DUF5353 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBN9_LEIMA

TriTrypDb:

LmjF.22.1080 , LMJLV39_220016300 , LMJSD75_220016500

Length:

252

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	5
GO:0016020	membrane	2	3

Expansion

Sequence features

Q4QBN9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBN9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	172	176	PF00656	0.476
CLV_NRD_NRD_1	121	123	PF00675	0.483
CLV_NRD_NRD_1	161	163	PF00675	0.538
CLV_NRD_NRD_1	196	198	PF00675	0.596
CLV_NRD_NRD_1	74	76	PF00675	0.566
CLV_PCSK_KEX2_1	222	224	PF00082	0.504
CLV_PCSK_KEX2_1	74	76	PF00082	0.622
CLV_PCSK_PC1ET2_1	222	224	PF00082	0.529
CLV_PCSK_SKI1_1	134	138	PF00082	0.614
CLV_PCSK_SKI1_1	144	148	PF00082	0.560
CLV_PCSK_SKI1_1	197	201	PF00082	0.449
CLV_PCSK_SKI1_1	222	226	PF00082	0.489
DEG_SPOP_SBC_1	136	140	PF00917	0.467
DOC_CYCLIN_RxL_1	141	149	PF00134	0.516
DOC_PP1_RVXF_1	220	227	PF00149	0.614
DOC_USP7_MATH_1	171	175	PF00917	0.658
DOC_USP7_MATH_1	204	208	PF00917	0.513
DOC_WW_Pin1_4	153	158	PF00397	0.563
DOC_WW_Pin1_4	36	41	PF00397	0.617
DOC_WW_Pin1_4	6	11	PF00397	0.605
LIG_APCC_ABBAyCdc20_2	74	80	PF00400	0.475
LIG_FHA_1	111	117	PF00498	0.454
LIG_FHA_1	200	206	PF00498	0.561
LIG_FHA_1	241	247	PF00498	0.550
LIG_FHA_2	136	142	PF00498	0.496
LIG_FHA_2	170	176	PF00498	0.544
LIG_FHA_2	42	48	PF00498	0.679
LIG_LIR_Gen_1	207	215	PF02991	0.440
LIG_LIR_Nem_3	214	218	PF02991	0.545
LIG_LIR_Nem_3	230	235	PF02991	0.371
LIG_LIR_Nem_3	89	93	PF02991	0.494
LIG_NRBOX	245	251	PF00104	0.494
LIG_SH2_CRK	247	251	PF00017	0.442
LIG_SH2_SRC	78	81	PF00017	0.594
LIG_SH2_STAP1	229	233	PF00017	0.506
LIG_SH2_STAT5	124	127	PF00017	0.602
LIG_SH2_STAT5	241	244	PF00017	0.494
LIG_SH2_STAT5	88	91	PF00017	0.522
LIG_SH3_3	165	171	PF00018	0.526
LIG_SUMO_SIM_anti_2	100	107	PF11976	0.476
LIG_SUMO_SIM_anti_2	47	53	PF11976	0.642
LIG_SUMO_SIM_par_1	113	121	PF11976	0.591
LIG_SUMO_SIM_par_1	143	149	PF11976	0.570
LIG_ULM_U2AF65_1	222	227	PF00076	0.619
LIG_WRC_WIRS_1	212	217	PF05994	0.573
MOD_CDK_SPK_2	157	162	PF00069	0.476
MOD_CDK_SPxK_1	157	163	PF00069	0.550
MOD_CK1_1	101	107	PF00069	0.592
MOD_CK1_1	173	179	PF00069	0.673
MOD_CK1_1	6	12	PF00069	0.687
MOD_CK2_1	135	141	PF00069	0.606
MOD_CK2_1	41	47	PF00069	0.611
MOD_GlcNHglycan	100	103	PF01048	0.506
MOD_GlcNHglycan	178	181	PF01048	0.692
MOD_GlcNHglycan	6	9	PF01048	0.739
MOD_GlcNHglycan	90	93	PF01048	0.494
MOD_GSK3_1	107	114	PF00069	0.437
MOD_GSK3_1	125	132	PF00069	0.582
MOD_GSK3_1	153	160	PF00069	0.729
MOD_GSK3_1	169	176	PF00069	0.572
MOD_GSK3_1	97	104	PF00069	0.511
MOD_N-GLC_1	153	158	PF02516	0.659
MOD_NEK2_1	125	130	PF00069	0.683
MOD_NEK2_1	211	216	PF00069	0.497
MOD_NEK2_1	4	9	PF00069	0.580
MOD_NEK2_1	69	74	PF00069	0.524
MOD_PIKK_1	199	205	PF00454	0.541
MOD_PIKK_1	25	31	PF00454	0.559
MOD_PKA_2	4	10	PF00069	0.582
MOD_Plk_4	101	107	PF00069	0.481
MOD_Plk_4	111	117	PF00069	0.436
MOD_Plk_4	204	210	PF00069	0.435
MOD_Plk_4	228	234	PF00069	0.487
MOD_ProDKin_1	153	159	PF00069	0.564
MOD_ProDKin_1	36	42	PF00069	0.610
MOD_ProDKin_1	6	12	PF00069	0.607
MOD_SUMO_rev_2	118	125	PF00179	0.556
TRG_DiLeu_BaEn_1	143	148	PF01217	0.568
TRG_DiLeu_BaEn_1	47	52	PF01217	0.641
TRG_DiLeu_BaLyEn_6	142	147	PF01217	0.516
TRG_ENDOCYTIC_2	247	250	PF00928	0.475
TRG_NLS_MonoExtN_4	219	226	PF00514	0.528
TRG_Pf-PMV_PEXEL_1	123	127	PF00026	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E4	Leptomonas seymouri	59%	100%
A0A1X0NTC5	Trypanosomatidae	36%	100%
A0A3Q8IC90	Leishmania donovani	92%	100%
A0A3R7NDY8	Trypanosoma rangeli	38%	100%
A4HCE9	Leishmania braziliensis	81%	100%
A4HZY0	Leishmania infantum	91%	100%
C9ZSL9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AVU0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	99%
V5BVV8	Trypanosoma cruzi	36%	100%