Putative small nuclear ribonucleoprotein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

small nuclear ribonucleoprotein, putative

Species:

Leishmania major

UniProt:

Q4QBP1_LEIMA

TriTrypDb:

LmjF.22.1060 , LMJLV39_220016100 , LMJSD75_220016300

Length:

103

Annotations

Annotations by Jardim et al.

Nucleic acid binding, small nuclear ribonucleo

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	yes	yes: 24

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

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Cellular components
Term	Name	Level	Count
GO:0000243	commitment complex	5	2
GO:0005634	nucleus	5	6
GO:0005681	spliceosomal complex	3	2
GO:0005682	U5 snRNP	5	2
GO:0005684	U2-type spliceosomal complex	4	2
GO:0005685	U1 snRNP	5	2
GO:0005686	U2 snRNP	5	2
GO:0005687	U4 snRNP	5	2
GO:0005689	U12-type spliceosomal complex	4	2
GO:0005737	cytoplasm	2	2

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Expansion

Sequence features

Q4QBP1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBP1

Function

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Biological processes
Term	Name	Level	Count
GO:0000387	spliceosomal snRNP assembly	7	3
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006396	RNA processing	6	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	9
GO:0016043	cellular component organization	3	3
GO:0016070	RNA metabolic process	5	6
GO:0022607	cellular component assembly	4	3

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Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
DEG_APCC_DBOX_1	20	28	PF00400	0.500
DOC_MAPK_gen_1	58	65	PF00069	0.541
DOC_MAPK_MEF2A_6	21	29	PF00069	0.475
DOC_USP7_UBL2_3	54	58	PF12436	0.475
DOC_WW_Pin1_4	2	7	PF00397	0.635
LIG_Actin_WH2_2	17	32	PF00022	0.541
LIG_Actin_WH2_2	77	93	PF00022	0.572
LIG_BIR_II_1	1	5	PF00653	0.653
LIG_Clathr_ClatBox_1	24	28	PF01394	0.500
LIG_FHA_1	84	90	PF00498	0.501

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P814	Leptomonas seymouri	89%	98%
A0A1X0PAE8	Trypanosomatidae	35%	90%
A0A3Q8ICE0	Leishmania donovani	100%	100%
A0A422NSZ6	Trypanosoma rangeli	33%	90%
A4HCC3	Leishmania braziliensis	93%	100%
A4HZX8	Leishmania infantum	100%	100%
C9ZSL7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	65%	97%
E9AVT8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O42661	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	45%	88%
P62314	Homo sapiens	46%	87%

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