Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QBM9_LEIMA

TriTrypDb:

LmjF.22.1180 , LMJLV39_220017300 , LMJSD75_220017500

Length:

579

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 1, no: 4
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	5
GO:0110165	cellular anatomical entity	1	5

Expansion

Sequence features

Q4QBM9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBM9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	342	346	PF00656	0.763
CLV_C14_Caspase3-7	392	396	PF00656	0.758
CLV_NRD_NRD_1	115	117	PF00675	0.459
CLV_NRD_NRD_1	253	255	PF00675	0.387
CLV_NRD_NRD_1	261	263	PF00675	0.388
CLV_NRD_NRD_1	295	297	PF00675	0.506
CLV_NRD_NRD_1	388	390	PF00675	0.610
CLV_NRD_NRD_1	452	454	PF00675	0.490
CLV_NRD_NRD_1	494	496	PF00675	0.512
CLV_NRD_NRD_1	506	508	PF00675	0.465
CLV_NRD_NRD_1	527	529	PF00675	0.520
CLV_NRD_NRD_1	60	62	PF00675	0.575
CLV_NRD_NRD_1	73	75	PF00675	0.575
CLV_PCSK_FUR_1	282	286	PF00082	0.488
CLV_PCSK_FUR_1	386	390	PF00082	0.488
CLV_PCSK_FUR_1	58	62	PF00082	0.575
CLV_PCSK_KEX2_1	115	117	PF00082	0.459
CLV_PCSK_KEX2_1	244	246	PF00082	0.392
CLV_PCSK_KEX2_1	252	254	PF00082	0.360
CLV_PCSK_KEX2_1	260	262	PF00082	0.337
CLV_PCSK_KEX2_1	284	286	PF00082	0.475
CLV_PCSK_KEX2_1	295	297	PF00082	0.433
CLV_PCSK_KEX2_1	388	390	PF00082	0.614
CLV_PCSK_KEX2_1	494	496	PF00082	0.512
CLV_PCSK_KEX2_1	506	508	PF00082	0.465
CLV_PCSK_KEX2_1	60	62	PF00082	0.605
CLV_PCSK_KEX2_1	73	75	PF00082	0.550
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.430
CLV_PCSK_PC1ET2_1	284	286	PF00082	0.447
CLV_PCSK_PC7_1	256	262	PF00082	0.432
CLV_PCSK_PC7_1	56	62	PF00082	0.563
CLV_PCSK_SKI1_1	173	177	PF00082	0.322
CLV_PCSK_SKI1_1	184	188	PF00082	0.337
CLV_PCSK_SKI1_1	261	265	PF00082	0.480
CLV_PCSK_SKI1_1	38	42	PF00082	0.556
CLV_PCSK_SKI1_1	494	498	PF00082	0.509
CLV_PCSK_SKI1_1	528	532	PF00082	0.585
CLV_PCSK_SKI1_1	61	65	PF00082	0.545
DEG_Nend_UBRbox_1	1	4	PF02207	0.426
DEG_SCF_TRCP1_1	395	401	PF00400	0.676
DOC_ANK_TNKS_1	295	302	PF00023	0.745
DOC_CKS1_1	165	170	PF01111	0.272
DOC_MAPK_gen_1	115	122	PF00069	0.644
DOC_MAPK_MEF2A_6	6	14	PF00069	0.379
DOC_MAPK_RevD_3	102	116	PF00069	0.499
DOC_PP2B_LxvP_1	246	249	PF13499	0.575
DOC_PP2B_LxvP_1	377	380	PF13499	0.701
DOC_SPAK_OSR1_1	495	499	PF12202	0.776
DOC_USP7_MATH_1	194	198	PF00917	0.506
DOC_USP7_MATH_1	218	222	PF00917	0.449
DOC_USP7_MATH_1	24	28	PF00917	0.435
DOC_USP7_MATH_1	393	397	PF00917	0.678
DOC_USP7_MATH_1	398	402	PF00917	0.657
DOC_USP7_MATH_1	412	416	PF00917	0.805
DOC_USP7_MATH_1	548	552	PF00917	0.831
DOC_USP7_UBL2_3	538	542	PF12436	0.788
DOC_WW_Pin1_4	164	169	PF00397	0.419
DOC_WW_Pin1_4	315	320	PF00397	0.665
DOC_WW_Pin1_4	354	359	PF00397	0.787
DOC_WW_Pin1_4	423	428	PF00397	0.731
DOC_WW_Pin1_4	436	441	PF00397	0.674
DOC_WW_Pin1_4	471	476	PF00397	0.765
DOC_WW_Pin1_4	498	503	PF00397	0.748
DOC_WW_Pin1_4	528	533	PF00397	0.736
LIG_14-3-3_CanoR_1	115	121	PF00244	0.674
LIG_14-3-3_CanoR_1	173	183	PF00244	0.419
LIG_14-3-3_CanoR_1	26	31	PF00244	0.436
LIG_14-3-3_CanoR_1	261	271	PF00244	0.576
LIG_14-3-3_CanoR_1	479	484	PF00244	0.731
LIG_BIR_III_4	399	403	PF00653	0.675
LIG_Clathr_ClatBox_1	133	137	PF01394	0.272
LIG_CtBP_PxDLS_1	480	484	PF00389	0.782
LIG_FHA_1	146	152	PF00498	0.351
LIG_FHA_1	15	21	PF00498	0.457
LIG_FHA_1	30	36	PF00498	0.403
LIG_FHA_1	525	531	PF00498	0.801
LIG_FHA_2	340	346	PF00498	0.788
LIG_FHA_2	433	439	PF00498	0.756
LIG_FHA_2	559	565	PF00498	0.762
LIG_GBD_Chelix_1	134	142	PF00786	0.419
LIG_HCF-1_HBM_1	517	520	PF13415	0.753
LIG_LIR_Gen_1	114	125	PF02991	0.510
LIG_LIR_Gen_1	13	23	PF02991	0.365
LIG_LIR_Gen_1	154	163	PF02991	0.324
LIG_LIR_Gen_1	177	187	PF02991	0.484
LIG_LIR_Gen_1	517	524	PF02991	0.736
LIG_LIR_Gen_1	88	97	PF02991	0.281
LIG_LIR_Gen_1	99	109	PF02991	0.322
LIG_LIR_Nem_3	114	120	PF02991	0.512
LIG_LIR_Nem_3	13	18	PF02991	0.432
LIG_LIR_Nem_3	154	159	PF02991	0.358
LIG_LIR_Nem_3	177	182	PF02991	0.335
LIG_LIR_Nem_3	198	204	PF02991	0.419
LIG_LIR_Nem_3	214	219	PF02991	0.304
LIG_LIR_Nem_3	308	312	PF02991	0.750
LIG_LIR_Nem_3	517	523	PF02991	0.736
LIG_LIR_Nem_3	88	92	PF02991	0.281
LIG_LIR_Nem_3	99	104	PF02991	0.322
LIG_LYPXL_yS_3	309	312	PF13949	0.751
LIG_LYPXL_yS_3	7	10	PF13949	0.381
LIG_Pex14_2	11	15	PF04695	0.372
LIG_Pex14_2	166	170	PF04695	0.322
LIG_Pex14_2	175	179	PF04695	0.322
LIG_SH2_CRK	117	121	PF00017	0.647
LIG_SH2_CRK	216	220	PF00017	0.281
LIG_SH2_CRK	520	524	PF00017	0.745
LIG_SH2_CRK	89	93	PF00017	0.284
LIG_SH2_NCK_1	520	524	PF00017	0.772
LIG_SH2_STAP1	124	128	PF00017	0.419
LIG_SH2_STAT5	149	152	PF00017	0.425
LIG_SH2_STAT5	231	234	PF00017	0.348
LIG_SH2_STAT5	236	239	PF00017	0.364
LIG_SH2_STAT5	240	243	PF00017	0.447
LIG_SH2_STAT5	247	250	PF00017	0.648
LIG_SH2_STAT5	520	523	PF00017	0.774
LIG_SH2_STAT5	71	74	PF00017	0.333
LIG_SH3_1	529	535	PF00018	0.706
LIG_SH3_3	162	168	PF00018	0.331
LIG_SH3_3	18	24	PF00018	0.422
LIG_SH3_3	304	310	PF00018	0.799
LIG_SH3_3	377	383	PF00018	0.700
LIG_SH3_3	472	478	PF00018	0.746
LIG_SH3_3	529	535	PF00018	0.785
LIG_SH3_4	454	461	PF00018	0.684
LIG_SUMO_SIM_anti_2	103	108	PF11976	0.315
LIG_SUMO_SIM_anti_2	137	143	PF11976	0.419
LIG_SUMO_SIM_anti_2	17	22	PF11976	0.400
LIG_SUMO_SIM_par_1	103	108	PF11976	0.315
LIG_SUMO_SIM_par_1	218	223	PF11976	0.322
LIG_TRAF2_1	128	131	PF00917	0.419
LIG_TRAF2_1	273	276	PF00917	0.642
LIG_TRAF2_1	501	504	PF00917	0.728
LIG_TYR_ITIM	181	186	PF00017	0.488
LIG_TYR_ITIM	307	312	PF00017	0.749
LIG_TYR_ITIM	87	92	PF00017	0.427
LIG_TYR_ITSM	212	219	PF00017	0.390
LIG_WRC_WIRS_1	172	177	PF05994	0.419
LIG_WRC_WIRS_1	98	103	PF05994	0.419
MOD_CDK_SPxxK_3	315	322	PF00069	0.722
MOD_CDK_SPxxK_3	354	361	PF00069	0.780
MOD_CDK_SPxxK_3	436	443	PF00069	0.677
MOD_CK1_1	108	114	PF00069	0.471
MOD_CK1_1	205	211	PF00069	0.598
MOD_CK1_1	308	314	PF00069	0.766
MOD_CK1_1	364	370	PF00069	0.780
MOD_CK1_1	522	528	PF00069	0.714
MOD_CK1_1	536	542	PF00069	0.750
MOD_CK1_1	551	557	PF00069	0.746
MOD_CK2_1	422	428	PF00069	0.837
MOD_CK2_1	432	438	PF00069	0.695
MOD_CK2_1	498	504	PF00069	0.746
MOD_CK2_1	552	558	PF00069	0.792
MOD_Cter_Amidation	58	61	PF01082	0.560
MOD_GlcNHglycan	107	110	PF01048	0.343
MOD_GlcNHglycan	192	195	PF01048	0.497
MOD_GlcNHglycan	232	235	PF01048	0.419
MOD_GlcNHglycan	395	398	PF01048	0.634
MOD_GlcNHglycan	399	403	PF01048	0.481
MOD_GlcNHglycan	419	422	PF01048	0.607
MOD_GlcNHglycan	550	553	PF01048	0.552
MOD_GlcNHglycan	79	82	PF01048	0.499
MOD_GSK3_1	10	17	PF00069	0.439
MOD_GSK3_1	145	152	PF00069	0.365
MOD_GSK3_1	190	197	PF00069	0.550
MOD_GSK3_1	313	320	PF00069	0.667
MOD_GSK3_1	359	366	PF00069	0.745
MOD_GSK3_1	398	405	PF00069	0.720
MOD_GSK3_1	413	420	PF00069	0.814
MOD_GSK3_1	428	435	PF00069	0.656
MOD_GSK3_1	45	52	PF00069	0.395
MOD_GSK3_1	462	469	PF00069	0.763
MOD_GSK3_1	494	501	PF00069	0.801
MOD_GSK3_1	518	525	PF00069	0.716
MOD_GSK3_1	548	555	PF00069	0.806
MOD_LATS_1	337	343	PF00433	0.741
MOD_LATS_1	49	55	PF00433	0.368
MOD_N-GLC_1	339	344	PF02516	0.482
MOD_N-GLC_1	364	369	PF02516	0.517
MOD_NEK2_1	10	15	PF00069	0.402
MOD_NEK2_1	16	21	PF00069	0.390
MOD_NEK2_1	171	176	PF00069	0.428
MOD_NEK2_1	264	269	PF00069	0.649
MOD_NEK2_1	363	368	PF00069	0.802
MOD_NEK2_1	45	50	PF00069	0.394
MOD_NEK2_1	496	501	PF00069	0.817
MOD_NEK2_1	85	90	PF00069	0.370
MOD_NEK2_1	96	101	PF00069	0.322
MOD_PIKK_1	29	35	PF00454	0.361
MOD_PIKK_1	413	419	PF00454	0.775
MOD_PIKK_1	522	528	PF00454	0.781
MOD_PKA_1	494	500	PF00069	0.706
MOD_PKA_2	189	195	PF00069	0.486
MOD_PKA_2	205	211	PF00069	0.536
MOD_PKA_2	494	500	PF00069	0.818
MOD_PKB_1	260	268	PF00069	0.633
MOD_Plk_1	359	365	PF00069	0.752
MOD_Plk_4	10	16	PF00069	0.398
MOD_Plk_4	129	135	PF00069	0.381
MOD_Plk_4	145	151	PF00069	0.425
MOD_Plk_4	158	164	PF00069	0.252
MOD_Plk_4	267	273	PF00069	0.552
MOD_Plk_4	479	485	PF00069	0.780
MOD_Plk_4	91	97	PF00069	0.389
MOD_ProDKin_1	164	170	PF00069	0.419
MOD_ProDKin_1	315	321	PF00069	0.664
MOD_ProDKin_1	354	360	PF00069	0.786
MOD_ProDKin_1	423	429	PF00069	0.731
MOD_ProDKin_1	436	442	PF00069	0.675
MOD_ProDKin_1	471	477	PF00069	0.764
MOD_ProDKin_1	498	504	PF00069	0.746
MOD_ProDKin_1	528	534	PF00069	0.735
TRG_DiLeu_BaEn_4	503	509	PF01217	0.734
TRG_ENDOCYTIC_2	117	120	PF00928	0.607
TRG_ENDOCYTIC_2	124	127	PF00928	0.287
TRG_ENDOCYTIC_2	183	186	PF00928	0.532
TRG_ENDOCYTIC_2	216	219	PF00928	0.358
TRG_ENDOCYTIC_2	309	312	PF00928	0.751
TRG_ENDOCYTIC_2	520	523	PF00928	0.748
TRG_ENDOCYTIC_2	7	10	PF00928	0.381
TRG_ENDOCYTIC_2	89	92	PF00928	0.284
TRG_ER_diArg_1	115	117	PF00400	0.698
TRG_ER_diArg_1	252	254	PF00400	0.589
TRG_ER_diArg_1	260	262	PF00400	0.592
TRG_ER_diArg_1	328	331	PF00400	0.631
TRG_ER_diArg_1	386	389	PF00400	0.818
TRG_ER_diArg_1	494	496	PF00400	0.715
TRG_ER_diArg_1	506	508	PF00400	0.673
TRG_ER_diArg_1	58	61	PF00400	0.378
TRG_ER_diArg_1	72	74	PF00400	0.371
TRG_NES_CRM1_1	131	144	PF08389	0.419
TRG_Pf-PMV_PEXEL_1	506	510	PF00026	0.535
TRG_Pf-PMV_PEXEL_1	528	533	PF00026	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8E2	Leptomonas seymouri	37%	88%
A0A3S7WX94	Leishmania donovani	88%	100%
A4HZY9	Leishmania infantum	88%	100%
E9AVV0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	71%	100%