Lactamase_B domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Beta-lactamase superfamily domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QBN4_LEIMA

TriTrypDb:

LmjF.22.1130 , LMJLV39_220016800 , LMJSD75_220017000

Length:

426

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 19
NetGPI	no	yes: 0, no: 19

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBN4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBN4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	149	151	PF00675	0.379
CLV_NRD_NRD_1	348	350	PF00675	0.410
CLV_NRD_NRD_1	44	46	PF00675	0.323
CLV_NRD_NRD_1	5	7	PF00675	0.539
CLV_PCSK_KEX2_1	149	151	PF00082	0.393
CLV_PCSK_KEX2_1	348	350	PF00082	0.452
CLV_PCSK_KEX2_1	44	46	PF00082	0.324
CLV_PCSK_KEX2_1	5	7	PF00082	0.539
CLV_PCSK_SKI1_1	403	407	PF00082	0.472
DEG_APCC_DBOX_1	379	387	PF00400	0.487
DEG_APCC_DBOX_1	5	13	PF00400	0.298
DEG_ODPH_VHL_1	84	97	PF01847	0.406
DEG_SPOP_SBC_1	199	203	PF00917	0.247
DOC_CDC14_PxL_1	154	162	PF14671	0.247
DOC_MAPK_gen_1	221	229	PF00069	0.476
DOC_MAPK_gen_1	376	385	PF00069	0.505
DOC_MAPK_gen_1	44	52	PF00069	0.321
DOC_MAPK_gen_1	5	11	PF00069	0.468
DOC_MAPK_gen_1	74	83	PF00069	0.280
DOC_MAPK_HePTP_8	375	387	PF00069	0.356
DOC_MAPK_MEF2A_6	221	229	PF00069	0.528
DOC_MAPK_MEF2A_6	313	321	PF00069	0.285
DOC_MAPK_MEF2A_6	378	387	PF00069	0.539
DOC_MAPK_MEF2A_6	44	52	PF00069	0.364
DOC_PP1_RVXF_1	400	407	PF00149	0.329
DOC_PP1_RVXF_1	6	12	PF00149	0.287
DOC_PP2B_LxvP_1	155	158	PF13499	0.230
DOC_USP7_MATH_1	186	190	PF00917	0.464
DOC_USP7_MATH_1	199	203	PF00917	0.318
DOC_USP7_MATH_1	276	280	PF00917	0.440
DOC_USP7_MATH_1	301	305	PF00917	0.472
DOC_USP7_MATH_1	328	332	PF00917	0.505
DOC_USP7_MATH_1	37	41	PF00917	0.502
DOC_USP7_MATH_1	388	392	PF00917	0.597
DOC_WW_Pin1_4	124	129	PF00397	0.426
DOC_WW_Pin1_4	164	169	PF00397	0.448
LIG_14-3-3_CanoR_1	121	127	PF00244	0.302
LIG_14-3-3_CanoR_1	137	145	PF00244	0.147
LIG_14-3-3_CanoR_1	200	208	PF00244	0.381
LIG_14-3-3_CanoR_1	348	352	PF00244	0.424
LIG_14-3-3_CanoR_1	409	414	PF00244	0.451
LIG_14-3-3_CanoR_1	45	51	PF00244	0.382
LIG_14-3-3_CanoR_1	6	12	PF00244	0.385
LIG_Actin_WH2_2	136	151	PF00022	0.189
LIG_BRCT_BRCA1_1	303	307	PF00533	0.465
LIG_BRCT_BRCA1_1	52	56	PF00533	0.311
LIG_Clathr_ClatBox_1	311	315	PF01394	0.369
LIG_CtBP_PxDLS_1	231	235	PF00389	0.405
LIG_eIF4E_1	91	97	PF01652	0.353
LIG_FHA_1	348	354	PF00498	0.326
LIG_FHA_2	208	214	PF00498	0.319
LIG_FHA_2	394	400	PF00498	0.362
LIG_IRF3_LxIS_1	48	53	PF10401	0.397
LIG_LIR_Gen_1	64	70	PF02991	0.325
LIG_LIR_Gen_1	78	87	PF02991	0.374
LIG_LIR_Nem_3	250	256	PF02991	0.362
LIG_LIR_Nem_3	64	68	PF02991	0.339
LIG_LIR_Nem_3	78	83	PF02991	0.332
LIG_Pex14_2	352	356	PF04695	0.436
LIG_RPA_C_Fungi	404	416	PF08784	0.290
LIG_SH2_CRK	254	258	PF00017	0.339
LIG_SH2_CRK	80	84	PF00017	0.416
LIG_SH2_SRC	91	94	PF00017	0.353
LIG_SH2_STAP1	122	126	PF00017	0.213
LIG_SH2_STAT3	417	420	PF00017	0.490
LIG_SH2_STAT5	264	267	PF00017	0.408
LIG_SH2_STAT5	293	296	PF00017	0.316
LIG_SH2_STAT5	333	336	PF00017	0.352
LIG_SH2_STAT5	351	354	PF00017	0.269
LIG_SH2_STAT5	91	94	PF00017	0.385
LIG_SH3_2	39	44	PF14604	0.438
LIG_SH3_3	225	231	PF00018	0.442
LIG_SH3_3	36	42	PF00018	0.475
LIG_SH3_3	382	388	PF00018	0.450
LIG_SH3_3	80	86	PF00018	0.353
LIG_SUMO_SIM_anti_2	315	320	PF11976	0.261
LIG_SUMO_SIM_anti_2	381	387	PF11976	0.373
LIG_SUMO_SIM_par_1	315	320	PF11976	0.268
LIG_UBA3_1	214	221	PF00899	0.400
LIG_WRC_WIRS_1	151	156	PF05994	0.415
MOD_CK1_1	127	133	PF00069	0.391
MOD_CK1_1	201	207	PF00069	0.247
MOD_CK1_1	279	285	PF00069	0.645
MOD_CK1_1	295	301	PF00069	0.319
MOD_CK2_1	200	206	PF00069	0.358
MOD_CK2_1	395	401	PF00069	0.496
MOD_CK2_1	58	64	PF00069	0.470
MOD_GlcNHglycan	133	136	PF01048	0.452
MOD_GlcNHglycan	140	143	PF01048	0.418
MOD_GlcNHglycan	17	20	PF01048	0.390
MOD_GlcNHglycan	188	191	PF01048	0.418
MOD_GlcNHglycan	203	206	PF01048	0.376
MOD_GlcNHglycan	236	239	PF01048	0.655
MOD_GlcNHglycan	328	331	PF01048	0.533
MOD_GlcNHglycan	39	42	PF01048	0.579
MOD_GlcNHglycan	390	393	PF01048	0.574
MOD_GlcNHglycan	60	63	PF01048	0.541
MOD_GlcNHglycan	77	80	PF01048	0.314
MOD_GSK3_1	122	129	PF00069	0.370
MOD_GSK3_1	131	138	PF00069	0.355
MOD_GSK3_1	182	189	PF00069	0.381
MOD_GSK3_1	191	198	PF00069	0.428
MOD_GSK3_1	230	237	PF00069	0.625
MOD_GSK3_1	242	249	PF00069	0.627
MOD_GSK3_1	272	279	PF00069	0.401
MOD_GSK3_1	46	53	PF00069	0.365
MOD_GSK3_1	7	14	PF00069	0.282
MOD_N-GLC_1	242	247	PF02516	0.625
MOD_N-GLC_1	46	51	PF02516	0.375
MOD_NEK2_1	217	222	PF00069	0.361
MOD_NEK2_1	234	239	PF00069	0.389
MOD_NEK2_1	50	55	PF00069	0.380
MOD_NEK2_1	7	12	PF00069	0.380
MOD_NEK2_1	95	100	PF00069	0.410
MOD_NEK2_2	72	77	PF00069	0.287
MOD_PIKK_1	169	175	PF00454	0.222
MOD_PIKK_1	279	285	PF00454	0.661
MOD_PKA_2	199	205	PF00069	0.399
MOD_PKA_2	272	278	PF00069	0.464
MOD_PKA_2	279	285	PF00069	0.576
MOD_PKA_2	347	353	PF00069	0.436
MOD_PKA_2	7	13	PF00069	0.378
MOD_Plk_1	295	301	PF00069	0.393
MOD_Plk_1	46	52	PF00069	0.370
MOD_Plk_4	150	156	PF00069	0.400
MOD_Plk_4	207	213	PF00069	0.376
MOD_Plk_4	46	52	PF00069	0.289
MOD_Plk_4	7	13	PF00069	0.373
MOD_ProDKin_1	124	130	PF00069	0.426
MOD_ProDKin_1	164	170	PF00069	0.448
MOD_SUMO_rev_2	213	222	PF00179	0.348
MOD_SUMO_rev_2	371	377	PF00179	0.465
MOD_SUMO_rev_2	397	405	PF00179	0.366
MOD_SUMO_rev_2	53	61	PF00179	0.400
TRG_ENDOCYTIC_2	264	267	PF00928	0.349
TRG_ENDOCYTIC_2	80	83	PF00928	0.337
TRG_ER_diArg_1	148	150	PF00400	0.393
TRG_ER_diArg_1	347	349	PF00400	0.436
TRG_ER_diArg_1	4	6	PF00400	0.518
TRG_NES_CRM1_1	206	219	PF08389	0.338
TRG_NES_CRM1_1	309	320	PF08389	0.357
TRG_Pf-PMV_PEXEL_1	370	374	PF00026	0.506

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0M2	Leptomonas seymouri	37%	94%
A0A0N1PFX0	Leptomonas seymouri	57%	94%
A0A0S4J8Q0	Bodo saltans	35%	100%
A0A0S4JLW1	Bodo saltans	24%	96%
A0A1X0NTE2	Trypanosomatidae	41%	100%
A0A1X0NX03	Trypanosomatidae	23%	100%
A0A3Q8IFK3	Leishmania donovani	46%	91%
A0A3S7WXD8	Leishmania donovani	93%	100%
A0A422NHR8	Trypanosoma rangeli	41%	100%
A4HCF4	Leishmania braziliensis	45%	91%
A4HZY3	Leishmania infantum	46%	91%
A4HZY4	Leishmania infantum	93%	100%
C9ZSM3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	100%
C9ZVB8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AVU4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	45%	91%
E9AVU5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	99%
Q4QBN5	Leishmania major	48%	92%
V5BVW3	Trypanosoma cruzi	40%	100%