Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBN1_LEIMA

TriTrypDb:

LmjF.22.1160 , LMJLV39_220017100 , LMJSD75_220017300

Length:

453

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBN1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBN1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	102	104	PF00675	0.652
CLV_NRD_NRD_1	19	21	PF00675	0.557
CLV_PCSK_KEX2_1	102	104	PF00082	0.652
CLV_PCSK_KEX2_1	19	21	PF00082	0.557
CLV_PCSK_KEX2_1	65	67	PF00082	0.507
CLV_PCSK_PC1ET2_1	65	67	PF00082	0.566
CLV_PCSK_SKI1_1	305	309	PF00082	0.449
CLV_PCSK_SKI1_1	327	331	PF00082	0.515
CLV_PCSK_SKI1_1	417	421	PF00082	0.543
CLV_PCSK_SKI1_1	87	91	PF00082	0.702
DEG_APCC_DBOX_1	21	29	PF00400	0.567
DOC_CKS1_1	88	93	PF01111	0.690
DOC_CYCLIN_RxL_1	299	312	PF00134	0.425
DOC_CYCLIN_yClb5_NLxxxL_5	54	63	PF00134	0.445
DOC_CYCLIN_yCln2_LP_2	189	195	PF00134	0.549
DOC_MAPK_gen_1	268	276	PF00069	0.515
DOC_PP1_RVXF_1	205	211	PF00149	0.505
DOC_USP7_MATH_1	117	121	PF00917	0.707
DOC_USP7_MATH_1	129	133	PF00917	0.729
DOC_USP7_MATH_1	181	185	PF00917	0.582
DOC_USP7_MATH_1	259	263	PF00917	0.662
DOC_WW_Pin1_4	130	135	PF00397	0.732
DOC_WW_Pin1_4	141	146	PF00397	0.602
DOC_WW_Pin1_4	282	287	PF00397	0.494
DOC_WW_Pin1_4	348	353	PF00397	0.524
DOC_WW_Pin1_4	373	378	PF00397	0.520
DOC_WW_Pin1_4	87	92	PF00397	0.621
LIG_14-3-3_CanoR_1	113	117	PF00244	0.691
LIG_14-3-3_CanoR_1	140	145	PF00244	0.666
LIG_14-3-3_CanoR_1	212	216	PF00244	0.597
LIG_14-3-3_CanoR_1	282	286	PF00244	0.436
LIG_14-3-3_CanoR_1	345	349	PF00244	0.519
LIG_14-3-3_CanoR_1	439	444	PF00244	0.538
LIG_BIR_II_1	1	5	PF00653	0.702
LIG_FHA_1	16	22	PF00498	0.544
LIG_FHA_1	170	176	PF00498	0.406
LIG_FHA_1	211	217	PF00498	0.579
LIG_FHA_1	309	315	PF00498	0.438
LIG_FHA_1	37	43	PF00498	0.564
LIG_FHA_1	382	388	PF00498	0.445
LIG_FHA_1	418	424	PF00498	0.534
LIG_FHA_1	49	55	PF00498	0.455
LIG_FHA_1	9	15	PF00498	0.592
LIG_FHA_2	304	310	PF00498	0.435
LIG_FHA_2	31	37	PF00498	0.665
LIG_FHA_2	411	417	PF00498	0.561
LIG_FHA_2	440	446	PF00498	0.569
LIG_FHA_2	88	94	PF00498	0.696
LIG_GBD_Chelix_1	216	224	PF00786	0.555
LIG_LIR_Apic_2	239	243	PF02991	0.519
LIG_LIR_Apic_2	347	352	PF02991	0.531
LIG_LIR_Apic_2	51	55	PF02991	0.375
LIG_LIR_Gen_1	442	451	PF02991	0.587
LIG_LIR_Nem_3	223	229	PF02991	0.517
LIG_LIR_Nem_3	362	368	PF02991	0.427
LIG_LIR_Nem_3	442	446	PF02991	0.573
LIG_LIR_Nem_3	51	56	PF02991	0.400
LIG_PALB2_WD40_1	48	56	PF16756	0.452
LIG_Pex14_2	365	369	PF04695	0.389
LIG_PTB_Apo_2	239	246	PF02174	0.498
LIG_PTB_Apo_2	55	62	PF02174	0.441
LIG_PTB_Phospho_1	239	245	PF10480	0.505
LIG_PTB_Phospho_1	55	61	PF10480	0.441
LIG_SH2_CRK	240	244	PF00017	0.509
LIG_SH2_CRK	283	287	PF00017	0.373
LIG_SH2_GRB2like	157	160	PF00017	0.630
LIG_SH2_NCK_1	283	287	PF00017	0.373
LIG_SH2_STAP1	443	447	PF00017	0.601
LIG_SH2_STAT5	157	160	PF00017	0.595
LIG_SH2_STAT5	245	248	PF00017	0.446
LIG_SH2_STAT5	27	30	PF00017	0.667
LIG_SH2_STAT5	283	286	PF00017	0.380
LIG_SH2_STAT5	372	375	PF00017	0.445
LIG_SH2_STAT5	61	64	PF00017	0.526
LIG_SH3_3	26	32	PF00018	0.589
LIG_SH3_3	349	355	PF00018	0.526
LIG_SH3_3	375	381	PF00018	0.429
LIG_SH3_3	78	84	PF00018	0.677
LIG_SH3_3	85	91	PF00018	0.750
LIG_UBA3_1	233	241	PF00899	0.514
MOD_CDC14_SPxK_1	137	140	PF00782	0.612
MOD_CDK_SPxK_1	134	140	PF00069	0.608
MOD_CK1_1	133	139	PF00069	0.691
MOD_CK1_1	143	149	PF00069	0.618
MOD_CK1_1	2	8	PF00069	0.689
MOD_CK1_1	219	225	PF00069	0.591
MOD_CK1_1	350	356	PF00069	0.494
MOD_CK1_1	41	47	PF00069	0.544
MOD_CK1_1	410	416	PF00069	0.558
MOD_CK2_1	143	149	PF00069	0.666
MOD_CK2_1	181	187	PF00069	0.464
MOD_CK2_1	364	370	PF00069	0.517
MOD_CK2_1	415	421	PF00069	0.540
MOD_CK2_1	439	445	PF00069	0.618
MOD_CK2_1	87	93	PF00069	0.673
MOD_GlcNHglycan	119	122	PF01048	0.710
MOD_GlcNHglycan	246	249	PF01048	0.498
MOD_GlcNHglycan	261	264	PF01048	0.702
MOD_GlcNHglycan	322	325	PF01048	0.409
MOD_GlcNHglycan	4	7	PF01048	0.745
MOD_GlcNHglycan	409	412	PF01048	0.564
MOD_GSK3_1	129	136	PF00069	0.641
MOD_GSK3_1	139	146	PF00069	0.598
MOD_GSK3_1	216	223	PF00069	0.531
MOD_GSK3_1	303	310	PF00069	0.491
MOD_GSK3_1	344	351	PF00069	0.529
MOD_GSK3_1	37	44	PF00069	0.485
MOD_N-GLC_1	320	325	PF02516	0.407
MOD_NEK2_1	112	117	PF00069	0.704
MOD_NEK2_1	216	221	PF00069	0.510
MOD_NEK2_1	307	312	PF00069	0.497
MOD_NEK2_1	339	344	PF00069	0.489
MOD_NEK2_2	196	201	PF00069	0.431
MOD_PK_1	103	109	PF00069	0.654
MOD_PK_1	232	238	PF00069	0.483
MOD_PKA_2	112	118	PF00069	0.701
MOD_PKA_2	139	145	PF00069	0.667
MOD_PKA_2	15	21	PF00069	0.596
MOD_PKA_2	211	217	PF00069	0.588
MOD_PKA_2	281	287	PF00069	0.424
MOD_PKA_2	344	350	PF00069	0.520
MOD_Plk_1	320	326	PF00069	0.413
MOD_Plk_1	390	396	PF00069	0.465
MOD_Plk_1	415	421	PF00069	0.534
MOD_Plk_1	92	98	PF00069	0.642
MOD_Plk_2-3	364	370	PF00069	0.450
MOD_Plk_4	103	109	PF00069	0.690
MOD_Plk_4	161	167	PF00069	0.527
MOD_Plk_4	169	175	PF00069	0.393
MOD_Plk_4	181	187	PF00069	0.399
MOD_Plk_4	211	217	PF00069	0.560
MOD_Plk_4	303	309	PF00069	0.421
MOD_Plk_4	339	345	PF00069	0.487
MOD_Plk_4	364	370	PF00069	0.393
MOD_Plk_4	381	387	PF00069	0.263
MOD_Plk_4	390	396	PF00069	0.404
MOD_Plk_4	48	54	PF00069	0.369
MOD_ProDKin_1	130	136	PF00069	0.732
MOD_ProDKin_1	141	147	PF00069	0.601
MOD_ProDKin_1	282	288	PF00069	0.491
MOD_ProDKin_1	348	354	PF00069	0.519
MOD_ProDKin_1	373	379	PF00069	0.525
MOD_ProDKin_1	87	93	PF00069	0.620
MOD_SUMO_for_1	298	301	PF00179	0.461
MOD_SUMO_rev_2	235	243	PF00179	0.516
TRG_DiLeu_BaLyEn_6	185	190	PF01217	0.518
TRG_ENDOCYTIC_2	27	30	PF00928	0.695
TRG_ENDOCYTIC_2	431	434	PF00928	0.502
TRG_ENDOCYTIC_2	443	446	PF00928	0.517
TRG_ER_diArg_1	19	22	PF00400	0.559
TRG_Pf-PMV_PEXEL_1	19	23	PF00026	0.665
TRG_Pf-PMV_PEXEL_1	417	421	PF00026	0.519

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P811	Leptomonas seymouri	80%	100%
A0A0S4JBD1	Bodo saltans	47%	100%
A0A3R7MFR3	Trypanosoma rangeli	54%	100%
A0A3S7WX76	Leishmania donovani	94%	100%
A4HCF8	Leishmania braziliensis	90%	100%
A4HZY7	Leishmania infantum	94%	94%
E9AVU8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BVW6	Trypanosoma cruzi	52%	100%