Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBM4_LEIMA

TriTrypDb:

LmjF.22.1230 , LMJLV39_220017800 , LMJSD75_220018000

Length:

932

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QBM4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBM4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	268	272	PF00656	0.672
CLV_C14_Caspase3-7	373	377	PF00656	0.499
CLV_C14_Caspase3-7	72	76	PF00656	0.711
CLV_C14_Caspase3-7	833	837	PF00656	0.534
CLV_NRD_NRD_1	153	155	PF00675	0.612
CLV_NRD_NRD_1	25	27	PF00675	0.671
CLV_NRD_NRD_1	303	305	PF00675	0.661
CLV_NRD_NRD_1	502	504	PF00675	0.389
CLV_NRD_NRD_1	520	522	PF00675	0.369
CLV_NRD_NRD_1	611	613	PF00675	0.457
CLV_NRD_NRD_1	632	634	PF00675	0.393
CLV_NRD_NRD_1	809	811	PF00675	0.407
CLV_NRD_NRD_1	817	819	PF00675	0.576
CLV_PCSK_KEX2_1	153	155	PF00082	0.613
CLV_PCSK_KEX2_1	233	235	PF00082	0.636
CLV_PCSK_KEX2_1	25	27	PF00082	0.633
CLV_PCSK_KEX2_1	303	305	PF00082	0.606
CLV_PCSK_KEX2_1	364	366	PF00082	0.538
CLV_PCSK_KEX2_1	489	491	PF00082	0.454
CLV_PCSK_KEX2_1	502	504	PF00082	0.368
CLV_PCSK_KEX2_1	520	522	PF00082	0.369
CLV_PCSK_KEX2_1	611	613	PF00082	0.457
CLV_PCSK_KEX2_1	631	633	PF00082	0.252
CLV_PCSK_KEX2_1	817	819	PF00082	0.604
CLV_PCSK_PC1ET2_1	233	235	PF00082	0.636
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.538
CLV_PCSK_PC1ET2_1	489	491	PF00082	0.474
CLV_PCSK_PC7_1	360	366	PF00082	0.541
CLV_PCSK_SKI1_1	286	290	PF00082	0.668
CLV_PCSK_SKI1_1	360	364	PF00082	0.544
CLV_PCSK_SKI1_1	54	58	PF00082	0.574
CLV_PCSK_SKI1_1	572	576	PF00082	0.483
CLV_PCSK_SKI1_1	595	599	PF00082	0.539
CLV_PCSK_SKI1_1	657	661	PF00082	0.487
CLV_PCSK_SKI1_1	779	783	PF00082	0.404
CLV_PCSK_SKI1_1	785	789	PF00082	0.385
CLV_PCSK_SKI1_1	810	814	PF00082	0.448
CLV_PCSK_SKI1_1	91	95	PF00082	0.469
DEG_APCC_DBOX_1	152	160	PF00400	0.465
DEG_APCC_DBOX_1	359	367	PF00400	0.539
DEG_SCF_FBW7_1	259	266	PF00400	0.609
DEG_SPOP_SBC_1	126	130	PF00917	0.507
DEG_SPOP_SBC_1	28	32	PF00917	0.599
DEG_SPOP_SBC_1	336	340	PF00917	0.580
DOC_CKS1_1	260	265	PF01111	0.676
DOC_CKS1_1	33	38	PF01111	0.602
DOC_CKS1_1	354	359	PF01111	0.559
DOC_CYCLIN_yCln2_LP_2	601	607	PF00134	0.451
DOC_MAPK_DCC_7	29	39	PF00069	0.609
DOC_MAPK_FxFP_2	94	97	PF00069	0.460
DOC_MAPK_MEF2A_6	434	442	PF00069	0.499
DOC_MAPK_MEF2A_6	672	680	PF00069	0.340
DOC_PP1_RVXF_1	89	95	PF00149	0.460
DOC_PP2B_LxvP_1	132	135	PF13499	0.400
DOC_PP2B_LxvP_1	481	484	PF13499	0.412
DOC_PP4_FxxP_1	94	97	PF00568	0.452
DOC_USP7_MATH_1	193	197	PF00917	0.555
DOC_USP7_MATH_1	263	267	PF00917	0.569
DOC_USP7_MATH_1	388	392	PF00917	0.712
DOC_USP7_MATH_1	399	403	PF00917	0.580
DOC_USP7_MATH_1	715	719	PF00917	0.372
DOC_USP7_MATH_1	79	83	PF00917	0.534
DOC_USP7_MATH_1	892	896	PF00917	0.616
DOC_USP7_UBL2_3	137	141	PF12436	0.474
DOC_USP7_UBL2_3	927	931	PF12436	0.468
DOC_WW_Pin1_4	141	146	PF00397	0.506
DOC_WW_Pin1_4	240	245	PF00397	0.620
DOC_WW_Pin1_4	259	264	PF00397	0.542
DOC_WW_Pin1_4	32	37	PF00397	0.603
DOC_WW_Pin1_4	353	358	PF00397	0.570
DOC_WW_Pin1_4	426	431	PF00397	0.603
DOC_WW_Pin1_4	678	683	PF00397	0.405
DOC_WW_Pin1_4	734	739	PF00397	0.628
DOC_WW_Pin1_4	744	749	PF00397	0.415
DOC_WW_Pin1_4	772	777	PF00397	0.362
DOC_WW_Pin1_4	800	805	PF00397	0.445
LIG_14-3-3_CanoR_1	211	215	PF00244	0.462
LIG_14-3-3_CanoR_1	26	36	PF00244	0.614
LIG_14-3-3_CanoR_1	306	314	PF00244	0.599
LIG_14-3-3_CanoR_1	320	328	PF00244	0.566
LIG_14-3-3_CanoR_1	365	375	PF00244	0.621
LIG_14-3-3_CanoR_1	414	420	PF00244	0.522
LIG_14-3-3_CanoR_1	423	431	PF00244	0.472
LIG_14-3-3_CanoR_1	439	443	PF00244	0.597
LIG_14-3-3_CanoR_1	490	500	PF00244	0.417
LIG_14-3-3_CanoR_1	623	630	PF00244	0.382
LIG_14-3-3_CanoR_1	640	649	PF00244	0.374
LIG_Actin_WH2_2	506	522	PF00022	0.387
LIG_Actin_WH2_2	551	566	PF00022	0.531
LIG_APCC_ABBA_1	523	528	PF00400	0.411
LIG_BIR_III_2	198	202	PF00653	0.495
LIG_BIR_III_2	427	431	PF00653	0.550
LIG_CtBP_PxDLS_1	588	592	PF00389	0.395
LIG_eIF4E_1	624	630	PF01652	0.434
LIG_FHA_1	127	133	PF00498	0.482
LIG_FHA_1	28	34	PF00498	0.614
LIG_FHA_1	320	326	PF00498	0.458
LIG_FHA_1	514	520	PF00498	0.388
LIG_FHA_1	564	570	PF00498	0.505
LIG_FHA_1	573	579	PF00498	0.419
LIG_FHA_1	924	930	PF00498	0.488
LIG_FHA_2	145	151	PF00498	0.503
LIG_FHA_2	260	266	PF00498	0.737
LIG_FHA_2	458	464	PF00498	0.408
LIG_FHA_2	531	537	PF00498	0.510
LIG_FHA_2	681	687	PF00498	0.554
LIG_FHA_2	70	76	PF00498	0.687
LIG_FHA_2	82	88	PF00498	0.506
LIG_FHA_2	831	837	PF00498	0.613
LIG_FHA_2	864	870	PF00498	0.523
LIG_FHA_2	919	925	PF00498	0.401
LIG_IBAR_NPY_1	743	745	PF08397	0.402
LIG_LIR_Apic_2	584	588	PF02991	0.387
LIG_LIR_Apic_2	742	748	PF02991	0.469
LIG_LIR_Gen_1	128	139	PF02991	0.451
LIG_LIR_Gen_1	326	336	PF02991	0.535
LIG_LIR_Gen_1	418	424	PF02991	0.490
LIG_LIR_Gen_1	463	473	PF02991	0.367
LIG_LIR_Gen_1	535	546	PF02991	0.509
LIG_LIR_Gen_1	616	624	PF02991	0.423
LIG_LIR_Gen_1	674	682	PF02991	0.357
LIG_LIR_Gen_1	87	97	PF02991	0.473
LIG_LIR_Nem_3	130	136	PF02991	0.363
LIG_LIR_Nem_3	326	331	PF02991	0.510
LIG_LIR_Nem_3	418	422	PF02991	0.632
LIG_LIR_Nem_3	463	468	PF02991	0.360
LIG_LIR_Nem_3	535	541	PF02991	0.517
LIG_LIR_Nem_3	584	589	PF02991	0.389
LIG_LIR_Nem_3	616	620	PF02991	0.405
LIG_LIR_Nem_3	621	627	PF02991	0.451
LIG_LIR_Nem_3	674	680	PF02991	0.344
LIG_LIR_Nem_3	87	92	PF02991	0.478
LIG_LIR_Nem_3	902	907	PF02991	0.456
LIG_LYPXL_yS_3	398	401	PF13949	0.581
LIG_MYND_1	12	16	PF01753	0.593
LIG_Pex14_1	641	645	PF04695	0.378
LIG_Pex14_2	609	613	PF04695	0.435
LIG_Pex14_2	793	797	PF04695	0.394
LIG_Pex14_2	89	93	PF04695	0.454
LIG_SH2_CRK	133	137	PF00017	0.344
LIG_SH2_CRK	204	208	PF00017	0.529
LIG_SH2_CRK	328	332	PF00017	0.554
LIG_SH2_CRK	745	749	PF00017	0.467
LIG_SH2_NCK_1	624	628	PF00017	0.453
LIG_SH2_PTP2	470	473	PF00017	0.366
LIG_SH2_PTP2	675	678	PF00017	0.342
LIG_SH2_PTP2	757	760	PF00017	0.363
LIG_SH2_SRC	470	473	PF00017	0.366
LIG_SH2_SRC	675	678	PF00017	0.397
LIG_SH2_STAP1	321	325	PF00017	0.515
LIG_SH2_STAP1	424	428	PF00017	0.523
LIG_SH2_STAT5	321	324	PF00017	0.581
LIG_SH2_STAT5	361	364	PF00017	0.543
LIG_SH2_STAT5	470	473	PF00017	0.366
LIG_SH2_STAT5	507	510	PF00017	0.378
LIG_SH2_STAT5	585	588	PF00017	0.324
LIG_SH2_STAT5	596	599	PF00017	0.477
LIG_SH2_STAT5	675	678	PF00017	0.342
LIG_SH2_STAT5	757	760	PF00017	0.363
LIG_SH2_STAT5	769	772	PF00017	0.394
LIG_SH2_STAT5	903	906	PF00017	0.455
LIG_SH3_1	714	720	PF00018	0.441
LIG_SH3_3	229	235	PF00018	0.632
LIG_SH3_3	253	259	PF00018	0.780
LIG_SH3_3	30	36	PF00018	0.610
LIG_SH3_3	313	319	PF00018	0.634
LIG_SH3_3	521	527	PF00018	0.395
LIG_SH3_3	559	565	PF00018	0.549
LIG_SH3_3	714	720	PF00018	0.441
LIG_SH3_3	778	784	PF00018	0.448
LIG_SH3_3	809	815	PF00018	0.627
LIG_SH3_3	880	886	PF00018	0.462
LIG_SUMO_SIM_anti_2	750	755	PF11976	0.358
LIG_SUMO_SIM_par_1	587	592	PF11976	0.389
LIG_SxIP_EBH_1	620	633	PF03271	0.436
LIG_TRAF2_1	533	536	PF00917	0.535
LIG_TRAF2_1	683	686	PF00917	0.457
LIG_TRAF2_1	85	88	PF00917	0.482
LIG_TRAF2_1	866	869	PF00917	0.464
LIG_TYR_ITIM	468	473	PF00017	0.369
LIG_TYR_ITSM	324	331	PF00017	0.501
LIG_WRC_WIRS_1	606	611	PF05994	0.361
LIG_WW_3	26	30	PF00397	0.621
LIG_WW_3	429	433	PF00397	0.519
LIG_WW_3	782	786	PF00397	0.476
MOD_CDC14_SPxK_1	429	432	PF00782	0.574
MOD_CDK_SPK_2	744	749	PF00069	0.464
MOD_CDK_SPxK_1	32	38	PF00069	0.581
MOD_CDK_SPxK_1	426	432	PF00069	0.578
MOD_CDK_SPxxK_3	141	148	PF00069	0.500
MOD_CDK_SPxxK_3	353	360	PF00069	0.563
MOD_CDK_SPxxK_3	772	779	PF00069	0.363
MOD_CK1_1	125	131	PF00069	0.517
MOD_CK1_1	144	150	PF00069	0.388
MOD_CK1_1	17	23	PF00069	0.578
MOD_CK1_1	237	243	PF00069	0.736
MOD_CK1_1	254	260	PF00069	0.582
MOD_CK1_1	309	315	PF00069	0.604
MOD_CK1_1	6	12	PF00069	0.754
MOD_CK1_1	622	628	PF00069	0.450
MOD_CK1_1	82	88	PF00069	0.507
MOD_CK1_1	843	849	PF00069	0.573
MOD_CK2_1	225	231	PF00069	0.672
MOD_CK2_1	259	265	PF00069	0.641
MOD_CK2_1	274	280	PF00069	0.545
MOD_CK2_1	366	372	PF00069	0.615
MOD_CK2_1	530	536	PF00069	0.498
MOD_CK2_1	678	684	PF00069	0.377
MOD_CK2_1	744	750	PF00069	0.462
MOD_CK2_1	81	87	PF00069	0.505
MOD_CK2_1	863	869	PF00069	0.474
MOD_CK2_1	878	884	PF00069	0.395
MOD_CK2_1	918	924	PF00069	0.378
MOD_GlcNHglycan	124	127	PF01048	0.547
MOD_GlcNHglycan	244	247	PF01048	0.690
MOD_GlcNHglycan	253	256	PF01048	0.759
MOD_GlcNHglycan	308	311	PF01048	0.781
MOD_GlcNHglycan	339	342	PF01048	0.607
MOD_GlcNHglycan	388	391	PF01048	0.691
MOD_GlcNHglycan	453	456	PF01048	0.452
MOD_GlcNHglycan	637	640	PF01048	0.464
MOD_GlcNHglycan	77	80	PF01048	0.651
MOD_GlcNHglycan	81	84	PF01048	0.594
MOD_GlcNHglycan	845	848	PF01048	0.581
MOD_GlcNHglycan	880	883	PF01048	0.484
MOD_GSK3_1	115	122	PF00069	0.623
MOD_GSK3_1	14	21	PF00069	0.642
MOD_GSK3_1	259	266	PF00069	0.576
MOD_GSK3_1	28	35	PF00069	0.637
MOD_GSK3_1	319	326	PF00069	0.584
MOD_GSK3_1	335	342	PF00069	0.584
MOD_GSK3_1	366	373	PF00069	0.498
MOD_GSK3_1	380	387	PF00069	0.545
MOD_GSK3_1	422	429	PF00069	0.607
MOD_GSK3_1	453	460	PF00069	0.510
MOD_GSK3_1	618	625	PF00069	0.449
MOD_GSK3_1	66	73	PF00069	0.737
MOD_GSK3_1	75	82	PF00069	0.766
MOD_GSK3_1	919	926	PF00069	0.511
MOD_LATS_1	491	497	PF00433	0.410
MOD_N-GLC_1	513	518	PF02516	0.473
MOD_N-GLC_1	599	604	PF02516	0.428
MOD_NEK2_1	124	129	PF00069	0.489
MOD_NEK2_1	239	244	PF00069	0.799
MOD_NEK2_1	366	371	PF00069	0.592
MOD_NEK2_1	519	524	PF00069	0.401
MOD_NEK2_1	570	575	PF00069	0.468
MOD_NEK2_1	589	594	PF00069	0.550
MOD_NEK2_1	605	610	PF00069	0.448
MOD_NEK2_1	840	845	PF00069	0.587
MOD_NEK2_1	890	895	PF00069	0.444
MOD_NEK2_1	918	923	PF00069	0.387
MOD_NEK2_2	805	810	PF00069	0.483
MOD_NMyristoyl	1	7	PF02799	0.471
MOD_PIKK_1	191	197	PF00454	0.633
MOD_PIKK_1	234	240	PF00454	0.640
MOD_PKA_2	210	216	PF00069	0.458
MOD_PKA_2	28	34	PF00069	0.624
MOD_PKA_2	280	286	PF00069	0.448
MOD_PKA_2	319	325	PF00069	0.566
MOD_PKA_2	366	372	PF00069	0.482
MOD_PKA_2	409	415	PF00069	0.564
MOD_PKA_2	422	428	PF00069	0.569
MOD_PKA_2	438	444	PF00069	0.613
MOD_PKA_2	492	498	PF00069	0.469
MOD_PKA_2	519	525	PF00069	0.379
MOD_PKA_2	563	569	PF00069	0.555
MOD_PKA_2	622	628	PF00069	0.389
MOD_PKA_2	830	836	PF00069	0.609
MOD_PKA_2	918	924	PF00069	0.378
MOD_PKB_1	304	312	PF00069	0.589
MOD_PKB_1	365	373	PF00069	0.519
MOD_Plk_1	570	576	PF00069	0.469
MOD_Plk_1	731	737	PF00069	0.534
MOD_Plk_4	127	133	PF00069	0.541
MOD_Plk_4	280	286	PF00069	0.541
MOD_Plk_4	29	35	PF00069	0.616
MOD_Plk_4	370	376	PF00069	0.654
MOD_Plk_4	415	421	PF00069	0.548
MOD_Plk_4	453	459	PF00069	0.545
MOD_Plk_4	494	500	PF00069	0.461
MOD_Plk_4	549	555	PF00069	0.444
MOD_Plk_4	581	587	PF00069	0.438
MOD_Plk_4	605	611	PF00069	0.556
MOD_Plk_4	785	791	PF00069	0.378
MOD_ProDKin_1	141	147	PF00069	0.498
MOD_ProDKin_1	240	246	PF00069	0.620
MOD_ProDKin_1	259	265	PF00069	0.537
MOD_ProDKin_1	32	38	PF00069	0.604
MOD_ProDKin_1	353	359	PF00069	0.559
MOD_ProDKin_1	426	432	PF00069	0.606
MOD_ProDKin_1	678	684	PF00069	0.405
MOD_ProDKin_1	734	740	PF00069	0.619
MOD_ProDKin_1	744	750	PF00069	0.410
MOD_ProDKin_1	772	778	PF00069	0.359
MOD_ProDKin_1	800	806	PF00069	0.445
MOD_SUMO_rev_2	160	168	PF00179	0.389
MOD_SUMO_rev_2	228	235	PF00179	0.624
MOD_SUMO_rev_2	264	272	PF00179	0.615
TRG_DiLeu_BaEn_1	549	554	PF01217	0.475
TRG_DiLeu_BaEn_1	884	889	PF01217	0.391
TRG_DiLeu_BaLyEn_6	9	14	PF01217	0.594
TRG_ENDOCYTIC_2	133	136	PF00928	0.424
TRG_ENDOCYTIC_2	204	207	PF00928	0.550
TRG_ENDOCYTIC_2	321	324	PF00928	0.522
TRG_ENDOCYTIC_2	328	331	PF00928	0.457
TRG_ENDOCYTIC_2	398	401	PF00928	0.558
TRG_ENDOCYTIC_2	465	468	PF00928	0.363
TRG_ENDOCYTIC_2	470	473	PF00928	0.366
TRG_ENDOCYTIC_2	507	510	PF00928	0.355
TRG_ENDOCYTIC_2	624	627	PF00928	0.462
TRG_ENDOCYTIC_2	675	678	PF00928	0.342
TRG_ENDOCYTIC_2	691	694	PF00928	0.354
TRG_ER_diArg_1	152	154	PF00400	0.614
TRG_ER_diArg_1	25	27	PF00400	0.633
TRG_ER_diArg_1	365	368	PF00400	0.526
TRG_ER_diArg_1	501	503	PF00400	0.388
TRG_ER_diArg_1	519	521	PF00400	0.361
TRG_ER_diArg_1	610	612	PF00400	0.448
TRG_ER_diArg_1	630	633	PF00400	0.243
TRG_ER_diArg_1	816	818	PF00400	0.594
TRG_NLS_MonoExtN_4	485	492	PF00514	0.486
TRG_Pf-PMV_PEXEL_1	599	603	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	875	880	PF00026	0.471

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMB4	Leptomonas seymouri	48%	97%
A0A3S7WXE8	Leishmania donovani	93%	96%
A4HCG3	Leishmania braziliensis	80%	100%
A4HZZ4	Leishmania infantum	93%	96%
C9ZSN5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AVV5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%