Lactamase_B domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Beta-lactamase superfamily domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QBN5_LEIMA

TriTrypDb:

LmjF.22.1120 , LMJLV39_220016700 , LMJSD75_220016900

Length:

463

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 21
NetGPI	no	yes: 0, no: 21

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBN5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBN5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	149	153	PF00656	0.339
CLV_C14_Caspase3-7	93	97	PF00656	0.742
CLV_NRD_NRD_1	274	276	PF00675	0.323
CLV_NRD_NRD_1	74	76	PF00675	0.537
CLV_PCSK_KEX2_1	274	276	PF00082	0.324
CLV_PCSK_KEX2_1	74	76	PF00082	0.535
CLV_PCSK_SKI1_1	409	413	PF00082	0.440
DEG_APCC_DBOX_1	73	81	PF00400	0.670
DEG_SPOP_SBC_1	112	116	PF00917	0.526
DOC_CKS1_1	235	240	PF01111	0.282
DOC_MAPK_DCC_7	74	82	PF00069	0.528
DOC_MAPK_gen_1	274	281	PF00069	0.319
DOC_MAPK_gen_1	288	296	PF00069	0.419
DOC_MAPK_gen_1	74	82	PF00069	0.606
DOC_MAPK_MEF2A_6	288	296	PF00069	0.463
DOC_MAPK_MEF2A_6	63	72	PF00069	0.393
DOC_MAPK_MEF2A_6	74	82	PF00069	0.592
DOC_MAPK_NFAT4_5	63	71	PF00069	0.379
DOC_USP7_MATH_1	120	124	PF00917	0.716
DOC_USP7_MATH_1	337	341	PF00917	0.368
DOC_USP7_MATH_1	362	366	PF00917	0.441
DOC_USP7_MATH_1	432	436	PF00917	0.400
DOC_USP7_MATH_1	55	59	PF00917	0.597
DOC_USP7_UBL2_3	215	219	PF12436	0.329
DOC_WW_Pin1_4	207	212	PF00397	0.421
DOC_WW_Pin1_4	234	239	PF00397	0.450
DOC_WW_Pin1_4	381	386	PF00397	0.419
DOC_WW_Pin1_4	387	392	PF00397	0.409
LIG_14-3-3_CanoR_1	226	230	PF00244	0.342
LIG_14-3-3_CanoR_1	274	282	PF00244	0.345
LIG_14-3-3_CanoR_1	63	69	PF00244	0.401
LIG_BIR_II_1	1	5	PF00653	0.674
LIG_BRCT_BRCA1_1	1	5	PF00533	0.561
LIG_BRCT_BRCA1_1	364	368	PF00533	0.439
LIG_Clathr_ClatBox_1	281	285	PF01394	0.445
LIG_Clathr_ClatBox_1	372	376	PF01394	0.370
LIG_deltaCOP1_diTrp_1	198	204	PF00928	0.445
LIG_FHA_1	113	119	PF00498	0.720
LIG_FHA_1	166	172	PF00498	0.445
LIG_FHA_2	147	153	PF00498	0.288
LIG_FHA_2	235	241	PF00498	0.345
LIG_FHA_2	275	281	PF00498	0.362
LIG_FHA_2	88	94	PF00498	0.765
LIG_LIR_Apic_2	131	136	PF02991	0.415
LIG_LIR_Apic_2	207	211	PF02991	0.415
LIG_LIR_Nem_3	152	157	PF02991	0.339
LIG_LIR_Nem_3	265	271	PF02991	0.432
LIG_LIR_Nem_3	311	317	PF02991	0.340
LIG_SH2_CRK	24	28	PF00017	0.387
LIG_SH2_CRK	315	319	PF00017	0.358
LIG_SH2_PTP2	133	136	PF00017	0.405
LIG_SH2_STAT5	133	136	PF00017	0.649
LIG_SH2_STAT5	154	157	PF00017	0.348
LIG_SH2_STAT5	208	211	PF00017	0.298
LIG_SH2_STAT5	223	226	PF00017	0.227
LIG_SH2_STAT5	325	328	PF00017	0.392
LIG_SH2_STAT5	354	357	PF00017	0.311
LIG_SH2_STAT5	394	397	PF00017	0.334
LIG_SH3_1	75	81	PF00018	0.482
LIG_SH3_3	14	20	PF00018	0.532
LIG_SH3_3	456	462	PF00018	0.481
LIG_SH3_3	51	57	PF00018	0.508
LIG_SH3_3	75	81	PF00018	0.688
LIG_SUMO_SIM_par_1	167	172	PF11976	0.445
LIG_UBA3_1	399	407	PF00899	0.317
LIG_WRC_WIRS_1	201	206	PF05994	0.440
LIG_WW_1	21	24	PF00397	0.459
MOD_CDK_SPxxK_3	381	388	PF00069	0.317
MOD_CK1_1	104	110	PF00069	0.743
MOD_CK1_1	162	168	PF00069	0.282
MOD_CK1_1	210	216	PF00069	0.326
MOD_CK1_1	228	234	PF00069	0.339
MOD_CK1_1	236	242	PF00069	0.389
MOD_CK1_1	32	38	PF00069	0.334
MOD_CK1_1	340	346	PF00069	0.443
MOD_CK1_1	356	362	PF00069	0.311
MOD_CK1_1	87	93	PF00069	0.764
MOD_CK2_1	234	240	PF00069	0.328
MOD_GlcNHglycan	106	109	PF01048	0.747
MOD_GlcNHglycan	2	5	PF01048	0.623
MOD_GlcNHglycan	230	233	PF01048	0.434
MOD_GlcNHglycan	31	34	PF01048	0.380
MOD_GlcNHglycan	385	388	PF01048	0.462
MOD_GlcNHglycan	56	60	PF01048	0.536
MOD_GlcNHglycan	86	89	PF01048	0.647
MOD_GSK3_1	100	107	PF00069	0.537
MOD_GSK3_1	165	172	PF00069	0.437
MOD_GSK3_1	200	207	PF00069	0.398
MOD_GSK3_1	209	216	PF00069	0.367
MOD_GSK3_1	25	32	PF00069	0.339
MOD_GSK3_1	299	306	PF00069	0.435
MOD_GSK3_1	333	340	PF00069	0.368
MOD_GSK3_1	383	390	PF00069	0.382
MOD_GSK3_1	64	71	PF00069	0.411
MOD_GSK3_1	7	14	PF00069	0.645
MOD_GSK3_1	82	89	PF00069	0.643
MOD_N-GLC_1	258	263	PF02516	0.455
MOD_N-GLC_1	64	69	PF02516	0.396
MOD_NEK2_1	169	174	PF00069	0.434
MOD_NEK2_1	25	30	PF00069	0.453
MOD_NEK2_1	68	73	PF00069	0.412
MOD_NEK2_2	120	125	PF00069	0.710
MOD_NEK2_2	146	151	PF00069	0.315
MOD_PIKK_1	11	17	PF00454	0.549
MOD_PIKK_1	340	346	PF00454	0.466
MOD_PKA_1	274	280	PF00069	0.367
MOD_PKA_2	118	124	PF00069	0.559
MOD_PKA_2	159	165	PF00069	0.266
MOD_PKA_2	225	231	PF00069	0.284
MOD_PKA_2	273	279	PF00069	0.317
MOD_PKA_2	333	339	PF00069	0.428
MOD_PKA_2	340	346	PF00069	0.404
MOD_Plk_1	217	223	PF00069	0.358
MOD_Plk_1	356	362	PF00069	0.340
MOD_Plk_1	450	456	PF00069	0.445
MOD_Plk_1	64	70	PF00069	0.392
MOD_Plk_4	165	171	PF00069	0.397
MOD_Plk_4	200	206	PF00069	0.412
MOD_Plk_4	25	31	PF00069	0.434
MOD_ProDKin_1	207	213	PF00069	0.421
MOD_ProDKin_1	234	240	PF00069	0.450
MOD_ProDKin_1	381	387	PF00069	0.419
MOD_SUMO_rev_2	87	97	PF00179	0.536
TRG_ENDOCYTIC_2	154	157	PF00928	0.370
TRG_ENDOCYTIC_2	24	27	PF00928	0.393
TRG_ENDOCYTIC_2	325	328	PF00928	0.358
TRG_ENDOCYTIC_2	454	457	PF00928	0.424
TRG_ER_diArg_1	273	275	PF00400	0.380
TRG_ER_diArg_1	73	75	PF00400	0.540
TRG_NES_CRM1_1	370	381	PF08389	0.371
TRG_Pf-PMV_PEXEL_1	75	79	PF00026	0.468

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0M2	Leptomonas seymouri	62%	100%
A0A0N1PFX0	Leptomonas seymouri	35%	100%
A0A0S4J8Q0	Bodo saltans	39%	100%
A0A0S4JLW1	Bodo saltans	24%	100%
A0A1X0NTE2	Trypanosomatidae	40%	100%
A0A1X0NX03	Trypanosomatidae	24%	100%
A0A3Q8IFK3	Leishmania donovani	92%	99%
A0A3S5IS87	Trypanosoma rangeli	24%	100%
A0A3S7WXD8	Leishmania donovani	42%	100%
A0A422NHR8	Trypanosoma rangeli	43%	100%
A4HCF4	Leishmania braziliensis	85%	99%
A4HZY3	Leishmania infantum	92%	99%
A4HZY4	Leishmania infantum	42%	100%
C9ZSM3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZVB8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AVU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%
E9AVU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	42%	100%
Q4QBN4	Leishmania major	48%	100%
V5BJ96	Trypanosoma cruzi	24%	100%
V5BVW3	Trypanosoma cruzi	43%	100%