CRAL-TRIO domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

CRAL/TRIO domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QBN8_LEIMA

TriTrypDb:

LmjF.22.1090 , LMJLV39_220016400 , LMJSD75_220016600

Length:

702

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBN8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBN8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	70	74	PF00656	0.390
CLV_NRD_NRD_1	182	184	PF00675	0.436
CLV_NRD_NRD_1	599	601	PF00675	0.529
CLV_NRD_NRD_1	649	651	PF00675	0.428
CLV_NRD_NRD_1	97	99	PF00675	0.382
CLV_PCSK_FUR_1	180	184	PF00082	0.345
CLV_PCSK_FUR_1	597	601	PF00082	0.518
CLV_PCSK_FUR_1	95	99	PF00082	0.396
CLV_PCSK_KEX2_1	180	182	PF00082	0.477
CLV_PCSK_KEX2_1	597	599	PF00082	0.532
CLV_PCSK_KEX2_1	651	653	PF00082	0.451
CLV_PCSK_KEX2_1	95	97	PF00082	0.395
CLV_PCSK_PC1ET2_1	651	653	PF00082	0.451
CLV_PCSK_PC7_1	594	600	PF00082	0.517
CLV_PCSK_SKI1_1	132	136	PF00082	0.327
CLV_PCSK_SKI1_1	166	170	PF00082	0.424
CLV_PCSK_SKI1_1	660	664	PF00082	0.486
CLV_PCSK_SKI1_1	97	101	PF00082	0.365
DEG_COP1_1	520	529	PF00400	0.649
DEG_SCF_FBW7_1	462	468	PF00400	0.725
DEG_SPOP_SBC_1	109	113	PF00917	0.416
DEG_SPOP_SBC_1	283	287	PF00917	0.345
DEG_SPOP_SBC_1	32	36	PF00917	0.593
DEG_SPOP_SBC_1	693	697	PF00917	0.595
DOC_CKS1_1	462	467	PF01111	0.728
DOC_CYCLIN_RxL_1	163	173	PF00134	0.345
DOC_CYCLIN_RxL_1	654	666	PF00134	0.466
DOC_MAPK_gen_1	405	412	PF00069	0.510
DOC_MAPK_gen_1	597	609	PF00069	0.574
DOC_MAPK_gen_1	78	87	PF00069	0.362
DOC_MAPK_MEF2A_6	102	109	PF00069	0.372
DOC_MAPK_MEF2A_6	132	139	PF00069	0.315
DOC_MAPK_MEF2A_6	154	162	PF00069	0.294
DOC_MAPK_MEF2A_6	22	29	PF00069	0.415
DOC_MAPK_MEF2A_6	610	618	PF00069	0.515
DOC_MAPK_MEF2A_6	660	667	PF00069	0.411
DOC_MAPK_NFAT4_5	22	30	PF00069	0.423
DOC_MAPK_NFAT4_5	660	668	PF00069	0.411
DOC_PP2B_LxvP_1	25	28	PF13499	0.390
DOC_PP2B_LxvP_1	389	392	PF13499	0.497
DOC_PP2B_PxIxI_1	104	110	PF00149	0.388
DOC_PP4_FxxP_1	142	145	PF00568	0.395
DOC_USP7_MATH_1	116	120	PF00917	0.324
DOC_USP7_MATH_1	190	194	PF00917	0.346
DOC_USP7_MATH_1	32	36	PF00917	0.643
DOC_USP7_MATH_1	379	383	PF00917	0.628
DOC_USP7_MATH_1	456	460	PF00917	0.664
DOC_USP7_MATH_1	534	538	PF00917	0.678
DOC_USP7_MATH_1	669	673	PF00917	0.390
DOC_USP7_MATH_1	693	697	PF00917	0.565
DOC_USP7_UBL2_3	170	174	PF12436	0.245
DOC_WW_Pin1_4	381	386	PF00397	0.574
DOC_WW_Pin1_4	425	430	PF00397	0.640
DOC_WW_Pin1_4	461	466	PF00397	0.662
DOC_WW_Pin1_4	48	53	PF00397	0.560
DOC_WW_Pin1_4	673	678	PF00397	0.513
LIG_14-3-3_CanoR_1	291	295	PF00244	0.452
LIG_14-3-3_CanoR_1	334	340	PF00244	0.313
LIG_14-3-3_CanoR_1	458	465	PF00244	0.724
LIG_BIR_II_1	1	5	PF00653	0.454
LIG_BRCT_BRCA1_1	118	122	PF00533	0.370
LIG_CtBP_PxDLS_1	312	316	PF00389	0.315
LIG_FHA_1	109	115	PF00498	0.305
LIG_FHA_1	139	145	PF00498	0.339
LIG_FHA_1	308	314	PF00498	0.294
LIG_FHA_1	338	344	PF00498	0.483
LIG_FHA_1	477	483	PF00498	0.754
LIG_FHA_1	526	532	PF00498	0.690
LIG_FHA_2	15	21	PF00498	0.349
LIG_FHA_2	218	224	PF00498	0.286
LIG_FHA_2	666	672	PF00498	0.509
LIG_FHA_2	68	74	PF00498	0.432
LIG_LIR_Apic_2	141	145	PF02991	0.345
LIG_LIR_Gen_1	119	129	PF02991	0.345
LIG_LIR_Gen_1	226	231	PF02991	0.245
LIG_LIR_Gen_1	668	677	PF02991	0.472
LIG_LIR_Nem_3	119	125	PF02991	0.395
LIG_LIR_Nem_3	226	230	PF02991	0.279
LIG_LIR_Nem_3	528	532	PF02991	0.691
LIG_LIR_Nem_3	60	65	PF02991	0.412
LIG_LIR_Nem_3	668	673	PF02991	0.440
LIG_LYPXL_yS_3	259	262	PF13949	0.315
LIG_MYND_3	144	148	PF01753	0.315
LIG_NRBOX	155	161	PF00104	0.294
LIG_NRBOX	658	664	PF00104	0.446
LIG_PCNA_PIPBox_1	69	78	PF02747	0.354
LIG_Pex3_1	659	670	PF04882	0.432
LIG_SH2_CRK	248	252	PF00017	0.245
LIG_SH2_GRB2like	136	139	PF00017	0.315
LIG_SH2_NCK_1	532	536	PF00017	0.678
LIG_SH2_NCK_1	567	571	PF00017	0.580
LIG_SH2_PTP2	136	139	PF00017	0.395
LIG_SH2_PTP2	390	393	PF00017	0.490
LIG_SH2_SRC	136	139	PF00017	0.502
LIG_SH2_SRC	390	393	PF00017	0.490
LIG_SH2_STAP1	248	252	PF00017	0.258
LIG_SH2_STAT5	136	139	PF00017	0.336
LIG_SH2_STAT5	390	393	PF00017	0.504
LIG_SH2_STAT5	532	535	PF00017	0.669
LIG_SH2_STAT5	608	611	PF00017	0.550
LIG_SH2_STAT5	75	78	PF00017	0.342
LIG_SH2_STAT5	79	82	PF00017	0.349
LIG_SH3_2	431	436	PF14604	0.657
LIG_SH3_3	382	388	PF00018	0.613
LIG_SH3_3	389	395	PF00018	0.510
LIG_SH3_3	423	429	PF00018	0.643
LIG_SH3_3	459	465	PF00018	0.673
LIG_SH3_3	46	52	PF00018	0.632
LIG_SUMO_SIM_anti_2	249	256	PF11976	0.427
LIG_SUMO_SIM_anti_2	265	270	PF11976	0.212
LIG_SUMO_SIM_par_1	105	113	PF11976	0.403
LIG_SUMO_SIM_par_1	145	151	PF11976	0.315
LIG_SUMO_SIM_par_1	155	161	PF11976	0.315
LIG_SUMO_SIM_par_1	259	265	PF11976	0.270
LIG_SUMO_SIM_par_1	661	666	PF11976	0.504
LIG_TRAF2_1	52	55	PF00917	0.591
LIG_TRAF2_1	575	578	PF00917	0.468
LIG_TYR_ITIM	134	139	PF00017	0.395
LIG_UBA3_1	251	257	PF00899	0.392
LIG_UBA3_1	76	83	PF00899	0.347
LIG_WRC_WIRS_1	139	144	PF05994	0.345
LIG_WW_3	384	388	PF00397	0.474
MOD_CAAXbox	699	702	PF01239	0.566
MOD_CDC14_SPxK_1	384	387	PF00782	0.483
MOD_CDK_SPxK_1	381	387	PF00069	0.509
MOD_CK1_1	108	114	PF00069	0.436
MOD_CK1_1	34	40	PF00069	0.728
MOD_CK1_1	448	454	PF00069	0.606
MOD_CK1_1	497	503	PF00069	0.762
MOD_CK1_1	565	571	PF00069	0.769
MOD_CK2_1	14	20	PF00069	0.327
MOD_CK2_1	282	288	PF00069	0.345
MOD_CK2_1	338	344	PF00069	0.434
MOD_CK2_1	48	54	PF00069	0.616
MOD_CK2_1	572	578	PF00069	0.490
MOD_CK2_1	619	625	PF00069	0.467
MOD_CK2_1	665	671	PF00069	0.514
MOD_GlcNHglycan	1	4	PF01048	0.480
MOD_GlcNHglycan	118	121	PF01048	0.338
MOD_GlcNHglycan	323	326	PF01048	0.420
MOD_GlcNHglycan	36	39	PF01048	0.706
MOD_GlcNHglycan	363	366	PF01048	0.743
MOD_GlcNHglycan	440	443	PF01048	0.707
MOD_GlcNHglycan	451	454	PF01048	0.680
MOD_GlcNHglycan	496	499	PF01048	0.723
MOD_GlcNHglycan	523	526	PF01048	0.634
MOD_GlcNHglycan	550	553	PF01048	0.660
MOD_GlcNHglycan	570	573	PF01048	0.573
MOD_GSK3_1	105	112	PF00069	0.413
MOD_GSK3_1	186	193	PF00069	0.320
MOD_GSK3_1	246	253	PF00069	0.402
MOD_GSK3_1	27	34	PF00069	0.637
MOD_GSK3_1	354	361	PF00069	0.731
MOD_GSK3_1	415	422	PF00069	0.677
MOD_GSK3_1	445	452	PF00069	0.685
MOD_GSK3_1	456	463	PF00069	0.788
MOD_GSK3_1	517	524	PF00069	0.704
MOD_GSK3_1	530	537	PF00069	0.564
MOD_GSK3_1	568	575	PF00069	0.556
MOD_GSK3_1	665	672	PF00069	0.439
MOD_GSK3_1	693	700	PF00069	0.547
MOD_LATS_1	519	525	PF00433	0.658
MOD_N-GLC_1	246	251	PF02516	0.395
MOD_N-GLC_1	326	331	PF02516	0.381
MOD_N-GLC_1	456	461	PF02516	0.643
MOD_N-GLC_1	619	624	PF02516	0.466
MOD_NEK2_1	100	105	PF00069	0.388
MOD_NEK2_1	240	245	PF00069	0.339
MOD_NEK2_1	262	267	PF00069	0.436
MOD_NEK2_1	306	311	PF00069	0.345
MOD_NEK2_1	328	333	PF00069	0.385
MOD_NEK2_1	337	342	PF00069	0.387
MOD_NEK2_1	396	401	PF00069	0.564
MOD_NEK2_1	415	420	PF00069	0.675
MOD_NEK2_1	449	454	PF00069	0.669
MOD_NEK2_1	538	543	PF00069	0.639
MOD_NEK2_1	548	553	PF00069	0.583
MOD_NEK2_1	663	668	PF00069	0.427
MOD_NEK2_1	67	72	PF00069	0.347
MOD_PIKK_1	338	344	PF00454	0.378
MOD_PIKK_1	396	402	PF00454	0.534
MOD_PIKK_1	468	474	PF00454	0.671
MOD_PK_1	619	625	PF00069	0.494
MOD_PKA_2	290	296	PF00069	0.502
MOD_PKA_2	457	463	PF00069	0.674
MOD_Plk_1	100	106	PF00069	0.395
MOD_Plk_1	246	252	PF00069	0.395
MOD_Plk_1	306	312	PF00069	0.322
MOD_Plk_1	619	625	PF00069	0.467
MOD_Plk_1	663	669	PF00069	0.420
MOD_Plk_2-3	14	20	PF00069	0.327
MOD_Plk_2-3	217	223	PF00069	0.245
MOD_Plk_2-3	488	494	PF00069	0.598
MOD_Plk_4	240	246	PF00069	0.315
MOD_Plk_4	247	253	PF00069	0.315
MOD_Plk_4	262	268	PF00069	0.294
MOD_Plk_4	328	334	PF00069	0.312
MOD_Plk_4	415	421	PF00069	0.630
MOD_Plk_4	445	451	PF00069	0.564
MOD_Plk_4	562	568	PF00069	0.604
MOD_Plk_4	619	625	PF00069	0.483
MOD_ProDKin_1	381	387	PF00069	0.558
MOD_ProDKin_1	425	431	PF00069	0.638
MOD_ProDKin_1	461	467	PF00069	0.663
MOD_ProDKin_1	48	54	PF00069	0.556
MOD_ProDKin_1	673	679	PF00069	0.520
MOD_SUMO_for_1	644	647	PF00179	0.496
MOD_SUMO_rev_2	350	360	PF00179	0.632
TRG_DiLeu_BaEn_1	151	156	PF01217	0.288
TRG_DiLeu_BaEn_1	226	231	PF01217	0.245
TRG_DiLeu_BaLyEn_6	257	262	PF01217	0.345
TRG_DiLeu_LyEn_5	151	156	PF01217	0.288
TRG_ENDOCYTIC_2	136	139	PF00928	0.315
TRG_ENDOCYTIC_2	248	251	PF00928	0.314
TRG_ENDOCYTIC_2	258	261	PF00928	0.454
TRG_ER_diArg_1	180	183	PF00400	0.500
TRG_ER_diArg_1	597	600	PF00400	0.536
TRG_ER_diArg_1	94	97	PF00400	0.384
TRG_NES_CRM1_1	627	641	PF08389	0.434
TRG_NLS_MonoExtC_3	649	654	PF00514	0.438
TRG_NLS_MonoExtN_4	650	655	PF00514	0.495

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P818	Leptomonas seymouri	51%	100%
A0A3Q8IAR1	Leishmania donovani	89%	98%
A4HCF0	Leishmania braziliensis	67%	99%
A4HZY1	Leishmania infantum	89%	99%
E9AVU1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	98%