Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QBM2_LEIMA

TriTrypDb:

LmjF.22.1250 , LMJLV39_220018000 , LMJSD75_220018200

Length:

452

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	7
GO:0032991	protein-containing complex	1	7
GO:0043226	organelle	2	7
GO:0043228	non-membrane-bounded organelle	3	7
GO:0043229	intracellular organelle	3	7
GO:0043232	intracellular non-membrane-bounded organelle	4	7
GO:0110165	cellular anatomical entity	1	7
GO:1990904	ribonucleoprotein complex	2	7

Expansion

Sequence features

Q4QBM2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QBM2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	282	286	PF00656	0.713
CLV_NRD_NRD_1	325	327	PF00675	0.772
CLV_NRD_NRD_1	94	96	PF00675	0.457
CLV_PCSK_KEX2_1	325	327	PF00082	0.772
CLV_PCSK_KEX2_1	94	96	PF00082	0.457
CLV_PCSK_SKI1_1	325	329	PF00082	0.694
CLV_PCSK_SKI1_1	384	388	PF00082	0.506
CLV_PCSK_SKI1_1	406	410	PF00082	0.412
CLV_PCSK_SKI1_1	424	428	PF00082	0.551
DEG_Nend_Nbox_1	1	3	PF02207	0.426
DEG_SCF_TRCP1_1	155	160	PF00400	0.493
DEG_SPOP_SBC_1	181	185	PF00917	0.410
DEG_SPOP_SBC_1	193	197	PF00917	0.468
DEG_SPOP_SBC_1	265	269	PF00917	0.622
DOC_CYCLIN_RxL_1	109	120	PF00134	0.437
DOC_CYCLIN_RxL_1	370	382	PF00134	0.417
DOC_CYCLIN_RxL_1	421	431	PF00134	0.433
DOC_PP1_RVXF_1	373	380	PF00149	0.395
DOC_PP2B_LxvP_1	114	117	PF13499	0.445
DOC_PP2B_LxvP_1	151	154	PF13499	0.425
DOC_PP2B_LxvP_1	252	255	PF13499	0.609
DOC_PP4_FxxP_1	238	241	PF00568	0.436
DOC_USP7_MATH_1	117	121	PF00917	0.615
DOC_USP7_MATH_1	207	211	PF00917	0.390
DOC_USP7_MATH_1	255	259	PF00917	0.716
DOC_USP7_MATH_1	265	269	PF00917	0.648
DOC_USP7_MATH_1	280	284	PF00917	0.638
DOC_USP7_MATH_1	287	291	PF00917	0.761
DOC_USP7_MATH_1	315	319	PF00917	0.683
DOC_USP7_MATH_1	342	346	PF00917	0.360
DOC_USP7_MATH_1	49	53	PF00917	0.600
DOC_WW_Pin1_4	16	21	PF00397	0.407
DOC_WW_Pin1_4	269	274	PF00397	0.635
DOC_WW_Pin1_4	418	423	PF00397	0.413
LIG_14-3-3_CanoR_1	180	190	PF00244	0.403
LIG_14-3-3_CanoR_1	209	214	PF00244	0.443
LIG_14-3-3_CanoR_1	230	236	PF00244	0.562
LIG_BRCT_BRCA1_1	14	18	PF00533	0.392
LIG_BRCT_BRCA1_1	289	293	PF00533	0.609
LIG_CSL_BTD_1	114	117	PF09270	0.426
LIG_DLG_GKlike_1	209	217	PF00625	0.530
LIG_FHA_1	181	187	PF00498	0.404
LIG_FHA_1	194	200	PF00498	0.436
LIG_FHA_1	37	43	PF00498	0.416
LIG_FHA_1	400	406	PF00498	0.451
LIG_FHA_1	443	449	PF00498	0.622
LIG_FHA_1	8	14	PF00498	0.420
LIG_FHA_2	183	189	PF00498	0.389
LIG_FHA_2	199	205	PF00498	0.387
LIG_FHA_2	22	28	PF00498	0.548
LIG_FHA_2	232	238	PF00498	0.559
LIG_FHA_2	32	38	PF00498	0.342
LIG_FHA_2	385	391	PF00498	0.382
LIG_FHA_2	427	433	PF00498	0.394
LIG_FHA_2	79	85	PF00498	0.492
LIG_LIR_Apic_2	236	241	PF02991	0.448
LIG_Pex14_1	439	443	PF04695	0.423
LIG_Pex14_2	349	353	PF04695	0.371
LIG_SH2_CRK	297	301	PF00017	0.626
LIG_SH2_SRC	147	150	PF00017	0.397
LIG_SH2_STAT5	147	150	PF00017	0.397
LIG_SH2_STAT5	373	376	PF00017	0.394
LIG_SH3_3	14	20	PF00018	0.361
LIG_SH3_3	187	193	PF00018	0.403
LIG_SH3_3	243	249	PF00018	0.440
LIG_SUMO_SIM_par_1	244	250	PF11976	0.490
LIG_SUMO_SIM_par_1	384	393	PF11976	0.388
MOD_CDC14_SPxK_1	421	424	PF00782	0.564
MOD_CDK_SPxK_1	418	424	PF00069	0.539
MOD_CK1_1	136	142	PF00069	0.420
MOD_CK1_1	182	188	PF00069	0.403
MOD_CK1_1	267	273	PF00069	0.807
MOD_CK1_1	389	395	PF00069	0.387
MOD_CK1_1	418	424	PF00069	0.421
MOD_CK2_1	153	159	PF00069	0.655
MOD_CK2_1	198	204	PF00069	0.385
MOD_CK2_1	21	27	PF00069	0.553
MOD_CK2_1	231	237	PF00069	0.565
MOD_CK2_1	390	396	PF00069	0.389
MOD_GlcNHglycan	103	106	PF01048	0.402
MOD_GlcNHglycan	130	133	PF01048	0.614
MOD_GlcNHglycan	138	141	PF01048	0.448
MOD_GlcNHglycan	155	158	PF01048	0.589
MOD_GlcNHglycan	159	162	PF01048	0.603
MOD_GlcNHglycan	249	252	PF01048	0.587
MOD_GlcNHglycan	281	285	PF01048	0.573
MOD_GlcNHglycan	317	320	PF01048	0.825
MOD_GlcNHglycan	34	37	PF01048	0.459
MOD_GlcNHglycan	417	420	PF01048	0.385
MOD_GSK3_1	12	19	PF00069	0.418
MOD_GSK3_1	123	130	PF00069	0.623
MOD_GSK3_1	153	160	PF00069	0.532
MOD_GSK3_1	194	201	PF00069	0.427
MOD_GSK3_1	265	272	PF00069	0.673
MOD_GSK3_1	3	10	PF00069	0.550
MOD_GSK3_1	310	317	PF00069	0.761
MOD_GSK3_1	32	39	PF00069	0.392
MOD_GSK3_1	386	393	PF00069	0.436
MOD_GSK3_1	414	421	PF00069	0.400
MOD_GSK3_1	71	78	PF00069	0.522
MOD_GSK3_1	80	87	PF00069	0.469
MOD_N-GLC_1	193	198	PF02516	0.368
MOD_N-GLC_1	220	225	PF02516	0.583
MOD_NEK2_1	179	184	PF00069	0.414
MOD_NEK2_1	219	224	PF00069	0.601
MOD_NEK2_1	30	35	PF00069	0.388
MOD_NEK2_1	414	419	PF00069	0.392
MOD_NEK2_1	426	431	PF00069	0.383
MOD_PIKK_1	49	55	PF00454	0.482
MOD_PKA_1	325	331	PF00069	0.674
MOD_PKA_2	123	129	PF00069	0.642
MOD_PKA_2	179	185	PF00069	0.411
MOD_PKA_2	325	331	PF00069	0.674
MOD_Plk_1	193	199	PF00069	0.397
MOD_Plk_1	220	226	PF00069	0.578
MOD_Plk_1	37	43	PF00069	0.452
MOD_Plk_1	390	396	PF00069	0.389
MOD_Plk_1	84	90	PF00069	0.492
MOD_Plk_4	12	18	PF00069	0.390
MOD_Plk_4	133	139	PF00069	0.376
MOD_Plk_4	194	200	PF00069	0.404
MOD_Plk_4	75	81	PF00069	0.576
MOD_ProDKin_1	16	22	PF00069	0.412
MOD_ProDKin_1	269	275	PF00069	0.635
MOD_ProDKin_1	418	424	PF00069	0.421
MOD_SUMO_rev_2	378	386	PF00179	0.543
TRG_DiLeu_BaLyEn_6	227	232	PF01217	0.502
TRG_ENDOCYTIC_2	297	300	PF00928	0.623
TRG_ER_diArg_1	324	326	PF00400	0.783
TRG_ER_diArg_1	93	95	PF00400	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM43	Leptomonas seymouri	68%	100%
A0A3S7WX82	Leishmania donovani	94%	100%
A4HCG2	Leishmania braziliensis	85%	100%
E9AGZ5	Leishmania infantum	94%	100%
E9AVV7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%