PF00082	0.237
CLV_PCSK_SKI1_1	799	803	PF00082	0.688
CLV_PCSK_SKI1_1	929	933	PF00082	0.618
DEG_APCC_DBOX_1	500	508	PF00400	0.316
DEG_APCC_DBOX_1	734	742	PF00400	0.438
DEG_COP1_1	68	78	PF00400	0.686
DEG_ODPH_VHL_1	450	463	PF01847	0.369
DEG_SCF_FBW7_1	26	33	PF00400	0.641
DEG_SCF_TRCP1_1	126	131	PF00400	0.304
DEG_SIAH_1	761	769	PF03145	0.434
DEG_SPOP_SBC_1	153	157	PF00917	0.325
DEG_SPOP_SBC_1	263	267	PF00917	0.316
DEG_SPOP_SBC_1	30	34	PF00917	0.663
DEG_SPOP_SBC_1	877	881	PF00917	0.484
DEG_SPOP_SBC_1	89	93	PF00917	0.694
DOC_CKS1_1	221	226	PF01111	0.304
DOC_CKS1_1	751	756	PF01111	0.508
DOC_CKS1_1	769	774	PF01111	0.399
DOC_CKS1_1	800	805	PF01111	0.443
DOC_CKS1_1	902	907	PF01111	0.426
DOC_CYCLIN_yCln2_LP_2	741	747	PF00134	0.485
DOC_CYCLIN_yCln2_LP_2	800	806	PF00134	0.441
DOC_MAPK_gen_1	9	19	PF00069	0.688
DOC_MAPK_HePTP_8	206	218	PF00069	0.369
DOC_MAPK_MEF2A_6	209	218	PF00069	0.369
DOC_MAPK_MEF2A_6	568	576	PF00069	0.469
DOC_PP1_RVXF_1	472	479	PF00149	0.514
DOC_PP2B_LxvP_1	134	137	PF13499	0.316
DOC_PP2B_LxvP_1	280	283	PF13499	0.304
DOC_PP2B_LxvP_1	676	679	PF13499	0.449
DOC_PP2B_LxvP_1	922	925	PF13499	0.415
DOC_PP2B_PxIxI_1	583	589	PF00149	0.303
DOC_PP4_FxxP_1	344	347	PF00568	0.452
DOC_PP4_FxxP_1	551	554	PF00568	0.469
DOC_PP4_FxxP_1	751	754	PF00568	0.495
DOC_SPAK_OSR1_1	209	213	PF12202	0.304
DOC_USP7_MATH_1	153	157	PF00917	0.325
DOC_USP7_MATH_1	263	267	PF00917	0.316
DOC_USP7_MATH_1	30	34	PF00917	0.714
DOC_USP7_MATH_1	354	358	PF00917	0.533
DOC_USP7_MATH_1	53	57	PF00917	0.707
DOC_USP7_MATH_1	563	567	PF00917	0.535
DOC_USP7_MATH_1	681	685	PF00917	0.511
DOC_USP7_MATH_1	689	693	PF00917	0.458
DOC_USP7_MATH_1	7	11	PF00917	0.732
DOC_USP7_MATH_1	733	737	PF00917	0.496
DOC_USP7_MATH_1	877	881	PF00917	0.550
DOC_USP7_MATH_1	90	94	PF00917	0.681
DOC_USP7_MATH_1	907	911	PF00917	0.514
DOC_WW_Pin1_4	220	225	PF00397	0.304
DOC_WW_Pin1_4	26	31	PF00397	0.646
DOC_WW_Pin1_4	343	348	PF00397	0.469
DOC_WW_Pin1_4	697	702	PF00397	0.468
DOC_WW_Pin1_4	740	745	PF00397	0.540
DOC_WW_Pin1_4	750	755	PF00397	0.487
DOC_WW_Pin1_4	758	763	PF00397	0.566
DOC_WW_Pin1_4	768	773	PF00397	0.410
DOC_WW_Pin1_4	799	804	PF00397	0.475
DOC_WW_Pin1_4	901	906	PF00397	0.453
DOC_WW_Pin1_4	920	925	PF00397	0.447
LIG_14-3-3_CanoR_1	235	239	PF00244	0.463
LIG_14-3-3_CanoR_1	355	363	PF00244	0.476
LIG_14-3-3_CanoR_1	364	372	PF00244	0.460
LIG_14-3-3_CanoR_1	388	398	PF00244	0.473
LIG_14-3-3_CanoR_1	54	61	PF00244	0.675
LIG_14-3-3_CanoR_1	81	86	PF00244	0.691
LIG_14-3-3_CanoR_1	811	817	PF00244	0.442
LIG_14-3-3_CanoR_1	847	852	PF00244	0.523
LIG_14-3-3_CanoR_1	878	884	PF00244	0.474
LIG_Actin_WH2_2	106	122	PF00022	0.463
LIG_Actin_WH2_2	459	476	PF00022	0.325
LIG_Actin_WH2_2	553	570	PF00022	0.505
LIG_BIR_III_4	562	566	PF00653	0.511
LIG_BRCT_BRCA1_1	126	130	PF00533	0.304
LIG_BRCT_BRCA1_1	155	159	PF00533	0.304
LIG_BRCT_BRCA1_1	214	218	PF00533	0.369
LIG_BRCT_BRCA1_1	270	274	PF00533	0.325
LIG_BRCT_BRCA1_1	340	344	PF00533	0.422
LIG_BRCT_BRCA1_1	411	415	PF00533	0.304
LIG_Clathr_ClatBox_1	838	842	PF01394	0.437
LIG_EH1_1	568	576	PF00400	0.469
LIG_eIF4E_1	110	116	PF01652	0.551
LIG_eIF4E_1	275	281	PF01652	0.369
LIG_eIF4E_1	569	575	PF01652	0.469
LIG_FHA_1	141	147	PF00498	0.321
LIG_FHA_1	153	159	PF00498	0.253
LIG_FHA_1	182	188	PF00498	0.494
LIG_FHA_1	263	269	PF00498	0.316
LIG_FHA_1	321	327	PF00498	0.422
LIG_FHA_1	371	377	PF00498	0.477
LIG_FHA_1	423	429	PF00498	0.269
LIG_FHA_1	444	450	PF00498	0.317
LIG_FHA_1	562	568	PF00498	0.519
LIG_FHA_1	571	577	PF00498	0.304
LIG_FHA_1	618	624	PF00498	0.502
LIG_FHA_1	691	697	PF00498	0.471
LIG_FHA_1	727	733	PF00498	0.448
LIG_FHA_1	795	801	PF00498	0.435
LIG_FHA_1	811	817	PF00498	0.480
LIG_FHA_2	364	370	PF00498	0.484
LIG_FHA_2	497	503	PF00498	0.284
LIG_LIR_Apic_2	341	347	PF02991	0.452
LIG_LIR_Gen_1	107	117	PF02991	0.554
LIG_LIR_Gen_1	190	200	PF02991	0.304
LIG_LIR_Gen_1	215	225	PF02991	0.304
LIG_LIR_Gen_1	389	398	PF02991	0.434
LIG_LIR_Gen_1	500	511	PF02991	0.269
LIG_LIR_Gen_1	543	551	PF02991	0.455
LIG_LIR_Nem_3	107	113	PF02991	0.560
LIG_LIR_Nem_3	190	195	PF02991	0.304
LIG_LIR_Nem_3	215	221	PF02991	0.304
LIG_LIR_Nem_3	269	275	PF02991	0.269
LIG_LIR_Nem_3	500	506	PF02991	0.393
LIG_LIR_Nem_3	543	548	PF02991	0.455
LIG_LIR_Nem_3	566	572	PF02991	0.547
LIG_MLH1_MIPbox_1	411	415	PF16413	0.304
LIG_MYND_1	873	877	PF01753	0.510
LIG_NRBOX	252	258	PF00104	0.369
LIG_Pex14_1	226	230	PF04695	0.469
LIG_Pex14_1	270	274	PF04695	0.304
LIG_Pex14_2	479	483	PF04695	0.304
LIG_Pex3_1	253	264	PF04882	0.237
LIG_PTB_Apo_2	205	212	PF02174	0.304
LIG_PTB_Apo_2	397	404	PF02174	0.289
LIG_PTB_Phospho_1	397	403	PF10480	0.289
LIG_SH2_CRK	545	549	PF00017	0.455
LIG_SH2_CRK	569	573	PF00017	0.469
LIG_SH2_CRK	705	709	PF00017	0.438
LIG_SH2_SRC	311	314	PF00017	0.484
LIG_SH2_STAP1	391	395	PF00017	0.484
LIG_SH2_STAT5	110	113	PF00017	0.551
LIG_SH2_STAT5	222	225	PF00017	0.369
LIG_SH2_STAT5	255	258	PF00017	0.304
LIG_SH2_STAT5	275	278	PF00017	0.183
LIG_SH2_STAT5	287	290	PF00017	0.244
LIG_SH2_STAT5	414	417	PF00017	0.372
LIG_SH2_STAT5	427	430	PF00017	0.269
LIG_SH3_2	744	749	PF14604	0.442
LIG_SH3_2	773	778	PF14604	0.485
LIG_SH3_2	873	878	PF14604	0.515
LIG_SH3_3	218	224	PF00018	0.304
LIG_SH3_3	446	452	PF00018	0.272
LIG_SH3_3	741	747	PF00018	0.554
LIG_SH3_3	751	757	PF00018	0.479
LIG_SH3_3	762	768	PF00018	0.448
LIG_SH3_3	770	776	PF00018	0.396
LIG_SH3_3	80	86	PF00018	0.732
LIG_SH3_3	867	873	PF00018	0.489
LIG_SH3_3	890	896	PF00018	0.503
LIG_SUMO_SIM_anti_2	502	508	PF11976	0.325
LIG_SUMO_SIM_anti_2	835	840	PF11976	0.443
LIG_SUMO_SIM_par_1	278	284	PF11976	0.304
LIG_SUMO_SIM_par_1	406	412	PF11976	0.304
LIG_SUMO_SIM_par_1	572	578	PF11976	0.304
LIG_TYR_ITIM	220	225	PF00017	0.304
LIG_TYR_ITIM	567	572	PF00017	0.498
LIG_UBA3_1	115	120	PF00899	0.304
LIG_UBA3_1	462	470	PF00899	0.308
LIG_WRC_WIRS_1	122	127	PF05994	0.304
LIG_WRC_WIRS_1	191	196	PF05994	0.304
LIG_WW_3	875	879	PF00397	0.520
MOD_CDK_SPxK_1	799	805	PF00069	0.465
MOD_CK1_1	124	130	PF00069	0.304
MOD_CK1_1	266	272	PF00069	0.316
MOD_CK1_1	359	365	PF00069	0.422
MOD_CK1_1	389	395	PF00069	0.529
MOD_CK1_1	406	412	PF00069	0.282
MOD_CK1_1	684	690	PF00069	0.504
MOD_CK1_1	715	721	PF00069	0.491
MOD_CK1_1	740	746	PF00069	0.507
MOD_CK1_1	880	886	PF00069	0.547
MOD_CK1_1	910	916	PF00069	0.526
MOD_CK2_1	363	369	PF00069	0.484
MOD_CK2_1	689	695	PF00069	0.483
MOD_CK2_1	884	890	PF00069	0.532
MOD_CK2_1	906	912	PF00069	0.411
MOD_GlcNHglycan	126	129	PF01048	0.304
MOD_GlcNHglycan	130	133	PF01048	0.304
MOD_GlcNHglycan	301	304	PF01048	0.377
MOD_GlcNHglycan	326	329	PF01048	0.297
MOD_GlcNHglycan	331	334	PF01048	0.313
MOD_GlcNHglycan	340	343	PF01048	0.206
MOD_GlcNHglycan	356	359	PF01048	0.268
MOD_GlcNHglycan	366	369	PF01048	0.243
MOD_GlcNHglycan	43	46	PF01048	0.504
MOD_GlcNHglycan	51	54	PF01048	0.465
MOD_GlcNHglycan	551	554	PF01048	0.297
MOD_GlcNHglycan	597	600	PF01048	0.603
MOD_GlcNHglycan	601	604	PF01048	0.637
MOD_GlcNHglycan	610	613	PF01048	0.615
MOD_GlcNHglycan	686	689	PF01048	0.727
MOD_GlcNHglycan	71	74	PF01048	0.398
MOD_GlcNHglycan	717	720	PF01048	0.729
MOD_GlcNHglycan	787	791	PF01048	0.679
MOD_GlcNHglycan	83	86	PF01048	0.459
MOD_GlcNHglycan	915	918	PF01048	0.733
MOD_GSK3_1	124	131	PF00069	0.304
MOD_GSK3_1	140	147	PF00069	0.269
MOD_GSK3_1	26	33	PF00069	0.698
MOD_GSK3_1	262	269	PF00069	0.316
MOD_GSK3_1	288	295	PF00069	0.325
MOD_GSK3_1	320	327	PF00069	0.484
MOD_GSK3_1	359	366	PF00069	0.479
MOD_GSK3_1	386	393	PF00069	0.425
MOD_GSK3_1	39	46	PF00069	0.785
MOD_GSK3_1	49	56	PF00069	0.651
MOD_GSK3_1	570	577	PF00069	0.470
MOD_GSK3_1	595	602	PF00069	0.448
MOD_GSK3_1	613	620	PF00069	0.402
MOD_GSK3_1	715	722	PF00069	0.532
MOD_GSK3_1	733	740	PF00069	0.430
MOD_GSK3_1	782	789	PF00069	0.536
MOD_GSK3_1	806	813	PF00069	0.477
MOD_GSK3_1	876	883	PF00069	0.565
MOD_GSK3_1	906	913	PF00069	0.520
MOD_GSK3_1	948	955	PF00069	0.508
MOD_LATS_1	79	85	PF00433	0.692
MOD_N-GLC_1	433	438	PF02516	0.516
MOD_N-GLC_1	49	54	PF02516	0.489
MOD_N-GLC_1	549	554	PF02516	0.295
MOD_N-GLC_1	81	86	PF02516	0.497
MOD_N-GLC_1	907	912	PF02516	0.687
MOD_NEK2_1	154	159	PF00069	0.300
MOD_NEK2_1	264	269	PF00069	0.316
MOD_NEK2_1	363	368	PF00069	0.446
MOD_NEK2_1	390	395	PF00069	0.516
MOD_NEK2_1	415	420	PF00069	0.304
MOD_NEK2_1	433	438	PF00069	0.269
MOD_NEK2_1	496	501	PF00069	0.455
MOD_NEK2_1	505	510	PF00069	0.304
MOD_NEK2_1	540	545	PF00069	0.490
MOD_NEK2_1	574	579	PF00069	0.304
MOD_NEK2_1	607	612	PF00069	0.495
MOD_NEK2_1	884	889	PF00069	0.514
MOD_NEK2_1	97	102	PF00069	0.643
MOD_NEK2_2	270	275	PF00069	0.369
MOD_NEK2_2	383	388	PF00069	0.516
MOD_NEK2_2	563	568	PF00069	0.535
MOD_NEK2_2	681	686	PF00069	0.511
MOD_PIKK_1	370	376	PF00454	0.508
MOD_PIKK_1	422	428	PF00454	0.269
MOD_PIKK_1	538	544	PF00454	0.469
MOD_PIKK_1	771	777	PF00454	0.476
MOD_PKA_1	299	305	PF00069	0.484
MOD_PKA_2	234	240	PF00069	0.469
MOD_PKA_2	354	360	PF00069	0.476
MOD_PKA_2	363	369	PF00069	0.460
MOD_PKA_2	53	59	PF00069	0.685
MOD_PKA_2	69	75	PF00069	0.618
MOD_PKA_2	719	725	PF00069	0.493
MOD_PKA_2	810	816	PF00069	0.482
MOD_PKA_2	877	883	PF00069	0.536
MOD_PKA_2	948	954	PF00069	0.510
MOD_Plk_1	368	374	PF00069	0.500
MOD_Plk_1	433	439	PF00069	0.269
MOD_Plk_1	907	913	PF00069	0.487
MOD_Plk_1	98	104	PF00069	0.614
MOD_Plk_4	105	111	PF00069	0.583
MOD_Plk_4	154	160	PF00069	0.300
MOD_Plk_4	187	193	PF00069	0.304
MOD_Plk_4	214	220	PF00069	0.304
MOD_Plk_4	234	240	PF00069	0.383
MOD_Plk_4	281	287	PF00069	0.325
MOD_Plk_4	403	409	PF00069	0.304
MOD_Plk_4	505	511	PF00069	0.313
MOD_Plk_4	540	546	PF00069	0.460
MOD_Plk_4	575	581	PF00069	0.370
MOD_ProDKin_1	220	226	PF00069	0.304
MOD_ProDKin_1	26	32	PF00069	0.647
MOD_ProDKin_1	343	349	PF00069	0.469
MOD_ProDKin_1	697	703	PF00069	0.468
MOD_ProDKin_1	740	746	PF00069	0.541
MOD_ProDKin_1	750	756	PF00069	0.486
MOD_ProDKin_1	758	764	PF00069	0.566
MOD_ProDKin_1	768	774	PF00069	0.412
MOD_ProDKin_1	799	805	PF00069	0.477
MOD_ProDKin_1	901	907	PF00069	0.450
MOD_ProDKin_1	920	926	PF00069	0.447
MOD_SUMO_rev_2	174	181	PF00179	0.516
TRG_DiLeu_BaLyEn_6	93	98	PF01217	0.726
TRG_ENDOCYTIC_2	110	113	PF00928	0.551
TRG_ENDOCYTIC_2	196	199	PF00928	0.369
TRG_ENDOCYTIC_2	222	225	PF00928	0.304
TRG_ENDOCYTIC_2	391	394	PF00928	0.516
TRG_ENDOCYTIC_2	545	548	PF00928	0.469
TRG_ENDOCYTIC_2	569	572	PF00928	0.497
TRG_ENDOCYTIC_2	705	708	PF00928	0.439
TRG_ER_diArg_1	473	475	PF00400	0.484
TRG_Pf-PMV_PEXEL_1	377	381	PF00026	0.316
TRG_Pf-PMV_PEXEL_1	886	890	PF00026	0.713
TRG_Pf-PMV_PEXEL_1	929	933	PF00026	0.618

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAL7	Leptomonas seymouri	50%	100%
A0A3S5H7B0	Leishmania donovani	91%	100%
A4HCC5	Leishmania braziliensis	69%	100%
A4HZX7	Leishmania infantum	91%	100%
E9AVT7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%