Gamma-glutamylcyclotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ChaC-like protein, putative

Species:

Leishmania major

UniProt:

Q4QBM8_LEIMA

TriTrypDb:

LmjF.22.1190 , LMJLV39_220017400 , LMJSD75_220017600

Length:

237

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 13
NetGPI	no	yes: 0, no: 13

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4QBM8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBM8

Function

Biological processes
Term	Name	Level	Count
GO:0006518	peptide metabolic process	4	14
GO:0006575	cellular modified amino acid metabolic process	3	14
GO:0006749	glutathione metabolic process	4	14
GO:0006751	glutathione catabolic process	5	14
GO:0006790	sulfur compound metabolic process	3	14
GO:0006807	nitrogen compound metabolic process	2	14
GO:0008152	metabolic process	1	14
GO:0009056	catabolic process	2	14
GO:0009987	cellular process	1	14
GO:0042219	cellular modified amino acid catabolic process	4	14
GO:0043171	peptide catabolic process	4	14
GO:0043603	amide metabolic process	3	14
GO:0044237	cellular metabolic process	2	14
GO:0044248	cellular catabolic process	3	14
GO:0044273	sulfur compound catabolic process	4	14
GO:0071704	organic substance metabolic process	2	14
GO:1901564	organonitrogen compound metabolic process	3	14
GO:1901565	organonitrogen compound catabolic process	4	14
GO:1901575	organic substance catabolic process	3	14

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0003839	gamma-glutamylcyclotransferase activity	5	14
GO:0016829	lyase activity	2	14
GO:0016840	carbon-nitrogen lyase activity	3	14
GO:0016842	amidine-lyase activity	4	14
GO:0061928	glutathione specific gamma-glutamylcyclotransferase activity	5	14

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	56	58	PF00082	0.267
CLV_PCSK_PC1ET2_1	56	58	PF00082	0.300
CLV_PCSK_SKI1_1	180	184	PF00082	0.288
CLV_PCSK_SKI1_1	56	60	PF00082	0.258
CLV_PCSK_SKI1_1	75	79	PF00082	0.258
DEG_APCC_DBOX_1	192	200	PF00400	0.534
DOC_MAPK_gen_1	102	112	PF00069	0.518
DOC_PP4_FxxP_1	18	21	PF00568	0.540
DOC_USP7_MATH_1	128	132	PF00917	0.432
DOC_WW_Pin1_4	147	152	PF00397	0.423
LIG_14-3-3_CanoR_1	10	18	PF00244	0.463
LIG_14-3-3_CanoR_1	180	188	PF00244	0.570
LIG_14-3-3_CanoR_1	75	80	PF00244	0.458
LIG_BIR_II_1	1	5	PF00653	0.588
LIG_BIR_III_2	127	131	PF00653	0.432
LIG_FHA_2	122	128	PF00498	0.451
LIG_FHA_2	132	138	PF00498	0.463
LIG_LIR_Apic_2	16	21	PF02991	0.560
LIG_LIR_Apic_2	168	172	PF02991	0.491
LIG_LIR_Gen_1	119	130	PF02991	0.531
LIG_LIR_Gen_1	25	36	PF02991	0.470
LIG_LIR_Nem_3	119	125	PF02991	0.531
LIG_LIR_Nem_3	25	31	PF02991	0.536
LIG_LIR_Nem_3	45	51	PF02991	0.337
LIG_Pex14_1	38	42	PF04695	0.458
LIG_SH2_CRK	33	37	PF00017	0.458
LIG_SH2_CRK	55	59	PF00017	0.458
LIG_SH2_CRK	94	98	PF00017	0.527
LIG_SH2_STAP1	118	122	PF00017	0.432
LIG_SH2_STAP1	48	52	PF00017	0.506
LIG_SH2_STAT3	14	17	PF00017	0.630
LIG_SH2_STAT5	169	172	PF00017	0.445
LIG_SH2_STAT5	195	198	PF00017	0.458
LIG_SH2_STAT5	51	54	PF00017	0.501
LIG_SH3_1	67	73	PF00018	0.476
LIG_SH3_1	94	100	PF00018	0.491
LIG_SH3_2	70	75	PF14604	0.476
LIG_SH3_2	97	102	PF14604	0.534
LIG_SH3_3	222	228	PF00018	0.359
LIG_SH3_3	67	73	PF00018	0.458
LIG_SH3_3	94	100	PF00018	0.500
LIG_UBA3_1	106	115	PF00899	0.432
LIG_WRC_WIRS_1	20	25	PF05994	0.538
MOD_CDK_SPxK_1	147	153	PF00069	0.423
MOD_CK1_1	131	137	PF00069	0.395
MOD_CK1_1	2	8	PF00069	0.578
MOD_CK2_1	131	137	PF00069	0.522
MOD_GlcNHglycan	188	191	PF01048	0.258
MOD_GSK3_1	182	189	PF00069	0.444
MOD_GSK3_1	2	9	PF00069	0.634
MOD_GSK3_1	75	82	PF00069	0.476
MOD_N-GLC_1	160	165	PF02516	0.232
MOD_NEK2_1	121	126	PF00069	0.432
MOD_NEK2_1	183	188	PF00069	0.492
MOD_PKA_2	9	15	PF00069	0.581
MOD_Plk_4	121	127	PF00069	0.480
MOD_Plk_4	32	38	PF00069	0.464
MOD_Plk_4	75	81	PF00069	0.458
MOD_ProDKin_1	147	153	PF00069	0.423
MOD_SUMO_rev_2	233	237	PF00179	0.422
TRG_ENDOCYTIC_2	118	121	PF00928	0.476
TRG_ENDOCYTIC_2	33	36	PF00928	0.458
TRG_ENDOCYTIC_2	55	58	PF00928	0.458
TRG_NES_CRM1_1	101	114	PF08389	0.525
TRG_NES_CRM1_1	215	226	PF08389	0.480
TRG_Pf-PMV_PEXEL_1	201	205	PF00026	0.297
TRG_Pf-PMV_PEXEL_1	221	226	PF00026	0.216

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P815	Leptomonas seymouri	56%	87%
A0A1X0NTG7	Trypanosomatidae	51%	100%
A0A3Q8ILN3	Leishmania donovani	95%	100%
A0A3R7NMW8	Trypanosoma rangeli	51%	100%
A0A3S5H7B1	Leishmania donovani	64%	85%
A4HCF7	Leishmania braziliensis	61%	85%
A4HZZ0	Leishmania infantum	95%	100%
A4HZZ1	Leishmania infantum	62%	73%
B3STU3	Rattus norvegicus	38%	100%
C9ZSN1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9AVV1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
E9AVV2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	73%
P32656	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
P87305	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	33%	100%
Q0IIH4	Bos taurus	37%	100%
Q4KMJ1	Danio rerio	43%	100%
Q4QBM7	Leishmania major	62%	100%
Q5PPV4	Xenopus laevis	45%	100%
Q5SPB6	Danio rerio	36%	100%
Q5ZI66	Gallus gallus	41%	100%
Q641Z5	Rattus norvegicus	42%	100%
Q84MC1	Arabidopsis thaliana	38%	100%
Q84QC1	Arabidopsis thaliana	40%	100%
Q8GY54	Arabidopsis thaliana	36%	100%
Q8R3J5	Mus musculus	38%	100%
Q8WUX2	Homo sapiens	42%	100%
Q9BUX1	Homo sapiens	37%	100%
Q9CQG1	Mus musculus	42%	100%